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Yves Le Loir

37
Documents

Présentation

**Yves Le Loir** is a research scientist working at the French National Institute for Agricultural Research (INRA). He dedicates his scientific carrier to the microbiology of the milk production chain (with food and veterinary aspects). He originally studied Biochemistry at the University of Rennes (France). In 1992, he passed the diploma of Engineer in Agronomy of the Ecole Nationale Supérieure d’Agronomie (ENSA), in Rennes. He moved to INRA Jouy en Josas, France, (Unit of Microbial Genetics, headed by S.D. Ehrlich) to work on conjugative DNA transfer in *Lactococcus lactis*, the model lactic acid bacterium (LAB). He stayed in the same team to prepare a PhD thesis (University of Paris XI) in Microbiology on heterologous proteins secretion in *L. lactis*. He defended in 1996 and was recruited in INRA to go on working on protein secretion and lately on respiration in *L. lactis*. In February 2001, Y. Le Loir moved to INRA Rennes to start a new laboratory (Unit of Microbiology, INRA ENSA, Rennes, France). His new projects focused on host adaptation (ruminants) in *Staphylococcus aureus* and interactions between *Staphylococcus aureus* and Lactic Acid Bacteria. In 2008-2016, he headed a research team (12 permanent positions) called Bacterial Biodiversity and In Situ Interactions. From 2011 to 2016, he was alos deputy director of the Research Unit STLO. Since January 2017, he is heading the STLO Unit in Rennes. **STLO (Science and Technology of Milk & Eggs)** is a joint research unit comprising INRA and Agrocampus Ouest staff members (83 permanent positions, 130-140 staff). Since 2000, Y. Le Loir tightly collaborates with Pr Vasco Azevedo (UFMG, Belo Horizonte) and he has been Pesquisador Visitante Especial at UFMG in 2014-2016 (PVE400721/2013-9; CNPq). He also coordinates an International Associated Laboratory involving STLO and Micalis Research Units at INRA and 3 research teams at UFMG, in Brazil.

Publications

aurelie-nicolas
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Different culture media and purification methods unveil the core proteome of Propionibacterium freudenreichii -derived extracellular vesicles

Vinícius de Rezende Rodovalho , Brenda Silva Rosa da Luz , Aurélie Nicolas , Julien Jardin , Valérie Briard-Bion
microLife, 2023, 4, pp.1-15. ⟨10.1093/femsml/uqad029⟩
Article dans une revue hal-04128282v1
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Impact of Environmental Conditions on the Protein Content of Staphylococcus aureus and Its Derived Extracellular Vesicles

Brenda Silva Rosa da Luz , Vinícius de Rezende Rodovalho , Aurélie Nicolas , Svetlana Chabelskaya , Julien Jardin
Microorganisms, 2022, 10 (9), pp.1808. ⟨10.3390/microorganisms10091808⟩
Article dans une revue hal-03780474v1
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The genomic basis of the Streptococcus thermophilus health-promoting properties

Emeline Roux , Aurélie Nicolas , Florence Valence , Grégoire Siekaniec , Victoria Chuat
BMC Genomics, 2022, 23, pp.1-23. ⟨10.1186/s12864-022-08459-y⟩
Article dans une revue hal-03612308v1
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Transcriptome Architecture of Osteoblastic Cells Infected With Staphylococcus aureus Reveals Strong Inflammatory Responses and Signatures of Metabolic and Epigenetic Dysregulation

Aurélie Nicolas , Martine Deplanche , Pierre-Henri Commere , Alan Diot , Clemence Genthon
Frontiers in Cellular and Infection Microbiology, 2022, 12, pp.854242. ⟨10.3389/fcimb.2022.854242⟩
Article dans une revue hal-03650997v1
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Environmental Conditions Modulate the Protein Content and Immunomodulatory Activity of Extracellular Vesicles Produced by the Probiotic Propionibacterium freudenreichii

Vinícius de Rezende Rodovalho , Brenda Silva Rosa da Luz , Aurélie Nicolas , Fillipe Luiz Rosa Do Carmo , Vasco Ariston de Carvalho Azevedo
Applied and Environmental Microbiology, 2021, 87 (4), ⟨10.1128/AEM.02263-20⟩
Article dans une revue hal-03137714v1
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Environmental Plasticity of the RNA Content of Staphylococcus aureus Extracellular Vesicles

Brenda Silva Rosa Da Luz , Aurélie Nicolas , Svetlana Chabelskaya , Vinícius de Rezende Rodovalho , Yves Le Loir
Frontiers in Microbiology, 2021, 12, ⟨10.3389/fmicb.2021.634226⟩
Article dans une revue hal-03169446v1
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Involvement of caspase-1 in inflammasomes activation and bacterial clearance in S. aureus-infected osteoblast-like MG-63 cells

Elma Lima Leite , Arthur Gautron , Martine Deplanche , Aurélie Nicolas , Jordane Ossemond
Cellular Microbiology, 2020, 22 (8), pp.e13204. ⟨10.1111/cmi.13204⟩
Article dans une revue hal-02565096v1
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Extracellular vesicles produced by human and animal Staphylococcus aureus strains share a highly conserved core proteome

Natayme Rocha Tartaglia , Aurélie Nicolas , Vinicius de Rezende Rodovalho , Brenda Silva Rosa Da Luz , Valérie Briard-Bion
Scientific Reports, 2020, 10 (1), pp.1-13. ⟨10.1038/s41598-020-64952-y⟩
Article dans une revue hal-02638124v1
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Author correction: exfoliative toxin e, a new Staphylococcus aureus virulence factor with host-specific activity

Ichiro Imanishi , Aurélie Nicolas , Ana-Carolina Barbosa Caetano , Thiago Luiz de Paula Castro , Natayme Rocha Tartaglia
Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-59360-1⟩
Article dans une revue hal-03359247v1
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Extracellular vesicles produced by the probiotic Propionibacterium freudenreichii CIRM-BIA 129 mitigate inflammation by modulating the NF-κB pathway

Vinicius de Rezende Rodovalho , Brenda Silva Rosa da Luz , Houem Rabah , Fillipe Luiz Rosa Do Carmo , Edson L Folador
Frontiers in Microbiology, 2020, 11, ⟨10.3389/fmicb.2020.01544⟩
Article dans une revue hal-02885846v1
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Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity

Ichiro Imanishi , Aurélie Nicolas , Ana-Carolina Barbosa Caetano , Thiago Luiz de Paula Castro , Natayme Rocha Tartaglia
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-52777-3⟩
Article dans une revue hal-02625122v1
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Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections

Rachid A. El-Aouar Filho , Aurélie Nicolas , Thiago L. de Paula Castro , Martine Deplanche , Vasco A. de Carvalho Azevedo
Frontiers in Cellular and Infection Microbiology, 2017, 7, pp.208. ⟨10.3389/fcimb.2017.00208⟩
Article dans une revue hal-03359289v1
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Corrigendum: Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections

Rachid El-Aouar Filho , Aurélie Nicolas , Thiago Luiz de Paula Castro , Vasco Ariston de Carvalho Azevedo , Pierre L. Goossens
Frontiers in Cellular and Infection Microbiology, 2017, 7 (article 208), pp.364. ⟨10.3389/fcimb.2017.00208⟩
Article dans une revue hal-01594586v1
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Bovine Teat Microbiome Analysis Revealed Reduced Alpha Diversity and Significant Changes in Taxonomic Profiles in Quarters with a History of Mastitis

Hélène Falentin , L. Rault, , Aurélie Nicolas , Damien S. Bouchard, , Jacques Lassalas
Frontiers in Microbiology, 2016, 7 (04), pp.1-14. ⟨10.3389/fmicb.2016.00480⟩
Article dans une revue anses-01333569v1
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Adaptation of Propionibacterium freudenreichii to long-term survival under gradual nutritional shortage

Flavia Aburjaile , Marine Rohmer , Hugues Parrinello , Marie-Bernadette Maillard , Eric Beaucher
BMC Genomics, 2016, 17 (1), open acess. ⟨10.1186/s12864-016-3367-x⟩
Article dans une revue hal-01416005v1
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Unveiling the Secrets of Long-Term Staphylococcus aureus Infections: Insights into Inflammation, Metabolism, and Epigenetic Changes from Non-Immune Cells Transcriptomes

Aurélie Nicolas , Martine Deplanche , Sandrine Péron , Pierre-Henri Commere , Alan Diot
Rendez-vous scientifique annuel d’Op+lait Réunion glande Mammaire lait, Galactinov, Réseau Oplait-Galctinov, Oct 2023, Québec (online), Canada
Communication dans un congrès hal-04251786v1
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Development of trained immunity and activation of inflammasomes are promising strategies to combat Staphylococcus aureus infection

Emmanuel Chaumond , Elma Lima Leite , Sandrine Péron , Nathalie Daniel , Yann Le Gouar
18e congrès national de la SFM « Un monde à explorer », Société Française de Microbiologie (SFM), Oct 2023, Rennes, France
Communication dans un congrès hal-04234405v1

Environmental Plasticity Of Staphylococcus aureus Extracellular Vesicles RNA Content

Brenda Silva Rosa Da Luz , Aurélie Nicolas , Svetlana Chabelskaya , Vinícius de Rezende Rodovalho , Yves Le Loir
Bactinflam, LIA BactInflam, INRAE STLO, Jun 2022, Webinar, France
Communication dans un congrès hal-03690596v1

Environmental conditions modulate the protein content and immunomodulatory activity of extracellular vesicles produced by the probiotic Propionibacterium freudenreichii

Vinícius de Rezende Rodovalho , Brenda Silva Rosa Da Luz , Aurélie Nicolas , Fillipe Luiz Rosa Do Carmo , Julien Jardin
Bactinflam, Lia Bactinflam, INRAE STLO, Jun 2022, Webinar, France
Communication dans un congrès hal-03690783v1

Environmental conditions modulate the protein content and immunomodulatory activity of extracellular vesicles produced by the probiotic Propionibacterium freudenreichii

Vinícius de Rezende Rodovalho , Brenda Silva Rosa Da Luz , Aurélie Nicolas , Fillipe Luiz Rosa Do Carmo , Julien Jardin
23ème édition du colloque du Club des Bactéries Lactiques, UMR INRAE - Institut Agro STLO (Science et Technologie du Lait et de l’Œuf), Jun 2022, Rennes, France
Communication dans un congrès hal-03693312v1
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Inflammasome activation and an involvement of Caspase-1 in a bacterial clearance during S. aureus infection.

Elma Lima Leite , Aurélie Nicolas , Arthur Gautron , Martine Deplanche , Jordane Ossemond
Bactinflan, Lia Bactinflam, INRAE STLO, Jun 2022, Webinar, France
Communication dans un congrès hal-03690660v1

Immunomodulatory role of Propionibacterium freudenreichii extracellular vesicles

Tales Fernando Da Silva , Vinícius de Rezende Rodovalho , Brenda Silva Rosa Da Luz , Fillipe Luiz Rosa Do Carmo , Aurélie Nicolas
FoodMicro2022, Aug 2022, Athènes, Greece
Communication dans un congrès hal-03781603v1

Environmental Plasticity Of Staphylococcus aureus Extracellular Vesicles RNA Content

Brenda Silva Rosa da Luz , Aurélie Nicolas , Svetlana Chabelskaya , Vinicius de Rezende Rodovalho , Yves Le Loir
ISEV2021 Annual Meeting, The International Society For Extracellular Vesicles (ISEV), May 2021, Virtual United States, United States
Communication dans un congrès hal-03259481v1

Environmental Plasticity of the RNA Content of Staphylococcus aureus Extracellular Vesicles

Brenda Silva Rosa da Luz , Aurélie Nicolas , Svetlana Chabelskaya , Vinicius de Rezende Rodovalho , Yves Le Loir
16e congrès national de la SFM, Société Française de Microbiologie, Sep 2021, Nantes, France
Communication dans un congrès hal-03340860v1

Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity

I. Imanishi , Aurélie Nicolas , A.C. B. Caetano , Thiago Luiz de Paula Castro , Natayme Rocha Tartaglia
Microbes, 15e Congrès National de la SFM, Sep 2019, Paris, France
Communication dans un congrès hal-02306146v1
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Inflammasomes involvement in Staphylococcus aureus infection of human osteoblast-like cells MG-63

Elma Lima Leite , Arthur Gautron , Martine Deplanche , Aurélie Nicolas , David Gilot
JAS DSA 2018 Journées d'animation scientifique du département Santé Animale, Oct 2018, Chapelle sur Erdre, France
Communication dans un congrès hal-01889269v1

Extracellular vesicles from Staphylococcus aureus remodulate the bovine mammary epithelial cell transcriptome

Brenda Silva Rosa da Luz , Aurélie Nicolas , Julia Papail , Danièle Vassaux , Nathalie Daniel
18e congrès national de la SFM « Un monde à explorer », Oct 2023, Rennes, France. , 2023
Poster de conférence hal-04234619v1
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Unleashing the power of inflammasomes and trained immunity: promising strategies in the fight against Staphylococcus aureus infection

Emmanuel Chaumond , Elma Lima Leite , Nathalie Daniel , Sandrine Peron , Yann Le Gouar
https://immunologisk-selskab.dk/calendar/lofoten-immunology-workshop-2023/. Lofoten Immunology Workshop 2023, Aug 2023, Lofoten Islands, Norway. , 2023
Poster de conférence hal-04195275v1
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Extracellular vesicles from Staphylococcus aureus remodulate the bovine mammary epithelial cell transcriptome

Brenda Silva Da Luz , Aurélie Nicolas , Julia Papail , Daniele Vassaux , Nathalie Daniel
https://www.sfm-microbiologie.org/evenement/staphosium-2023/. Staphosium 2023, Nov 2023, Lyon, France. , 2023
Poster de conférence hal-04295498v1
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The genomic basis of the Streptococcus thermophilus health-promoting properties

Emeline Roux , Aurélie Nicolas , Florence Valence , Grégoire Siekaniec , Victoria Chuat
JOBIM 2022 - Les journées Ouvertes en Biologie, Informatique et Mathématiques, Jul 2022, Rennes, France. , pp.1-1, 2022
Poster de conférence hal-03717986v1
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Key role of caspase-1 in bacterial clearance during S. aureus infection of osteoblasts-like cells.

Elma Lima Leite , Arthur Gautron , Aurélie Nicolas , Jordane Ossemond , Fillipe L R Do Carmo
SFM Microbes 2021, Sep 2021, Nantes, France. , 2021
Poster de conférence hal-03356389v1
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Inflammasomes involvement in Staphylococcus aureus infection of human osteoblast-like cells MG-63

Elma Lima Leite , Arthur Gautron , Martine Deplanche , Aurélie Nicolas , David Gilot
14.congrès national de la Société Française de Microbiologie (SFM), Oct 2018, Paris, France. , 2018
Poster de conférence hal-01888292v1

Adaptation of Propionibacterium freudenreichii to long-term survival under gradual nutritional shortage

Flavia Aburjaile , Marine Rohmer , Hugues Parrinello , Marie-Bernadette Maillard , Eric Beaucher
19. International Conference on Bacilli & Gram-Positive Bacteria, Jun 2017, Berlin, Germany. , 2017
Poster de conférence hal-01535200v1

Mutations and genomic islands can explain the strain dependency of sugar utilization in 21 strains of Propionibacterium freudenreichii

Valentin Loux , Mahendra Mariadassou , Sintia Almeida da Silva , Helene Chiapello , Amal Hammami
JOBIM 16. Journées Ouvertes de Biologie, Informatique et Mathématiques, Jul 2015, Clermont-Ferrand, France. , 2015, ⟨10.1186/s12864-015-1467-7⟩
Poster de conférence hal-01209851v1
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Microbiota of bovine udder and susceptibility to mastitis in dairy cows

Hélène Falentin , Lucie Rault , Damien Bouchard , Aurélie Nicolas , Jacques Lassalas
Pathobiome: Pathogens in microbiota in host, Jun 2015, Paris, France. 2015
Poster de conférence hal-01209836v1
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Microbiota of bovine udder foremilk and susceptibility to mastitis in dairy cows.

Hélène Falentin , Lucie Rault , Damien Bouchard , Aurélie Nicolas , Jacques Lassalas
20. Edition du Club des Bactéries Lactiques, Jun 2015, Lille, France. , 2015
Poster de conférence hal-01209835v1

Mutations and genomic islands can explain the strain dependency of sugar utilization in 21 strains of Propionibacterium freudenreichii

Valentin Loux , Mahendra Mariadassou , Sintia Almeida da Silva , Hélène Chiapello , Amal Hammami
20. Colloque du Club des Bactéries Lactiques, Jun 2015, Lille, France. , 2015
Poster de conférence hal-01170054v1