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Mounir TAREK


Mounir Tarek
CNRS section 13, DR1
Senior Research Director


Laboratoire de Physique et Chimie Théoriques
UMR 7019 LPCT Université de Lorraine, 
Boulevard des Aiguillettes, BP 70239 
54506 Vandoeuvre-lès-Nancy, cedex France
tel: +33 (0) 3-72-74-52 74

RESEARCH INTERESTSimulation of model membranes and membrane bound species is in biophysics a frontier area of research seething with excitements and challenges. The availability of all the ingredients to investigate membranes, in-silico, opens new perspectives particularly in the biological front. The aim of my research is to take computer simulations to an extra level, where manipulation of molecular nano-objects in-silico, by reproducing realistic mechanisms, sheds light onto challenging multidisciplinary problems. TOPICS • Electroporation of cell membranes (drug and gene delivery, electroshock healing, antibacterial treatment).... • Transport through voltage-gated potassium ion channels (ion conduction and selectivity, regulation, mutations, chanellopathies) • Action of synthetic peptides on membranes (antibacterial action) • Interaction of carbon nanostructures with membranes and membrane proteins. • Membrane Oxidation, Mecanisms. • Development of Coarse grained force fields for biomolecular simulation
   

 

 


Francois Dehez   

Journal articles1 document

  • Daniel Bonhenry, Francois Dehez, Mounir Tarek. Effects of hydration on the protonation state of a lysine analog crossing a phospholipid bilayer – insights from molecular dynamics and free-energy calculations. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2018, 20 (14), pp.9101-9107. ⟨10.1039/C8CP00312B⟩. ⟨hal-02336378⟩