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Yves Le Loir
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Documents
Présentation
**Yves Le Loir** is a research scientist working at the French National Institute for Agricultural Research (INRA). He dedicates his scientific carrier to the microbiology of the milk production chain (with food and veterinary aspects). He originally studied Biochemistry at the University of Rennes (France). In 1992, he passed the diploma of Engineer in Agronomy of the Ecole Nationale Supérieure d’Agronomie (ENSA), in Rennes. He moved to INRA Jouy en Josas, France, (Unit of Microbial Genetics, headed by S.D. Ehrlich) to work on conjugative DNA transfer in *Lactococcus lactis*, the model lactic acid bacterium (LAB). He stayed in the same team to prepare a PhD thesis (University of Paris XI) in Microbiology on heterologous proteins secretion in *L. lactis*. He defended in 1996 and was recruited in INRA to go on working on protein secretion and lately on respiration in *L. lactis*. In February 2001, Y. Le Loir moved to INRA Rennes to start a new laboratory (Unit of Microbiology, INRA ENSA, Rennes, France). His new projects focused on host adaptation (ruminants) in *Staphylococcus aureus* and interactions between *Staphylococcus aureus* and Lactic Acid Bacteria. In 2008-2016, he headed a research team (12 permanent positions) called Bacterial Biodiversity and In Situ Interactions. From 2011 to 2016, he was alos deputy director of the Research Unit STLO. Since January 2017, he is heading the STLO Unit in Rennes. **STLO (Science and Technology of Milk & Eggs)** is a joint research unit comprising INRA and Agrocampus Ouest staff members (83 permanent positions, 130-140 staff). Since 2000, Y. Le Loir tightly collaborates with Pr Vasco Azevedo (UFMG, Belo Horizonte) and he has been Pesquisador Visitante Especial at UFMG in 2014-2016 (PVE400721/2013-9; CNPq). He also coordinates an International Associated Laboratory involving STLO and Micalis Research Units at INRA and 3 research teams at UFMG, in Brazil.
Publications
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- 16
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Transcriptome Architecture of Osteoblastic Cells Infected With Staphylococcus aureus Reveals Strong Inflammatory Responses and Signatures of Metabolic and Epigenetic DysregulationFrontiers in Cellular and Infection Microbiology, 2022, 12, pp.854242. ⟨10.3389/fcimb.2022.854242⟩
Article dans une revue
hal-03650997v1
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Author correction: exfoliative toxin e, a new Staphylococcus aureus virulence factor with host-specific activityScientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-59360-1⟩
Article dans une revue
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Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activityScientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-52777-3⟩
Article dans une revue
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Staphylococcus aureus Extracellular Vesicles Elicit an Immunostimulatory Response in vivo on the Murine Mammary GlandFrontiers in Cellular and Infection Microbiology, 2018, 8 (article 277), pp.277. ⟨10.3389/fcimb.2018.00277⟩
Article dans une revue
hal-01860012v1
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Extracellular vesicles from Staphylococcus aureus follow different pathways to manipulate host cells18e congrès national de la SFM « Un monde à explorer », Société Française de Microbiologie (SFM), Oct 2023, Rennes, France
Communication dans un congrès
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Interaction mechanisms with host of EVs derived from the opportunistic pathogen Staphylococcus aureusJournée GO-EVs sur les vésicules extracellulaires, INRAE, Oct 2023, NANTES, France
Communication dans un congrès
hal-04257450v1
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New Insights into Host-Pathogen Interactions of Staphylococcus aureus: Involvement of Extracellular Vesicles to Manipulate Host CellsStaphosium 2023, Le groupe de travail « staphylococci » organise son premier colloque. L’ objectif est de stimuler le réseau pour l’ensemble des acteurs travaillant sur les staphylocoques afin de faciliter les échanges et les collaborations., Nov 2023, LYON, France
Communication dans un congrès
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Development of trained immunity and activation of inflammasomes are promising strategies to combat Staphylococcus aureus infection18e congrès national de la SFM « Un monde à explorer », Société Française de Microbiologie (SFM), Oct 2023, Rennes, France
Communication dans un congrès
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Unveiling the Secrets of Long-Term Staphylococcus aureus Infections: Insights into Inflammation, Metabolism, and Epigenetic Changes from Non-Immune Cells TranscriptomesRendez-vous scientifique annuel d’Op+lait Réunion glande Mammaire lait, Galactinov, Réseau Oplait-Galctinov, Oct 2023, Québec (online), Canada
Communication dans un congrès
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Inflammasome activation and an involvement of Caspase-1 in a bacterial clearance during S. aureus infection.Bactinflan, Lia Bactinflam, INRAE STLO, Jun 2022, Webinar, France
Communication dans un congrès
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Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activityMicrobes, 15e Congrès National de la SFM, Sep 2019, Paris, France
Communication dans un congrès
hal-02306146v1
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Staphylococcus aureus extracellular vesicles elicit an immunostimulatory response in vivo on the murine mammary gland14.congrès national de la Société Française de Microbiologie (SFM), Oct 2018, Paris, France
Communication dans un congrès
hal-01889276v1
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Staphylococcus aureus-derived extracellular vesicles induce an inflammatory response in murine model of mastitisCongrès FSEV 2017, Nov 2017, Paris, France
Communication dans un congrès
hal-01645112v1
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Unleashing the power of inflammasomes and trained immunity: promising strategies in the fight against Staphylococcus aureus infectionhttps://immunologisk-selskab.dk/calendar/lofoten-immunology-workshop-2023/. Lofoten Immunology Workshop 2023, Aug 2023, Lofoten Islands, Norway. , 2023
Poster de conférence
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Involvement of Extracellular Vesicles from Staphylococcus aureus in host cells manipulationPoster de conférence hal-04215082v1 |
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Staphylococcus aureus induces DNA damage in host cellPoster de conférence hal-03859134v1 |