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Yves Le Loir

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Documents

Présentation

**Yves Le Loir** is a research scientist working at the French National Institute for Agricultural Research (INRA). He dedicates his scientific carrier to the microbiology of the milk production chain (with food and veterinary aspects). He originally studied Biochemistry at the University of Rennes (France). In 1992, he passed the diploma of Engineer in Agronomy of the Ecole Nationale Supérieure d’Agronomie (ENSA), in Rennes. He moved to INRA Jouy en Josas, France, (Unit of Microbial Genetics, headed by S.D. Ehrlich) to work on conjugative DNA transfer in *Lactococcus lactis*, the model lactic acid bacterium (LAB). He stayed in the same team to prepare a PhD thesis (University of Paris XI) in Microbiology on heterologous proteins secretion in *L. lactis*. He defended in 1996 and was recruited in INRA to go on working on protein secretion and lately on respiration in *L. lactis*. In February 2001, Y. Le Loir moved to INRA Rennes to start a new laboratory (Unit of Microbiology, INRA ENSA, Rennes, France). His new projects focused on host adaptation (ruminants) in *Staphylococcus aureus* and interactions between *Staphylococcus aureus* and Lactic Acid Bacteria. In 2008-2016, he headed a research team (12 permanent positions) called Bacterial Biodiversity and In Situ Interactions. From 2011 to 2016, he was alos deputy director of the Research Unit STLO. Since January 2017, he is heading the STLO Unit in Rennes. **STLO (Science and Technology of Milk & Eggs)** is a joint research unit comprising INRA and Agrocampus Ouest staff members (83 permanent positions, 130-140 staff). Since 2000, Y. Le Loir tightly collaborates with Pr Vasco Azevedo (UFMG, Belo Horizonte) and he has been Pesquisador Visitante Especial at UFMG in 2014-2016 (PVE400721/2013-9; CNPq). He also coordinates an International Associated Laboratory involving STLO and Micalis Research Units at INRA and 3 research teams at UFMG, in Brazil.

Publications

"julien-jardin"
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Different culture media and purification methods unveil the core proteome of Propionibacterium freudenreichii -derived extracellular vesicles

Vinícius de Rezende Rodovalho , Brenda Silva Rosa da Luz , Aurélie Nicolas , Julien Jardin , Valérie Briard-Bion
microLife, 2023, 4, pp.1-15. ⟨10.1093/femsml/uqad029⟩
Article dans une revue hal-04128282v1
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Comprehensive probiogenomics analysis of the commensal Escherichia coli CEC15 as a potential probiotic strain

Tales Fernando da Silva , Rafael de Assis Glória , Thiago Jesus de Sousa , Monique Ferrary Americo , Andria Dos
BMC Microbiology, 2023, 23 (364), ⟨10.1186/s12866-023-03112-4⟩
Article dans une revue hal-04308495v1
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Impact of Environmental Conditions on the Protein Content of Staphylococcus aureus and Its Derived Extracellular Vesicles

Brenda Silva Rosa da Luz , Vinícius de Rezende Rodovalho , Aurélie Nicolas , Svetlana Chabelskaya , Julien Jardin
Microorganisms, 2022, 10 (9), pp.1808. ⟨10.3390/microorganisms10091808⟩
Article dans une revue hal-03780474v1
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Environmental Conditions Modulate the Protein Content and Immunomodulatory Activity of Extracellular Vesicles Produced by the Probiotic Propionibacterium freudenreichii

Vinícius de Rezende Rodovalho , Brenda Silva Rosa da Luz , Aurélie Nicolas , Fillipe Luiz Rosa Do Carmo , Vasco Ariston de Carvalho Azevedo
Applied and Environmental Microbiology, 2021, 87 (4), ⟨10.1128/AEM.02263-20⟩
Article dans une revue hal-03137714v1
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Extracellular vesicles produced by the probiotic Propionibacterium freudenreichii CIRM-BIA 129 mitigate inflammation by modulating the NF-κB pathway

Vinicius de Rezende Rodovalho , Brenda Silva Rosa da Luz , Houem Rabah , Fillipe Luiz Rosa Do Carmo , Edson L Folador
Frontiers in Microbiology, 2020, 11, ⟨10.3389/fmicb.2020.01544⟩
Article dans une revue hal-02885846v1
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Extracellular vesicles produced by human and animal Staphylococcus aureus strains share a highly conserved core proteome

Natayme Rocha Tartaglia , Aurélie Nicolas , Vinicius de Rezende Rodovalho , Brenda Silva Rosa Da Luz , Valérie Briard-Bion
Scientific Reports, 2020, 10 (1), pp.1-13. ⟨10.1038/s41598-020-64952-y⟩
Article dans une revue hal-02638124v1
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Mutation of the Surface Layer Protein SlpB Has Pleiotropic Effects in the Probiotic Propionibacterium freudenreichii CIRM-BIA 129

Fillipe Luiz Rosa Do Carmo , Wanderson M. Silva , Guilherme C. Tavares , Izabela C. Ibraim , Barbara F. Cordeiro
Frontiers in Microbiology, 2018, 9, ⟨10.3389/fmicb.2018.01807⟩
Article dans une revue hal-01857987v1
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Staphylococcus aureus Extracellular Vesicles Elicit an Immunostimulatory Response in vivo on the Murine Mammary Gland

Natayme Rocha Tartaglia , Koen Breyne , Evelyne Meyer , Chantal Cauty , Julien Jardin
Frontiers in Cellular and Infection Microbiology, 2018, 8 (article 277), pp.277. ⟨10.3389/fcimb.2018.00277⟩
Article dans une revue hal-01860012v1
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Growth in Hyper-Concentrated Sweet Whey Triggers Multi Stress Tolerance and Spray Drying Survival in Lactobacillus casei BL23: From the Molecular Basis to New Perspectives for Sustainable Probiotic Production

Song Huang , Floriane Gaucher , Chantal Cauty , Julien Jardin , Yves Le Loir
Frontiers in Microbiology, 2018, 9 article 2548, ⟨10.3389/fmicb.2018.02548⟩
Article dans une revue hal-01901454v1
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Contribution of sortase SrtA2 to Lactobacillus casei BL23 inhibition of Staphylococcus aureus internalization into bovine mammary epithelial cells

Renata Faria Silva Souza , Julien Jardin , Chantal Cauty , Lucie Rault , Damien Bouchard
PLoS ONE, 2017, 12 (3), pp.e0174060. ⟨10.1371/journal.pone.0174060⟩
Article dans une revue hal-01506640v1
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Propionibacterium freudenreichii Surface Protein SlpB Is Involved in Adhesion to Intestinal HT-29 Cells

Fillipe Luiz Rosa Do Carmo , Houem Rabah , Song Huang , Floriane Gaucher , Martine Deplanche
Frontiers in Microbiology, 2017, 8 (article 1033), pp.1033. ⟨10.3389/fmicb.2017.01033⟩
Article dans une revue hal-01535209v1

Hyperconcentrated sweet whey, a new culture medium that enhances Propionibacterium freudenreichii stress tolerance

Song Huang , Houem Rabah , Julien Jardin , Valérie Briard-Bion , Sandrine Parayre
Applied and Environmental Microbiology, 2016, 82 (15), pp.4641-4651. ⟨10.1128/AEM.00748-16⟩
Article dans une revue hal-01454632v1

Phenol-soluble modulin α induce G2/M phase transition delay in eukaryotic HeLa cells.

Martine Deplanche , Rachid El-Aouar Filho , Ludmila Alekseeva , Emilie Ladier , Julien Jardin
FASEB Journal, 2015, 29 (5), pp.1950-1959. ⟨10.1096/fj.14-260513⟩
Article dans une revue hal-01209778v1

Serological proteome analysis of [i]Corynebacterium pseudotuberculosis[/i] isolated from different hosts reveals novel candidates for prophylactics to control caseous lymphadenitis

Nubia Seyffert , Renata Faria Silva , Julien Jardin , Wanderson Silva , Thiago Luiz de Paula Castro
Veterinary Microbiology, 2014, 174, pp.255-260. ⟨10.1016/j.vetmic.2014.08.024⟩
Article dans une revue hal-01209718v1
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Fine-tuned characterization of Staphylococcus aureus Newbould 305, a strain associated with mild and chronic mastitis in bovines

Vincent Peton , Damien S Bouchard , Sintia Almeida , Lucie Rault , Hélène Falentin
Veterinary Research, 2014, 45 (1), pp.106. ⟨10.1186/s13567-014-0106-7⟩
Article dans une revue hal-01290602v1
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Fine-tuned characterization of [i]Staphylococcus aureus[/i] Newbould 305, a strain associated with mild and chronic mastitis in bovines

Vincent Péton , Damien Bouchard , Sintia Almeida da Silva , Lucie Rault , Hélène Falentin
Veterinary Research, 2014, 45 (106), pp.1-15. ⟨10.1186/PREACCEPT-6950585981338355⟩
Article dans une revue hal-01209743v1
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Staphylococcus aureus proteins differentially produced in ewe gangrenous mastitis or ewe milk

Caroline Le Maréchal , Julien Jardin , Valérie Briard-Bion , Lucie Rault , Nadia Berkova
Veterinary Microbiology, 2013, 164, pp.150-157. ⟨10.1016/j.vetmic.2013.01.013⟩
Article dans une revue hal-01209415v1

[i]Staphylococcus aureus[/i] proteins differentially recognized by the ovine immune response in mastitis or nasal carriage

Nubia Seyffert , Caroline Le Maréchal , Julien Jardin , John.A Mcculloch , Fabio Rogerio Rosado
Veterinary Microbiology, 2012, 157 (3-4), pp.439-447. ⟨10.1016/j.vetmic.2012.01.016⟩
Article dans une revue hal-01209309v1
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Molecular basis of virulence in Staphylococcus aureus mastitis

Caroline Le Maréchal , Nubia Seyffert , Julien Jardin , David Hernandez , Gwénaël Jan
PLoS ONE, 2011, 6 (11), ⟨10.1371/journal.pone.0027354⟩
Article dans une revue hal-01189501v1
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Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis

Caroline Le Maréchal , Julien Jardin , Gwénaël Jan , Sergine Even , Coralie Pulido
Veterinary Research, 2011, 42 (35), pp.1-20. ⟨10.1186/1297-9716-42-35⟩
Article dans une revue hal-01454159v1
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Extracellular vesicles from Staphylococcus aureus follow different pathways to manipulate host cells

Julia Papail , Ligia Prado , Nathalie Daniel , Brenda Silva Rosa da Luz , Daniele Vassaux
18e congrès national de la SFM « Un monde à explorer », Société Française de Microbiologie (SFM), Oct 2023, Rennes, France
Communication dans un congrès hal-04234337v1

New Insights into Host-Pathogen Interactions of Staphylococcus aureus: Involvement of Extracellular Vesicles to Manipulate Host Cells

Julia Papail , Ligia Prado , Nathalie Daniel , Brenda Silva Rosa da Luz , Yann Le Gouar
Staphosium 2023, Le groupe de travail « staphylococci » organise son premier colloque. L’ objectif est de stimuler le réseau pour l’ensemble des acteurs travaillant sur les staphylocoques afin de faciliter les échanges et les collaborations., Nov 2023, LYON, France
Communication dans un congrès hal-04299256v1
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Interaction mechanisms with host of EVs derived from the opportunistic pathogen Staphylococcus aureus

Julia Papail , Ligia Prado , Nathalie Daniel , Daniele Vassaux , Yann Le Gouar
Journée GO-EVs sur les vésicules extracellulaires, INRAE, Oct 2023, NANTES, France
Communication dans un congrès hal-04257450v1

Environmental conditions modulate the protein content and immunomodulatory activity of extracellular vesicles produced by the probiotic Propionibacterium freudenreichii

Vinícius de Rezende Rodovalho , Brenda Silva Rosa Da Luz , Aurélie Nicolas , Fillipe Luiz Rosa Do Carmo , Julien Jardin
23ème édition du colloque du Club des Bactéries Lactiques, UMR INRAE - Institut Agro STLO (Science et Technologie du Lait et de l’Œuf), Jun 2022, Rennes, France
Communication dans un congrès hal-03693312v1

Immunomodulatory role of Propionibacterium freudenreichii extracellular vesicles

Tales Fernando Da Silva , Vinícius de Rezende Rodovalho , Brenda Silva Rosa Da Luz , Fillipe Luiz Rosa Do Carmo , Aurélie Nicolas
FoodMicro2022, Aug 2022, Athènes, Greece
Communication dans un congrès hal-03781603v1

Environmental conditions modulate the protein content and immunomodulatory activity of extracellular vesicles produced by the probiotic Propionibacterium freudenreichii

Vinícius de Rezende Rodovalho , Brenda Silva Rosa Da Luz , Aurélie Nicolas , Fillipe Luiz Rosa Do Carmo , Julien Jardin
Bactinflam, Lia Bactinflam, INRAE STLO, Jun 2022, Webinar, France
Communication dans un congrès hal-03690783v1

Staphylococcus aureus extracellular vesicles elicit an immunostimulatory response in vivo on the murine mammary gland

Yves Le Loir , Eric Guédon , Natayme Rocha Tartaglia , Koen Breyne , Evelyne Meyer
14.congrès national de la Société Française de Microbiologie (SFM), Oct 2018, Paris, France
Communication dans un congrès hal-01889276v1

Propionibacterium freudenreichii Surface Protein SlpB Is Involved in Adhesion to Intestinal HT-29 Cells.

Gwénaël Jan , Fillipe Luiz Rosa Do Carmo , Houem Rabah , Song Huang , Floriane Gaucher
12.International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health - IPC2018, Jun 2018, Budapest, Hungary
Communication dans un congrès hal-01824996v1

Staphylococcus aureus-derived extracellular vesicles induce an inflammatory response in murine model of mastitis

Natayme Rocha Tartaglia , Koene Breyne , Kristel Demeyere , Julien Jardin , Chantal Cauty
Congrès FSEV 2017, Nov 2017, Paris, France
Communication dans un congrès hal-01645112v1
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Analise immunoproteomica de staphylococcus aureus causador da mastite ovina revela polipepideos diferencialmente reconhecidos por soros de animais infectados e portadores

Nubia Seyffert , Caroline Le Maréchal , Julien Jardin , J.A. Mc Culloch , Fabio Rogerio Rosado
26 Congresso Brasileiro de Microbiologia, Oct 2011, Iguacu, Brazil
Communication dans un congrès hal-01454337v1

Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis

Caroline Le Maréchal , Julien Jardin , Gwénaël Jan , Sergine Even , C. Pulido
4 Congress of European Microbiologists, Jun 2011, Genève, Switzerland
Communication dans un congrès hal-01454339v1

Comprehensive “omic” analysis of Staphylococcus aureus strains isolated from gangrenous and subclinical ewe mastitis

Caroline Le Maréchal , Julien Jardin , D. Hernandez , Gwénaël Jan , P. François
14 International Symposium on Staphylococci and Staphylococcal Infections (ISSSI), Sep 2010, Bath, United Kingdom
Communication dans un congrès hal-01454357v1

Comparaison exhaustives de souches de staphylococcus aureus isolées de mammites gangéneuses et subcliniques en élevage ovin

Caroline Le Maréchal , Julien Jardin , D. Hernandez , Gwénaël Jan , P. François
8 Congrès National de la Société de Microbiologie, Jun 2010, Marseille, France
Communication dans un congrès hal-01454352v1

Serological proteome analysis of Staphylococcus aureus strains isolated from gangrenous and subclinical ewe mastitis reveals core and accessory seroproteomes

Caroline Le Maréchal , Gwénaël Jan , Julien Jardin , Sergine Even , Nadejda Berkova
14 International Symposium on Staphylococci and Staphylococcal Infections (ISSSI), Sep 2010, Bath, United Kingdom
Communication dans un congrès hal-01454355v1

La caractérisation omique de souches de Staphylococcus aureus isolées de mammites ovines révèle une forte proximité génétique mais des transcriptomes et protéomes associés à des tableaux cliniques radicalement différents

Caroline Le Maréchal , Nubia Seyffert , Julien Jardin , H. Hernandez , Gwénaël Jan
SYMPOSTAPH, Oct 2010, Lyon, France
Communication dans un congrès hal-01454347v1

Approche séroprotéomique de souches de staphylococcus aureus isolées de mammites subcliniques et gangréneuses chez la brebis : détermination du séroprotéome central et accessoire

Caroline Le Maréchal , Gwénaël Jan , Julien Jardin , Sergine Even , Nadejda Berkova
8 Congrès de la Société Française de Microbiologie, Jun 2010, Marseille, France
Communication dans un congrès hal-01454354v1
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Involvement of Extracellular Vesicles from Staphylococcus aureus in host cells manipulation

Julia Papail , Ligia Prado , Nathalie Daniel , Yann Le Gouar , Nadia Berkova
GENÉTICA 23 – 68th Brazilian Congress of Genetics 2023, Sep 2023, Ouro Preto – MG, Brazil. , 2023
Poster de conférence hal-04215082v1

Propionibacterium freudenreichii secretes extracellular vesicles containing immunomodulatory proteins

Vinicius de Rezende Rodovalho , Brenda Silva Rosa da Luz , Filippe Luiz Rosa Do Carmoa , Julien Jardin , Valérie Briard-Bion
Meeting du LIA Bact-Inflam, Aug 2019, Belo Horizonte, Brazil. , 2019
Poster de conférence hal-02790249v1

Double use of hyperconcentrated sweet whey: a novel strategy for production of [i]Propionibacterium freudenreichii[/i]

Song Huang , Houem Rabah , Julien Jardin , Valérie Briard-Bion , Sandrine Parayre
4. International Symposium on Propionibacteria and Bibfidobacteria, Sep 2016, Cork, Ireland. , 2016
Poster de conférence hal-01372137v1

Phenol-soluble modulins alpha induce G2/M phase transition delay and impair immune response of eukaryotic cells

Martine Deplanche , Rachid El-Aouar Filho , Ksenia Semenovskaya , Liudmila Alekseeva , Julien Jardin
ICI 2016 International Congress of Immunology, Aug 2016, Melbourne, Australia. John Wiley and Sons, European Journal of Immunology, 46 Supplement: 1 Special Issue: SI Meeting Abstract: 1425, pp.1: 351, 2016, European Journal of Immunology
Poster de conférence hal-01389063v1

Phenol soluble modulin alpha alters the cell cycle of eukaryotic cells.

Martine Deplanche , Rachid El-Aouar Filho , Luidmila Alexseeva , Emilie Ladier , Julien Jardin
6. Congress of European Microbiologists (FEMS 2015), Jun 2015, Maastricht, Netherlands. , 2015
Poster de conférence hal-01209855v1

Staphylococcus aureus modulates the cell cycle of eukaryotic cells

Rachid El-Aouar Filho , Martine Deplanche , Luidmila Alexseeva , Emilie Ladier , Sintia Almeida da Silva
SYMPOSTAPH, Oct 2014, Lyon, France. , 2014
Poster de conférence hal-01209739v1

[i]Staphylococcus aureus[/i] Newbould 305, a strain associated with mild and chronic mastitis in bovines

Vincent Péton , Damien Bouchard , Sintia Almeida da Silva , Lucie Rault , Hélène Falentin
SYMPOSTAPH, Oct 2014, Lyon, France. , 2014
Poster de conférence hal-01209740v1

Staphylococcus aureus Newbould 305, a strain associated to mild and chronic mastitis, is well armed to invade bovine mammary tissue.

Vincent Péton , Damien Bouchard , Sintia Almeida da Silva , Lucie Rault , Hélène Falentin
60. Congress of the Brazilian Society for Genetics, Aug 2014, Guarujà, Brazil. 2014
Poster de conférence hal-01209664v1

[i]Staphylococcus aureus[/i] proteins differentially recognized by the ovine immune response in mastitis or nasal carriage

Nubia Seyffert , Caroline Le Maréchal , Valérie Briard-Bion , Julien Jardin , A. Miyoshi
EUPA 2013, Oct 2013, Saint-Malo, France. , 2013
Poster de conférence hal-01209500v1

Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis

Caroline Le Maréchal , Julien Jardin , Gwénaël Jan , Sergine Even , Coralie Pulido
1.congrés international atelier sur les technologies et prospect immunogènes appliqué à la mammite, Jun 2012, Juiz de Fora, Brazil. , 2012
Poster de conférence hal-01209344v1

Molecular and phenotypic comparison of two Staphylococcus aureus strains associated to severe or mild mastitis in cows

Vincent Péton , Damien Bouchard , Sintia Almeida da Silva , Julien Jardin , Caroline Le Maréchal
Journées des Microbiologistes de l'INRA 2012, Nov 2012, L'Isle sur la Sorgue, France. , 2012
Poster de conférence hal-01209364v1

Molecular and phenotypic comparison of two Staphylococcus aureus strains associated to severe or mild mastitis in cows

Vincent Péton , Damien Bouchard , Sintia Almeida da Silva , Julien Jardin , Caroline Le Maréchal
15th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI), Aug 2012, Lyon, France. 2012
Poster de conférence hal-01209665v1

Molecular basis of virulence in staphylococcus aureus mastitis

Caroline Le Maréchal , Nubia Seyffert , Julien Jardin , David Hernandez , Gwénaël Jan
International Symposium on Staphylococci and Staphylococcal Infections -ISSSI-2012, Aug 2012, Lyon, France. , 2012
Poster de conférence hal-01209358v1

Serological proteome analysis of Staphylococcus aureus strains isolated from gangrenous and subclinical ewe mastitis reveals core and accessory seroproteomes

Caroline Le Maréchal , Julien Jardin , Gwénaël Jan , Sergine Even , Coralie Pulido
ADSA ASAS Joint Annual Meeting, Jul 2011, New Orleans, United States. , Journal of Dairy Science, 94, 2011, Journal of Dairy Science
Poster de conférence hal-01454333v1

Molecular basis of virulence in Staphylococcus aureus ovine mastitis

Caroline Le Maréchal , Nubia Seyffert , Julien Jardin , D Hernandez , Gwénaël Jan
ADSA ASAS Joint Annual Meeting, Jul 2011, New Orleans, United States. Journal of Dairy Science, 2011, Journal of Dairy Science
Poster de conférence hal-01454334v1

Comparaison exhaustives de souches de staphylococcus aureus isolées de mammites gangréneuses et subcliniques en élevage ovin

Caroline Le Maréchal , Julien Jardin , D. Hernandez , Gwénaël Jan , P. François
Journées des microbiologistes de l'Inra 2010, May 2010, Poitier, France. 2010, JOURNÉES des MICROBIOLOGISTES de l’INRA 2010
Poster de conférence hal-01454358v1

Approche séroprotéomique de souches de staphylococcus aureus isolées de mammites subcliniques et gangréneuses chez la brebis : détermination du séroprotéome central et accessoire

Caroline Le Maréchal , Gwénaël Jan , Julien Jardin , Sergine Even , Nadejda Berkova
Journées des microbiologistes de l'Inra 2010, May 2010, Poitier, France. , 194 p., 2010
Poster de conférence hal-01454360v1
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Genetic and proteomic comparison of [i]Staphylococcus aureus[/i] isolates causing gangrenous or subclinical intramammary infections in a dairy sheep flock

Caroline Le Maréchal , M. Chevalier , Gwénaël Jan , Julien Jardin , Sergine Even
3. Congress Federation of European Microbiological Societies (FEMS), Jun 2009, Goteborg, Sweden. 2009
Poster de conférence hal-01190819v1