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164

Genetic and nutritional regulation of mammary gland function affecting milk component synthesis and secretion


Christine Leroux (women, PhD, HDR) is a research director from INRAE, the French national institute for research in agriculture, nutrition and environment. After obtaining her PhD in Molecular Genetics (University of Orsay-Paris XI, France) in 1992, Christine started to work at INRA on milk components biosynthesis and secretion in dairy ruminants. She studies the effects of different factors (mainly genetics and nutritional) influencing mammary gland functioning during lactation. Christine’s research aims to improve nutritional quality of milk for consumers and to identify indicators of animal metabolism and health using strategies of nutrigenomics. She firstly studied the effects of genetics polymorphism on protein synthesis, and then she worked on effects of ruminant nutrition on mammary and in a lesser extent on adipose tissues gene expression associated with milk fat composition. More recently, she initiated studies on microRNA and their nutritional regulation in mammary gland. She was visiting researcher scientist at University of California Davis (2017-2019) where she investigated the potential role of milk microRNA as a food source bioactive and contributor to human health.  End of 2020, she had 5383 citations and an h-index of 41 referenced by Google Scholar. She participated to 15 national and international research projects. She has 8 years of experience of management of research groups (more than 15 persons) and of a transcriptomic platform, and she has supervised over 26 students (both undergraduates and graduates).


Journal articles69 documents

  • Pierre-Henry Esposito, Christine Leroux, Vasile Heresanu, Thomas Neisius, Véronique Madigou, et al.. Influence of texture and microstructure on the reactivity of aluminum powders. Materialia, Elsevier, 2020, 14, pp.100880. ⟨10.1016/j.mtla.2020.100880⟩. ⟨hal-02932872⟩
  • Nathalie Beaujean, Marion Boutinaud, Ève Devinoy, Hélène Jammes, Sandrine Le Guillou, et al.. L’épigénétique et la construction du phénotype chez le bovin. INRAE Productions Animales, 2020, 33 (2), pp.109-124. ⟨10.20870/productions-animales.2020.33.2.4477⟩. ⟨hal-02947903⟩
  • Pierre-Alexis Billa, Yannick Faulconnier, Torben Larsen, Christine Leroux, José Pires. Milk metabolites as noninvasive indicators of nutritional status of mid-lactation Holstein and Montbéliarde cows. Journal of Dairy Science, American Dairy Science Association, 2020, 103 (4), pp.3133-3146. ⟨10.3168/jds.2019-17466⟩. ⟨hal-02624734⟩
  • Sandrine Le Guillou, Johann Laubier, Christine Longin, Etienne Aujean, Johan Castille, et al.. Defects of the endoplasmic reticulum and changes to lipid droplet size in mammary epithelial cells due to miR-30b-5p overexpression are correlated to a reduction in Atlastin 2 expression. Biochemical and Biophysical Research Communications, Elsevier, 2019, 512 (2), pp.283-288. ⟨10.1016/j.bbrc.2019.03.022⟩. ⟨hal-02627428⟩
  • José Pires, Karol Pawlowski, Jacques Rouel, Carole Delavaud, Gilles Foucras, et al.. Undernutrition modified metabolic responses to intramammary lipopolysaccharide but had limited effects on selected inflammation indicators in early-lactation cows. Journal of Dairy Science, American Dairy Science Association, 2019, 102 (6), pp.5347-5360. ⟨10.3168/jds.2018-15446⟩. ⟨hal-02620566⟩
  • Yannick Faulconnier, Céline Boby, José Pires, Cyril Labonne, Christine Leroux. Effects of Azgp1-/- on mammary gland, adipose tissue and liver gene expression and milk lipid composition in lactating mice. Gene, Elsevier, 2019, 692, pp.201-207. ⟨10.1016/j.gene.2019.01.010⟩. ⟨hal-02627788⟩
  • Karol Pawlowski, José Pires, Yannick Faulconnier, Christophe Chambon, Pierre Germon, et al.. Mammary gland transcriptome and proteome modifications by nutrient restriction in early lactation Holstein cows challenged with intramammary lipopolysaccharide. International Journal of Molecular Sciences, MDPI, 2019, 20 (9), pp.1156. ⟨10.3390/ijms20051156⟩. ⟨hal-02625031⟩
  • Pierre-Alexis Billa, Yannick Faulconnier, T. Ye, M. Chervet, Fabienne Le Provost, et al.. Deep RNA-Seq reveals miRNome differences in mammary tissue of lactating Holstein and Montbéliarde cows. BMC Genomics, BioMed Central, 2019, 20. ⟨hal-02620652⟩
  • Madjid Arab, Rafael Hernandez Damascena dos Passos, Carlson Pereira de Souza, Christine Leroux. Catalytic properties of Sr1−xCexWO4: The role of mixed conduction in methane oxidation. International Journal of Hydrogen Energy, Elsevier, 2018, 43 (33), pp.15918 - 15930. ⟨10.1016/j.ijhydene.2018.06.143⟩. ⟨hal-01871793⟩
  • Yannick Faulconnier, Laurence Bernard, Céline Boby, Jordann Domagalski, Yves Chilliard, et al.. Extruded linseed alone or in combination with fish oil modifies mammary gene expression profiles in lactating goats. animal, Cambridge University Press (CUP), 2018, 12 (8), pp.1564-1575. ⟨10.1017/S1751731117002816⟩. ⟨hal-02622050⟩
  • Lenha Mobuchon, Sandrine Le Guillou, Sylvain Marthey, Johann Laubier, Denis Laloë, et al.. Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland. PLoS ONE, Public Library of Science, 2017, 12 (12), pp.e0185511. ⟨10.1371/journal.pone.0185511⟩. ⟨hal-02617650⟩
  • Christine Leroux, Laurence Bernard, Yannick Faulconnier, Jacques Rouel, Anne de la Foye, et al.. Bovine mammary nutrigenomics and changes in the milk composition due to rapeseed or sunflower oil supplementation of high-forage or high-concentrate diets. Journal of Nutrigenetics and Nutrigenomics, 2016, 9 (2-4), pp.65-82. ⟨10.1159/000445996⟩. ⟨hal-02640940⟩
  • Lenha Mobuchon, Sylvain Marthey, Mekki Boussaha, Sandrine Le Guillou, Christine Leroux, et al.. Annotation of the goat genome using next generation sequencing of microRNA expressed by the lactating mammary gland: comparison of three approaches. BMC Genomics, BioMed Central, 2015, 16, pp.285. ⟨10.1186/s12864-015-1471-y⟩. ⟨hal-01194123⟩
  • Laurence Bernard, Christophe Richard, Valerie Gelin, Christine Leroux, Yvan Heyman. Milk fatty acid composition and mammary lipogenic genes expression in bovine cloned and control cattle. Livestock Science, Elsevier, 2015, 176, pp.188-195. ⟨10.1016/j.livsci.2015.03.016⟩. ⟨hal-02640576⟩
  • Laurence Bernard, Christine Leroux, Jacques Rouel, Carole Delavaud, Kevin John Shingfield, et al.. Effect of extruded linseeds alone or in combination with fish oil on intake, milk production, plasma metabolite concentrations and milk fatty acid composition in lactating goats. animal, Cambridge University Press (CUP), 2015, 9 (5), pp.810-821. ⟨10.1017/S1751731114003048⟩. ⟨hal-02631935⟩
  • T. Castro-Carrera, P. Frutos, Christine Leroux, Yves Chilliard, G. Hervás, et al.. Dietary sunflower oil modulates milk fatty acid composition without major changes in adipose and mammary tissue fatty acid profile or related gene mRNA abundance in sheep. animal, Cambridge University Press (CUP), 2015, 9 (4), pp.582-591. ⟨10.1017/S1751731114002882⟩. ⟨hal-02636182⟩
  • Lenha Mobuchon, Sylvain Marthey, Sandrine Le Guillou, Denis Laloë, Fabienne Le Provost, et al.. Food deprivation affects the miRNome in the lactating goat mammary gland. PLoS ONE, Public Library of Science, 2015, 10 (10), 20 p. ⟨10.1371/journal.pone.0140111⟩. ⟨hal-02630964⟩
  • Sandrine Le Guillou, Sylvain Marthey, Denis Laloë, Johann Laubier, Lenha Mobuchon, et al.. Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes. PLoS ONE, Public Library of Science, 2014, 9 (3), pp.e91938. ⟨10.1371/journal.pone.0091938⟩. ⟨hal-01193833⟩
  • Yves Chilliard, Pablo Gutierrez Toral, Kevin John Shingfield, Jacques Rouel, Christine Leroux, et al.. Effects of diet and physiological factors on milk fat synthesis, milk fat composition and lipolysis in the goat: A short review. Small Ruminant Research, Elsevier, 2014, 122 (1-3), pp.31-37. ⟨10.1016/j.smallrumres.2014.07.014⟩. ⟨hal-02639525⟩
  • Dragan Milenkovic, Wim Vanden Berghe, Céline Boby, Christine Leroux, K. Declerc, et al.. Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state. PLoS ONE, Public Library of Science, 2014, 9 (4), pp.e95527. ⟨10.1371/journal.pone.0095527⟩. ⟨hal-02634108⟩
  • Muriel Bonnet, Laurence Bernard, Sébastien Bes, Christine Leroux. Selection of reference genes for quantitative real-time PCR normalisation in adipose tissue, muscle, liver and mammary gland from ruminants. animal, Cambridge University Press (CUP), 2013, 7 (8), pp.1344-1353. ⟨10.1017/S1751731113000475⟩. ⟨hal-02645011⟩
  • Laurence Bernard, Christine Leroux, Yves Chilliard. Nutritional regulation of mammary lipogenesis and milk fat in ruminant: contribution to sustainable milk production. Revista Colombiana de Ciencias Pecuarias, 2013, 26, pp.292-302. ⟨hal-02642036⟩
  • Laurence Bernard, Mohammed Bagher Montazer Torbati, Benoit Graulet, Christine Leroux, Yves Chilliard. Long-chain fatty acids differentially alter lipogenesis in bovine and caprine mammary slices. Journal of Dairy Research, Cambridge University Press (CUP), 2013, 80 (1), pp.89-95. ⟨10.1017/S0022029912000726⟩. ⟨hal-02643537⟩
  • Madjid Arab, André Luis Lopes-Moriyama, Tiago Renovato dos Santos, Carlson Pereira de Souza, Jean-Raymond Gavarri, et al.. Strontium and cerium tungstate materials SrWO4 and Ce2(WO4)3: Methane oxidation and mixed conduction. Catalysis Today, Elsevier, 2013, 208, pp.35 - 41. ⟨10.1016/j.cattod.2012.09.036⟩. ⟨hal-01872813⟩
  • Bernardo Valenti, Bruno Martin, Jesus Donato Andueza, Christine Leroux, Cyril Labonne, et al.. Infrared spectroscopic methods for the discrimination of cow milk according to the feeding systems, cow breed and altitude of the dairy farms. International Dairy Journal, Elsevier, 2013, 32 (1), pp.26-32. ⟨10.1016/j.idairyj.2013.02.014⟩. ⟨hal-01000927⟩
  • Jesus Donato Andueza Urra, Jacques Rouel, Yves Chilliard, Christine Leroux, Anne Ferlay. Prediction of the goat milk fatty acids by near infrared reflectance spectroscopy. European Journal of Lipid Science and Technology, Wiley-VCH Verlag, 2013, 115 (6), pp.612 - 620. ⟨10.1002/ejlt.201200315⟩. ⟨hal-02649107⟩
  • Pablo Gutierrez Toral, Laurence Bernard, Carole Delavaud, Dominique Gruffat, Christine Leroux, et al.. Effects of fish oil and additional starch on tissue fatty acid profile and lipogenic gene mRNA abundance in lactating goats fed a diet containing sunflower-seed oil. animal, Cambridge University Press (CUP), 2013, 7 (6), pp.948-956. ⟨10.1017/S1751731113000049⟩. ⟨hal-02643437⟩
  • Christine Leroux, Laurence Bernard, Frederic Dessauge, Fabienne Le Provost, Patrice Martin. La fonction de lactation : régulation de la biosynthèse des constituants du lait. INRA Productions Animales, Paris: INRA, 2013, 26 (2), pp.117-128. ⟨hal-01019559⟩
  • Philippe Faverdin, Christine Leroux. Numéro spécial "La vache et le lait". Avant Propos. INRA Productions Animales, Paris: INRA, 2013, 26 (2), pp.71-76. ⟨hal-01210610⟩
  • Laurence Bernard, Christine Leroux, Jacques Rouel, Muriel Bonnet, Yves Chilliard. Effect of the level and type of starchy concentrate on tissue lipid metabolism, gene expression and milk fatty acid secretion in Alpine goats receiving a diet rich in sunflower-seed oil. British Journal of Nutrition, Cambridge University Press (CUP), 2012, 107 (8), pp.1147-1159. ⟨10.1017/S0007114511004181⟩. ⟨hal-02648706⟩
  • Joaquin Angulo, Liliana Mahecha, Karin Nuernberg, Gerd Nuernberg, Dirk Dannenberger, et al.. Effects of polyunsaturated fatty acids from plant oils and algae on milk fat yield and composition are associated with mammary lipogenic and SREBF1 gene expression. animal, Cambridge University Press (CUP), 2012, 6 (12), pp.1961-1972. ⟨10.1017/S1751731112000845⟩. ⟨hal-02652522⟩
  • Yannick Faulconnier, Yves Chilliard, Mohammed Bagher Montazer Torbati, Christine Leroux. The Transcriptomic profiles of adipose tissues are modified by feed deprivation in lactating goats. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, Elsevier, 2011, 6 (2), pp.139-149. ⟨10.1016/j.cbd.2010.12.002⟩. ⟨hal-02648271⟩
  • Mauro Coppa, Anne Ferlay, Christine Leroux, Michel Jestin, Yves Chilliard, et al.. Prediction of milk fatty acid composition by near infrared reflectance spectroscopy. International Dairy Journal, Elsevier, 2010, 20 (3), pp.182-189. ⟨10.1016/j.idairyj.2009.11.003⟩. ⟨hal-02659184⟩
  • Christine Leroux, Isabelle Cassar-Malek. La nutrigénomique. Agro Mag, 2010. ⟨hal-02659035⟩
  • Severine Ollier, Christine Leroux, Anne de la Foye, Laurence Bernard, Jacques Rouel, et al.. Whole intact rapeseeds or sunflower oil in high-forage or high-concentrate diets affects milk yield, milk composition, and mammary gene expression profile in goats. Journal of Dairy Science, American Dairy Science Association, 2009, 92 (11), pp.5544-5560. ⟨10.3168/jds.2009-2022⟩. ⟨hal-02665026⟩
  • Laurence Bernard, Muriel Bonnet, Christine Leroux, Kevin John Shingfield, Yves Chilliard. Effect of sunflower-seed oil and linseed oil on tissue lipid metabolism, gene expression, and milk fatty acid secretion in Alpine goats fed maize silage–based diets. Journal of Dairy Science, American Dairy Science Association, 2009, 92 (12), pp.6083-6094. ⟨10.3168/jds.2009-2048⟩. ⟨hal-02657889⟩
  • Jean-François Hocquette, Abdelhamid Boudra, Isabelle Cassar-Malek, Christine Leroux, Brigitte Picard, et al.. Perspectives offertes par les approches en «omique» pour l'amélioration de la durabilité de l'élevage des herbivores. 1999, 2009, 22 (5), pp.385-396. ⟨hal-00490658⟩
  • Jean-François Hocquette, Abdelhamid Boudra, Isabelle Cassar-Malek, Christine Leroux, Brigitte Picard, et al.. Perspectives offertes par les approches en «omique» pour l'amélioration de la durabilité de l'élevage des herbivores. 1999, 2009, 22 (5), pp.385-396. ⟨hal-00489775⟩
  • Jean-François Hocquette, Abdelhamid Boudra, Isabelle Cassar-Malek, Christine Leroux, Brigitte Picard, et al.. Perspectives offertes par les approches en «omique» pour l'amélioration de la durabilité de l'élevage des herbivores. 1999, 2009, 22 (5), pp.385-396. ⟨hal-00490218⟩
  • Jean-François Hocquette, Hamid Boudra, Isabelle Cassar-Malek, Christine Leroux, Brigitte Picard, et al.. Perspectives offertes par les approches en «omique» pour l’amélioration de la durabilité de l’élevage des herbivores. INRA Productions Animales, Paris: INRA, 2009, 22 (5), pp.385-396. ⟨hal-02662984⟩
  • Severine Ollier, Stéphanie Chauvet, Patrice Martin, Yves Chilliard, Christine Leroux. Goat's alpha(S1)-casein polymorphism affects gene expression profile of lactating mammary gland. animal, Cambridge University Press (CUP), 2008, 2 (4), pp.566-573. ⟨10.1017/S1751731108001584⟩. ⟨hal-02662192⟩
  • Ali Kpatcha Kadanga, Christine Leroux, Muriel Bonnet, Stéphanie Chauvet, Bruno Meunier, et al.. Image analysis and data normalization procedures are crucial for microarray analyses. Gene Regulation and Systems Biology, 2008, 2, pp.107-112. ⟨hal-02654575⟩
  • Severine Ollier, Christèle Robert Granié, Laurence Bernard, Yves Chilliard, Christine Leroux. Mammary transcriptome analysis of food-deprived lactating goats highlights genes involved in milk secretion and programmed cell death 1,2. Journal of Nutrition, American Society for Nutrition, 2007, 137, pp.560-567. ⟨hal-02657141⟩
  • Catherine Jurie, Isabelle Cassar-Malek, Muriel Bonnet, Christine Leroux, Dominique Bauchart, et al.. Adipocyte fatty acid-binding protein and mitochondrial enzyme activities in muscles as relevant indicators of marbling in cattle. Journal of Animal Science, American Society of Animal Science, 2007, 85 (10), pp.2660-2669. ⟨hal-02656889⟩
  • Muriel Bonnet, Yannick Faulconnier, Christine Leroux, Catherine Jurie, Isabelle Cassar-Malek, et al.. Glucose-6-phosphate dehydrogenase and leptin are related to marbling differences among Limousin and Angus or Japanese Black x Angus steers. Journal of Animal Science, American Society of Animal Science, 2007, 85 (11), pp.2882-2894. ⟨hal-02653399⟩
  • Yves Chilliard, Jacques Rouel, Christine Leroux. Goat's alpha-s1 casein genotype influences its milk fatty acid composition and delta-9 desaturation ratios. Animal Feed Science and Technology, Elsevier Masson, 2006, 131 (3-4), pp.474-487. ⟨hal-02663227⟩
  • Laurence Bernard, Christine Leroux, Muriel Bonnet, Jacques Rouel, Patrice Martin, et al.. Expression and nutritional regulation of lipogenic genes in mammary gland and adipose tissues of lactating goats. Journal of Dairy Research, Cambridge University Press (CUP), 2005, 72, pp.250-255. ⟨10.1017/S0022029905000786⟩. ⟨hal-02682974⟩
  • Laurence Bernard, Jacques Rouel, Christine Leroux, Anne Ferlay, Yannick Faulconnier, et al.. Mammary lipid metabolism and milk fatty acid secretion in alpine goasts fed vegetable lipids. Journal of Dairy Science, American Dairy Science Association, 2005, 88 (4), pp.1478-1482. ⟨10.3168/jds.S0022-0302(05)72816-2⟩. ⟨hal-02680222⟩
  • Carine Bernard, Severine Degrelle, Severine Ollier, Evelyne Campion, Isabelle Cassar-Malek, et al.. A cDNA macroarray resource for gene expression profiling in ruminant tissues involved in reproduction and production (milk and beef) traits. Journal of Physiology and Pharmacology, Krakow Polish Physiological Society, 2005, 56 (suppl 3), pp.215-224. ⟨hal-02677050⟩
  • Séverine Sudre, Isabelle Cassar-Malek, Anne Listrat, Yasuko Ueda, Christine Leroux, et al.. Biochemical and transcriptomic analyses of two bovine skeletal muscles in Charolais bulls divergently selected for muscle growth. Meat Science, Elsevier, 2005, 70 (2), pp.267-277. ⟨hal-02676737⟩
  • K. Sudre, Christine Leroux, Isabelle Cassar-Malek, Jean-François Hocquette, Patrice Martin. A collection of bovine cDNA probes for gene expression profiling in muscle. Molecular and Cellular Probes, Elsevier, 2005, 19 (1), pp.61-70. ⟨10.1016/j.mcp.2004.07.005⟩. ⟨hal-02678442⟩
  • Muriel Bonnet, Yannick Faulconnier, Jean-François Hocquette, François Bocquier, Christine Leroux, et al.. Nutritional status induces divergent variations of GLUT4 protein content, but not lipoprotein lipase activity, between adipose tissues and muscles in adult cattle. British Journal of Nutrition, Cambridge University Press (CUP), 2004, 92 (4), pp.617-625. ⟨10.1079/BJN20041240⟩. ⟨hal-02680426⟩
  • A. Carta, G. Piredda, M. Addis, Andrea Cabiddu, M. Fiori, et al.. Fatty acid composition of sheep milk from a backcross Sarda x Lacaune resource population: Preliminary QTL detection for CLA content. Options Méditerranéennes. Série A : Séminaires Méditerranéens, 2003, pp.107-113. ⟨hal-02673054⟩
  • Karine Sudre, Christine Leroux, Geneviève Pietu, Isabelle Cassar-Malek, Anne Listrat, et al.. Transcriptome analysis of two bovine muscles during ontogenesis. Journal of Biochemistry, Oxford University Press (OUP), 2003, 133 (6), pp.745-756. ⟨10.1093/jb/mvg096⟩. ⟨hal-02682738⟩
  • Christine Leroux, Fabienne Le Provost, Elisabeth Petit, Laurence Bernard, Yves Chilliard, et al.. Real-time RT-PCR and cDNA macroarray to study the impact of the genetic polymorphism at the $\alpha_{s1}$-casein locus on the expression of genes in the goat mammary gland during lactation. Reproduction Nutrition Development, EDP Sciences, 2003, 43 (5), pp.459-469. ⟨10.1051/rnd:2003032⟩. ⟨hal-00900521⟩
  • Muriel Bonnet, Carole Delavaud, K. Laud, Isabelle Gourdou, Christine Leroux, et al.. Mammary leptin synthesis, milk leptin and their putative physiological roles. Reproduction Nutrition Development, EDP Sciences, 2002, 42, pp.399-413. ⟨hal-02672237⟩
  • A. Tadlaoui Ouafi, Jean-Marc Babilliot, Christine Leroux, Patrice Martin. Genetic diversity of the two main Moroccan goat breeds: phylogenetic relationships with four breeds reared in France. Small Ruminant Research, Elsevier, 2002, 45, pp.225-233. ⟨hal-02672706⟩
  • Patrice Martin, M. Szymanowska, L. Zwierzchowski, Christine Leroux. The impact of genetic polymorphisms on the protein composition of ruminant milks. Reproduction Nutrition Development, EDP Sciences, 2002, 42, pp.433-459. ⟨hal-02679211⟩
  • Dragan Milenkovic, Patrice Martin, Gérard Guérin, Christine Leroux. A specific pattern of splicing for the horse αS1-Casein mRNA and partial genomic characterization of the relevant locus. Genetics Selection Evolution, BioMed Central, 2002, 34 (4), pp.509-519. ⟨hal-02670100⟩
  • Muriel Bonnet, Carole Delavaud, Karine Laud, Isabelle Gourdou, Christine Leroux, et al.. Mammary leptin synthesis, milk leptin and their putative physiological roles. Reproduction Nutrition Development, EDP Sciences, 2002, 42 (5), pp.399-413. ⟨10.1051/rnd:2002034⟩. ⟨hal-00900336⟩
  • Patrice Martin, Małgorzata Szymanowska, Lech Zwierzchowski, Christine Leroux. The impact of genetic polymorphisms on the protein composition of ruminant milks. Reproduction Nutrition Development, EDP Sciences, 2002, 42 (5), pp.433-459. ⟨10.1051/rnd:2002036⟩. ⟨hal-00900338⟩
  • Dragan Milenkovic, Patrice Martin, Gérard Guérin, Christine Leroux. A specific pattern of splicing for the horse $\alpha$S1-Casein mRNA and partial genomic characterization of the relevant locus. Genetics Selection Evolution, BioMed Central, 2002, 34 (4), pp.509-519. ⟨10.1051/gse:2002020⟩. ⟨hal-00894424⟩
  • Laurence Bernard, Christine Leroux, Hélène Hayes, Mathieu Gautier, Yves Chilliard, et al.. Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3'-UTR sequence arising from a single exon. Gene, Elsevier, 2001, 281 (1-2), pp.53-61. ⟨10.1016/S0378-1119(01)00822-8⟩. ⟨hal-02683444⟩
  • Yannick Faulconnier, Muriel Bonnet, François Bocquier, Christine Leroux, Jean-François Hocquette, et al.. Régulation du métabolisme lipidique des tissus adipeux et musculaires chez le ruminant. Effets du niveau alimentaire et de la photopériode. Productions animales, Institut National de la Recherche Agronomique, 1999, 12 (4), pp.287-300. ⟨hal-02694594⟩
  • M. Bonnet, Christine Leroux, Corinne Giraud-Delville, Yves Chilliard, Patrice Martin. Real time PCR quantitation of mRNA encoding key enzymes of lipogenesis. Application to LPL assay in ovine adipose tissue.. Animal Genetics, Wiley-Blackwell, 1998, suppl. 1, pp.53. ⟨hal-02684991⟩
  • F. Pilla, Claudia Bevilacqua, Christine Leroux, A. Fraghi, Patrice Martin. Genotyping of alpha-s1 casein in sheep.. Animal Genetics, Wiley-Blackwell, 1998, 29, pp.472-473. ⟨hal-02694324⟩
  • Muriel Bonnet, Yannick Faulconnier, Jeanne FlÉchet, Jean-François Hocquette, Christine Leroux, et al.. Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows. Reproduction Nutrition Development, EDP Sciences, 1998, 38 (3), pp.297-307. ⟨hal-00900209⟩
  • L. Méténier-Delisse, Andre Eggen, Hélène Hayes, Christine Leroux, Corinne Giraud-Delville, et al.. Isolation and molecular characterization of bovine Rhesus-like transcripts and chromosome mapping of the relevant locus.. Animal Genetics, Wiley-Blackwell, 1996, suppl. 2, pp.95. ⟨hal-02693204⟩
  • Christine Leroux, Nathalie Mazure, Patrice Martin. Mutations away from splice site recognition sequences might cis-modulate alternative splicing of goat alpha S1-casein transcripts. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1992, 267 (9), pp.6147-6157. ⟨hal-02709720⟩

Conference papers80 documents

  • Carole Delavaud, José Pires, Mylène Delosière, Christine Leroux, Muriel Bonnet. Examples of current research on indicators of adaptative response in periparturient dairy ruminants: Adipose tissue in livestock. Cycle de conférences 'Global Health', Jan 2020, Clermont-Ferrand, France. ⟨hal-02503309⟩
  • José Pires, Christine Leroux, Torben Larsen. Milk metabolites as noninvasive indicators of physiological state and energy balance of early lactation cows. 10. International Symposium on the Nutrition of Herbivores (ISNH10), Sep 2018, Clermont-Ferrand, France. ⟨hal-02738279⟩
  • Mathilde Chervet, Zuzana Krupova, Claudia Bevilacqua, Bruce German, Christine Leroux, et al.. Influence of caprine alphaS1-casein genotype on milk exosomal miRNAs. International Milk Genomics Consortium IMGC, Nov 2018, Sacramento, United States. ⟨hal-02734577⟩
  • Brigitte Picard, Laurence Bernard, Isabelle Cassar-Malek, Carole Delavaud, Mylène Delosière, et al.. Des biomarqueurs aux outils de prédiction des performances des ruminants et de la qualité de leurs produits. Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France. ⟨hal-02940696⟩
  • Isabelle Cassar-Malek, Mylène Delosière, Laurence Bernard, Céline Boby, Carole Delavaud, et al.. Une approche intégrée pour comprendre le dialogue entre tissus/organes chez les ruminants producteurs. Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France. ⟨hal-02940675⟩
  • Pierre-Alexis Billa, Yannick Faulconnier, Torben Larsen, Christine Leroux, José Pires. Les métabolites du lait comme indicateurs non invasifs du statut nutritionnel chez les vaches Holstein et Montbéliarde en milieu de lactation. 24. Rencontres autour des Recherches sur les Ruminants (3R), Dec 2018, Paris, France. ⟨hal-02734722⟩
  • Emmanuelle Truong-Minh, Gaëlle Gili, Julie Chailley, Christine Leroux. Paroles de psychologues auprès de patients sans parole : L’absence de parole, une crise pour le psychologue. Entretiens de la Psychologie, FFPP- Fédération Française des Psychologues et de Psychologie, Oct 2017, Lille, France. ⟨hal-02378713⟩
  • Maxime Gasselin, Marion Boutinaud, Laura Notebaert, Jean-Philippe Perrier, Francois Piumi, et al.. Signatures épigénétiques associées à l’état physiologique, nutritionnel et pathologique chez la vache laitière en postpartum. 3. Journée de Séminaires du Département Phase sur l'Epigénétique EpiPhase, May 2017, Jouy-en-Josas, France. 1 p. ⟨hal-01605492⟩
  • Lenha Mobuchon, Sandrine Le Guillou, Sylvain Marthey, Johann Laubier, Mekki Boussaha, et al.. Impact des microARNs sur la lactation et la régulation nutritionnelle de leur expression dans la glande mammaire. 2. Réunion d'Animation épiPHASE, Institut National de Recherche Agronomique (INRA). UAR Département Physiologie Animale et Systèmes d'Elevage (0558)., Mar 2016, Saint-Pée-sur-Nivelle, France. ⟨hal-02795094⟩
  • Karol Pawlowski, Daiane Lago Novais, José Pires, Lenha Mobuchon, Yannick Faulconnier, et al.. Milk fat globules as a source of mammary microRNA. International Symposium on Microgenomics 2016, Jun 2016, Paris, France. ⟨hal-02743285⟩
  • Sandrine Le Guillou, Sylvain Marthey, Denis Laloë, Johann Laubier, Lenha Mobuchon, et al.. Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes. Gordon Research Conference on Mammary Gland Biology, Jun 2014, Lucca, Italy. 1 p. ⟨hal-01193894⟩
  • Lenha Mobuchon, Sylvain Marthey, Sandrine Le Guillou, Denis Laloë, Christine Leroux, et al.. Nutritional regulation of microRNAs in the lactating goat mammary gland. Gordon Research Conference on Mammary Gland Biology, Jun 2014, Lucca, Italy. ⟨hal-01193908⟩
  • Leonardo Bianchi, Bruno Martin, Adeline Védrine, Christine Leroux, Eloi Haudebourg, et al.. Caractérisation de l’aptitude à coagulation du lait des vaches Salers et identification d’un variant rare de la caséine kappa. 21. Rencontres autour des Recherches sur les Ruminants, Dec 2014, Paris, France. ⟨hal-01194034⟩
  • Isabelle Cassar-Malek, Brigitte Picard, Alain Boissy, Christine Leroux, Lenha Mobuchon, et al.. Exploiting the knowledge about model species and humans to revisit the biology of livestock animals. Workshop of translational biology in Agriculture and Medecine ‘From Bench to Bed in Medecine and from Pot to Plot in Agriculture', Institut National de Recherche Agronomique (INRA). UMR Génétique Diversité et Ecophysiologie des Céréales (1095)., Oct 2014, Aubière, France. 1 p. ⟨hal-02799064⟩
  • Laurence Bernard, Christine Leroux, Yves Chilliard. Nutritional regulation of mammary lipogenesis and milk fat in ruminant: contribution to sustainable milk production. 12. Encuentro Nacional y 5. Internacional de los Investigadores de las Ciencias Pecuarias: ENICIP, 2013, Medellin, Colombia. ⟨hal-02805781⟩
  • Pablo Gutierrez Toral, T. Castro-Carrera, Christine Leroux, G. Hervás, Laurence Bernard, et al.. Regulacion nutricional de la expresion de los genes implicados en la lipogenesis en ovejas alimentadas con aceite de girasol. 2. Tejidos adiposos subcutaneo y perirrenal. 15. Jornadas sobre Produccion Animal, Zaragoza 14 y 15 de mayo de 2013., May 2013, Saragosse, España. pp.213-215. ⟨hal-02747675⟩
  • Pablo Gutierrez Toral, T. Castro-Carrera, Laurence Bernard, G. Hervás, Christine Leroux, et al.. Regulacion nutricional de la expresion de los genes implicados en la lipogenesis en ovejas alimentadas con aceite de girasol. 1. Tejido secretor mamario. 15. Jornadas sobre Produccion Animal, May 2013, Zaragoza, España. pp.210-212. ⟨hal-02747345⟩
  • M. Eknaes, H. Volden, K. Hove, Ra. Inglingstad, Laurence Bernard, et al.. Feeding different lipid supplements through lactation in dairy goats: 1) effects on energy balance and milk production. European Regional Conference On Goats, Jun 2013, Tromso, Norway. 2 p. ⟨hal-02744993⟩
  • Yves Chilliard, Pablo Gutierrez Toral, J Shingfield, Jacques Rouel, Christine Leroux, et al.. Effects of feeding and physiological factors on goat milk fatty acid secretion and milk fat lipolysis. European Regional Conference On Goats, Jun 2013, Tromso, Norway. 3 p. ⟨hal-02746500⟩
  • Sandrine Le Guillou, Sylvain Marthey, Denis Laloë, Johann Laubier, Jordann Domagalski, et al.. Species comparison of lactating mammary gland miRNomes: to the identification of conserved lactation-related microRNA. 12th International Meeting - Cellular aspects of mRNA fate, Université Pierre et Marie Curie - Paris 6 (UPMC). FRA., Jun 2013, Paris, France. pp.1. ⟨hal-01001041⟩
  • Christine Leroux, Christian Beauvallet, Laurence Bernard, Claudia Bevilacqua, Frédéric Bouvier, et al.. MilkChEST, an integrative approach of the secretion pathways in the mammary epithelial cell: molecular dissection of milk fat adaptability. European Regional Conference On Goats, Jun 2013, Tromsø, Norway. ⟨hal-01194090⟩
  • Christine Leroux. Etat des recherches nutrigénomiques chez les ruminants. Journee Nutrigenomique - UNCEIA, Valorial et Alltech, Nov 2010, Ploufragan, France. n. p. ⟨hal-02813895⟩
  • Sophie Lemosquet-Simon, Marion Boutinaud, Eric Chanat, Yves Chilliard, Eve Devinoy, et al.. Vers une représentation conceptuelle minimale du fonctionnement intégratif verticale de la glande mammaire. Journées d’Animation des Crédits Incitatifs du Département de Physiologie Animale et Systèmes d’Elevage (JACI Phase), Oct 2010, Tours, France. ⟨hal-01173652⟩
  • M. Brochard, F. Faucon, Francis Barillet, M. Bolard, P. Brunschwig, et al.. PhénoFinLait : Un programme national français de détection de QTL et/ou de gènes majeurs affectant la composition fine du lait des ruminants laitiers. 16. Rencontres autour des Recherches sur les Ruminants, Dec 2009, Paris, France. ⟨hal-01193513⟩
  • K.J. Shingfield, Laurence Bernard, Christine Leroux, Yves Chilliard. Role of trans fatty acids in the nutritional regulation of mammary lipogenesis in ruminants. 11. International Symposium on Ruminant Physiology (ISRP), Sep 2009, Clermont-Ferrand, France. ⟨10.1017/S1751731110000510⟩. ⟨hal-02758507⟩
  • Kevin J. Shingfield, Laurence Bernard, Christine Leroux, Yves Chilliard. Trans fatty acids and mammary lipogenesis in ruminants. 11. International Symposium on Ruminant Physiology, Sep 2009, Clermont-Ferrand, France. ⟨hal-02755716⟩
  • Felicie Faucon, Emmanuelle Rebours, Christèle Robert-Granie, Laurence Bernard, Olivia Ménard, et al.. DGAT1 K232A polymorphism greatly affects mammary tissue activity of milk component synthesis. 60. Annual Meeting of the European Association for Animal Production, Aug 2009, Barcelone, Spain. ⟨hal-01193503⟩
  • Christine Leroux, Jacques Rouel, Yannick Faulconnier, Jordann Domagalski, Yoan Gaudron, et al.. La nature du fourrage modifie la matière grasse laitière et le transcriptome mammaire de chèvres en lactation. 3. Journées d’Animation Scientifique du Département de Physiologie Animale et Systèmes d’Elevage, Oct 2009, Tours, France. ⟨hal-02757811⟩
  • Yannick Faulconnier, Jordann Domagalski, Mohammed Bagher Montazer Torbati, Yoan Gaudron, Didier Bany, et al.. Transcriptomic profile in adipose tissues is modified by nutrition in lactating goats. 11. International Symposium on Ruminant Physiology, Sep 2009, Clermont-Ferrand, France. ⟨hal-02751987⟩
  • Yannick Faulconnier, Jordann Domagalski, Mohammed Bagher Montazer Torbati, Didier Bany, Yves Chilliard, et al.. Effet de la non alimentation sur le transcriptome adipocytaire de chèvres en lactation. 3. Journées d’Animation Scientifique du Département de Physiologie Animale et Systèmes d’Elevage, Oct 2009, Tours, France. ⟨hal-02752062⟩
  • Jean-François Hocquette, Hamid Boudra, Isabelle Cassar-Malek, Christine Leroux, Brigitte Picard, et al.. Contribution des approches en « omique » à l’élevage durable des herbivores. 15. Rencontres Recherches Ruminants (3R), Dec 2008, Paris, France. ⟨hal-02752116⟩
  • Felicie Faucon, Emmanuelle Rebours, Laurence Bernard, Catherine Hurtaud, Guy Miranda, et al.. Effet du polymorphisme (AA/GC) au locus DGAT1 sur l'activité transcriptionnelle du tissu mammaire bovin, sur la composition du lait et sur les caractéristiques des globules gras et des micelles de caséines. 15. Rencontres autour des Recherches sur les Ruminants, Dec 2008, Paris, France. ⟨hal-01193493⟩
  • Philippe Schmidely, Christine Leroux, Frédéric Bouvier, Yves Chilliard. Effect of genotype for alphaS1 casein on milk fatty acid composition in dairy goat. 25. IGA International Symposium of the quality of goat products, May 2007, Bella, Italy. ⟨hal-01173420⟩
  • Augustin Scalbert, Dragan Milenkovic, Rafael Llorach, Claudine Manach, Christine Leroux. Nutrigenomics: techniques and applications. 2. International Symposium on Energy and Protein Metabolism and Nutrition (ISEP 2007), Sep 2007, Vichy, France. ⟨hal-02758072⟩
  • Jean-François Hocquette, Sophie Tesseraud, Isabelle Cassar-Malek, Christine Leroux. Responses to nutrients in farm animals: implications for product quality. Annual Conference of the British Society of Animal Science (BSAS), Apr 2007, Southport, United Kingdom. ⟨hal-02750985⟩
  • Ali Kpatcha Kadanga, Christine Leroux, Muriel Bonnet, Isabelle Cassar-Malek, Jean-François Hocquette. Genomic tools to analyse bovine muscle and adipose tissues transcriptomes. 2. International Symposium on Energy and Protein Metabolism and Nutrition (ISEP 2007), Sep 2007, Vichy, France. ⟨hal-02753466⟩
  • Severine Ollier, Stéphanie Chauvet, Patrice Martin, Yves Chilliard, Christine Leroux. Étude de l'impact du polymorphisme au locus CSN1S1 sur le transcriptome mammaire de chèvre en lactation. 2. Journées d'Animation Scientifique du Département de Physiologie Animale et Systèmes d'Élevage, Oct 2007, Tours, France. ⟨hal-02750556⟩
  • Christine Leroux, Severine Ollier, Sébastien Bes, Marion Goutte, Laurence Bernard, et al.. Transcriptomic profile in mammary gland is modified by nutrition in lactating goats. 2. International Symposium on Energy and Protein Metabolism and Nutrition (ISEP 2007), Sep 2007, Vichy, France. ⟨hal-02752602⟩
  • Lucie Tosca, Christine Chabrolle, Sabine Crochet, Sophie Tesseraud, Guillaume Ferreira, et al.. AMP-activated protein kinase (AMPK) et reproduction. 2. Journées d'Animation Scientifique du Département de Physiologie Animale et Systèmes d'Élevage, Oct 2007, Tours, France. ⟨hal-02752729⟩
  • Isabelle Cassar-Malek, Christine Leroux, Dominique Gruffat, Muriel Bonnet, Laurence Bernard, et al.. Diet and physiological state influence gene expression in herbivores. 7. International Symposium on the Nutrition of Herbivores, Sep 2007, Beijing, China. ⟨hal-02750923⟩
  • Yves Chilliard, Frederic Glasser, Anne Ferlay, Alexandre Roy, Jacques Rouel, et al.. Rumen biohydrogenation and nutritional quality of cow and goat milk fat. 4. Euro Fed Lipid Congress, Oct 2006, Madrid, Spain. ⟨hal-02750620⟩
  • Yves Chilliard, Severine Ollier, Jacques Rouel, Laurence Bernard, Christine Leroux. Milk fatty acid profile in goats receiving high forage or high concentrate diets supplemented, or not, with either whole rapeseeds or sunflower oil. 57. Annual Meeting of the European Association for Animal Production (EAAP), Sep 2006, Antalya, Turkey. ⟨hal-02753643⟩
  • Severine Ollier, Christèle Robert Granié, Sébastien Bes, Marion Goutte, Yannick Faulconnier, et al.. Impact of nutrition on mammary transcriptome and its interaction with the CSN1S1 genotype in lactating goats. 57. Annual Meeting of the European Association for Animal Production (EAAP), Sep 2006, Antalya, Turkey. ⟨hal-02753041⟩
  • Patrice Martin, Naomi Seely, Claudia Bevilacqua, Jean-Marc Elalouf, Christian Beauvallet, et al.. L’expression de la caséine ! est-elle nécessaire à la différenciation fonctionnelle de l’epithelium alvéolaire mammaire ?. Journée de l'animation transversale "Glande Mammaire, Lait", 2005. ⟨hal-02829135⟩
  • Severine Ollier, Sophie Pollet, Caroline Bauchart, Marion Goutte, Sébastien Bes, et al.. Comparaison des transcriptomes mammaires de chèvres placées dans des conditions nutritionnelles extrêmes, pour étudier la synthèse et la sécrétion des lipides du lait. 12. Rencontres autour des Recherches sur les Ruminants, Dec 2005, Paris, France. ⟨hal-02764381⟩
  • Patrice Martin, Naomi Seely, Claudia Bevilacqua, Jean-Marc Elalouf, Christian Beauvallet, et al.. La caséine κ joue-t-elle un rôle dans le processus de différenciation de l'epithelium alvéolaire mammaire ?. 1. Journées d'Animation Scientifique du Département de Physiologie Animale et Systèmes d'Élevage, Mar 2005, Tours, France. ⟨hal-02762339⟩
  • Patrice Martin, Naomi Seely, Claudia Bevilacqua, Jean-Marc Elalouf, Christian Beauvallet, et al.. La caséine k joue-t-elle un rôle dans le processus de différenciation de épithélium alvéolaire mammaire ?. 1. Journées d'Animation Scientifiques du département Phase, Mar 2005, Tours, France. ⟨hal-02763921⟩
  • Severine Ollier, Sophie Pollet, Caroline Bauchart, Marion Goutte, Sébastien Bes, et al.. La nutri-génomique de la glande mammaire de chèvres dans des conditions nutritionnelles extrêmes, en relation avec la synthèse et la sécrétion des lipides du lait. 1. Journées d'Animation Scientifique du Département de Physiologie Animale et Systèmes d'Élevage, Mar 2005, Tours, France. ⟨hal-02764246⟩
  • Muriel Bonnet, Yannick Faulconnier, Christine Leroux, Catherine Jurie, Isabelle Cassar-Malek, et al.. L'activité de la glucose-6-phosphate deshydrogenase est liée aux différences d'adiposite tissulaires et raciales chez le bovin en croissance. 1ères Journées d'Animation Scientifique du Département de Physiologie Animale et Systèmes d'Elevage, Mar 2005, Tours, France. ⟨hal-02759104⟩
  • Carine Bernard, Severine Degrelle, Severine Ollier, Evelyne Campion, Isabelle Cassar-Malek, et al.. Une collection d'ADNc pour l'étude du profil d'expression de gènes des tissus bovins impliqués dans les caractéristiques de reproduction et de production (lait et viande). 1. Journées d’Animation Scientifique du Département de Physiologie Animale et Systèmes d'Elevage, Mar 2005, Tours, France. ⟨hal-02764511⟩
  • Muriel Bonnet, Yannick Faulconnier, Christine Leroux, Catherine Jurie, Isabelle Cassar-Malek, et al.. Glucose-6-Phosphate dehydrogenase and leptin are linked to marbling differences between Limousin and angus or japanese black x angus steers. 56. Annual Meeting of the European Association for Animal Production (EAAP), Jun 2005, Uppsala, Sweden. ⟨hal-02760645⟩
  • Laurence Bernard, Christine Leroux, Yannick Faulconnier, Denis Durand, Yves Chilliard. Effects of concentrate level and starch degradability on expression of mammary lipogenic genes in goats receiving a diet supplemented in sunflower oil. 56. Annual Meeting of the European Association for Animal Production (EAAP), Jun 2005, Uppsala, Sweden. ⟨hal-02759524⟩
  • Laurence Bernard, Christine Leroux, Yannick Faulconnier, Denis Durand, Yves Chilliard. Effects of concentrate level and starch degradability on expression of mammary lipogenic genes in goats receiving a diet supplemented with sunflower oil. 3. International Workshop on Mammary Gland and Biotechnology : Nutrition, Genomics and Breast Cancer, Sep 2005, Barcelone, Spain. ⟨hal-02759093⟩
  • Karine Sudre, Christine Leroux, Isabelle Cassar-Malek, Jean-François Hocquette, Patrice Martin. A repertoire of cDNA probes for gene expression profiling in muscles of beef-producing cattle. 29. International Symposium on Animal Genetics, Sep 2004, Tokyo, Japan. 1 p. ⟨hal-02828733⟩
  • Isabelle Cassar-Malek, Y. Ueda, Carine Bernard, Catherine Jurie, Séverine Sudre, et al.. Molecular and biochemical muscle characteristics of Charolais bulls divergently selected for muscle growth. 55. Annual Meeting of the European Association for Animal Production (EAAP), Sep 2004, Bled, Slovenia. ⟨hal-02763896⟩
  • C. Bernard, Séverine Degrelle, S. Ollier, Evelyne Campion, Isabelle Cassar-Malek, et al.. A cDNA macro-array resource for gene expression profiling in bovine tissues involved in reproduction and production (milk and beef) traits. 5. Polish-French symposium "Animal Growth and Development: regulatory mechanisms", Sep 2004, Paris, France. n.p. ⟨hal-02833642⟩
  • Antonello Carta, M. Fiori, Giovanni Piredda, Christine Leroux, Francis Barillet. A genome scan to detect QTL for CLA content in the milk fat of dairy sheep. 54. Annual meeting of the European Association for Animal Production (EAAP), Aug 2003, Roma, Italy. 454 p. ⟨hal-02761268⟩
  • Patrice Martin, Jean-François Hocquette, Isabelle Hue, Christine Leroux, Sophie Pollet, et al.. ROGER : Un Répertoire Ordonné de Gènes pour l'analyse de l'Expression génique chez les Ruminants. Application à l'identification de marqueurs de la différenciation dans le muscle, le tissu adipeux, l'embryon et la glande mammaire. 10. Rencontres autour des Recherches sur les Ruminants, Dec 2003, Paris, France. ⟨hal-02763483⟩
  • Anne Listrat, K. Sudre, Isabelle Cassar-Malek, Y. Ueda, I. Barnola, et al.. Validation d'un repertoire d'ADNc de muscles de bovins : application à la recherche de gènes marqueurs de la croissance musculaire. 10. Rencontres autour des Recherches sur les Ruminants, Dec 2003, Paris, France. ⟨hal-02763766⟩
  • Muriel Bonnet, Yannick Faulconnier, Jean-François Hocquette, Christine Leroux, P. Boulesteix, et al.. Lipogenesis in subcutaneous adipose tissue and in oxidative or glycolytic muscles from Angus, Black Japanese x Angus and Limousin. Progress in research on energy and protein metabolism, Sep 2003, Rostock-Warnemünde, Germany. ⟨hal-02761029⟩
  • Christine Leroux, Fabienne Le Provost, F. Petit, Laurence Bernard, Yves Chilliard, et al.. Real-time RT-PCR and cDNA macroarray to study the impact of the genetic polymorphism at the alphaS1-casein locus on the expression of genes in the goat mammary gland during lactation. INRA Meeting on Genomic, Proteomic and Lactation, Nov 2002, Jouy en Josas, France. ⟨10.1051/rnd:2003032⟩. ⟨hal-02764107⟩
  • Karine Sudre, Isabelle Cassar-Malek, Christine Leroux, Anne Listrat, Catherine Jurie, et al.. Etude du transcriptome du muscle pour l'identification de gènes déterminant les caractéristiques musculaires et les qualités sensorielles de la viande bovine.. 9èmes Journées des Sciences du Muscle et Technologie de la Viande, Oct 2002, Clermont-Ferrand, France. ⟨hal-02828454⟩
  • K. Sudre, Isabelle Cassar-Malek, Christine Leroux, Anne Listrat, Y. Ueda, et al.. Transcriptome analysis of muscle in order to identify genes which determine muscle characteristics and sensory quality traits of beef. 9. Meat Science and Technology Symposium, Oct 2002, Clermont-Ferrand, France. ⟨10.3166/sda.23.65-69⟩. ⟨hal-02764401⟩
  • Karine Sudre, Christine Leroux, Elisabeth Petit, Isabelle Cassar-Malek, Claudie Auffray, et al.. Utilisation de filtres à haute densité pour l'analyse de l'expression des gènes dans deux muscles squelettiques de taurillon.. Congrès commun AFERO, 2001, Paris, France. pp.Inconnu. ⟨hal-02828657⟩
  • Laurence Bernard, Christine Leroux, Yves Chilliard, Patrice Martin. Characterisation of the caprine stearoyl-CoA desaturase gene: application to the quantification of its mRNA in the mammary gland by real time RT-PCR.. 4th French-Polish Symposium, 2001, Paris, pp.Inconnu. ⟨hal-02828602⟩
  • Claudia Bevilacqua, F. Pilla, Cristina Veltri, R. Lagonigro, E. Pietrolà, et al.. Interallelic recombination at the alpha-s1 casein locus is likely responsible for the occurrence of a new rare variant in goats. 7ème Conférence Internationale sur les caprins, 7th International Conference on Goats, May 2000, Tours. ⟨hal-02770138⟩
  • Patrice Martin, Christine Leroux, N. Seely, Sophie Pollet, J.M. Elalouf, et al.. Functional genomics: how to assign function to the genes.. 7ème Conférence Internationale sur les caprins, 7th International Conference on Goats, May 2000, Tours. ⟨hal-02770227⟩
  • Fabienne Le Provost, Christine Leroux, Elisabeth Petit, G. Pietu, Patrice Martin. Use of macroarrays enriched for ruminant mammary cDNAs to study the mechanisms underlying the mammary function.. 27th International Conference on Animal Genetics, Jul 2000, Minnesota. ⟨hal-02768875⟩
  • Christine Leroux, Rachel Rupp, S. Lohner, Johann Laubier, Jean Djiane, et al.. Genomic structural organisation and expression of the small ruminants gene encoding the prolactin receptor.. 7ème Conférence Internationale sur les caprins, 7th International Conference on Goats, May 2000, Tours. ⟨hal-02765165⟩
  • Michel Blanc, Christine Leroux, Patrice Martin, D Molle, Jean-Claude Poirier, et al.. Production and invitro bioactivity of porcine and ovine leptins. Euroconférences Institut Pasteur - Cellules souches, Nov 1999, Paris, France. ⟨hal-02840579⟩
  • Gilles Bruneau, Christine Leroux, Patrice Martin, Daniel Mollé, Jean-Claude Poirier, et al.. Production de leptines recombinantes porcine et ovine. 2ème journées d'information du département de Physiologie animale, 1999, Montpellier, France. ⟨hal-02840948⟩
  • Gilles Bruneau, Christine Leroux, Patrice Martin, Daniel Mollé, Jean-Claude Poirier, et al.. Production de leptines recombinantes porcine et ovine. 4ème colloque de la Société des Neurosciences, May 1999, Marseille, France. ⟨hal-02770208⟩
  • Fabienne Le Provost, Christine Leroux, Patrice Martin. La génomique fonctionnelle de la glande mammaire des ruminants.. Séminaire, La génétique moléculaire et ses applications, Sep 1999, Cap d Agde, France. ⟨hal-02769391⟩
  • M. Bonnet, Christine Leroux, Corinne Giraud-Delville, Yves Chilliard, Patrice Martin. Real time PCR quantitation of mRNA encoding key enzymes of lipogenesis. Application to LPL assay in ovine adipose tissue.. XXVI International Conference on Animal Genetics, International Society for Animal Genetics, 1998, Auckland, New Zealand. ⟨hal-02834629⟩
  • Christine Leroux, Patrice Martin. The caprine alpha-s1 and beta-casein genes are 12-kb apart and convergently transcribed.. XXV International Conference on Animal Genetics, Jul 1996, Tours. ⟨hal-02768871⟩
  • L. Méténier-Delisse, Andre Eggen, Hélène Hayes, Christine Leroux, Corinne Giraud-Delville, et al.. Isolation and molecular characterization of bovine Rhesus-like transcripts and chromosome mapping of the relevant locus.. XXV International Conference on Animal Genetics, Jul 1996, Tours. ⟨hal-02771346⟩
  • Patrice Martin, Christine Leroux. Characterization of a further alpha-S1-casein variant generated by exon-skipping.. XXIV International Conference on Animal Genetics, Jul 1994, Prague. ⟨hal-02779442⟩
  • L. Pépin, Yves Amigues, M Francois Mahe, Marie-Annick Persuy, Christine Leroux. Linkage disequilibrium between two multi-allelic markers at the cluster of caseins in goat.. XXIV International Conference on Animal Genetics, Jul 1994, Prague. ⟨hal-02778654⟩
  • Christine Leroux, Fabienne Le Provost, Patrice Martin, P. Gaye, Jean Djiane. The gene encoding prolactin is expressed in the mammary gland of goats and ewes.. XXIV International Conference on Animal Genetics, Jul 1994, Prague. ⟨hal-02777942⟩
  • M. Jansa, Christine Leroux, A. Sanchez, Patrice Martin. Characterization of a LINE insertion in the goat alpha s1-Casein E allele and development of a PCR typing protocol.. XXIV International Conference on Animal Genetics, Jul 1994, Prague. ⟨hal-02778506⟩

Book sections8 documents

  • Dragan Milenkovic, Irena Krga, Hnin H Aung, Christine Leroux. Molecular Nutrition and Epigenetics. Reference Module in Food Science, Elsevier, 2018, Reference Module, 9780081005965. ⟨10.1016/B978-0-08-100596-5.21037-8⟩. ⟨hal-02008728⟩
  • Christine Leroux, Dragan Milenkovic, Lenha Mobuchon, Sandrine Le Guillou, Yannick Faulconnier, et al.. Nutritional Regulation of Mammary miRNome: Implications for Human Studies. Handbook of Nutrition, Diet, and Epigenetics, Editions Springer, 2017, 978-3-319-55530-0. ⟨10.1007/978-3-319-31143-2⟩. ⟨hal-01906536⟩
  • Laurence Bernard, Christine Leroux, Yves Chilliard. Expression and nutritional regulation of Stearoyl-CoA desaturase genes in the ruminant mammary gland: relationship with milk fatty acid composition. Stearoyl-CoA desaturase genes in lipid metabolism, Springer Science+Business Media, 239 p., 2013, 978-1-4614-7968-0. ⟨10.1007/978-1-4614-7969-7_13⟩. ⟨hal-02810768⟩
  • Jean-François Hocquette, Hamid Boudra, Isabelle Cassar-Malek, Christine Leroux, Brigitte Picard, et al.. Contribution of 'Omics' Approaches to Sustainable Herbivore Production. Sustainable Agriculture and New Biotechnologies (Advances in Agroecology), CRC Press, 2011, 978-1439825044. ⟨10.1201/b10977-6⟩. ⟨hal-02811152⟩
  • Laurence Bernard, Christine Leroux, Yves Chilliard. Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland. Bioactive Components of Milk, 606, Springer, 2008, Advances in Experimental Medicine and Biology, 978-0-387-74086-7 (Print) 978-0-387-74087-4 (Online). ⟨hal-02822333⟩
  • Laurence Bernard, Christine Leroux, Yves Chilliard. Characterisation and nutritional regulation of the main lipogenic genes in the ruminant lactating mammary gland. Ruminant Physiology: Digestion, metabolism and impact of nutrition on gene expression, immunology and stress, Wageningen Academic Publishers, 2006, 978-90-76998-640. ⟨hal-02813288⟩
  • Yves Chilliard, Jacques Rouel, Anne Ferlay, Laurence Bernard, Patrice Gaborit, et al.. Optimising goat's milk and cheese fatty acid composition. Improving the fat content of foods, Woodhead Publishing Ltd, 2006, 978-1-85573-965-9. ⟨hal-02814060⟩
  • Patrice Martin, Pasquale Ferranti, Christine Leroux, F. Addeo. Non-bovine caseins : quantitative variability and molecular diversity. Advanced Dairy Chemistry, Volume 1 : Proteins, Kluwer Academic/Plenum Publishers, 2003. ⟨hal-02831014⟩

Directions of work or proceedings6 documents

  • Christine Leroux, Mathilde Chervet, Bruce German. Les effets potentiels des microARNs du lait sur la santé des nouveaux nés. Séminaire Défis Scientifiques du Département Physiologie Animale et Systèmes d'Elevage, Nov 2019, Rennes, France. 2 p., 2019. ⟨hal-02788550⟩
  • Christine Leroux, Karol Pawlowski, Daiane Lago-Novais, Sébastien Bes, Claudia Bevilacqua, et al.. La comparaison des profils miARN des globules gras du lait et des cellules épithéliales mammaires suggèrent une distribution différente selon les compartiments cellulaires. Séminaire Défis Scientifiques du Département Physiologie Animale et Systèmes d'Elevage, Nov 2019, Rennes, France. 2 p., 2019. ⟨hal-02790011⟩
  • Pierre-Alexis Billa, Yannick Faulconnier, T. Larsen, Christine Leroux, José Pires. Les métabolites du lait comme indicateurs non invasifs du statut nutritionnel chez les vaches Holstein et Montbéliarde en milieu de lactation. Séminaire Défis Scientifiques du Département Physiologie Animale et Systèmes d'Elevage, Nov 2019, Rennes, France. 2019. ⟨hal-02788283⟩
  • Pierre-Alexis Billa, José Pires, Yannick Faulconnier, Christine Leroux. Identification de biomarqueurs d’un bilan énergétique négatif. 17. Journée de l'animation transversale glande mammaire, lait (GML), Nov 2019, Paris, France. 1 p., 2019. ⟨hal-02789817⟩
  • Pierre-Alexis Billa, Yannick Faulconnier, T. Ye, Sébastien Bes, José Pires, et al.. Deep RNA-Seq reveals genetics and nutritional regulation of miRNomes in mammary gland of lactating Holstein and Montbéliarde cows. American Dairy Science Association Annual Meeting, 2019, Cincinnati, Ohio, United States. Volume 102, Supplement 1, 2019, Journal of Dairy Science. ⟨hal-02788559⟩
  • Pierre-Alexis Billa, Yannick Faulconnier, Torben Larsen, Christine Leroux, José Pires. Milk metabolites as noninvasive indicators of nutritional status of mid-lactation Holstein and Montbéliarde cows. American Dairy Science Association Annual Meeting, Jun 2019, Cincinnati, Ohio, United States. 102, suppl. 1, 2019, Journal of Dairy Science. ⟨hal-02791592⟩

Habilitation à diriger des recherches1 document

  • Christine Leroux. Régulation de l'expression génique de la biosynthèse et de la sécrétion des constituants du lait des ruminants. Sciences agricoles. Université d'Auvergne - Clermont-Ferrand I, 2012. ⟨tel-02819102⟩