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Yanxia HOU-BROUTIN

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Présentation

**FUNCTION** CRCN at CNRS **Section 11**: Systèmes et matériaux supra et macromoléculaires : élaboration, propriétés, fonctions **Professional Adresse**: Laboratoire Systèmes Moléculaires et Nanomatériaux pour l’Energie et la Santé (SyMMES UMR 5819, CNRS-CEA-UGA), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), CEA-Grenoble, 17 Rue des Martyrs 38054, Grenoble Cedex 9, France **Telephone**: +33 4 38 78 94 78, **Email**: yanxia.hou-broutin@cea.fr Personal page: https://www.symmes.fr/en/Pages/Portrait/Yanxia-Hou-Broutin.aspx **EDUCATION** 19 September 2019 **Habilitation à Diriger des Recherches**, Ecole Doctorale Chimie et Sciences du Vivant, Université Grenoble Alpes (France) Sep 2002-Nov 2005 **PhD in Analytical Chemistry**, Ecole Centrale de Lyon (France)/ Central China Normal University (China) Sep 1999-Jul 2002 **Master of Science in Chemistry**, Central China Normal University (China) Sep 1995-Jul 1999 **Bachelor of Science in Chemistry**, Yanbei Normal College (China) **PROFESSIONAL EXPERIENCES** Since January 2021 **Head of group CREAB** at SyMMES October 2008-present **Permanent Researcher** (Chargée de recherche) at CNRS (section 11) Jan 2007-Sep 2008 **Postdoc**, CEA-LETI, Grenoble (France) Jan 2006-Dec 2006 **Postdoc**, University of California San Francisco, Touro University (USA) **MAIN RESEARCH ACTIVITIES** Combining my competences and expertise on **physico-chemistry**, **surface chemistry** and **analytical chemistry,** my main research interests focus on: \- Development of **innovative bioinspired and biomimetic electronic tongues and noses** by design and elaboration of **thin films** via **self-assembly** with original **physico-chemical properties and functionalities**; Study of **thin film properties/function relationship** such as **sensing properties** at **different interfaces** using electronic tongues and noses; **- Surface functionalization** and **engineering of nanoparticles** for the elaboration of **hybrid multifunctional nanoparticles** for biomedical applications. **FUNDINGS** ![](https://www.symmes.fr/PublishingImages/flecheSousTitre.gif) **European projects:** **H2020-FETOPEN** (Project Abiomater 11/2015-10/2018, participant) **EURONANMMED II** (Project Nanoviber 01/2017-12/2019, participant) ![](https://www.symmes.fr/PublishingImages/flecheSousTitre.gif) **National projects:** **ANR eSPRi** (**coordinator,** to start 10/2022) **ANR Project** Siena (workpackage responsible, 10/2021-09/2025) **ANR Project** OBP-Optinose (**Coordinator**, 03/2019-02/2022) **ANR project** Sentinel (workpackage responsible, 10/2019-09/2023) **ANR Project** Nano-SHARK (workpackage responsible, 11/2011-10/2015) **FUI Project** WISE (workpackage responsible, 07/2016-06/2019) ![](https://www.symmes.fr/PublishingImages/flecheSousTitre.gif) **Local projects:** **Fondation Nanosciences** (**Coordinator** for a PhD program 12/2017-11/2020, workpackage responsible for a Chair of Industrial Excellence Program 2017-2019) **Labex Lanef PhD program** (**Coordinator for 2 projects** 11/2019-10/2022, 10/2012-09/2015) **Labex Arcane AAP Valo** (Project Supernose, **Coordinator,** 06/2015-05/2016) **CEA DRF Impulsion** (Project Hybridimer, Participant, 01/2018-02/2020) **Programme Transversal de Compétences du CEA** (Projet Graphon, workpackage responsible, 10/2019-09/2020) **Programme Transversal Nanosciences CEA** (Project NanoGAGs2Gre, **Coordinator,** 10/2013-09/2015) ![](https://www.symmes.fr/PublishingImages/flecheSousTitre.gif) **Industrial contracts:** Specific contracts with Aryballe Technologies (Scientific responsible, 2014-2019)

Publications

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Microstructured Magnetoelastic Membrane for Magnetic Bioactuators and Soft Artificial Muscles Applications

Svetlana Ponomareva , Marie Carriere , Yanxia Hou , Robert Morel , Bernard Dieny
Advanced Intelligent Systems, 2023, Advanced Intelligent Systems, pp.2300022. ⟨10.1002/aisy.202300022⟩
Article dans une revue hal-04174715v1
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Interaction between nanoparticles, membranes and proteins: A surface plasmon resonance study

Erenildo Ferreira de Macedo , Nivia Salles Santos , Lucca Silva Nascimento , Raphaël Mathey , Sophie Brenet
International Journal of Molecular Sciences, 2023, 24, pp.591. ⟨10.3390/ijms24010591⟩
Article dans une revue hal-04229980v1
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Recent Advances on Peptide-Based Biosensors and Electronic Noses for Foodborne Pathogen Detection

Vanessa Escobar , Natale Scaramozzino , Jasmina Vidic , Arnaud Buhot , Raphaël Mathey
Biosensors, 2023, 13, ⟨10.3390/bios13020258⟩
Article dans une revue hal-04307631v1
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Ligand Binding Properties of Odorant-Binding Protein OBP5 from Mus musculus

Lucie Moitrier , Christine Belloir , Maxence Lalis , Yanxia Hou , Jérémie Topin
Biology, 2023, 12 (1), pp.2. ⟨10.3390/biology12010002⟩
Article dans une revue hal-03994361v1
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Recent Advances in Electrochemical Biosensors for Food Control

Francesco Rizzotto , Majd Khalife , Yanxia Hou , Carole Chaix , Florence Lagarde
Micromachines, 2023, 14 (7), pp. 1412. ⟨10.3390/mi14071412⟩
Article dans une revue hal-04172926v1
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Surfactant-like peptide self-assembled into hybrid nanostructures for electronic nose applications

Jonathan Weerakkody , Marielle El Kazzy , Elise Jacquier , Pierre-Henri Elchinger , Raphael Mathey
ACS Nano, 2022, 414, pp.1c10734. ⟨10.1021/acsnano.1c10734⟩
Article dans une revue hal-03607954v1
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Magneto-mechanical treatment of human glioblastoma cells with engineered iron oxide powder microparticles for triggering apoptosis

C. Thébault , M. Marmiesse , C. Naud , K. Pernet-Gallay , E. Billiet
Nanoscale Advances, 2021, ⟨10.1039/D1NA00461A⟩
Article dans une revue hal-03375349v1
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Development of an optoelectronic nose based on surface plasmon resonance imaging with peptide and hairpin DNA for sensing volatile organic compounds

Sara Gaggiotti , Charlotte Hurot , Jonathan Weerakkody , Raphaël Mathey , Arnaud Buhot
Sensors and Actuators B: Chemical, 2020, 303, pp.127188. ⟨10.1016/j.snb.2019.127188⟩
Article dans une revue hal-02376321v1
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Improvement of Sensitivity of Surface Plasmon Resonance Imaging for the Gas-Phase Detection of Volatile Organic Compounds

Sophie Brenet , Jonathan S. Weerakoddy , Arnaud Buhot , Francois-Xavier Gallat , Raphaël Mathey
Talanta, 2020, 212, pp.120777. ⟨10.1016/j.talanta.2020.120777⟩
Article dans une revue hal-02946475v1
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Bio-Inspired Strategies for Improving the Selectivity and Sensitivity of Artificial Noses: A Review

Charlotte Hurot , Natale Scaramozzino , Arnaud Buhot , Yanxia Hou
Sensors, 2020, 20 (6), pp.1803. ⟨10.3390/s20061803⟩
Article dans une revue hal-02527981v1
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Optical Index Prism Sensitivity of Surface Plasmon Resonance Imaging in Gas Phase: Experiment versus Theory

Jonathan Shilanthan Weerakkody , Sophie Brenet , Thierry Livache , Cyril Herrier , Yanxia Hou
Journal of Physical Chemistry C, 2020, 124 (6), pp.3756-3767. ⟨10.1021/acs.jpcc.9b09973⟩
Article dans une revue hal-02485279v1
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Cancer treatment by magneto-mechanical effect of particles, a review

Cécile Naud , Caroline Thébault , Marie Carrière , Yanxia Hou , Robert Morel
Nanoscale Advances, 2020, 2 (9), pp.3632. ⟨10.1039/d0na00187b⟩
Article dans une revue hal-02884942v1
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Aqueous Synthesis of DNA-Functionalized Near-Infrared AgInS 2 /ZnS Core/Shell Quantum Dots

Annette Delices , Davina Moodelly , Charlotte Hurot , Yanxia Hou , Wai-Li Ling
ACS Applied Materials & Interfaces, 2020, 12 (39), pp.44026-44038. ⟨10.1021/acsami.0c11337⟩
Article dans une revue hal-02946449v1

Optical Response of Magnetically Actuated Biocompatible Membranes

Hélène Joisten , Alain Truong , Svetlana Ponomareva , Cécile Naud , Robert Morel
Nanoscale, 2019, ⟨10.1039/C9NR00585D⟩
Article dans une revue hal-02105377v1

Highly sensitive olfactory biosensors for the detection of volatile organic compounds by surface plasmon resonance imaging

Charlotte Hurot , Sophie Brenet , Arnaud Buhot , Emilie Barou , Christine Belloir
Biosensors and Bioelectronics, 2019, 123, pp.230 - 236. ⟨10.1016/j.bios.2018.08.072⟩
Article dans une revue hal-01915890v1

Mode of PEG Coverage on Carbon Nanotubes Affects Binding of Innate Immune Protein C1q

Agathe Bélime , Edmond Gravel , Sophie Brenet , Sarah Ancelet , Charlotte Caneiro
Journal of Physical Chemistry B, 2018, 122 (2), pp.757-763. ⟨10.1021/acs.jpcb.7b06596⟩
Article dans une revue hal-01596679v1

Highly-Selective Optoelectronic Nose Based on Surface Plasmon Resonance Imaging for Sensing Volatile Organic Compounds

Sophie Brenet , Aurelian John-Herpin , François-Xavier Gallat , Benjamin Musnier , Arnaud Buhot
Analytical Chemistry, 2018, 90 (16), pp.9879 - 9887. ⟨10.1021/acs.analchem.8b02036⟩
Article dans une revue hal-01925324v1

Fabrication of monodisperse magnetic nanoparticles released in solution using a block copolymer template

Mélissa Morcrette , Guillermo Ortiz , Salomé Tallegas , Hélène Joisten , Raluca Tiron
Journal of Physics D: Applied Physics, 2017, 50, pp.295001. ⟨10.1088/1361-6463/aa790b⟩
Article dans une revue hal-01585374v1

A Versatile Electronic Tongue Based on Surface Plasmon Resonance Imaging and Cross-Reactive Sensor Arrays

Laurie-Amandine Garçon , Maria Genua , Yanjie Hou , Arnaud Buhot , Roberto Calemczuk
Sensors, 2017, 17 (5), pp.1046. ⟨10.3390/s17051046⟩
Article dans une revue hal-01522527v1

Fabrication of nanotweezers and their remote actuation by magnetic fields

C. Iss , G. Ortiz , A. Truong , Y. Hou , T. Livache
Scientific Reports, 2017, 7, pp.451. ⟨10.1038/s41598-017-00537-6⟩
Article dans une revue hal-01578735v1

Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane

Selma Leulmi , Xavier Chauchet , Mélissa Morcrette , Guillermo Ortiz , Hélène Joisten
Nanoscale, 2015, 7 (38), pp.15904-15914. ⟨10.1039/c5nr03518j⟩
Article dans une revue hal-01615206v1

Integrating Multi-Functionalities Into Non-Spherical Microparticles Fabricated by Top-Down Approach

Maria Genua , Nora Reinhardt , Jérôme Faure-Vincent , Roberto Calemczuk , Thierry Livache
SCIENCE OF ADVANCED MATERIALS, 2015, 7 (9), pp.1779-1784. ⟨10.1166/sam.2015.2429⟩
Article dans une revue hal-01593306v1

SPR imaging based electronic tongue via landscape images for complex mixture analysis

Maria Genua , Laurie-Amandine Garçon , Violette Mounier , Hillary Wehry , Arnaud Buhot
Talanta, 2014, 130, pp.49 - 54. ⟨10.1016/j.talanta.2014.06.038⟩
Article dans une revue hal-01925388v1

Electronic tongue generating continuous recognition patterns for protein analysis.

Yanxia Hou , Maria Genua , Laurie-Amandine Garçon , Arnaud Buhot , Roberto Calemczuk
Journal of visualized experiments : JoVE, 2014, 91, pp.DOI 10.3791/51901. ⟨10.3791/51901⟩
Article dans une revue hal-01072629v1

Landscapes of taste by a novel Electronic tongue for the analysis of complex mixtures

Laurie-Amandine Garçon , Yanjie Hou , Maria Genua , Arnaud Buhot , Roberto Calemczuk
Sensor letters, 2014, 12 (6), pp.1059 - 1064. ⟨10.1166/sl.2014.3164⟩
Article dans une revue hal-01925383v1

Continuous Evolution Profiles for Electronic-Tongue-Based Analysis

Yanxia Hou , Maria Genua , Dayane Tada batista , Roberto Calemczuk , Arnaud Buhot
Angewandte Chemie International Edition, 2012, 51 (41), pp.10394-10398. ⟨10.1002/anie.201205346⟩
Article dans une revue hal-02105334v1

Nanobiosensors based on individual olfactory receptors

Vladimir Akimov , Eleonora Alfinito , Joan Bausells , Iryna V. Benilova , Ignacio Casuso Paramo
Analog Integrated Circuits and Signal Processing, 2008, 57 (3), pp.197-203. ⟨10.1007/s10470-007-9114-0⟩
Article dans une revue hal-02105336v1

Artificial Ion Channel Biosensor in Human Immunodeficiency Virus gp41 Drug Sensing

Yanxia Hou , Miriam Gochin
Analytical Chemistry, 2008, 80 (15), pp.5924-5929. ⟨10.1021/ac800511n⟩
Article dans une revue hal-02105335v1

Gold Surface Functionalization and Patterning for Specific Immobilization of Olfactory Receptors Carried by Nanosomes

Jasmina Vidic , Mateu Pla-Roca , Jeanne Grosclaude , Marie-Annick Persuy , Regine Monnerie
Analytical Chemistry, 2007, 79 (9), pp.3280-3290. ⟨10.1021/ac061774m⟩
Article dans une revue hal-02107926v1

A novel detection strategy for odorant molecules based on controlled bioengineering of rat olfactory receptor 17

Yanxia X. Hou , Nicole Jaffrezic-Renault , Claude Martelet , Aidong D. Zhang , Jasmina Minic-Vidic
Biosensors and Bioelectronics, 2007, 22 (7), pp.1550-1555. ⟨10.1016/j.bios.2006.06.018⟩
Article dans une revue hal-00140599v1

Detection of olfactory receptor I7 self-assembled multilayer formation and immobilization using a quartz crystal microbalance

S. R. Segui , M. Pla , Jasmina Minic-Vidic , Edith Pajot-Augy , Roland Salesse
Analytical Letters, 2006, 39 (8), pp.1735-1745
Article dans une revue hal-00141434v1

Immobilization of rhodopsin on a self-assembled multilayer and its specific detection by electrochemical impedance spectroscopy

Yanxia Hou , Salwa Helali , Aidong D. Zhang , Nicole Jaffrezic-Renault , Claude Martelet
Biosensors and Bioelectronics, 2006, 21 (7), pp.1393-1402. ⟨10.1016/j.bios.2005.06.002⟩
Article dans une revue hal-02107927v1

Detection of Olfactory Receptor I7 Self‐Assembled Multilayer Formation and Immobilization Using a Quartz Crystal Microbalance

S. Rodríguez Seguí , M. Pla , J. Minic , E. Pajot‐augy , R. Salesse
Analytical Letters, 2006, 39 (8), pp.1735-1745. ⟨10.1080/00032710600714030⟩
Article dans une revue hal-02107929v1

Advances in the production, immobilization, and electrical characterization of olfactory receptors for olfactory nanobiosensor development

G. Gomila , I. Casuso , A. Errachid , O. Ruiz , E. Pajot
Sensors and Actuators B: Chemical, 2006, 116 (1-2), pp.66-71. ⟨10.1016/j.snb.2005.11.083⟩
Article dans une revue hal-02107932v1

Elaboration of odorant biosensors based on Langmuir-Blodgett technique

Yanxia Hou , Nicole Jaffrezic-Renault , Claude Martelet , Chaker Tlili , Aidong Zhang
Journal of Advanced Science, 2005, 17 (1/2), pp.49-54. ⟨10.2978/jsas.17.49⟩
Article dans une revue hal-02107936v1
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Langmuir and Langmuir-Blodgett films of odorant binding protein/amphiphile study for odorant biosensor

Yanxia Hou , Nicole Jaffrezic-Renault , Claude Martelet , Chaker Tlili , Aidong D. Zhang
Langmuir, 2005, 21 (9), pp.4058-4065. ⟨10.1021/la0471801⟩
Article dans une revue hal-02881790v1

Quantitative determination of zinc in milkvetch by anodic stripping voltammetry with bismuth film electrodes

Z. Guo , F. Feng , Yanxia Hou , Nicole Jaffrezic-Renault
Talanta, 2005, 65 (4), pp.1052-1055. ⟨10.1016/j.talanta.2004.08.060⟩
Article dans une revue hal-00141461v1

Immobilization of native membrane-bound rhodopsin on biosensor surfaces

Jasmina Minic , Jeanne Grosclaude , Josiane Aioun , Marie-Annick Persuy , Tatiana Gorojankina
Biochimica et Biophysica Acta (BBA) - General Subjects, 2005, 1724 (3), pp.324-332. ⟨10.1016/j.bbagen.2005.04.017⟩
Article dans une revue hal-02107938v1

Impedance-Probing of Mixed Amphiphile-Antibody Films Transferred onto Silver Electrodes

Chaker Tlili , Yanxia Hou , Hafsa Korri-Youssoufi , Laurence Ponsonnet , Claude Martelet
Sensor letters, 2004, 2 (3), pp.246-251. ⟨10.1166/sl.2004.056⟩
Article dans une revue hal-02107942v1

Study of mixed Langmuir–Blodgett films of immunoglobulin G/amphiphile and their application for immunosensor engineering

Yanxia Hou , Chaker Tlili , Nicole Jaffrezic-Renault , Aidong D. Zhang , Claude Martelet
Biosensors and Bioelectronics, 2004, 20 (6), pp.1126-1133. ⟨10.1016/j.bios.2004.05.017⟩
Article dans une revue hal-02107944v1

Study of mixed Langmuir-Blodgett films of immunoglobulin G/amphiphile and their application for immunosensor engineering

Yanxia X. Hou , C. Tlili , Nicole Jaffrezic-Renault , Aidong D. Zhang , Claude Martelet
Biosensors and Bioelectronics, 2004, 20 (6), pp.1126-1133
Article dans une revue hal-00140629v1

Mixed urease/amphiphile LB films and their application for biosensor development

Aidong D. Zhang , Yanxia Hou , Nicole Jaffrezic-Renault , Jialiang Wan , Alexey P. Soldatkin
Bioelectrochemistry, 2002, 56 (1-2), pp.157-158. ⟨10.1016/S1567-5394(02)00045-2⟩
Article dans une revue hal-02107951v1

Optimization of the mixed urease/amphiphile Langmuir–Blodgett film and its application for biosensor development

Aidong D. Zhang , Nicole Jaffrezic-Renault , Jialiang Wan , Yanxia Hou , Jean-Marc Chovelon
Materials Science and Engineering: C, 2002, 21 (1-2), pp.91-96. ⟨10.1016/S0928-4931(02)00065-6⟩
Article dans une revue hal-02107953v1

Study of pure urease Langmuir–Blodgett film and application for biosensor development

Y Hou
Sensors and Actuators B: Chemical, 2002, 86 (2-3), pp.143-149. ⟨10.1016/S0925-4005(02)00158-2⟩
Article dans une revue hal-02107948v1
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Biomimetic olfactory biosensors and bioelectronic noses

Marielle El Kazzy , Charlotte Hurot , Jonathan Weerakkody , Arnaud Buhot , Yanxia Hou
Sergey Y. Yurish. Advances in Biosensors: Reviews Volume 3, 3, International Frequency Sensor Association (IFSA), pp.15-63, 2020, 978-84-09-25125-4
Chapitre d'ouvrage hal-03340460v1

Nanostructuration and nanoimaging of biomolecules for biosensors

Yanxia Hou
Applied Scanning Probe Methods VII, pp.225-257, 2007, 978-3-540-37320-9. ⟨10.1007/978-3-540-37321-6_6⟩
Chapitre d'ouvrage hal-02107962v1

Towards the realization of noanobiosensors based on G-protein coupled receptors

Cecilia Pennetta , Vladimir Akimov , Eleonora Alfinito , Lino Reggiani , Tatiana Corojankina
Nanodevices for the Life sciences, ‎ Wiley, 2006
Chapitre d'ouvrage hal-02107978v1

Procédé de détection d’objets biologiques par imagerie par résonance plasmonique de surface

Cristina-Cassiana Andrei , Cyril Herrier , Salim Slimani , Thierry Livache , Yanxia Hou-Broutin
France, N° de brevet: FR2200324. 2022
Brevet hal-03723128v1

Capteur biologique et/ou biochimique et/ou chimique

Thomas Alava , Pascal Mailley , Yanxia Hou-Broutin , Loïc Leroy
France, N° de brevet: FR2005584. 2020
Brevet hal-02946499v1

Système de détection pour nez électronique permettant une classification physicochimique des odeurs et nez électronique comprenant un tel système

Yanxia Hou-Broutin , Sophie Brenet , Arnaud Buhot , Thierry Livache , Cyril Herrier
France, N° de brevet: FR1907884. 2019
Brevet hal-02946513v1

Procédé de calibration d’un nez électronique

Thierry Livache , Francois-Xavier Gallat , Yanxia Hou-Broutin , Cyril Herrier , Tristan Rousselle
France, Patent n° : FR1751751. 2017
Brevet hal-02108015v1

Composés chimiques mis en œuvre comme surfaces de référence pour déterminer le bruit d'un capteur multiplexé de type nez électronique et d'en diminuer la dérive

Yanxia Hou-Broutin , Sophie Brenet , Thierry Livache , Cyril Herrier , Tristan Rousselle
France, N° de brevet: FR1758547. 2017
Brevet hal-02108017v1

Capteurs de nez ou de langue électronique

A. Buhot , David Bonnaffe , Yanxia Hou-Broutin , Thierry Livache
France, N° de brevet: FR 1251579. 2012
Brevet hal-02108013v1

Device for detecting gases and/or volatile organic compounds (VOC)

Guillaume Delapierre , Yanxia Hou-Broutin , Heather Mccaig , Edward Myers , Michael L. Roukes
France, Patent n° : WO201136565. 2011
Brevet hal-02108010v1