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Zeynep Baharoglu, Chargée de recherche expert, Institut Pasteur


2020 sept.            HDR, Sorbonne Université, Paris

2008-2013           Post-doc in microbial genetics, Institut Pasteur             

2005-2008           PhD thesis, Microbial Genetics, CGM-CNRS, Gif-sur-Yvette, UPMC

2005                     Masters degree, Microbiology, University of Paris VII Diderot

2004                     Undergraduate degree, Cell and Integrative Biology, University of Grenoble I, in exchange program with University of California Irvine



2021 jan             Chef de groupe "Bacterial responses to antimicrobial stress" at Unité Plasticité du génome bactérien -     Institut Pasteur.

2017-present     Chargée de recherche expert at Unité Plasticité du génome bactérien - Institut Pasteur

2014-2017          Chargée de recherche at Unité Plasticité du génome bactérien - Institut Pasteur.

2008-2013          Postdoctoral researcher. Unité Plasticité du génome bactérien - Institut Pasteur

2005-2008           Doctoral research fellow in Microbiology at Centre de Génétique Moléculaire – CNRS. Gif-sur-Yvette. Université Paris 6. Collaboration with University College London



      19 publications (11 as first author, 3 articles as last author, 3 articles as corresponding author)

      11 poster and 5 oral presentations in scientific meetings.

Journal articles17 documents

  • Anamaria Babosan, David Skurnik, Anaëlle Muggeo, Gerald Pier, Zeynep Baharoglu, et al.. A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli. eLife, eLife Sciences Publication, 2022, 11, ⟨10.7554/eLife.69511⟩. ⟨hal-03550548⟩
  • André Carvalho, Evelyne Krin, Chloé Korlowski, Didier Mazel, Zeynep Baharoglu. Interplay between Sublethal Aminoglycosides and Quorum Sensing: Consequences on Survival in V. cholerae. Cells, MDPI, 2021, 10 (11), pp.3227. ⟨10.3390/cells10113227⟩. ⟨pasteur-03443810v2⟩
  • André Carvalho, Didier Mazel, Zeynep Baharoglu. Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae. PLoS Genetics, Public Library of Science, 2021, 17 (10), pp.e1009748. ⟨10.1371/journal.pgen.1009748⟩. ⟨pasteur-03417428v2⟩
  • Manon Lang, Evelyne Krin, Chloé Korlowski, Odile Sismeiro, Hugo Varet, et al.. Sleeping ribosomes: bacterial signaling triggers RaiA mediated persistence to aminoglycosides. iScience, Elsevier, 2021, pp.103128. ⟨10.1016/j.isci.2021.103128⟩. ⟨pasteur-03349141⟩
  • Veronica Negro, Evelyne Krin, Sebastian Aguilar Pierlé, Thibault Chaze, Quentin Giai Gianetto, et al.. RadD Contributes to R-Loop Avoidance in Sub-MIC Tobramycin. mBio, American Society for Microbiology, 2019, 10 (4), pp.e01173-19. ⟨10.1128/mBio.01173-19⟩. ⟨pasteur-02171194⟩
  • Zeynep Baharoglu, Didier Mazel. SOS, the formidable strategy of bacteria against aggressions. FEMS Microbiology Reviews, Wiley-Blackwell, 2014, 38 (6), pp.1126-1145. ⟨10.1111/1574-6976.12077⟩. ⟨pasteur-01423593⟩
  • Z. Baharoglu, A. Babosan, D. Mazel. Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase.. Nucleic Acids Research, Oxford University Press, 2014, 42 (4), pp.2366-2379. ⟨10.1093/nar/gkt1259⟩. ⟨pasteur-01423602⟩
  • Zeynep Baharoglu, Didier Mazel. Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli.. Research in Microbiology, Elsevier, 2014, 165 (6), pp.476-80. ⟨10.1016/j.resmic.2014.05.039⟩. ⟨pasteur-01423361⟩
  • A. Gutierrez, L. Laureti, S. Crussard, H. Abida, A. Rodríguez-Rojas, et al.. β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity. Nature Communications, Nature Publishing Group, 2013, 4, pp.1610. ⟨10.1038/ncomms2607⟩. ⟨pasteur-01691736⟩
  • Zeynep Baharoglu, Evelyne Krin, Didier Mazel. RpoS Plays a Central Role in the SOS Induction by Sub-Lethal Aminoglycoside Concentrations in Vibrio cholerae. PLoS Genetics, Public Library of Science, 2013, 9 (4), pp.e1003421. ⟨10.1371/journal.pgen.1003421⟩. ⟨pasteur-01691109⟩
  • Zeynep Baharoglu, Geneviève Garriss, Didier Mazel. Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance. Antibiotics, MDPI, 2013, Antibiotic Resistance, 2 (2), pp.288-315. ⟨10.3390/antibiotics2020288⟩. ⟨pasteur-01691592⟩
  • Zeynep Baharoglu, Didier Mazel. Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2011, 55 (5), pp.2438-2441. ⟨10.1128/AAC.01549-10⟩. ⟨pasteur-01423615⟩
  • Zeynep Baharoglu, David Bikard, Didier Mazel. Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation. PLoS Genetics, Public Library of Science, 2010, 6 (10), pp.e1001165. ⟨10.1371/journal.pgen.1001165⟩. ⟨pasteur-02477623⟩
  • David Bikard, Céline Loot, Zeynep Baharoglu, Didier Mazel. Folded DNA in Action: Hairpin Formation and Biological Functions in Prokaryotes. Microbiology and Molecular Biology Reviews, American Society for Microbiology, 2010, 74 (4), pp.570-588. ⟨10.1128/MMBR.00026-10⟩. ⟨pasteur-02505407⟩
  • Zeynep Baharoglu, Roxane Lestini, Stéphane Duigou, Bénédicte Michel. RNA polymerase mutations that facilitate replication progression in the rep uvrD recF mutant lacking two accessory replicative helicases. Molecular Microbiology, Wiley, 2010, 77 (2), pp.324. ⟨10.1111/j.1365-2958.2010.07208.x⟩. ⟨hal-00552639⟩
  • Bénédicte Michel, Hasna Boubakri, Zeynep Baharoglu, Marie Lemasson, Roxane Lestini. Recombination proteins and rescue of arrested replication forks.. DNA Repair, Elsevier, 2007, 6 (7), pp.967-80. ⟨10.1016/j.dnarep.2007.02.016⟩. ⟨hal-00167418⟩
  • Zeynep Baharoglu, Mirjana Petranovic, Maria-Jose Flores, Bénédicte Michel. RuvAB is essential for replication forks reversal in certain replication mutants.. EMBO Journal, EMBO Press, 2006, 25 (3), pp.596-604. ⟨10.1038/sj.emboj.7600941⟩. ⟨hal-00130946⟩