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Geneviève ALMOUZNI

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Identifiants chercheurs

Présentation

**Personal** Name: Geneviève Almouzni Date of birth: August 9, 1960 Nationality: French Married, one Child: Emmanuel (Dec 5,1990) **Position** **Director of Research CNRS** **Honorary Director RC Institut Curie** **Group leader** **Chromatin Dynamics team**, UMR3664, Institut Curie, Paris, France ORCID: 0000-0001-5570-0723 **Education/Institution & location** **Degree** **Year(s)** **Field of study** CNRS- IPGR (Giovanni Domenico Cassini Class) 1998-99 Management qualification Habilitation for Direction of Research (HDR) HDR 1996 Chromatin Biology University Paris VI, France PhD 1988 Microbiology Ecole Normale Supérieure - University Paris VI & Institut Pasteur, France Master 1985 Microbiology – Virology Ecole Normale Supérieure Fontenay aux Roses & University Paris VI, France Agregation & B.S. 1980-84 1984 Biochemistry & Nutrition Biochemistry Current & Previous Positions 2015 – now **Director of Research (DRCE) CNRS & honorary Director, Research Center** at Institut Curie 1994 – now **Group leader of the Chromatin Dynamics team**, UMR3664, Institut Curie, Paris, France 2013 – 2018 **Director of the Research Center** at Institut Curie, Paris, France 2009 – 2013 **Deputy Director for the Research Center- Educational Programme** at Institut Curie 2000 – 2015 **Director of the Nuclear Dynamics Dept (UMR3664)** **(DR1** CNRS) 1999 – 2000 Director of the Genotoxicology and Modulation of the Gene Expression Dept (UMR218) 1994 – 1998 **CNRS ATIPE/ Junior team, Chromatin Dynamics**, UMR 144, I. Curie, Paris, France (CR1 CNRS) 1991 – 1993 **Postdoctoral Associate**: EMBO & Fogarty, National Institute of Health, USA 1989 – 1993 **CNRS Research Scientist (CR2)**, Institut J. Monod, Paris, France 1988 – 1989 **Post-doctoral Fellow**: short term EMBO, National Institute of Health, USA 1985 – 1988 **PhD thesis**, Institut J. Monod, Paris, France **Major scientific responsabilities & Grants (latest)** 2018 – now **Co-Chair of the European initiative LifeTime,** with Prof. N. Rajewski (MDC, Berlin, Germany) https://lifetime-fetflagship.eu/ 2018 – 2020 **Chair of EU-LIFE**, alliance of 13 European Institutes : http://eu-life.eu/ 2016 – 2021 **Leader of the ERC Advanced Grant-** ChromADICT 2018 – 2022 **Partner of MSCA – ITN 2018:** ChromDesign: Chromatin architecture and Design 2017 – 2021 **Partner of MSCA – ITN** **2017:** EpiSystem 2013 – 2018 **Director of the Research Center** at the Institut Curie, Paris, France 2012 – 2019 **Coordinator** **of the LABEX** (Laboratory of Excellence): **DEEP** Development, Epigenesis, Epigenetics & life-time Potential with Prof. E. Heard (I. Curie): http://www.labex-deep.fr/ 2020 – 2025 **Coordinator** **of the LABEX DEEP** (renewed) with Dr. P. Leopold 2010 – 2016 **Coordinator of the European Network of Excellence** EpiGeneSys 2000 – 2015 **Director of the Nuclear Dynamics Dept**, UMR3664, Institut Curie, Paris, France Since 1994 **Team Leader, Chromatin Dynamics,** Institut Curie, Paris, France **Distinctions & Awards** 2019 – 2023 Member of the ERC Council 2017 Trophy XXI for Diversity 2017, Officer of the Merit Order 2016 Special Star of Europe Award 2016 for the European Network EpiGeneSys 2015 European Academy of Cancer Sciences – Fellow 2014 Grand prix de Fondation de la Recherche Médicale (FRM), France 2013 FEBS/EMBO Women in Science Award 2013 Fellow of American Ass. for the Advancement of Science, of French Academy of Sciences 2011 Grand Prix Louis D. Institut de France, Knight of the Legion of Honors 2007 Member of Academia Europaea, Knight of the Merit Order 2006 Grand Prix Cino et Simone del Duca Fondation by the Institut de France 2003 Prize from La Ligue contre le Cancer, France 2000 EMBO Member, CNRS Silver Medal, Paris, France **Education and mentoring Activities** 2009 – 2013: **Deputy Director - Educational Program**, Research Center at I. Curie Since 2004: **Regular involvement in international** **courses (Master and PhD levels)** in France and Europe. Since 1996: **PhD & HDR committees**: over 70 in France, UK, Switzerland, etc. **Mentoring Graduate students and Post-doctoral fellows,** alumni now independent group leaders with academic positions in universities (including ERC awardees), industries & patent law firms. **Promoting career of Junior PI:** support and mentoring via the LabEx DEEP and the EpiGeneSys network. **Promoting women in sciences**, through mentees and the LIBRA initiative as chair of EU Life and conferences **Engagement for scientific integrity**, workshops at the Institut Curie and development of a dedicated course. **Science Dissemination & Policy** · **Organisation of international conferences**: including EMBO Conference, Keystone Symp, Cold Spring Harbor Laboratory Symposium, … · **Invited speaker** to conferences and symposiums including as keynote speaker (>350). · **Science policy contribution** through EU Life and LifeTime for example: white papers · **Science for citizens:** interviews on the media, with Labex DEEP initiatives and with LifeTime actions.

Publications

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The cell cycle choreography of H3 variants shapes the genome

Kamila Delaney , Nicole Weiss , Geneviève Almouzni
Molecular Cell, 2023
Article dans une revue hal-04217778v1

HIRA-dependent boundaries between H3 variants shape early replication in mammals

Alberto Gatto , Audrey Forest , Jean-Pierre Quivy , Geneviève Almouzni
Molecular Cell, 2022, 82 (10), pp.1909-1923.e5. ⟨10.1016/j.molcel.2022.03.017⟩
Article dans une revue hal-03634442v1
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H3–H4 histone chaperones and cancer

Dominique Ray-Gallet , Geneviève Almouzni
Current Opinion in Genetics and Development, 2022, 73, pp.101900. ⟨10.1016/j.gde.2022.101900⟩
Article dans une revue hal-03602708v1
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CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

Leticia Laura Niborski , Paul Gueguen , Mengliang Ye , Allan Thiolat , Rodrigo Nalio Ramos
Nature Communications, 2022, 13 (1), pp.3739. ⟨10.1038/s41467-022-31504-z⟩
Article dans une revue hal-03812171v1

CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas

Leticia Laura Niborski , Paul Gueguen , Mengliang Ye , Allan Thiolat , Rodrigo Nalio Ramos
Nature Communications, 2022, 13 (1), pp.3739. ⟨10.1038/s41467-022-31504-z⟩
Article dans une revue hal-03810409v1
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CENP-A overexpression promotes distinct fates in human cells, depending on p53 status

Daniel Jeffery , Alberto Gatto , Katrina Podsypanina , Charlène Renaud-Pageot , Rebeca Ponce Landete
Communications Biology, 2021, 4 (1), pp.417. ⟨10.1038/s42003-021-01941-5⟩
Article dans une revue hal-03184130v1
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PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Roman M Chabanon , Daphné Morel , Thomas Eychenne , Léo Colmet-Daage , Ilirjana Bajrami
Cancer Research, 2021, 81 (11), pp.2888-2902. ⟨10.1158/0008-5472.CAN-21-0628⟩
Article dans une revue hal-03447176v1

PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Roman Chabanon , Daphné Morel , Thomas Eychenne , Léo Colmet-Daage , Ilirjana Bajrami
Cancer Research, 2021, 81 (11), pp.2888-2902. ⟨10.1158/0008-5472.CAN-21-0628⟩
Article dans une revue hal-03951734v1
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CENP-A Subnuclear Localization Pattern as Marker Predicting Curability by Chemoradiation Therapy for Locally Advanced Head and Neck Cancer Patients

Pierre Verrelle , Didier Meseure , Frédérique Berger , Audrey Forest , Renaud Leclère
Cancers, 2021, 13 (16), pp.3928. ⟨10.3390/cancers13163928⟩
Article dans une revue hal-03352581v1
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Epigenomics in the single cell era, an important read out for genome function and cell identity

Inês Pinheiro , Maria-Elena Torres-Padilla , Geneviève Almouzni
Epigenomics, 2021, ⟨10.2217/epi-2021-0153⟩
Article dans une revue hal-03259937v1
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The LifeTime initiative: Towards cell-based medicine in Europe

Hans Clevers , Bart de Strooper , Angelika Eggert , Jan Ellenberg , Xosé Fernández
Nature, 2020, 587 (7834), pp.377-386. ⟨10.1038/s41586-020-2715-9⟩
Article dans une revue hal-03027059v1
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LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky , Geneviève Almouzni , Stanislaw A Gorski , Stein Aerts , Ido Amit
Nature, 2020, 587, pp.377 - 386. ⟨10.1038/s41586-020-2715-9⟩
Article dans une revue hal-04023884v2
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JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability

Francisco Saavedra , Zachary A Gurard-Levin , Camila Rojas-Villalobos , Isabelle Vassias , Raquel Quatrini
Epigenetics & Chromatin, 2020, 13 (1), pp.6. ⟨10.1186/s13072-020-00331-1⟩
Article dans une revue hal-02538094v1
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Dynamics of Asymmetric and Symmetric Divisions of Muscle Stem Cells In Vivo and on Artificial Niches

Brendan Evano , Sara Khalilian , Gilles Le Carrou , Geneviève Almouzni , Shahragim Tajbakhsh
Cell Reports, 2020, 30 (10), pp.3195-3206.e7. ⟨10.1016/j.celrep.2020.01.097⟩
Article dans une revue hal-03028731v1
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Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription

Júlia Torné , Dominique Ray-Gallet , Ekaterina Boyarchuk , Mickaël Garnier , Patricia Le Baccon
Nature Structural and Molecular Biology, 2020, 27 (11), pp.1057-1068. ⟨10.1038/s41594-020-0492-7⟩
Article dans une revue hal-03028701v1
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Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

Song My Hoang , Nicole Kaminski , Ragini Bhargava , Jonathan Barroso-González , Michelle L Lynskey
Nature Structural and Molecular Biology, 2020, 27 (12), pp.1152-1164. ⟨10.1038/s41594-020-0512-7⟩
Article dans une revue hal-03138406v1
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Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise

Daphné Morel , Daniel Jeffery , Sandrine Aspeslagh , Geneviève Almouzni , Sophie Postel-Vinay
Nature Reviews Clinical Oncology, 2019, 17 (2), pp.91-107. ⟨10.1038/s41571-019-0267-4⟩
Article dans une revue hal-02371032v1
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Vision 2030 for the optimal approach to cancer research and care in Europe: A mission or a network of networks?

Thierry Philip , Geneviève Almouzni , Philip Poortmans
Tumori, 2019, 105 (3), pp.265-270. ⟨10.1177/0300891618783655⟩
Article dans une revue hal-02370961v1
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Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity

Geneviève Almouzni , Raphaël Rodriguez , Renata Basto
Current Biology - CB, 2019, 29 (18), pp.3072-3080.e5. ⟨10.1016/j.cub.2019.07.052⟩
Article dans une revue hal-03041317v1
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Dynamic Histone H3 Incorporation Fuels Metastatic Progression

Iva Simeonova , Geneviève Almouzni
Trends in Molecular Medicine, 2019, 25 (11), pp.933-935. ⟨10.1016/j.molmed.2019.09.003⟩
Article dans une revue hal-02371000v1
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Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity

Simon Gemble , Anthony Simon , Carole Pennetier , Marie Dumont , Solène Hervé
Current Biology - CB, 2019, 29, pp.3072 - 3080.e5. ⟨10.1016/j.cub.2019.07.052⟩
Article dans une revue hal-03455007v1

Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity

Simon Gemble , Anthony Simon , Carole Pennetier , Marie Dumont , Solène Hervé
Current Biology - CB, 2019, 29 (18), pp.3072-3080.e5. ⟨10.1016/j.cub.2019.07.052⟩
Article dans une revue hal-02332535v1
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Histone supply: Multitiered regulation ensures chromatin dynamics throughout the cell cycle

Shweta Mendiratta , Alberto Gatto , Geneviève Almouzni
Journal of Cell Biology, 2019, 218 (1), pp.39-54. ⟨10.1083/jcb.201807179⟩
Article dans une revue hal-02311298v1
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Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1

May Bakail , Albane Gaubert , Jessica Andreani , Gwenaëlle Moal , Guillaume Pinna
Cell Chemical Biology, 2019, 26 (11), pp.1573-1585.e10. ⟨10.1016/j.chembiol.2019.09.002⟩
Article dans une revue hal-02385251v1

The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells

Charles Ng , Martin Aichinger , Tung Nguyen , Christy Au , Tariq Najar
Genes and Development, 2019, 33 (11-12), pp.669-683. ⟨10.1101/gad.322024.118⟩
Article dans une revue hal-02326664v1

Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2

Aaron Mendez-Bermudez , Liudmyla Lototska , Serge Bauwens , Marie-Josèphe Giraud-Panis , Olivier Croce
Molecular Cell, 2018, 70 (3), pp.449-461.e5. ⟨10.1016/j.molcel.2018.03.036⟩
Article dans une revue hal-02104993v1
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High-resolution visualization of H3 variants during replication reveals their controlled recycling

Camille Clement , Guillermo A Orsi , Alberto Gatto , Ekaterina Boyarchuk , Audrey Forest
Nature Communications, 2018, 9 (1), pp.3181. ⟨10.1038/s41467-018-05697-1⟩
Article dans une revue hal-01981686v1
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Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure

Marie-Thérèse El-Daher , Nicolas Cagnard , Marine Gil , Marie Chansel da Cruz , Claire Leveau
Cell Discovery, 2018, 4 (1), ⟨10.1038/s41421-018-0061-y⟩
Article dans une revue hal-01922535v1
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Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

Dominique Ray-Gallet , M. Daniel Ricketts , Yukari Sato , Kushol Gupta , Ekaterina Boyarchuk
Nature Communications, 2018, 9 (1), pp.3103 article number. ⟨10.1038/s41467-018-05581-y⟩
Article dans une revue hal-02370978v1

The epigenetic control of stemness in CD8 + T cell fate commitment

Luigia Pace , Christel L Goudot , Elina Zueva , Paul Gueguen , Nina Burgdorf
Science, 2018, 359 (6372), pp.177-186. ⟨10.1126/science.aah6499⟩
Article dans une revue hal-02370943v1

Chromatin plasticity: A versatile landscape that underlies cell fate and identity

Tejas Yadav , Jean-Pierre Quivy , Geneviève Almouzni
Science, 2018, 361 (6409), pp.1332-1336. ⟨10.1126/science.aat8950⟩
Article dans une revue hal-02326606v1
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POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication

Roberto Bellelli , Ondrej Belan , Valerie E Pye , Camille Clement , Sarah L Maslen
Molecular Cell, 2018, 72 (1), pp.112. ⟨10.1016/j.molcel.2018.08.043⟩
Article dans une revue hal-01902527v1
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KAP1 facilitates reinstatement of heterochromatin after DNA replication

Suk Min Jang , Annamaria Kauzlaric , Jean-Pierre Quivy , Julien Pontis , Benjamin Rauwel
Nucleic Acids Research, 2018, 46 (17), pp.8788-8802. ⟨10.1093/nar/gky580⟩
Article dans une revue hal-01953846v1

Challenges and guidelines toward 4D nucleome data and model standards

Marc Marti-Renom , Geneviève Almouzni , Wendy Bickmore , Kerstin Bystricky , Giacomo Cavalli
Nature Genetics, 2018, 50 (10), pp.1352-1358. ⟨10.1038/s41588-018-0236-3⟩
Article dans une revue hal-01980465v1
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Essential role for centromeric factors following p53 loss and oncogenic transformation

Dan Filipescu , Monica Naughtin , Katrina Podsypanina , Vincent Lejour , Laurence Wilson
Genes and Development, 2017, 31 (5), pp.463 - 480. ⟨10.1101/gad.290924.116⟩
Article dans une revue hal-01504857v1
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Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1

Paul Victor Sauer , Jennifer Timm , Danni Liu , David Sitbon , Elisabetta Boeri Erba
eLife, 2017, 6, pp.e23474. ⟨10.7554/eLife.23474⟩
Article dans une revue hal-01522557v1

Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage

Salomé Adam , Juliette Dabin , Odile Chevallier , Olivier Leroy , Céline Baldeyron
Molecular Cell, 2016, 64 (1), pp.65-78. ⟨10.1016/j.molcel.2016.08.019⟩
Article dans une revue hal-03045967v1
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The CENP-T/-W complex is a binding partner of the histone chaperone FACT

Lisa Prendergast , Sebastian Müller , Yiwei Liu , Hongda Huang , Florent Dingli
Genes and Development, 2016, 30 (11), pp.1313-1326 ⟨10.1101/gad.275073.115⟩
Article dans une revue hal-01332229v1
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The methyltransferase Suv39h1 links the SUMO pathway to HP1a marking at pericentric heterochromatin

Christèle Maison , Delphine Bailly , Jean-Pierre Quivy , Geneviève Almouzni
Nature Communications, 2016, 7, pp.12224. ⟨10.1038/ncomms12224⟩
Article dans une revue hal-01360113v1
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HJURP Involvement in De Novo CenH3CENP-A and CENP-C Recruitment

Hiroaki Tachiwana , Sebastian Müller , Julia Blümer , Kerstin Klare , Andrea Musacchio
Cell Reports, 2015, 11 (1), pp.22-32. ⟨10.1016/j.celrep.2015.03.013⟩
Article dans une revue hal-01224138v1
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The SENP7 SUMO-Protease Presents a Module of Two HP1 Interaction Motifs that Locks HP1 Protein at Pericentric Heterochromatin

Kelly Romeo , Yann Louault , Sylvain Cantaloube , Isabelle Loiodice , Geneviève Almouzni
Cell Reports, 2015, 10 (5), pp.771-782. ⟨10.1016/j.celrep.2015.01.004⟩
Article dans une revue hal-01213889v1
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Methylation of histone H3 lysine 9 occurs during translation

Carlos Rivera , Francisco Saavedra , Francisca Alvarez , César Díaz-Celis , Valentina Ugalde
Nucleic Acids Research, 2015, 43 (19), pp.9097-9106. ⟨10.1093/nar/gkv929⟩
Article dans une revue hal-01278078v1

Chromatin dynamics after DNA damage: The legacy of the access–repair–restore model

Sophie Polo , Geneviève Almouzni
DNA Repair, 2015, 36, pp.114-121. ⟨10.1016/j.dnarep.2015.09.014⟩
Article dans une revue hal-03082229v1
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Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork

Nicolas Richet , Danni Liu , Pierre Legrand , Christophe Velours , Armelle Corpet
Nucleic Acids Research, 2015, 43 (3), pp.1905-1917. ⟨10.1093/nar/gkv021⟩
Article dans une revue hal-01279066v1
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Relationship between genome and epigenome - challenges and requirements for future research

Geneviève Almouzni , Lucia Altucci , Bruno Amati , Neil Ashley , David Baulcombe
BMC Genomics, 2014, 15 (1), pp.487. ⟨10.1186/1471-2164-15-487⟩
Article dans une revue hal-02365238v1
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Phosphorylation and DNA Binding of HJURP Determine Its Centromeric Recruitment and Function in CenH3 CENP-A Loading

Sebastian Müller , Rocio Montes de Oca , Nicolas Lacoste , Florent Dingli , Damarys Loew
Cell Reports, 2014, 8 (1), pp.190-203. ⟨10.1016/j.celrep.2014.06.002⟩
Article dans une revue hal-01312876v1

DNA Damage Leaves its Mark on Chromatin

Sophie Polo , Geneviève Almouzni
Cell Cycle, 2014, 6 (19), pp.2355-2359. ⟨10.4161/cc.6.19.4756⟩
Article dans une revue hal-03082103v1

How to restore chromatin structure and function in response to DNA damage - let the chaperones play

Salomé Adam , Sophie Polo , Geneviève Almouzni
FEBS Journal, 2014, 281 (10), pp.2315-2323. ⟨10.1111/febs.12793⟩
Article dans une revue hal-03082196v1

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA

Salomé Adam , Sophie e. Polo , Geneviève Almouzni
Cell, 2013, 155 (1), pp.94-106. ⟨10.1016/j.cell.2013.08.029⟩
Article dans une revue hal-03082189v1
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A developmental requirement for HIRA-dependent H3.3 deposition revealed at gastrulation in Xenopus.

Emmanuelle Szenker , Nicolas Lacoste , Geneviève Almouzni
Cell Reports, 2012, 1 (6), pp.730-40. ⟨10.1016/j.celrep.2012.05.006⟩
Article dans une revue hal-00765971v1
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A unified phylogeny-based nomenclature for histone variants

Paul Talbert , Kami Ahmad , Geneviève Almouzni , Juan Ausió , Frederic Berger
Epigenetics & Chromatin, 2012, 5 (1), pp.7. ⟨10.1186/1756-8935-5-7⟩
Article dans une revue inserm-00710902v1

A centriolar lifeline

Simon Gemble , Renata Basto , Oumou Goundiam , Alix Goupil , Maddalena Nano
Nature Reviews Molecular Cell Biology, 2012, 13 (11), pp.686-686. ⟨10.1038/nrm3460⟩
Article dans une revue hal-03453016v1
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The DNA damage response in chromatin: a focus on histone variants and heterochromatin proteins

Gaston Soria , Sophie E Polo , Geneviève Almouzni
Molecular Cell, 2012, 46 (6), pp.722-34. ⟨10.1016/j.molcel.2012.06.002⟩
Article dans une revue hal-00765972v1
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The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.

Christèle Maison , Kelly Romeo , Delphine Bailly , Marion Dubarry , Jean-Pierre Quivy
Nature Structural and Molecular Biology, 2012, 19 (4), pp.458-60. ⟨10.1038/nsmb.2244⟩
Article dans une revue hal-00765968v1
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Heterochromatin maintenance and establishment: lessons from the mouse pericentromere.

Geneviève Almouzni , Aline V Probst
Nucleus, 2011, 2 (5), pp.332-8. ⟨10.4161/nucl.2.5.17707⟩
Article dans une revue hal-00742945v1
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Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity

Dominique Ray-Gallet , Adam Woolfe , Isabelle Vassias , Céline Pellentz , Nicolas Lacoste
Molecular Cell, 2011, 44 (6), pp.928-41. ⟨10.1016/j.molcel.2011.12.006⟩
Article dans une revue hal-00743096v1
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Cell cycle dynamics of histone variants at the centromere, a model for chromosomal landmarks.

Ekaterina Boyarchuk , Rocío Montes de Oca , Geneviève Almouzni
Current Opinion in Cell Biology, 2011, 23 (3), pp.266-76. ⟨10.1016/j.ceb.2011.03.006⟩
Article dans une revue hal-00742742v1
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The double face of the histone variant H3.3.

Emmanuelle Szenker , Dominique Ray-Gallet , Geneviève Almouzni
Cell Research, 2011, 21 (3), pp.421-34. ⟨10.1038/cr.2011.14⟩
Article dans une revue hal-00742959v1
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HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

Céline Baldeyron , Gaston Soria , Danièle Roche , Adam J L Cook , Geneviève Almouzni
Journal of Cell Biology, 2011, 193 (1), pp.81-95. ⟨10.1083/jcb.201101030⟩
Article dans une revue hal-00742640v1
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A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain.

Adam J L Cook , Zachary A Gurard-Levin , Isabelle Vassias , Geneviève Almouzni
Molecular Cell, 2011, 44 (6), pp.918-27. ⟨10.1016/j.molcel.2011.11.021⟩
Article dans une revue hal-00743102v1
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Heterochromatin establishment in the context of genome-wide epigenetic reprogramming.

Aline V Probst , Geneviève Almouzni
Trends in Genetics, 2011, 27 (5), pp.177-85. ⟨10.1016/j.tig.2011.02.002⟩
Article dans une revue hal-00742753v1
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H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G₁ phase.

Elaine M Dunleavy , Geneviève Almouzni , Gary H Karpen
Nucleus, 2011, 2 (2), pp.146-57. ⟨10.4161/nucl.2.2.15211⟩
Article dans une revue hal-00742956v1
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SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin.

Christèle Maison , Delphine Bailly , Danièle Roche , Rocio Montes de Oca , Aline V Probst
Nature Genetics, 2011, 43 (3), pp.220-7. ⟨10.1038/ng.765⟩
Article dans une revue hal-00685744v1
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Clinical significance and prognostic value of Chromatin Assembly Factor-1 overexpression in human solid tumors

Sophie E Polo , Stamatios E Theocharis , Laure Grandin , Laetitia Gambotti , Guillemette Antoni
Histopathology, 2010, 57 (5), pp.716. ⟨10.1111/j.1365-2559.2010.03681.x⟩
Article dans une revue hal-00593448v1
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A strand-specific burst in transcription of pericentric satellites is required for chromocenter formation and early mouse development.

Aline V. Probst , Ikuhiro Okamoto , Miguel Casanova , Fatima El-Marjou , Patricia Le Baccon
Developmental Cell, 2010, 19 (4), pp.625-38. ⟨10.1016/j.devcel.2010.09.002⟩
Article dans une revue hal-00685732v1
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The histone chaperone Asf1 is dispensable for direct de novo histone deposition in Xenopus egg extracts

Dominique Ray-Gallet , Jean-Pierre Quivy , Herman W W Silljé , Erich A Nigg , Geneviève Almouzni
Chromosoma, 2007, 116, pp.487 - 496. ⟨10.1007/s00412-007-0112-x⟩
Article dans une revue hal-03048224v1

Dynamique de la chromatine lors de la réparation des lésions de l’ADN

Sophie Polo , Geneviève Almouzni
Médecine/Sciences, 2007, 23 (1), pp.29-31. ⟨10.1051/medsci/200723129⟩
Article dans une revue hal-03082097v1

Chromatin assembly: a basic recipe with various flavours

Sophie Polo , Geneviève Almouzni
Current Opinion in Genetics and Development, 2006, 16 (2), pp.104-111. ⟨10.1016/j.gde.2006.02.011⟩
Article dans une revue hal-03082075v1

New Histone Incorporation Marks Sites of UV Repair in Human Cells

Sophie Polo , Danièle Roche , Geneviève Almouzni
Cell, 2006, 127 (3), pp.481-493. ⟨10.1016/j.cell.2006.08.049⟩
Article dans une revue hal-03082083v1
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CAF-1 is essential for heterochromatin organization in pluripotent embryonic cells.

Martin Houlard , Soizik Berlivet , Aline V Probst , Jean-Pierre Quivy , Patrick Héry
PLoS Genetics, 2006, 2 (11), pp.e181. ⟨10.1371/journal.pgen.0020181⟩
Article dans une revue cea-00161340v1

Histone metabolic pathways and chromatin assembly factors as proliferation markers

Sophie Polo , Geneviève Almouzni
Cancer Letters, 2005, 220 (1), pp.1-9. ⟨10.1016/j.canlet.2004.08.024⟩
Article dans une revue hal-03082067v1
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DNA synthesis-dependent and -independent chromatin assembly pathways in xenopus egg extracts

Dominique Ray-Gallet , Geneviève Almouzni
Methods in Enzymology, 2004
Article dans une revue hal-03048283v1

Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis

Hideaki Tagami , Dominique Ray-Gallet , Geneviève Almouzni , Yoshihiro Nakatani
Cell, 2004
Article dans une revue hal-03046816v1

Chromatin Assembly Factor-1, a Marker of Clinical Value to Distinguish Quiescent from Proliferating Cells

Sophie Polo , Stamatios Theocharis , Jerzy Klijanienko , Alexia Savignoni , Bernard Asselain
Cancer Research, 2004, 64 (7), pp.2371-2381. ⟨10.1158/0008-5472.can-03-2893⟩
Article dans une revue hal-03082063v1
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CENP-A, a histone H3 variant with key roles in centromere architecture in healthy and diseased states

Daniel Jeffery , Marina Lochhead , Geneviève Almouzni
Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine, inPress
Chapitre d'ouvrage hal-03810681v1
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The Histone H3 Family and Its Deposition Pathways

Dominique Ray-Gallet , Geneviève Almouzni
Advances in Experimental Medicine and Biology book series. Histone Mutations and Cancer, 1283, Springer Nature, pp.17-42, 2020, Advances in Experimental Medicine and Biology b, 978-9-81-158103-8, 978-9-81-158104-5. ⟨10.1007/978-981-15-8104-5_2⟩
Chapitre d'ouvrage hal-03028662v1
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Après Darwin : épigénétique et évolution – L’architecture du génome : ses briques et sa plasticité

Geneviève Almouzni
Darwin au Collège de France XIXè-XXIè siècle, PSL/République des Savoirs, Collège de France, 2020, Passage des Disciplines, 9782722605329. ⟨10.4000/books.cdf.7303⟩
Chapitre d'ouvrage hal-03052794v1
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Metabolic Deregulations Affecting Chromatin Architecture: One-Carbon Metabolism and Krebs Cycle Impact Histone Methylation.

Francisco Saavedra , Ekaterina Boyarchuk , Francisca Alvarez , Geneviève Almouzni , Alejandra Loyola
The DNA,RNA, and Histone Methylomes. RNA Technologies., RNATECHN, pp.573-606, 2019, 978-3-030-14791-4. ⟨10.1007/978-3-030-14792-1_23⟩
Chapitre d'ouvrage hal-02371144v1

Imaging Newly Synthesized and Old Histone Variant Dynamics Dependent on Chaperones Using the SNAP-Tag System

Júlia Torné , Guillermo A Orsi , Dominique Ray-Gallet , Geneviève Almouzni
Histone Variants, pp.207-221, 2018, ⟨10.1007/978-1-4939-8663-7_11⟩
Chapitre d'ouvrage hal-02371170v1

Chromatin Dynamics in Cancer: Epigenetic Parameters and Cellular Fate—Histone Variants and Their Chaperones: New Targets?

Daniel Jeffery , Katrina Podsypanina , Tejas Yadav , Geneviève Almouzni
Reference Module in Biomedical Sciences, Elsevier, 2018, ⟨10.1016/B978-0-12-801238-3.65276-5⟩
Chapitre d'ouvrage hal-02371158v1

Methods for Studying Chromatin Assembly Coupled to DNA Repair

Annabelle Gérard , Sophie Polo , Danièle Roche , Geneviève Almouzni
Methods Enzymol, pp.358-374, 2006, ⟨10.1016/S0076-6879(05)09021-X⟩
Chapitre d'ouvrage hal-03082078v1