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Yves Le Loir

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Documents

Présentation

**Yves Le Loir** is a research scientist working at the French National Institute for Agricultural Research (INRA). He dedicates his scientific carrier to the microbiology of the milk production chain (with food and veterinary aspects). He originally studied Biochemistry at the University of Rennes (France). In 1992, he passed the diploma of Engineer in Agronomy of the Ecole Nationale Supérieure d’Agronomie (ENSA), in Rennes. He moved to INRA Jouy en Josas, France, (Unit of Microbial Genetics, headed by S.D. Ehrlich) to work on conjugative DNA transfer in *Lactococcus lactis*, the model lactic acid bacterium (LAB). He stayed in the same team to prepare a PhD thesis (University of Paris XI) in Microbiology on heterologous proteins secretion in *L. lactis*. He defended in 1996 and was recruited in INRA to go on working on protein secretion and lately on respiration in *L. lactis*. In February 2001, Y. Le Loir moved to INRA Rennes to start a new laboratory (Unit of Microbiology, INRA ENSA, Rennes, France). His new projects focused on host adaptation (ruminants) in *Staphylococcus aureus* and interactions between *Staphylococcus aureus* and Lactic Acid Bacteria. In 2008-2016, he headed a research team (12 permanent positions) called Bacterial Biodiversity and In Situ Interactions. From 2011 to 2016, he was alos deputy director of the Research Unit STLO. Since January 2017, he is heading the STLO Unit in Rennes. **STLO (Science and Technology of Milk & Eggs)** is a joint research unit comprising INRA and Agrocampus Ouest staff members (83 permanent positions, 130-140 staff). Since 2000, Y. Le Loir tightly collaborates with Pr Vasco Azevedo (UFMG, Belo Horizonte) and he has been Pesquisador Visitante Especial at UFMG in 2014-2016 (PVE400721/2013-9; CNPq). He also coordinates an International Associated Laboratory involving STLO and Micalis Research Units at INRA and 3 research teams at UFMG, in Brazil.

Publications

"sergine-even"
"nadejda-nadia-berkova"
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Towards more biomimetic and sustainable infant formula: challenges and future opportunities

Amélie Deglaire , Jeehyun Lee , Luca Lanotte , Thomas Croguennec , Cécile Le Floch-Fouéré
Trends in Food Science and Technology, 2023, 137, pp.109-123. ⟨10.1016/j.tifs.2023.05.010⟩
Article dans une revue hal-04109370v1
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Author correction: exfoliative toxin e, a new Staphylococcus aureus virulence factor with host-specific activity

Ichiro Imanishi , Aurélie Nicolas , Ana-Carolina Barbosa Caetano , Thiago Luiz de Paula Castro , Natayme Rocha Tartaglia
Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-59360-1⟩
Article dans une revue hal-03359247v1
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Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity

Ichiro Imanishi , Aurélie Nicolas , Ana-Carolina Barbosa Caetano , Thiago Luiz de Paula Castro , Natayme Rocha Tartaglia
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-52777-3⟩
Article dans une revue hal-02625122v1

Disruption of the sigS gene attenuates the local innate immune response to Staphylococcus aureus in a mouse mastitis model

Vincent Péton , Koene Breyne , Lucie Rault , Kristel Demeyyere , Nadia Berkova
Veterinary Microbiology, 2016, 186, pp.44-51. ⟨10.1016/j.vetmic.2016.02.014⟩
Article dans une revue hal-01454594v1
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Fine-tuned characterization of Staphylococcus aureus Newbould 305, a strain associated with mild and chronic mastitis in bovines

Vincent Peton , Damien S Bouchard , Sintia Almeida , Lucie Rault , Hélène Falentin
Veterinary Research, 2014, 45 (1), pp.106. ⟨10.1186/s13567-014-0106-7⟩
Article dans une revue hal-01290602v1
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Fine-tuned characterization of [i]Staphylococcus aureus[/i] Newbould 305, a strain associated with mild and chronic mastitis in bovines

Vincent Péton , Damien Bouchard , Sintia Almeida da Silva , Lucie Rault , Hélène Falentin
Veterinary Research, 2014, 45 (106), pp.1-15. ⟨10.1186/PREACCEPT-6950585981338355⟩
Article dans une revue hal-01209743v1
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Staphylococcus aureus-induced G2/M phase transition delay in host epithelial cells increases bacterial infective efficiency.

Ludmila Alekseeva , Lucie Rault , Sintia Almeida , Patrick Legembre , Valérie Edmond
PLoS ONE, 2013, 8 (5), pp.e63279. ⟨10.1371/journal.pone.0063279⟩
Article dans une revue hal-00873672v1

Inhibition of [i]Staphylococcus aureus[/i] invasion into bovine mammary epithelial cells by contact with live Lactobacillus casei

Damien Bouchard , Lucie Rault , Nadia Berkova , Yves Le Loir , Sergine Even
Applied and Environmental Microbiology, 2013, 79 (3), pp.877-885. ⟨10.1128/AEM.03323-12⟩
Article dans une revue hal-01209393v1
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Staphylococcus aureus proteins differentially produced in ewe gangrenous mastitis or ewe milk

Caroline Le Maréchal , Julien Jardin , Valérie Briard-Bion , Lucie Rault , Nadia Berkova
Veterinary Microbiology, 2013, 164, pp.150-157. ⟨10.1016/j.vetmic.2013.01.013⟩
Article dans une revue hal-01209415v1

[i]Staphylococcus aureus[/i] proteins differentially recognized by the ovine immune response in mastitis or nasal carriage

Nubia Seyffert , Caroline Le Maréchal , Julien Jardin , John.A Mcculloch , Fabio Rogerio Rosado
Veterinary Microbiology, 2012, 157 (3-4), pp.439-447. ⟨10.1016/j.vetmic.2012.01.016⟩
Article dans une revue hal-01209309v1
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Genome sequence of [i]Staphylococcus aureus[/i] newbould 305, a strain associated with mild bovine mastitis

Damien Bouchard , Vincent Péton , Sintia Almeida da Silva , Caroline Le Maréchal , Anderson Miyoshi
Journal of Bacteriology, 2012, 194 (22), pp.6292-6293. ⟨10.1128/JB.01188-12⟩
Article dans une revue hal-01209374v1
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Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis

Caroline Le Maréchal , Julien Jardin , Gwénaël Jan , Sergine Even , Coralie Pulido
Veterinary Research, 2011, 42 (35), pp.1-20. ⟨10.1186/1297-9716-42-35⟩
Article dans une revue hal-01454159v1
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Molecular basis of virulence in Staphylococcus aureus mastitis

Caroline Le Maréchal , Nubia Seyffert , Julien Jardin , David Hernandez , Gwénaël Jan
PLoS ONE, 2011, 6 (11), ⟨10.1371/journal.pone.0027354⟩
Article dans une revue hal-01189501v1

Genome sequences of two Staphylococcus aureus ovine strains that induce severe (strain O11) and mild (strain O46) mastitis

Caroline Le Maréchal , David Hernandez , Jacques Schrenzel , Sergine Even , Nadia Berkova
Journal of Bacteriology, 2011, 193 (9), pp.2353-2354. ⟨10.1128/JB.00045-11⟩
Article dans une revue hal-01454188v1

Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity

I. Imanishi , Aurélie Nicolas , A.C. B. Caetano , Thiago Luiz de Paula Castro , Natayme Rocha Tartaglia
Microbes, 15e Congrès National de la SFM, Sep 2019, Paris, France
Communication dans un congrès hal-02306146v1
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Analise immunoproteomica de staphylococcus aureus causador da mastite ovina revela polipepideos diferencialmente reconhecidos por soros de animais infectados e portadores

Nubia Seyffert , Caroline Le Maréchal , Julien Jardin , J.A. Mc Culloch , Fabio Rogerio Rosado
26 Congresso Brasileiro de Microbiologia, Oct 2011, Iguacu, Brazil
Communication dans un congrès hal-01454337v1

Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis

Caroline Le Maréchal , Julien Jardin , Gwénaël Jan , Sergine Even , C. Pulido
4 Congress of European Microbiologists, Jun 2011, Genève, Switzerland
Communication dans un congrès hal-01454339v1

Serological proteome analysis of Staphylococcus aureus strains isolated from gangrenous and subclinical ewe mastitis reveals core and accessory seroproteomes

Caroline Le Maréchal , Gwénaël Jan , Julien Jardin , Sergine Even , Nadejda Berkova
14 International Symposium on Staphylococci and Staphylococcal Infections (ISSSI), Sep 2010, Bath, United Kingdom
Communication dans un congrès hal-01454355v1

La caractérisation omique de souches de Staphylococcus aureus isolées de mammites ovines révèle une forte proximité génétique mais des transcriptomes et protéomes associés à des tableaux cliniques radicalement différents

Caroline Le Maréchal , Nubia Seyffert , Julien Jardin , H. Hernandez , Gwénaël Jan
SYMPOSTAPH, Oct 2010, Lyon, France
Communication dans un congrès hal-01454347v1

Comparaison exhaustives de souches de staphylococcus aureus isolées de mammites gangéneuses et subcliniques en élevage ovin

Caroline Le Maréchal , Julien Jardin , D. Hernandez , Gwénaël Jan , P. François
8 Congrès National de la Société de Microbiologie, Jun 2010, Marseille, France
Communication dans un congrès hal-01454352v1

Comprehensive “omic” analysis of Staphylococcus aureus strains isolated from gangrenous and subclinical ewe mastitis

Caroline Le Maréchal , Julien Jardin , D. Hernandez , Gwénaël Jan , P. François
14 International Symposium on Staphylococci and Staphylococcal Infections (ISSSI), Sep 2010, Bath, United Kingdom
Communication dans un congrès hal-01454357v1

Approche séroprotéomique de souches de staphylococcus aureus isolées de mammites subcliniques et gangréneuses chez la brebis : détermination du séroprotéome central et accessoire

Caroline Le Maréchal , Gwénaël Jan , Julien Jardin , Sergine Even , Nadejda Berkova
8 Congrès de la Société Française de Microbiologie, Jun 2010, Marseille, France
Communication dans un congrès hal-01454354v1
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Staphylococcus aureus alters cell cycle in human and bovine epithelial cells

Ludmila Alekseeva , Lucie Rault , Sintia Almeida da Silva , Fabien Cousin , Patrick Legembre
16. International Symposium on Staphylococci and Staphylococcal Infections, Aug 2014, Chicago, United States. 2014
Poster de conférence hal-01209709v1

[i]Staphylococcus aureus[/i] Newbould 305, a strain associated with mild and chronic mastitis in bovines

Vincent Péton , Damien Bouchard , Sintia Almeida da Silva , Lucie Rault , Hélène Falentin
SYMPOSTAPH, Oct 2014, Lyon, France. , 2014
Poster de conférence hal-01209740v1

Staphylococcus aureus Newbould 305, a strain associated to mild and chronic mastitis, is well armed to invade bovine mammary tissue.

Vincent Péton , Damien Bouchard , Sintia Almeida da Silva , Lucie Rault , Hélène Falentin
60. Congress of the Brazilian Society for Genetics, Aug 2014, Guarujà, Brazil. 2014
Poster de conférence hal-01209664v1

Lactobacillus casei inhibe l'invasion de cellules épithéliales mammaires bovines par staphylococcus aureus

Damien Bouchard , Lucie Rault , Nadejda Berkova , Yves Le Loir , Sergine Even
CIFMA colloque international francophone de microbiologie animale, May 2014, Toulouse, France. , 2014
Poster de conférence hal-01209629v1

[i]Lactobacillus casei[/i] inhibe l’invasion de cellules épithéliales mammaires bovines par [i]Staphylococcus aureus[/i]

Damien Bouchard , Lucie Rault , Nadejda Berkova , Yves Le Loir , Sergine Even
SYMPOSTAPH, Oct 2014, Lyon, France. , 2014
Poster de conférence hal-01209738v1

Inhibition of Staphylococcus aureus invasion into bovine mammary epithelial cells by contact with live Lactobacillus casei.

Damien Bouchard , Lucie Rault , Nadejda Berkova , Yves Le Loir , Sergine Even
Cell Symposia " Microbiome and host health, May 2013, Lisbonne, Portugal. , 2013
Poster de conférence hal-01454235v1

[i]Staphylococcus aureus[/i] proteins differentially recognized by the ovine immune response in mastitis or nasal carriage

Nubia Seyffert , Caroline Le Maréchal , Valérie Briard-Bion , Julien Jardin , A. Miyoshi
EUPA 2013, Oct 2013, Saint-Malo, France. , 2013
Poster de conférence hal-01209500v1

Soluble factor produced by [i]Staphylococcus aureus[/i] modulates the cell cycle of eukaryotic cells.

Emilie Ladier , Luidmila Alexseeva , Martine Deplanche , Sintia Almeida da Silva , Vasco Azevedo
15. International Congress of Immunology, Aug 2013, Milan, Italy. , 2013
Poster de conférence hal-01209486v1

Staphylococcus aureus-induced alteration of histone H3 phosphorylation status in human epithelial cells reveals its impact on cell cycle regulation.

Ludmila Alekseeva , Emilie Ladier , Sergine Even , Frederic Taieb , Yannick Arlot-Bonnemains
Cell Symposia Microbiome and Host Health, May 2013, Lisbonne, Portugal. , 2013
Poster de conférence hal-01454234v1

Staphylococcus aureus alters cell cycle in human and bovine epithelial cells.

Ludmila Alekseeva , Lucie Rault , Sintia Almeida da Silva , Valérie Edmond , Vasco Azevado
International Symposium on Staphylococci and Staphylococcal Infections -ISSSI-2012, Aug 2012, Lyon, France. , 2012
Poster de conférence hal-01209356v1

Staphylococcus aureus cells induce G2/M phase transition delay in the human and bovine epithelial cells.

Ludmila Alekseeva , Lucie Rault , Sintia Almeida da Silva , Valérie Edmond , Vasco Azevedo
EMBO, May 2012, Villars sur Ollon, Switzerland. , 2012
Poster de conférence hal-01454214v1

Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis

Caroline Le Maréchal , Julien Jardin , Gwénaël Jan , Sergine Even , Coralie Pulido
1.congrés international atelier sur les technologies et prospect immunogènes appliqué à la mammite, Jun 2012, Juiz de Fora, Brazil. , 2012
Poster de conférence hal-01209344v1

Inhibition of S. aureus invasion into mammary epithelial cells by Lactobacillus casei CIRM-BIA 667

Damien Bouchard , Lucie Rault , Nadejda Berkova , Yves Le Loir , Sergine Even
International Symposium on Staphylococci and Staphylococcal Infections-ISSSI-2012, Aug 2012, Lyon, France. , 2012
Poster de conférence hal-01209355v1

Molecular basis of virulence in staphylococcus aureus mastitis

Caroline Le Maréchal , Nubia Seyffert , Julien Jardin , David Hernandez , Gwénaël Jan
International Symposium on Staphylococci and Staphylococcal Infections -ISSSI-2012, Aug 2012, Lyon, France. , 2012
Poster de conférence hal-01209358v1

Staphylococcus aureus alters cell cycle in human and bovine epithelial cells.

Ludmila Alekseeva , Vincent Péton , Sintia Almeida da Silva , Fabien Cousin , Patrick Legembre
journées des Microbiologistes de l' INRA 2012, Nov 2012, L'Isle sur la Sorgue, France. , 2012
Poster de conférence hal-01209365v1

Inhibition of Staphylococcus aureus invasion into mammary epithelial cells by Lactobacillus casei CIRM-BIA 667

Damien Bouchard , Lucie Rault , Nadejda Berkova , Yves Le Loir , Sergine Even
18 Colloque du Club des Bactéries Lactiques, May 2012, Clermont Ferrand, France. , 2012
Poster de conférence hal-01209332v1

Inhibition of S. aureus invasion into mammary epithelial cells by Lactobacillus casei CIRM-BIA 667

Damien Bouchard , Lucie Rault , Nadejda Berkova , Yves Le Loir , Sergine Even
Journées ds Microbiologistes de l'INRA 2012, Nov 2012, L'Isle sur la Sorgue, France. , 2012
Poster de conférence hal-01209363v1

Molecular and phenotypic comparison of two Staphylococcus aureus strains associated to severe or mild mastitis in cows

Vincent Péton , Damien Bouchard , Sintia Almeida da Silva , Julien Jardin , Caroline Le Maréchal
Journées des Microbiologistes de l'INRA 2012, Nov 2012, L'Isle sur la Sorgue, France. , 2012
Poster de conférence hal-01209364v1

Molecular and phenotypic comparison of two Staphylococcus aureus strains associated to severe or mild mastitis in cows

Vincent Péton , Damien Bouchard , Sintia Almeida da Silva , Julien Jardin , Caroline Le Maréchal
15th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI), Aug 2012, Lyon, France. 2012
Poster de conférence hal-01209665v1

Serological proteome analysis of Staphylococcus aureus strains isolated from gangrenous and subclinical ewe mastitis reveals core and accessory seroproteomes

Caroline Le Maréchal , Julien Jardin , Gwénaël Jan , Sergine Even , Coralie Pulido
ADSA ASAS Joint Annual Meeting, Jul 2011, New Orleans, United States. , Journal of Dairy Science, 94, 2011, Journal of Dairy Science
Poster de conférence hal-01454333v1

Molecular basis of virulence in Staphylococcus aureus ovine mastitis

Caroline Le Maréchal , Nubia Seyffert , Julien Jardin , D Hernandez , Gwénaël Jan
ADSA ASAS Joint Annual Meeting, Jul 2011, New Orleans, United States. Journal of Dairy Science, 2011, Journal of Dairy Science
Poster de conférence hal-01454334v1

Staphylococcus aureus-induced cytopathic effect on the mammalian cells

Ludmila Alekseeva , Rémy Le Guével , Lucie Rault , Caroline Le Marechal , Claire Piquet-Pellorce
4 Congress of European Microbiologists FEMS 2011, Jun 2011, Genève, Switzerland. , 2011
Poster de conférence hal-02808973v1

Comparaison exhaustives de souches de staphylococcus aureus isolées de mammites gangréneuses et subcliniques en élevage ovin

Caroline Le Maréchal , Julien Jardin , D. Hernandez , Gwénaël Jan , P. François
Journées des microbiologistes de l'Inra 2010, May 2010, Poitier, France. 2010, JOURNÉES des MICROBIOLOGISTES de l’INRA 2010
Poster de conférence hal-01454358v1

Approche séroprotéomique de souches de staphylococcus aureus isolées de mammites subcliniques et gangréneuses chez la brebis : détermination du séroprotéome central et accessoire

Caroline Le Maréchal , Gwénaël Jan , Julien Jardin , Sergine Even , Nadejda Berkova
Journées des microbiologistes de l'Inra 2010, May 2010, Poitier, France. , 194 p., 2010
Poster de conférence hal-01454360v1