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Phil M. Oger

8
Documents
Identifiants chercheurs

Présentation

Education 2007 Habilitation (University of Lyon) 1995 PhD summa cum laude in Plant Pathology (Paris University X1- Orsay) 1991 MS Plant Pathology (Paris University X1- Orsay) 1991 Engineer degree in Agronomy (National Institute ofr Agronomy, Paris) Professional experience 2016-present CNRS Scientist, Head Adaptation to Extreme Environment group, UMR 5240, INSA Lyon 2000-2015 CNRS Scientist, Head Geomicrobiology group, Earth Sciences Laboratory, ENS Lyon 1999-2000 Post-Doctoral Investigator, Institut des Sciences du Végétal, CNRS, Gif-sur-Yvette 1996-1999 Post-Doctoral Investigator, University of Illinois, Urbana-Champaign (USA) Teaching 2014 - 2nd and 3rd year BS at INSA de Lyon and ENS de Lyon 2005 - 2014 4th year BS and MS level at ENS de Lyon and University of Lyon 1992 - 1995 1st year BS at University of Paris XI-Orsay Teaching 2014 - 2005 - 2014 1992 - 1995 CNRS Scientist, Head Adaptation to Extreme Environment group, UMR 5240, INSA Lyon CNRS Scientist, Head Geomicrobiology group, Earth Sciences Laboratory, ENS Lyon Post-Doctoral Investigator, Institut des Sciences du Végétal, CNRS, Gif-sur-Yvette Post-Doctoral Investigator, University of Illinois, Urbana-Champaign (USA) 2nd and 3rd year BS at INSA de Lyon and ENS de Lyon 4th year BS and MS level at ENS de Lyon and University of Lyon 1st year BS at University of Paris XI-Orsay Research interests Research in my group aims at deciphering from the atomic to the genetic level the behavior and adaptation of Archaea in response to environmental stresses. Our aim is to explore the limits of life in the deep-biosphere, with an emphasis on the adaptation to hydrostatic pressure, temperature and salinity variations in deep-sea hydrothermal vents. Over the years we have developped the two widely accepted hypethermophilic archaea, e.g. Thermococcus barophilus and Pyrococcus yayanosii, as genetic models for the study of high-hydrostatic pressure adaptation in deep-sea hydrothermal vents. Our approaches are multi- and trans-disciplinary since we aim at understanding the physics behind the physiologic adaptation of cells. To this avail we use techniques ranging from spectral physics (Xray and Neutron diffraction and diffusion) to meta-omics (RNASeq and Proteomics, in order to track the genetic imprint of these adaptations from the cell level to the molecule. This combination of approaches has led to two major scientific discoveries over the last two years. First, we have described the first atomistic model of of high hydrostatic pressure adaptation (Martinez Sci Rep 2016; Cario Sci Rep 2016) and described a novel membrane ultrstructure as a new adaptation strategy to high hydrostatic pressure and temperature in hyperthermohpiv Archaea (Cario Front Microbiol 2105).
Education 2007 Habilitation à Diriger des Recherches de l'Université Claude Bernard Lyon 1 1995 PhD summa cum laude en Phytopathologie (Université Paris X1-Orsay) 1991 DEA en Phytopathologie (Université Paris X1-Orsay/INAP-G) 1991 Ingénieur agronome (Institut National Agronomique Paris-Grignon) Expérience professionelle 2016-present DR CNRS, Adaptation aux Milieux Extrêmes, UMR 5240, INSA Lyon 2000-2015 CR puis DR CNRS, Géomicrobiology, Lab. de Géologie de Lyon, ENS de Lyon 1999-2000 Post-Doc, Institut des Sciences du Végétal, CNRS, Gif-sur-Yvette 1996-1999 Post-Doc, University of Illinois, Urbana-Champaign (USA) Enseignement 2014 - auj. 2005 - 2014 1992 - 1995

Publications

757395
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Molecular Rearrangements in Protomembrane Models Probed by Laurdan Fluorescence

Loreto Misuraca , Roland Winter , Bruno Demé , Philippe M Oger , Judith Peters
Membranes, 2023, 13 (4), pp.386. ⟨10.3390/membranes13040386⟩
Article dans une revue hal-04297292v1
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Alkanes as Membrane Regulators of the Response of Early Membranes to Extreme Temperatures

Loreto Misuraca , Antonino Caliò , Josephine Loricco , Ingo Hoffmann , Roland Winter
Life, 2022, 12 (3), pp.445. ⟨10.3390/life12030445⟩
Article dans une revue hal-03930744v1
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Characterisation of a synthetic Archeal membrane reveals a possible new adaptation route to extreme conditions

Marta Salvador-Castell , Maksym Golub , Nelli Erwin , Bruno Demé , Nicholas J Brooks
Communications Biology, 2021, 4, ⟨10.1038/s42003-021-02178-y⟩
Article dans une revue hal-03272003v1
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Alkanes increase the stability of early life membrane models under extreme pressure and temperature conditions

Loreto Misuraca , Bruno Demé , Philippe Oger , Judith Peters
Communications Chemistry, 2021, ⟨10.1038/s42004-021-00467-5⟩
Article dans une revue hal-03154757v1
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Apolar Polyisoprenoids Located in the Midplane of the Bilayer Regulate the Response of an Archaeal-like Membrane to High Temperature and Pressure

Josephine G Loricco , Marta Salvador-Castell , Bruno Demé , Judith Peters , Philippe Oger
Frontiers in Chemistry, 2020
Article dans une revue hal-02987030v1
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Lipid phase separation induced by the apolar polyisoprenoid squalane demonstrates its role in membrane domain formation in archaeal membranes

Marta Salvador-Castell , Bruno Demé , Phil Oger , Judith Peters
Langmuir, 2020, 36 (26), pp.7375-7382. ⟨10.1021/acs.langmuir.0c00901⟩
Article dans une revue hal-02862864v1
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Apolar Polyisoprenoids Located in the Midplane of the Bilayer Regulate the Response of an Archaeal-Like Membrane to High Temperature and Pressure

Josephine G Loricco , Marta Salvador-Castell , Bruno Demé , Judith Peters , Philippe Oger
Frontiers in Chemistry, 2020, 8, ⟨10.3389/fchem.2020.594039⟩
Article dans une revue hal-03000614v1
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High-Temperature Behavior of Early Life Membrane Models

Loreto Misuraca , Antonino Caliò , Isabelle Grillo , Axelle Grélard , Philippe Marie Oger
Article dans une revue hal-02988681v1