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Christine Leroux

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Présentation

Christine Leroux (women, PhD, HDR) is a research director from INRAE, the French national institute for research in agriculture, nutrition and environment. After obtaining her PhD in Molecular Genetics (University of Orsay-Paris XI, France) in 1992, Christine started to work at INRA on milk components biosynthesis and secretion in dairy ruminants. She studies the effects of different factors (mainly genetics and nutritional) influencing mammary gland functioning during lactation. Christine’s research aims to improve nutritional quality of milk for consumers and to identify indicators of animal metabolism and health using strategies of nutrigenomics. She firstly studied the effects of genetics polymorphism on protein synthesis, and then she worked on effects of ruminant nutrition on mammary and in a lesser extent on adipose tissues gene expression associated with milk fat composition. More recently, she initiated studies on microRNA and their nutritional regulation in mammary gland. She was visiting researcher scientist at University of California Davis (2017-2019) where she investigated the potential role of milk microRNA as a food source bioactive and contributor to human health. End of 2020, she had 5383 citations and an h-index of 41 referenced by Google Scholar. She participated to 15 national and international research projects. She has 8 years of experience of management of research groups (more than 15 persons) and of a transcriptomic platform, and she has supervised over 26 students (both undergraduates and graduates).

Publications

"yannick-faulconnier"

MiRNome variations in milk fractions during feed restrictions of different intensities in dairy cows

Antoine Leduc , Sandrine Le Guillou , Denis Laloë , Lucile Herve , Johann Laubier
BMC Genomics, 2023, 24 (1), pp.680. ⟨10.1186/s12864-023-09769-5⟩
Article dans une revue hal-04284310v1
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Milk fat miRNome changes in response to LPS challenge in Holstein cows

Christine Leroux , Matteo Cuccato , Karol Pawłowski , Francesca Tiziana Cannizzo , Paola Sacchi
Veterinary Research, 2023, 54 (1), pp.111. ⟨10.1186/s13567-023-01231-4⟩
Article dans une revue hal-04328606v1

Comparative transcriptome analysis of goat (Capra hircus) adipose tissue reveals physiological regulation of body reserve recovery after the peak of lactation

Yannick Faulconnier , Céline Boby , Fanny Coulpier , Sophie Lemoine , Patrice Martin
Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 2022, 41, pp.100956. ⟨10.1016/j.cbd.2021.100956⟩
Article dans une revue hal-03524137v1
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Nutrigenomic analyses reveal miRNAs and mRNAs affected by feed restriction in the mammary gland of midlactation dairy cows

Pierre-Alexis Billa , Yannick Faulconnier , Tao Ye , Céline Bourdon , José Pires
PLoS ONE, 2021, 16 (4), ⟨10.1371/journal.pone.0248680⟩
Article dans une revue hal-03200342v1

Nutritional Regulation of Mammary Gland Development and Milk Synthesis in Animal Models and Dairy Species

Cathy Hue-Beauvais , Yannick Faulconnier , Madia Charlier , Christine Leroux
Genes, 2021, 12 (4), pp.523. ⟨10.3390/genes12040523⟩
Article dans une revue hal-03223225v1

Different miRNA contents between mammary epithelial cells and milk fat globules: a random or a targeted process?

Karol Pawlowski , Daiane Lago-Novais , Claudia Bevilacqua , Lenha Mobuchon , Nicolas Crapart
Molecular Biology Reports, 2020, 47 (10), pp.8259-8264. ⟨10.1007/s11033-020-05787-8⟩
Article dans une revue hal-03151812v1
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Milk metabolites as noninvasive indicators of nutritional status of mid-lactation Holstein and Montbéliarde cows

Pierre-Alexis Billa , Yannick Faulconnier , Torben Larsen , Christine Leroux , José Pires
Journal of Dairy Science, 2020, 103 (4), pp.3133-3146. ⟨10.3168/jds.2019-17466⟩
Article dans une revue hal-02624734v1
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Deep RNA-Seq reveals miRNome differences in mammary tissue of lactating Holstein and Montbéliarde cows

Pierre-Alexis Billa , Yannick Faulconnier , T. Ye , M. Chervet , Fabienne Le Provost
BMC Genomics, 2019, 20, pp.621
Article dans une revue hal-02620652v1
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Effects of Azgp1-/- on mammary gland, adipose tissue and liver gene expression and milk lipid composition in lactating mice

Yannick Faulconnier , Céline Boby , José Pires , Cyril Labonne , Christine Leroux
Gene, 2019, 692, pp.201-207. ⟨10.1016/j.gene.2019.01.010⟩
Article dans une revue hal-02627788v1
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Mammary gland transcriptome and proteome modifications by nutrient restriction in early lactation Holstein cows challenged with intramammary lipopolysaccharide

Karol Pawlowski , José Pires , Yannick Faulconnier , Christophe Chambon , Pierre Germon
International Journal of Molecular Sciences, 2019, 20 (5), 19 p. ⟨10.3390/ijms20051156⟩
Article dans une revue hal-02625031v1

Extruded linseed alone or in combination with fish oil modifies mammary gene expression profiles in lactating goats

Yannick Faulconnier , Laurence Bernard , Céline Boby , Jordann Domagalski , Yves Chilliard
Animal, 2018, 12 (8), pp.1564-1575. ⟨10.1017/S1751731117002816⟩
Article dans une revue hal-02622050v1

Bovine mammary nutrigenomics and changes in the milk composition due to rapeseed or sunflower oil supplementation of high-forage or high-concentrate diets

Christine Leroux , Laurence Bernard , Yannick Faulconnier , Jacques J. Rouel , Anne de La Foye
Journal of Nutrigenetics and Nutrigenomics, 2016, 9 (2-4), pp.65-82. ⟨10.1159/000445996⟩
Article dans une revue hal-02640940v1

The Transcriptomic profiles of adipose tissues are modified by feed deprivation in lactating goats

Yannick Faulconnier , Yves Y. Chilliard , Mohammed Bagher M. B. Montazer Torbati , Christine Leroux
Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 2011, 6 (2), pp.139-149. ⟨10.1016/j.cbd.2010.12.002⟩
Article dans une revue hal-02648271v1

Glucose-6-phosphate dehydrogenase and leptin are related to marbling differences among Limousin and Angus or Japanese Black x Angus steers

Muriel Bonnet , Yannick Faulconnier , Christine Leroux , Catherine C. Jurie , Isabelle Cassar-Malek
Journal of Animal Science, 2007, 85 (11), pp.2882-2894
Article dans une revue hal-02653399v1

Mammary lipid metabolism and milk fatty acid secretion in alpine goasts fed vegetable lipids

Laurence Bernard , Jacques Rouel , Christine Leroux , Anne Ferlay , Yannick Faulconnier
Journal of Dairy Science, 2005, 88 (4), pp.1478-1482. ⟨10.3168/jds.S0022-0302(05)72816-2⟩
Article dans une revue hal-02680222v1

Nutritional status induces divergent variations of GLUT4 protein content, but not lipoprotein lipase activity, between adipose tissues and muscles in adult cattle

Muriel Bonnet , Yannick Faulconnier , Jean-François J.-F. Hocquette , Francois Bocquier , Christine Leroux
British Journal of Nutrition, 2004, 92 (4), pp.617-625. ⟨10.1079/BJN20041240⟩
Article dans une revue hal-02680426v1

Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration

Yves Chilliard , Muriel Bonnet , Carole Delavaud , Yannick Faulconnier , Christine Leroux
Domestic Animal Endocrinology, 2001, 21 (4), pp.271-295
Article dans une revue hal-02670107v1

Effects of photoperiod and feeding level on adipose tissue and muscle lipoprotein lipase activity and mRNA level in dry non-pregnant sheep

Yannick Faulconnier , Muriel Bonnet , Francois Bocquier , Christine Leroux , Yves Chilliard
British Journal of Nutrition, 2001, 85 (3), pp.299-306
Article dans une revue hal-02671384v1

Lipoprotein lipase activity and mRNA are up-regulated by refeeding in adipose tissue and cardiac muscle of sheep

Muriel Bonnet , Christine Leroux , Yannick Faulconnier , Jean-François J.-F. Hocquette , Francois Bocquier
Journal of Nutrition, 2000, 130, pp.749-756
Article dans une revue hal-02694885v1
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Régulation du métabolisme lipidique des tissus adipeux et musculaires chez le ruminant. Effets du niveau alimentaire et de la photopériode

Yannick Faulconnier , Muriel Bonnet , Francois Bocquier , Christine Leroux , Jean-François J.-F. Hocquette
Productions Animales, 1999, 12 (4), pp.287-300
Article dans une revue hal-02694594v1

Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows

Muriel Bonnet , Yannick Faulconnier , Jean-François J.-F. Hocquette , Christine Leroux , Dominique Langin
Reproduction Nutrition Development, 1998, 38 (3), pp.297-307
Article dans une revue hal-02698559v1
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Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows

Muriel Bonnet , Yannick Faulconnier , Jeanne Fléchet , Jean-François J.-F. Hocquette , Christine Leroux
Reproduction Nutrition Development, 1998, 38 (3), pp.297-307
Article dans une revue hal-00900209v1

Study of lipoprotein lipase mRNAs in ovine adipose tissue by quantitative fluorescence polymerase chain reaction

Muriel Bonnet , Christine Leroux , J.P. Furet , Patrice Martin , Fabienne Le Provost
Reproduction Nutrition Development, 1997, 37 (3), pp.371
Article dans une revue hal-02685426v1

mRNAs encoding lipogenic and lipolytic enzymes in the adipose tissue of underfed-refed ewes and cows

M. Bonnet , Yannick Faulconnier , Jean-François J.-F. Hocquette , Christine Leroux , Dominique Langin
International Journal of Obesity, 1996, 20 (Suppl4), pp.148
Article dans une revue hal-02684856v1

Quantitative fluorescence PCR assay for studing the expression of the gene encoding lipoprotein lipase in ovine adipose tissue

M. Bonnet , Christine Leroux , J.P. Furet , Fabienne Le Provost , Yannick Faulconnier
Animal Genetics, 1996, 27 (Suppl2), pp.87
Article dans une revue hal-02685736v1

La composition en microARN du lait sous influence des races bovines

Sandrine Le Guillou , Ouleye Sidibe , Antoine Leduc , Johann Laubier , Yannick Faulconnier
Journées Scientifiques du Département Génétique Animale (JSGA), Département Génétique Animale, INRAE, Sep 2022, Bordeaux, France
Communication dans un congrès hal-04227375v1
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Les exosomes : des véhicules de signatures moléculaires pour comprendre le dialogue entre les organes des ruminants

Céline Boby , José Pires , Arnaud Delavaud , Laurent-Emmanuel Monfoulet , Laurence Bernard
1. Rencontres Clermontoises sur les Vésicules Extracellulaires, Laurent-Emmanuel MONFOULET-INRAE-UNH (Organisateur), Feb 2022, Clermont-Ferrand, France. ⟨10.17180/ev22-co02⟩
Communication dans un congrès hal-03561304v1
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Les métabolites et les acides gras du lait : des indicateurs non invasifs du statut métabolique et du bilan énergétique chez les vaches laitières

José Pires , Pierre-Alexis Billa , Torben Larsen , Yannick Faulconnier , Christine Leroux
Résumés - Réunion virtuelle Glande mammaire lait / Galactinnov, INRAE, Animation transversale Phase Galactinov, Nov 2021, en ligne, France
Communication dans un congrès hal-03958170v1

Impact d’une restriction alimentaire sur les miRNome et protéome du lait chez la vache laitière

Antoine Leduc , Sandrine Le Guillou , L. Bianchi , Lydie Oliveira Correia , Andrea Rau
Glande mammaire lait / Galactinnov, Nov 2021, En ligne, France
Communication dans un congrès hal-03747713v1

Feed restriction affects protein and microRNA levels in dairy cows' milk

Antoine Leduc , Sandrine Le Guillou , L Bianchi , M. Gelé , Lucile Herve
72. Annual meeting of the european federation of animal science (EAAP), Aug 2021, Davos, Switzerland. pp.620
Communication dans un congrès hal-03318595v1

MiRNA profile in milk extracellular vesicles is modulated by caprine alphaS1-casein genotype

Christine Leroux , M. Chervet , Zuzana Krupova , Claudia Bevilacqua , Yannick Faulconnier
8. IDF International Symposium on Sheep, goat and other non-cow milk, Nov 2020, Inconnue, Belgium
Communication dans un congrès hal-03155018v1

Une approche intégrée pour comprendre le dialogue entre tissus/organes chez les ruminants producteurs

Isabelle Cassar-Malek , Mylène Delosière , Laurence Bernard , Céline Boby , Carole Delavaud
Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France
Communication dans un congrès hal-02940675v1

Des biomarqueurs aux outils de prédiction des performances des ruminants et de la qualité de leurs produits

Brigitte Picard , Laurence Bernard , Isabelle Cassar-Malek , Carole Delavaud , Mylène Delosière
Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France
Communication dans un congrès hal-02940696v1
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Les métabolites du lait comme indicateurs non invasifs du statut nutritionnel chez les vaches Holstein et Montbéliarde en milieu de lactation

Pierre-Alexis Billa , Yannick Faulconnier , Torben Larsen , Christine Leroux , José Pires
24. Rencontres autour des Recherches sur les Ruminants (3R), Dec 2018, Paris, France
Communication dans un congrès hal-02734722v1

Milk fat globules as a source of mammary microRNA

Karol Pawlowski , Daiane Lago Novais , José Pires , Lenha Mobuchon , Yannick Faulconnier
International Symposium on Microgenomics 2016, Jun 2016, Paris, France
Communication dans un congrès hal-02743285v1
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MilkChEST, an integrative approach of the secretion pathways in the mammary epithelial cell: molecular dissection of milk fat adaptability

Christine Leroux , Christian Beauvallet , Laurence Bernard , Claudia Bevilacqua , Frédéric Bouvier
European Regional Conference On Goats, Jun 2013, Tromsø, Norway
Communication dans un congrès hal-01194090v1

Effet de la non alimentation sur le transcriptome adipocytaire de chèvres en lactation

Yannick Faulconnier , Jordann J. Domagalski , Mohammed Bagher M. B. Montazer Torbati , Didier Bany , Yves Y. Chilliard
3. Journées d’Animation Scientifique du Département de Physiologie Animale et Systèmes d’Elevage, Oct 2009, Tours, France
Communication dans un congrès hal-02752062v1

La nature du fourrage modifie la matière grasse laitière et le transcriptome mammaire de chèvres en lactation

Christine Leroux , Jacques J. Rouel , Yannick Faulconnier , Jordann J. Domagalski , Yoan Gaudron
3. Journées d’Animation Scientifique du Département de Physiologie Animale et Systèmes d’Elevage, Oct 2009, Tours, France
Communication dans un congrès hal-02757811v1

Transcriptomic profile in adipose tissues is modified by nutrition in lactating goats

Yannick Faulconnier , Jordann J. Domagalski , Mohammed Bagher M. B. Montazer Torbati , Yoan Gaudron , Didier Bany
11. International Symposium on Ruminant Physiology, Sep 2009, Clermont-Ferrand, France
Communication dans un congrès hal-02751987v1

Effect of nutrition on mammary transcriptome and its interaction with the CSN1S1 genotype in lactating goats.

S. Ollier , Christèle Robert-Granié , Sébastien Bes , Marion Goutte , Yannick Faulconnier
Journée Ecole Doctorale, Mars 2006., 2006, Inconnu, pp.Inconnu
Communication dans un congrès hal-02816310v1

Impact of nutrition on mammary transcriptome and its interaction with the CSN1S1 genotype in lactating goats.

S. Ollier , Christèle Robert-Granié , P. Martin , Sébastien Bes , Marion Goutte
3rd International Symposium on Milk Genomics & Human Health, Sep 2006, Bruxelles, pp.Inconnu
Communication dans un congrès hal-02811809v1

Impact of nutrition on mammary transcriptome and its interaction with the CSN1S1 genotype in lactating goats

Severine Ollier , Christèle Robert-Granié , Sébastien Bes , Marion Goutte , Yannick Faulconnier
57. Annual Meeting of the European Association for Animal Production (EAAP), Sep 2006, Antalya, Turkey
Communication dans un congrès hal-02753041v1

Glucose-6-Phosphate dehydrogenase and leptin are linked to marbling differences between Limousin and angus or japanese black x angus steers

Muriel Bonnet , Yannick Faulconnier , Christine Leroux , Catherine C. Jurie , Isabelle Cassar-Malek
56. Annual Meeting of the European Association for Animal Production (EAAP), Jun 2005, Uppsala, Sweden
Communication dans un congrès hal-02760645v1

L'activité de la glucose-6-phosphate deshydrogenase est liée aux différences d'adiposite tissulaires et raciales chez le bovin en croissance

Muriel Bonnet , Yannick Faulconnier , Christine Leroux , Catherine C. Jurie , Isabelle Cassar-Malek
1ères Journées d'Animation Scientifique du Département de Physiologie Animale et Systèmes d'Elevage, Mar 2005, Tours, France
Communication dans un congrès hal-02759104v1

Effects of concentrate level and starch degradability on expression of mammary lipogenic genes in goats receiving a diet supplemented in sunflower oil

Laurence Bernard , Christine Leroux , Yannick Faulconnier , Denys Durand , Yves Y. Chilliard
56. Annual Meeting of the European Association for Animal Production (EAAP), Jun 2005, Uppsala, Sweden
Communication dans un congrès hal-02759524v1

Effects of concentrate level and starch degradability on expression of mammary lipogenic genes in goats receiving a diet supplemented with sunflower oil

Laurence Bernard , Christine Leroux , Yannick Faulconnier , Denys Durand , Yves Y. Chilliard
3. International Workshop on Mammary Gland and Biotechnology : Nutrition, Genomics and Breast Cancer, Sep 2005, Barcelone, Spain
Communication dans un congrès hal-02759093v1

Lipogenesis in subcutaneous adipose tissue and in oxidative or glycolytic muscles from Angus, Black Japanese x Angus and Limousin

Muriel Bonnet , Yannick Faulconnier , Jean-François J.-F. Hocquette , Christine Leroux , P. Boulesteix
Progress in research on energy and protein metabolism, Sep 2003, Rostock-Warnemünde, Germany
Communication dans un congrès hal-02761029v1

Effects of energy intake and photoperiod on the expression of genes encoding enzymes of energy metabolism in adipose tissue and muscle of ewes and cows

M. Bonnet , Yannick Faulconnier , Francois Bocquier , Christine Leroux , Jean-François J.-F. Hocquette
3. Colloque Franco-Britannique de Nutrition : Fonctionnalité des nutriments, Sep 1998, Nancy, France
Communication dans un congrès hal-02766020v1

Effect of refeeding on two mRNA species of lipoprotein lipase in adipose tissue and cardiac muscle of sheep

M. Bonnet , Yannick Faulconnier , Christine Leroux , Francois Bocquier , Patrice Martin
3. French-British meeting on nutrition, Sep 1998, Nancy, France
Communication dans un congrès hal-02764580v1

Quantitative fluorescence PCR assay for studing the expression of the gene encoding lipoprotein lipase in ovine adipose tissue

M. Bonnet , Christine Leroux , J.P. Furet , Fabienne Le Provost , Yannick Faulconnier
25. ISAG Conference, Jul 1996, Tours, France
Communication dans un congrès hal-02842032v1

Quantitative fluorescence PCR assay for studying the expression of the gene encoding lipoprotein lipase in ovine adipose tissue

M. Bonnet , Christine Leroux , J.P. Furet , Fabienne Le Provost , Yannick Faulconnier
25. International conference on animal genetics, Jul 1996, Tours, France
Communication dans un congrès hal-02836367v1

Study of lipoprotein lipase mRNAs in ovine adipose tissue by quantitative fluorescence polymerase chain reaction

Muriel Bonnet , Christine Leroux , J.P. Furet , Patrice Martin , Fabienne Le Provost
Annual Symposium on Animal and Human Nutrition, Oct 1996, Nantes, France
Communication dans un congrès hal-02835538v1

mRNAs encoding lipogenic and lipolytic enzymes in the adipose tissue of underfed-refed ewes and cows

M. Bonnet , Yannick Faulconnier , Jean-François J.-F. Hocquette , Christine Leroux , Dominique Langin
7. European congress on obesity, May 1996, Barcelone, Spain
Communication dans un congrès hal-02834871v1