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Geneviève ALMOUZNI – Curriculum Vitae


Personal 

Name: Geneviève Almouzni

Date of birth: August 9, 1960

Nationality: French

Married, one Child: Emmanuel (Dec 5,1990)

Position

Director of Research CNRS 

Honorary Director RC Institut Curie 

Group leader Chromatin Dynamics team, UMR3664, Institut Curie, Paris, France

ORCID: 0000-0001-5570-0723

Education/Institution & location 

Degree 

Year(s)

Field of study 

CNRS- IPGR (Giovanni Domenico Cassini Class)

 

1998-99

Management qualification

Habilitation for Direction of Research (HDR)

HDR

1996

Chromatin Biology 

University Paris VI, France

PhD

1988

Microbiology

Ecole Normale Supérieure - University Paris VI & Institut Pasteur, France

Master

1985

Microbiology – Virology

Ecole Normale Supérieure Fontenay aux Roses & University Paris VI, France

Agregation & B.S.

1980-84

1984

Biochemistry & Nutrition

Biochemistry

 

Current & Previous Positions

2015 – now      Director of Research (DRCE) CNRS & honorary Director, Research Center at Institut Curie

1994 – now       Group leader of the Chromatin Dynamics team, UMR3664, Institut Curie, Paris, France 

2013 – 2018    Director of the Research Center at Institut Curie, Paris, France 

2009 – 2013    Deputy Director for the Research Center- Educational Programme at Institut Curie

2000 – 2015    Director of the Nuclear Dynamics Dept (UMR3664) (DR1 CNRS)

1999 – 2000    Director of the Genotoxicology and Modulation of the Gene Expression Dept (UMR218)

1994 – 1998    CNRS ATIPE/ Junior team, Chromatin Dynamics, UMR 144, I. Curie, Paris, France (CR1 CNRS)

1991 – 1993    Postdoctoral Associate: EMBO & Fogarty, National Institute of Health, USA

1989 – 1993    CNRS Research Scientist (CR2), Institut J. Monod, Paris, France

1988 – 1989     Post-doctoral Fellow: short term EMBO, National Institute of Health, USA

1985 – 1988    PhD thesis, Institut J. Monod, Paris, France

 

Major scientific responsabilities & Grants (latest)

2018 – now      Co-Chair of the European initiative LifeTime, with Prof. N. Rajewski (MDC, Berlin, Germany) https://lifetime-fetflagship.eu/

2018 – 2020     Chair of EU-LIFE, alliance of 13 European Institutes : http://eu-life.eu/

2016 – 2021    Leader of the ERC Advanced Grant- ChromADICT

2018 – 2022     Partner of MSCA – ITN 2018: ChromDesign: Chromatin architecture and Design

2017 – 2021     Partner of MSCA – ITN 2017: EpiSystem

2013 – 2018    Director of the Research Center at the Institut Curie, Paris, France 

2012 – 2019     Coordinator of the LABEX (Laboratory of Excellence): DEEP Development, Epigenesis, Epigenetics & life-time Potential with Prof. E. Heard (I. Curie): http://www.labex-deep.fr/ 

2020 – 2025    Coordinator of the LABEX DEEP (renewed) with Dr. P. Leopold

2010 – 2016     Coordinator of the European Network of Excellence EpiGeneSys   

2000 – 2015     Director of the Nuclear Dynamics Dept, UMR3664, Institut Curie, Paris, France

Since 1994       Team Leader, Chromatin Dynamics, Institut Curie, Paris, France

 

Distinctions & Awards 

2019 – 2023     Member of the ERC Council

2017                Trophy XXI for Diversity 2017, Officer of the Merit Order 

2016                Special Star of Europe Award 2016 for the European Network EpiGeneSys 

2015                European Academy of Cancer Sciences – Fellow

2014                Grand prix de Fondation de la Recherche Médicale (FRM), France

2013                FEBS/EMBO Women in Science Award

2013                Fellow of American Ass. for the Advancement of Science, of French Academy of Sciences  

2011                Grand Prix Louis D. Institut de France, Knight of the Legion of Honors 

2007                Member of Academia Europaea, Knight of the Merit Order 

2006                Grand Prix Cino et Simone del Duca Fondation by the Institut de France 

2003                Prize from La Ligue contre le Cancer, France

2000                EMBO Member, CNRS Silver Medal, Paris, France         

 

Education and mentoring Activities

2009 – 2013:  Deputy Director - Educational Program, Research Center at I. Curie 

Since 2004:     Regular involvement in international courses (Master and PhD levels) in France and Europe.

Since 1996:    PhD & HDR committees: over 70 in France, UK, Switzerland, etc.

Mentoring Graduate students and Post-doctoral fellowsalumni now independent group leaders with academic positions in universities (including ERC awardees), industries & patent law firms.

Promoting career of Junior PI: support and mentoring via the LabEx DEEP and the EpiGeneSys network.

Promoting women in sciences, through mentees and the LIBRA initiative as chair of EU Life and conferences

Engagement for scientific integrityworkshops at the Institut Curie and development of a dedicated course.

 

Science Dissemination & Policy

·       Organisation of international conferences: including EMBO Conference, Keystone Symp, Cold Spring Harbor Laboratory Symposium, …

·       Invited speaker to conferences and symposiums including as keynote speaker (>350).

·       Science policy contribution through EU Life and LifeTime for example: white papers 

·       Science for citizens: interviews on the media, with Labex DEEP initiatives and with LifeTime actions.

 


Journal articles42 documents

  • Daniel Jeffery, Alberto Gatto, Katrina Podsypanina, Charlène Renaud-Pageot, Rebeca Ponce Landete, et al.. CENP-A overexpression promotes distinct fates in human cells, depending on p53 status. Communications Biology, Nature Publishing Group, 2021, 4 (1), pp.417. ⟨10.1038/s42003-021-01941-5⟩. ⟨hal-03184130⟩
  • Júlia Torné, Dominique Ray-Gallet, Ekaterina Boyarchuk, Mickaël Garnier, Patricia Le Baccon, et al.. Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription. Nature Structural and Molecular Biology, Nature Publishing Group, 2020, 27 (11), pp.1057-1068. ⟨10.1038/s41594-020-0492-7⟩. ⟨hal-03028701⟩
  • Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw Gorski, Stein Aerts, Ido Amit, et al.. LifeTime and improving European healthcare through cell-based interceptive medicine. Nature, Nature Publishing Group, 2020, 587 (7834), pp.377-386. ⟨10.1038/s41586-020-2715-9⟩. ⟨hal-02999344⟩
  • Hans Clevers, Bart de Strooper, Angelika Eggert, Jan Ellenberg, Xosé Fernández, et al.. The LifeTime initiative: Towards cell-based medicine in Europe. Nature, Nature Publishing Group, 2020, 587 (7834), pp.377-386. ⟨10.1038/s41586-020-2715-9⟩. ⟨hal-03027059⟩
  • Song My Hoang, Nicole Kaminski, Ragini Bhargava, Jonathan Barroso-González, Michelle Lynskey, et al.. Regulation of ALT-associated homology-directed repair by polyADP-ribosylation. Nature Structural and Molecular Biology, Nature Publishing Group, 2020, 27 (12), pp.1152-1164. ⟨10.1038/s41594-020-0512-7⟩. ⟨hal-03138406⟩
  • Brendan Evano, Sara Khalilian, Gilles Le Carrou, Geneviève Almouzni, Shahragim Tajbakhsh. Dynamics of Asymmetric and Symmetric Divisions of Muscle Stem Cells In Vivo and on Artificial Niches. Cell Reports, Elsevier Inc, 2020, 30 (10), pp.3195-3206.e7. ⟨10.1016/j.celrep.2020.01.097⟩. ⟨hal-03028731⟩
  • Júlia Torné, Dominique Ray-Gallet, Ekaterina Boyarchuk, Mickaël Garnier, Patricia Le Baccon, et al.. Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription. Nature Structural and Molecular Biology, Nature Publishing Group, 2020, 27 (11), pp.1057-1068. ⟨10.1038/s41594-020-0492-7⟩. ⟨hal-03014199⟩
  • May Bakail, Albane Gaubert, Jessica Andreani, Gwenaëlle Moal, Guillaume Pinna, et al.. Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1. Cell Chemical Biology, 2019, ⟨10.1016/j.chembiol.2019.09.002⟩. ⟨hal-02301617⟩
  • Daphné Morel, Daniel Jeffery, Sandrine Aspeslagh, Geneviève Almouzni, Sophie Postel-Vinay. Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise. Nature Reviews Clinical Oncology, Nature Publishing Group, 2019, 17 (2), pp.91-107. ⟨10.1038/s41571-019-0267-4⟩. ⟨hal-02371032⟩
  • Geneviève Almouzni, Raphaël Rodriguez, Renata Basto. Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity. Current Biology - CB, Elsevier, 2019, 29 (18), pp.3072-3080.e5. ⟨10.1016/j.cub.2019.07.052⟩. ⟨hal-03041317⟩
  • May Bakail, Albane Gaubert, Jessica Andreani, Gwenaëlle Moal, Guillaume Pinna, et al.. Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1. Cell Chemical Biology, Cell Press, 2019, 26 (11), pp.1573-1585.e10. ⟨10.1016/j.chembiol.2019.09.002⟩. ⟨hal-02385251⟩
  • Aaron Mendez-Bermudez, Liudmyla Lototska, Serge Bauwens, Marie-Josèphe Giraud-Panis, Olivier Croce, et al.. Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2. Molecular Cell, Elsevier, 2018, 70 (3), pp.449-461.e5. ⟨10.1016/j.molcel.2018.03.036⟩. ⟨hal-02104993⟩
  • Paul Victor Sauer, Jennifer Timm, Danni Liu, David Sitbon, Elisabetta Boeri Erba, et al.. Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1. eLife, eLife Sciences Publication, 2017, 6, pp.e23474. ⟨10.7554/eLife.23474⟩. ⟨hal-01522557⟩
  • Dan Filipescu, Monica Naughtin, Katrina Podsypanina, Vincent Lejour, Laurence Wilson, et al.. Essential role for centromeric factors following p53 loss and oncogenic transformation. Genes and Development, Cold Spring Harbor Laboratory Press, 2017, 31 (5), pp.463 - 480. ⟨10.1101/gad.290924.116⟩. ⟨hal-01504857⟩
  • Salomé Adam, Juliette Dabin, Odile Chevallier, Olivier Leroy, Céline Baldeyron, et al.. Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage. Molecular Cell, Elsevier, 2016, 64 (1), pp.65-78. ⟨10.1016/j.molcel.2016.08.019⟩. ⟨hal-03045967⟩
  • Lisa Prendergast, Sebastian Müller, Yiwei Liu, Hongda Huang, Florent Dingli, et al.. The CENP-T/-W complex is a binding partner of the histone chaperone FACT. Genes and Development, Cold Spring Harbor Laboratory Press, 2016, 30 (11), pp.1313-1326 ⟨10.1101/gad.275073.115⟩. ⟨hal-01332229⟩
  • Christèle Maison, Delphine Bailly, Jean-Pierre Quivy, Geneviève Almouzni. The methyltransferase Suv39h1 links the SUMO pathway to HP1a marking at pericentric heterochromatin. Nature Communications, Nature Publishing Group, 2016, 7, pp.12224. ⟨10.1038/ncomms12224⟩. ⟨hal-01360113⟩
  • Hiroaki Tachiwana, Sebastian Müller, Julia Blümer, Kerstin Klare, Andrea Musacchio, et al.. HJURP Involvement in De Novo CenH3CENP-A and CENP-C Recruitment. Cell Reports, Elsevier Inc, 2015, 11 (1), pp.22-32. ⟨10.1016/j.celrep.2015.03.013⟩. ⟨hal-01224138⟩
  • Nicolas Richet, Danni Liu, Pierre Legrand, Christophe Velours, Armelle Corpet, et al.. Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork. Nucleic Acids Research, Oxford University Press, 2015, 43 (3), pp.1905-1917. ⟨10.1093/nar/gkv021⟩. ⟨hal-01279066⟩
  • Kelly Romeo, Yann Louault, Sylvain Cantaloube, Isabelle Loiodice, Geneviève Almouzni, et al.. The SENP7 SUMO-Protease Presents a Module of Two HP1 Interaction Motifs that Locks HP1 Protein at Pericentric Heterochromatin. Cell Reports, Elsevier Inc, 2015, 10 (5), pp.771-782. ⟨10.1016/j.celrep.2015.01.004⟩. ⟨hal-01213889⟩
  • Sophie Polo, Geneviève Almouzni. Chromatin dynamics after DNA damage: The legacy of the access–repair–restore model. DNA Repair, Elsevier, 2015, 36, pp.114-121. ⟨10.1016/j.dnarep.2015.09.014⟩. ⟨hal-03082229⟩
  • Carlos Rivera, Francisco Saavedra, Francisca Alvarez, César Díaz-Celis, Valentina Ugalde, et al.. Methylation of histone H3 lysine 9 occurs during translation. Nucleic Acids Research, Oxford University Press, 2015, 43 (19), pp.9097-9106. ⟨10.1093/nar/gkv929⟩. ⟨hal-01278078⟩
  • Salomé Adam, Sophie Polo, Geneviève Almouzni. How to restore chromatin structure and function in response to DNA damage - let the chaperones play. FEBS Journal, Wiley, 2014, 281 (10), pp.2315-2323. ⟨10.1111/febs.12793⟩. ⟨hal-03082196⟩
  • Sophie Polo, Geneviève Almouzni. DNA Damage Leaves its Mark on Chromatin. Cell Cycle, Taylor & Francis, 2014, 6 (19), pp.2355-2359. ⟨10.4161/cc.6.19.4756⟩. ⟨hal-03082103⟩
  • Sebastian Müller, Rocio Montes de Oca, Nicolas Lacoste, Florent Dingli, Damarys Loew, et al.. Phosphorylation and DNA Binding of HJURP Determine Its Centromeric Recruitment and Function in CenH3 CENP-A Loading. Cell Reports, Elsevier Inc, 2014, 8 (1), pp.190-203. ⟨10.1016/j.celrep.2014.06.002⟩. ⟨hal-01312876⟩
  • Salomé Adam, Sophie e. Polo, Geneviève Almouzni. Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA. Cell, Elsevier, 2013, 155 (1), pp.94-106. ⟨10.1016/j.cell.2013.08.029⟩. ⟨hal-03082189⟩
  • Emmanuelle Szenker, Nicolas Lacoste, Geneviève Almouzni. A developmental requirement for HIRA-dependent H3.3 deposition revealed at gastrulation in Xenopus.. Cell Reports, Elsevier Inc, 2012, 1 (6), pp.730-40. ⟨10.1016/j.celrep.2012.05.006⟩. ⟨hal-00765971⟩
  • Paul Talbert, Kami Ahmad, Geneviève Almouzni, Juan Ausió, Frederic Berger, et al.. A unified phylogeny-based nomenclature for histone variants. Epigenetics & Chromatin, BioMed Central, 2012, 5 (1), pp.7. ⟨10.1186/1756-8935-5-7⟩. ⟨inserm-00710902⟩
  • Gaston Soria, Sophie E Polo, Geneviève Almouzni. The DNA damage response in chromatin: a focus on histone variants and heterochromatin proteins. Molecular Cell, Elsevier, 2012, 46 (6), pp.722-34. ⟨10.1016/j.molcel.2012.06.002⟩. ⟨hal-00765972⟩
  • Christèle Maison, Kelly Romeo, Delphine Bailly, Marion Dubarry, Jean-Pierre Quivy, et al.. The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.. Nature Structural and Molecular Biology, Nature Publishing Group, 2012, 19 (4), pp.458-60. ⟨10.1038/nsmb.2244⟩. ⟨hal-00765968⟩
  • Christèle Maison, Delphine Bailly, Danièle Roche, Rocio Montes de Oca, Aline V Probst, et al.. SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin.. Nature Genetics, Nature Publishing Group, 2011, 43 (3), pp.220-7. ⟨10.1038/ng.765⟩. ⟨hal-00685744⟩
  • Dominique Ray-Gallet, Adam Woolfe, Isabelle Vassias, Céline Pellentz, Nicolas Lacoste, et al.. Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Molecular Cell, Elsevier, 2011, 44 (6), pp.928-41. ⟨10.1016/j.molcel.2011.12.006⟩. ⟨hal-00743096⟩
  • Aline Probst, Ikuhiro Okamoto, Miguel Casanova, Fatima El-Marjou, Patricia Le Baccon, et al.. A strand-specific burst in transcription of pericentric satellites is required for chromocenter formation and early mouse development.. Developmental Cell, Elsevier, 2010, 19 (4), pp.625-38. ⟨10.1016/j.devcel.2010.09.002⟩. ⟨hal-00685732⟩
  • Sophie Polo, Geneviève Almouzni. Dynamique de la chromatine lors de la réparation des lésions de l’ADN. médecine/sciences, EDP Sciences, 2007, 23 (1), pp.29-31. ⟨10.1051/medsci/200723129⟩. ⟨hal-03082097⟩
  • Dominique Ray-Gallet, Jean-Pierre Quivy, Herman Silljé, Erich Nigg, Geneviève Almouzni. The histone chaperone Asf1 is dispensable for direct de novo histone deposition in Xenopus egg extracts. Chromosoma, Springer Verlag, 2007, 116, pp.487 - 496. ⟨10.1007/s00412-007-0112-x⟩. ⟨hal-03048224⟩
  • Sophie Polo, Geneviève Almouzni. Chromatin assembly: a basic recipe with various flavours. Current Opinion in Genetics and Development, Elsevier, 2006, 16 (2), pp.104-111. ⟨10.1016/j.gde.2006.02.011⟩. ⟨hal-03082075⟩
  • Sophie Polo, Danièle Roche, Geneviève Almouzni. New Histone Incorporation Marks Sites of UV Repair in Human Cells. Cell, Elsevier, 2006, 127 (3), pp.481-493. ⟨10.1016/j.cell.2006.08.049⟩. ⟨hal-03082083⟩
  • Martin Houlard, Soizik Berlivet, Aline V Probst, Jean-Pierre Quivy, Patrick Héry, et al.. CAF-1 is essential for heterochromatin organization in pluripotent embryonic cells.. PLoS Genetics, Public Library of Science, 2006, 2 (11), pp.e181. ⟨10.1371/journal.pgen.0020181⟩. ⟨cea-00161340⟩
  • Sophie Polo, Geneviève Almouzni. Histone metabolic pathways and chromatin assembly factors as proliferation markers. Cancer Letters, Elsevier, 2005, 220 (1), pp.1-9. ⟨10.1016/j.canlet.2004.08.024⟩. ⟨hal-03082067⟩
  • Sophie Polo, Stamatios Theocharis, Jerzy Klijanienko, Alexia Savignoni, Bernard Asselain, et al.. Chromatin Assembly Factor-1, a Marker of Clinical Value to Distinguish Quiescent from Proliferating Cells. Cancer Research, American Association for Cancer Research, 2004, 64 (7), pp.2371-2381. ⟨10.1158/0008-5472.can-03-2893⟩. ⟨hal-03082063⟩
  • Hideaki Tagami, Dominique Ray-Gallet, Geneviève Almouzni, Yoshihiro Nakatani. Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell, 2004. ⟨hal-03046816⟩
  • Dominique Ray-Gallet, Geneviève Almouzni. DNA synthesis-dependent and -independent chromatin assembly pathways in xenopus egg extracts. Methods in Enzymology, Elsevier, 2004. ⟨hal-03048283⟩

Book sections4 documents

  • Geneviève Almouzni. Après Darwin : épigénétique et évolution – L’architecture du génome : ses briques et sa plasticité. Darwin au Collège de France XIXè-XXIè siècle, PSL/République des Savoirs, Collège de France, 2020, Passage des Disciplines, 9782722605329. ⟨10.4000/books.cdf.7303⟩. ⟨hal-03052794⟩
  • Dominique Ray-Gallet, Geneviève Almouzni. The Histone H3 Family and Its Deposition Pathways. Advances in Experimental Medicine and Biology book series. Histone Mutations and Cancer, 1283, Springer Nature, pp.17-42, 2020, Advances in Experimental Medicine and Biology b, 978-9-81-158103-8, 978-9-81-158104-5. ⟨10.1007/978-981-15-8104-5_2⟩. ⟨hal-03028662⟩
  • Francisco Saavedra, Ekaterina Boyarchuk, Francisca Alvarez, Geneviève Almouzni, Alejandra Loyola. Metabolic Deregulations Affecting Chromatin Architecture: One-Carbon Metabolism and Krebs Cycle Impact Histone Methylation.. The DNA,RNA, and Histone Methylomes. RNA Technologies., pp.573-606, 2019, 978-3-030-14791-4. ⟨10.1007/978-3-030-14792-1_23⟩. ⟨hal-02371144⟩
  • Annabelle Gérard, Sophie Polo, Danièle Roche, Geneviève Almouzni. Methods for Studying Chromatin Assembly Coupled to DNA Repair. Methods Enzymol, pp.358-374, 2006, ⟨10.1016/S0076-6879(05)09021-X⟩. ⟨hal-03082078⟩

Preprints, Working Papers, ...4 documents

  • Leticia Laura Niborski, Paul Gueguen, Mengliang Ye, Allan Thiolat, Rodrigo Nalio Ramos, et al.. Epigenetic control of CD8+ T cell responsiveness to a-PD-1 by Suv39h1: Contrôle épigénétique de la réactivité des cellules T CD8+ à l'a-PD-1 par Suv39h1. 2020. ⟨hal-03041343⟩
  • Daniel Jeffery, Katrina Podsypanina, Alberto Gatto, Rebeca Ponce Landete, Lorraine Bonneville, et al.. CENP-A overexpression drives distinct cell fates depending on p53 status. 2020. ⟨hal-03041329⟩
  • David Sitbon, Ekaterina Boyarchuk, Geneviève Almouzni. Regardless of the deposition pathway, aminoacid 31 in histone variant H3 is essential at gastrulation in Xenopus. 2020. ⟨hal-03041039⟩
  • Brendan Evano, Gilles Le Carrou, Geneviève Almouzni, Shahragim Tajbakhsh. Differential cell fates of muscle stem cells are accompanied by symmetric segregation of canonical H3 histones in vivo. 2017. ⟨hal-03052823⟩