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Phil M. Oger

9
Documents
Identifiants chercheurs

Présentation

Education 2007 Habilitation (University of Lyon) 1995 PhD summa cum laude in Plant Pathology (Paris University X1- Orsay) 1991 MS Plant Pathology (Paris University X1- Orsay) 1991 Engineer degree in Agronomy (National Institute ofr Agronomy, Paris) Professional experience 2016-present CNRS Scientist, Head Adaptation to Extreme Environment group, UMR 5240, INSA Lyon 2000-2015 CNRS Scientist, Head Geomicrobiology group, Earth Sciences Laboratory, ENS Lyon 1999-2000 Post-Doctoral Investigator, Institut des Sciences du Végétal, CNRS, Gif-sur-Yvette 1996-1999 Post-Doctoral Investigator, University of Illinois, Urbana-Champaign (USA) Teaching 2014 - 2nd and 3rd year BS at INSA de Lyon and ENS de Lyon 2005 - 2014 4th year BS and MS level at ENS de Lyon and University of Lyon 1992 - 1995 1st year BS at University of Paris XI-Orsay Teaching 2014 - 2005 - 2014 1992 - 1995 CNRS Scientist, Head Adaptation to Extreme Environment group, UMR 5240, INSA Lyon CNRS Scientist, Head Geomicrobiology group, Earth Sciences Laboratory, ENS Lyon Post-Doctoral Investigator, Institut des Sciences du Végétal, CNRS, Gif-sur-Yvette Post-Doctoral Investigator, University of Illinois, Urbana-Champaign (USA) 2nd and 3rd year BS at INSA de Lyon and ENS de Lyon 4th year BS and MS level at ENS de Lyon and University of Lyon 1st year BS at University of Paris XI-Orsay Research interests Research in my group aims at deciphering from the atomic to the genetic level the behavior and adaptation of Archaea in response to environmental stresses. Our aim is to explore the limits of life in the deep-biosphere, with an emphasis on the adaptation to hydrostatic pressure, temperature and salinity variations in deep-sea hydrothermal vents. Over the years we have developped the two widely accepted hypethermophilic archaea, e.g. Thermococcus barophilus and Pyrococcus yayanosii, as genetic models for the study of high-hydrostatic pressure adaptation in deep-sea hydrothermal vents. Our approaches are multi- and trans-disciplinary since we aim at understanding the physics behind the physiologic adaptation of cells. To this avail we use techniques ranging from spectral physics (Xray and Neutron diffraction and diffusion) to meta-omics (RNASeq and Proteomics, in order to track the genetic imprint of these adaptations from the cell level to the molecule. This combination of approaches has led to two major scientific discoveries over the last two years. First, we have described the first atomistic model of of high hydrostatic pressure adaptation (Martinez Sci Rep 2016; Cario Sci Rep 2016) and described a novel membrane ultrstructure as a new adaptation strategy to high hydrostatic pressure and temperature in hyperthermohpiv Archaea (Cario Front Microbiol 2105).
Education 2007 Habilitation à Diriger des Recherches de l'Université Claude Bernard Lyon 1 1995 PhD summa cum laude en Phytopathologie (Université Paris X1-Orsay) 1991 DEA en Phytopathologie (Université Paris X1-Orsay/INAP-G) 1991 Ingénieur agronome (Institut National Agronomique Paris-Grignon) Expérience professionelle 2016-present DR CNRS, Adaptation aux Milieux Extrêmes, UMR 5240, INSA Lyon 2000-2015 CR puis DR CNRS, Géomicrobiology, Lab. de Géologie de Lyon, ENS de Lyon 1999-2000 Post-Doc, Institut des Sciences du Végétal, CNRS, Gif-sur-Yvette 1996-1999 Post-Doc, University of Illinois, Urbana-Champaign (USA) Enseignement 2014 - auj. 2005 - 2014 1992 - 1995

Publications

anais-cario
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Novel intact polar and core lipid compositions in the Pyrococcus model species, P. furiosus and P. yayanosii, reveal the largest lipid diversity amongst Thermococcales

Maxime Tourte , Vanessa Kuentz , Philippe Schaeffer , Vincent Grossi , Anaïs Cario
Biomolecules, 2020, 10 (6), pp.830. ⟨10.3390/biom10060830⟩
Article dans une revue hal-02861881v1
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High protein flexibility and reduced hydration water dynamics are key pressure adaptive strategies in prokaryotes

Nicolas Martinez , G. Michoud , A. Cario , J. Ollivier , Bruno Franzetti
Scientific Reports, 2016, 6, ⟨10.1038/srep32816⟩
Article dans une revue hal-01427793v1
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Molecular chaperone accumulation as a function of stress evidences adaptation to high hydrostatic pressure in the piezophilic archaeon Thermococcus barophilus

A. Cario , M. Jebbar , A. Thiel , N. Kervarec , P. M. Oger
Scientific Reports, 2016, 6, pp.29483. ⟨10.1038/srep29483⟩
Article dans une revue hal-02001331v1

Restoration of the di-myo-inositol-phosphate pathway in the piezo-hyperthermophilic archaeon Thermococcus barophilus

Anaïs Cario , Alex Mizgier , Axel Thiel , Mohamed Jebbar , Phil M. Oger
Biochimie, 2015, 118, pp.286-293. ⟨10.1016/j.biochi.2015.05.011⟩
Article dans une revue hal-02122725v1
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Membrane homeoviscous adaptation in the piezo-hyperthermophilic archaeon Thermococcus barophilus

Anaïs Cario , Vincent Grossi , Philippe Schaeffer , Philippe M. Oger
Frontiers in Microbiology, 2015, 6, pp.1152. ⟨10.3389/fmicb.2015.01152⟩
Article dans une revue hal-01366758v1

High hydrostatic pressure increases amino acid requirements in the piezo-hyperthermophilic archaeon Thermococcus barophilus

Anaïs Cario , Florence Lormières , Xiao Xiang , Phil M. Oger
Research in Microbiology, 2015, 166 (9), pp.710-716. ⟨10.1016/j.resmic.2015.07.004⟩
Article dans une revue hal-02122717v1

La vie sous pression des microorganismes piézophiles

Phil M. Oger , Anaïs Cario
Biologie Aujourd'hui, 2014, 208 (3), pp.193-206. ⟨10.1051/jbio/2014023⟩
Article dans une revue hal-02122751v1
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Deep sea microbes probed by incoherent neutron scattering under high hydrostatic pressure.

Judith Peters , Nicolas Martinez , Grégoire Michoud , Anaïs Cario , Bruno Franzetti
Zeitschrift für Physikalische Chemie, 2014, 228, 10-12, pp.1121-1133. ⟨10.1515/zpch-2014-0547⟩
Article dans une revue hal-01149032v1

Adaptation of the membrane in Archaea

Anaïs Cario , Phil M. Oger
Biophysical Chemistry, 2013, 183, pp.42-56. ⟨10.1016/j.bpc.2013.06.020⟩
Article dans une revue hal-02122759v1