Skip to Main content


Number of documents


Mounir TAREK

Mounir Tarek
CNRS section 13, DR1
Senior Research Director

Laboratoire de Physique et Chimie Théoriques
UMR 7019 LPCT Université de Lorraine, 
Boulevard des Aiguillettes, BP 70239 
54506 Vandoeuvre-lès-Nancy, cedex France
tel: +33 (0) 3-72-74-52 74

RESEARCH INTERESTSimulation of model membranes and membrane bound species is in biophysics a frontier area of research seething with excitements and challenges. The availability of all the ingredients to investigate membranes, in-silico, opens new perspectives particularly in the biological front. The aim of my research is to take computer simulations to an extra level, where manipulation of molecular nano-objects in-silico, by reproducing realistic mechanisms, sheds light onto challenging multidisciplinary problems. TOPICS • Electroporation of cell membranes (drug and gene delivery, electroshock healing, antibacterial treatment).... • Transport through voltage-gated potassium ion channels (ion conduction and selectivity, regulation, mutations, chanellopathies) • Action of synthetic peptides on membranes (antibacterial action) • Interaction of carbon nanostructures with membranes and membrane proteins. • Membrane Oxidation, Mecanisms. • Development of Coarse grained force fields for biomolecular simulation



Journal articles20 documents

  • Wojciech Szlasa, Anna Szewczyk, Małgorzata Drąg-Zalesińska, Hanna Czapor-Irzabek, Olga Michel, et al.. Mechanisms of curcumin-based photodynamic therapy and its effects in combination with electroporation: An in vitro and molecular dynamics study. Bioelectrochemistry, Elsevier, 2021, 140, pp.107806. ⟨10.1016/j.bioelechem.2021.107806⟩. ⟨hal-03453861⟩
  • Gildas Loussouarn, Mounir Tarek. Editorial: Molecular Mechanisms of Voltage-Gating in Ion Channels. Frontiers in Pharmacology, Frontiers, 2021, 12, ⟨10.3389/fphar.2021.768153⟩. ⟨hal-03348830⟩
  • Daniel Wiczew, Natalia Szulc, Mounir Tarek. Molecular dynamics simulations of the effects of lipid oxidation on the permeability of cell membranes. Bioelectrochemistry, Elsevier, 2021, 141, pp.107869. ⟨10.1016/j.bioelechem.2021.107869⟩. ⟨hal-03453851⟩
  • Wojciech Szlasa, Aleksander Kiełbik, Anna Szewczyk, Vitalij Novickij, Mounir Tarek, et al.. Atorvastatin Modulates the Efficacy of Electroporation and Calcium Electrochemotherapy. International Journal of Molecular Sciences, MDPI, 2021, 22 (20), pp.11245. ⟨10.3390/ijms222011245⟩. ⟨hal-03453867⟩
  • Aleksander Kiełbik, Wojciech Szlasa, Olga Michel, Anna Szewczyk, Mounir Tarek, et al.. In Vitro Study of Calcium Microsecond Electroporation of Prostate Adenocarcinoma Cells. Molecules, MDPI, 2020, 25 (22), pp.5406. ⟨10.3390/molecules25225406⟩. ⟨hal-03096075⟩
  • Jean-Michel Escoffre, Pablo Campomanes, Mounir Tarek, Ayache Bouakaz. New insights on the role of ROS in the mechanisms of sonoporation-mediated gene delivery. Ultrasonics Sonochemistry, Elsevier, 2020, 64, pp.104998. ⟨10.1016/j.ultsonch.2020.104998⟩. ⟨inserm-02488866⟩
  • Wojciech Szlasa, Aleksander Kiełbik, Anna Szewczyk, Nina Rembiałkowska, Vitalij Novickij, et al.. Oxidative Effects during Irreversible Electroporation of Melanoma Cells—In Vitro Study. Molecules, MDPI, 2020, 26 (1), pp.154. ⟨10.3390/molecules26010154⟩. ⟨hal-03104922⟩
  • Wojciech Szlasa, Iga Zendran, Aleksandra Zalesińska, Mounir Tarek, Julita Kulbacka. Lipid composition of the cancer cell membrane. Journal of Bioenergetics and Biomembranes, Springer Verlag, 2020, 52 (5), pp.321-342. ⟨10.1007/s10863-020-09846-4⟩. ⟨hal-03089978⟩
  • Karolina Cierluk, Wojciech Szlasa, Joanna Rossowska, Mounir Tarek, Anna Szewczyk, et al.. Cepharanthine induces ROS stress in glioma and neuronal cells via modulation of VDAC permeability. Saudi Pharmaceutical Journal, Elsevier, 2020, 28 (11), pp.1364-1373. ⟨10.1016/j.jsps.2020.08.026⟩. ⟨hal-03096148⟩
  • Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, et al.. Two-stage electro-mechanical coupling of a KV channel in voltage-dependent activation. Nature Communications, Nature Publishing Group, 2020, 11, ⟨10.1038/s41467-020-14406-w⟩. ⟨hal-03089983⟩
  • Tadej Kotnik, Lea Rems, Mounir Tarek, Damijan Miklavčič. Membrane Electroporation and Electropermeabilization: Mechanisms and Models. Annual Review of Biophysics and Biomolecular Structure, Annual Reviews, 2019, 48 (1), pp.63-91. ⟨10.1146/annurev-biophys-052118-115451⟩. ⟨hal-02275571⟩
  • Lea Rems, Marilyne Viano, Damijan Miklavčič, Marina A. Kasimova, Mounir Tarek. The contribution of lipid peroxidation to membrane permeability in electropermeabilization: A molecular dynamics study. Bioelectrochemistry, Elsevier, 2019, 125, pp.46-57. ⟨10.1016/j.bioelechem.2018.07.018⟩. ⟨hal-02275573⟩
  • Daniel Bonhenry, Francois Dehez, Mounir Tarek. Effects of hydration on the protonation state of a lysine analog crossing a phospholipid bilayer – insights from molecular dynamics and free-energy calculations. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2018, 20 (14), pp.9101-9107. ⟨10.1039/C8CP00312B⟩. ⟨hal-02336378⟩
  • Audrey Deyawe, Marina A. Kasimova, Lucie Delemotte, Gildas Loussouarn, Mounir Tarek. Studying Kv Channels Function using Computational Methods. Methods in Molecular Biology, Humana Press/Springer Imprint, 2018, Equipe IIa, 1684, pp.321--341. ⟨10.1007/978-1-4939-7362-0_24⟩. ⟨hal-01833334⟩
  • Jérôme Hénin, Marina A. Kasimova, Antonios Kolocouris, Michael L. Klein, Syma Khalid, et al.. Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory.. J. Membr. Biol., 2015, 248, ⟨10.1007/s00232-015-9802-0⟩. ⟨hal-01498031⟩
  • Julian Garrec, Antonio Monari, Xavier Assfeld, Lluis M. Mir, Mounir Tarek. Lipid Peroxidation in Membranes: The Peroxyl Radical Does Not “Float”. Journal of Physical Chemistry Letters, American Chemical Society, 2014, 5 (10), pp.1653-1658. ⟨10.1021/jz500502q⟩. ⟨hal-01153355⟩
  • Lara Lacerda, Hanene Ali-Boucetta, Sebastian Kraszewski, Mounir Tarek, Maurizio Prato, et al.. How do functionalized carbon nanotubes land on, bind to and pierce through model and plasma membranes.. Nanoscale, Royal Society of Chemistry, 2013, 5 (21), pp.10242-10250. ⟨10.1039/c3nr03184e⟩. ⟨hal-02558864⟩
  • Sebastian Kraszewski, Alberto Bianco, Mounir Tarek, Christophe Ramseyer. Insertion of short amino-functionalized single-walled carbon nanotubes into phospholipid bilayer occurs by passive diffusion.. PLoS ONE, Public Library of Science, 2012, 7 (7), pp.e40703. ⟨10.1371/journal.pone.0040703⟩. ⟨hal-00741382⟩
  • Adil Khalfa, Mounir Tarek. On the Antibacterial Action of Cyclic Peptides: Insights from Coarse-Grained MD Simulations. Journal of Physical Chemistry B, American Chemical Society, 2010, 114 (8), pp.2676-2684. ⟨10.1021/jp9064196⟩. ⟨hal-02736236⟩
  • A. Khalfa, W. Treptow, Bernard Maigret, M. Tarek. Self assembly of peptides near or within membranes using coarse grained MD simulations. Chemical Physics, Elsevier, 2009, 358 (1-2), pp.161-170. ⟨10.1016/j.chemphys.2009.01.012⟩. ⟨inria-00435164⟩