Xavier Thuru

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Documents

Affiliations actuelles

27459
1004619

Identifiants chercheurs

xavier-thuru
IdRef : 190928859
0000-0002-0998-4160

Présentation

Publications

	A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint Inhibition Xavier Thuru , Romain Magnez , Gérard Vergoten , Christian Bailly Biomedicine hub = Biomed Hub, 2023, 8 (1), pp.1-9. ⟨10.1159/000528499⟩ Article dans une revue inserm-03990317v1
	Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties Romain Regnault , Frédérique Klupsch , Hassiba El-Bouazzati , Romain Magnez , Raphaël Le Biannic Molecules, 2023, 28 (8), pp.3491. ⟨10.3390/molecules28083491⟩ Article dans une revue hal-04139041v1
	Soluble TIM-3 as a biomarker of progression and therapeutic response in cancers and other of human diseases Christian Bailly , Xavier Thuru , Laurence Goossens , Jean-François Goossens Biochemical Pharmacology, 2023, 209, pp.115445. ⟨10.1016/j.bcp.2023.115445⟩ Article dans une revue hal-03990928v1
	Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction Raphaël Le Biannic , Romain Magnez , Frédérique Klupsch , Natascha Leleu-Chavain , Bryan Thiroux European Journal of Medicinal Chemistry, 2022, 236, pp.114343. ⟨10.1016/j.ejmech.2022.114343⟩ Article dans une revue hal-03641793v1
	Microscale Thermophoresis as a Tool to Study Protein Interactions and Their Implication in Human Diseases Romain Magnez , Christian Bailly , Xavier Thuru International Journal of Molecular Sciences, 2022, 23 (14), pp.7672. ⟨10.3390/ijms23147672⟩ Article dans une revue hal-03857337v1
	Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors Xavier Thuru , Romain Magnez , Hassiba El-Bouazzati , Gérard Vergoten , Bruno Quesnel Cancers, 2022, 14 (14), pp.3368. ⟨10.3390/cancers14143368⟩ Article dans une revue hal-03857329v1
	Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease. Ilda Coku , Eugénie Mutez , Sabiha Eddarkaoui , Sébastien Carrier , Antoine Marchand Movement Disorders, 2022, ⟨10.1002/mds.29124⟩ Article dans une revue hal-03703786v1
	p65/RelA NF‐κB fragments generated by RIPK3 activity regulate tumorigenicity, cell metabolism, and stemness characteristics Yasmine Touil , Céline Latreche‐carton , Hassiba El Bouazzati , Anne‐lucie Nugues , Nathalie Jouy Journal of Cellular Biochemistry, 2022, 123 (3), pp.543-556. ⟨10.1002/jcb.30198⟩ Article dans une revue hal-03641788v1
	A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively Antoine Marchand , Alessia Sarchione , Panagiotis Athanasopoulos , Hélène Bauderlique-Le Roy , Liesel Goveas Cells, 2022, 11 (6), pp.1018. ⟨10.3390/cells11061018⟩ Article dans une revue inserm-03625821v1
	IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein Silvia Gaggero , Jonathan Martinez-Fabregas , Adeline Cozzani , Paul Fyfe , Malo Leprohon Science Immunology, 2022, 7 (78), pp.ade5686. ⟨10.1126/sciimmunol.ade5686⟩ Article dans une revue hal-04276595v1
	Mono- and bis-edaravone adducts formed in the presence of vanillin in an aqueous solution Romain Regnault , Mostafa Kouach , Laurence Goossens , Xavier Thuru , Christian Bailly SEPARATION SCIENCE PLUS, 2022, SEPARATION SCIENCE PLUS, ⟨10.1002/sscp.202200031⟩ Article dans une revue hal-04201660v1
	Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents Natascha Leleu , Romain Regnault , Hania Ahouari , Raphael Le Biannic , Mostafa Kouach Molecules, 2022, Molecules, 27 (10), pp.3316. ⟨10.3390/molecules27103316⟩ Article dans une revue hal-03714935v1
	Tau Stabilizes Chromatin Compaction Thomas Rico , Melissa Gilles , Alban Chauderlier , Thomas Comptdaer , Romain Magnez Frontiers in Cell and Developmental Biology, 2021, 9, pp.740550. ⟨10.3389/fcell.2021.740550⟩ Article dans une revue hal-03429442v1
	Soluble Programmed Death Ligand-1 (sPD-L1): A Pool of Circulating Proteins Implicated in Health and Diseases Christian Bailly , Xavier Thuru , Bruno Quesnel Cancers, 2021, 13 (12), pp.3034. ⟨10.3390/cancers13123034⟩ Article dans une revue hal-03278429v1
	Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors Manon Sturbaut , Fabrice Bailly , Mathilde Coevoet , Pasquale Sileo , Martine Pugniere European Journal of Medicinal Chemistry, 2021, 226, pp.113835. ⟨10.1016/j.ejmech.2021.113835⟩ Article dans une revue hal-03429462v1
	The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis Nicolas Stoup , Maxime Liberelle , Céline Schulz , Sumeyye Cavdarli , Romain Vasseur Cancers, 2021, 13 (22), pp.5746. ⟨10.3390/cancers13225746⟩ Article dans une revue hal-03641795v1
	Properties and reactivity of the folic acid and folate photoproduct 6-formylpterin Jean-François Goossens , Xavier Thuru , Christian Bailly Free Radical Biology and Medicine, 2021, 171, pp.1-10. ⟨10.1016/j.freeradbiomed.2021.05.002⟩ Article dans une revue hal-03226670v1
	Modulation of the Gal-9/TIM-3 Immune Checkpoint with α-Lactose. Does Anomery of Lactose Matter? Christian Bailly , Xavier Thuru , Bruno Quesnel Cancers, 2021, 13 (24), pp.6365. ⟨10.3390/cancers13246365⟩ Article dans une revue hal-03641796v1
	Combined cytotoxic chemotherapy and immunotherapy of cancer: modern times Christian Bailly , Xavier Thuru , Bruno Quesnel NAR Cancer, 2020, 2 (1), pp.zcaa002. ⟨10.1093/narcan/zcaa002⟩ Article dans une revue hal-02873714v1
	Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone Christian Bailly , Paul-Emile Hecquet , Mostafa Kouach , Xavier Thuru , Jean-Francois Goossens Bioorganic and Medicinal Chemistry, 2020, 28 (10), pp.115463. ⟨10.1016/j.bmc.2020.115463⟩ Article dans une revue hal-02873617v1
	Measurement of Protein-Protein Interactions through Microscale Thermophoresis (MST) Magnez Romain , Bryan Thiroux , Morgane Tardy , Bruno Quesnel , Xavier Thuru Bio-protocol , 2020, Bio-protocol, 10 (7), ⟨10.21769/bioprotoc.3574⟩ Article dans une revue hal-03185893v1
	Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands Alina Ghinet , Xavier Thuru , Emilie Floquet , Joëlle Dubois , Amaury Farce Bioorganic Chemistry, 2020, 96, pp.103643. ⟨10.1016/j.bioorg.2020.103643⟩ Article dans une revue hal-02873632v1
	Aggressiveness potential of spontaneous canine mucosal melanoma can dictate distinct cancer stem cell compartment behaviors in regard to their initial size and expansion abilities Yasmine S. Touil , Zacharie Segaoula , Xavier Thuru , Sylvie Zouitina , Dominique Tierny Stem Cells and Development, 2020, 29 (14), pp.919-928. ⟨10.1089/scd.2019.0223⟩ Article dans une revue hal-02873700v1
	Exploring isoxazoles and pyrrolidinones decorated with the 4,6‐dimethoxy‐1,3,5‐triazine unit as human farnesyltransferase inhibitors Liliana Lucescu , Alina Ghinet , Sergiu Shova , Romain Magnez , Xavier Thuru Archiv der Pharmazie / Chemistry in Life Sciences, 2019, 352 (5), pp.1800227. ⟨10.1002/ardp.201800227⟩ Article dans une revue hal-02873628v1
	MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis Maxime Liberelle , Romain Magnez , Xavier Thuru , Yamina Bencheikh , Séverine Ravez Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-53099-0⟩ Article dans une revue hal-02407901v1
	Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface Floriane Gibault , Mathilde Coevoet , Manon Sturbaut , Amaury Farce , Nicolas Renault Cancers, 2018, 10 (5), pp.140. ⟨10.3390/cancers10050140⟩ Article dans une revue hal-02060686v1
	Isolation and characterization of two canine melanoma cell lines new models for comparative oncology Zacharie Segaoula , Aline Primot , Frederic Lepretre , Benoit Hedan , Emmanuel Bouchaert BMC Cancer, 2018, 18 (1), pp.1219. ⟨10.1186/s12885-018-5114-y⟩ Article dans une revue hal-01972446v1
	PD-1/PD-L1 binding studies using microscale thermophoresis Romain Magnez , Bryan Thiroux , Solenne Taront , Zacharie Segaoula , Bruno Quesnel Scientific Reports, 2017, 7 (1), pp.17623. ⟨10.1038/s41598-017-17963-1⟩ Article dans une revue hal-02873635v1
	Synthesis and Biological Evaluation of N -[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity Zacharie Segaoula , Julien Leclercq , Valérie Verones , Nathalie Flouquet , Marie Lecoeur Journal of Medicinal Chemistry, 2016, 59 (18), pp.8422-8440. ⟨10.1021/acs.jmedchem.6b00847⟩ Article dans une revue hal-02060584v1
	Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma D. Tierny , F. Serres , Z. Segaoula , I. Bemelmans , E. Bouchaert Clinical Cancer Research, 2015, 21 (23), pp.5314-5323. ⟨10.1158/1078-0432.ccr-14-3174⟩ Article dans une revue hal-02873640v1
	Synthesis and biological evaluation of phenstatin metabolites Alina Ghinet , Benoit Rigo , Jean-Pierre Hénichart , Delphine Le Broc-Ryckewaert , Jean Pommery Bioorganic and Medicinal Chemistry, 2011, 19 (20), pp.6042-6054. ⟨10.1016/j.bmc.2011.08.047⟩ Article dans une revue hal-02873643v1
	Colonization of Mice by Candida albicans Is Promoted by Chemically Induced Colitis and Augments Inflammatory Responses through Galectin‐3 Samir Jawhara , Xavier Thuru , Annie Standaert‐vitse , Thierry Jouault , Serge Mordon Journal of Infectious Diseases, 2008, 197 (7), pp.972-980. ⟨10.1086/528990⟩ Article dans une revue hal-02873647v1
	P176 C-Reactive Protein (crp), a novel adipocytokine overexpressed in Mesenteric fat in Crohn's disease F. Gonzalez , L. Peyrin-Biroulet , C. Rousseaux , Xavier Thuru , C. Decourcelle Journal of Crohn's and Colitis, 2007, 1 (1), pp.49. ⟨10.1016/s1873-9954(07)70188-x⟩ Article dans une revue hal-02873662v1
	Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors Christel Rousseaux , Xavier Thuru , Agathe Gelot , Nicolas Barnich , Christel Neut Nature Medicine, 2007, 13 (1), pp.35-37. ⟨10.1038/nm1521⟩ Article dans une revue hal-02667010v1
	C-reactive protein (CRP), a novel adipocytokine overexpressed in mesenteric fat in Crohnʼs disease F. Gonzalez , L. Peyrin-Biroulet , C. Rousseaux , L. Dubuquoy , Xavier Thuru Inflammatory Bowel Diseases, 2007, 13 (supplement), pp.650. ⟨10.1097/00054725-200705001-00026⟩ Article dans une revue hal-02873652v1
	C-reactive protein (CRP), a novel adipocytokine overexpressed in mesenteric fat in Crohnʼs disease F Gonzalez , L Peyrin-Biroulet , C Rousseaux , Laurent Dubuquoy , Xavier Thuru Inflammatory Bowel Diseases, 2007, Inflammatory Bowel Diseases, 13 (5), pp.650. ⟨10.1097/00054725-200705005-00026⟩ Article dans une revue hal-03113336v1
	micro-Opioid receptor activation prevents acute hepatic inflammation and cell death. Dania Chakass , David Philippe , Edmone Erdual , Sébastien Dharancy , Mathilde Malapel Gut, 2007, 56 (7), pp.974-81. ⟨10.1136/gut.2006.105122⟩ Article dans une revue hal-00189969v1
	Peroxisome Proliferator-Activated Receptor Gamma Functions As An Antibacterial Factor L. Peyrin-Biroulet , Xavier Thuru , C. Vignal , L. Dubuquoy , E. Merour Journal of Crohn's and Colitis, 2007, 1 (1), pp.2. ⟨10.1016/s1873-9954(07)70004-6⟩ Article dans une revue hal-02873659v1
	PPAR as a new therapeutic target in inflammatory bowel diseases Xavier Thuru , L. Dubuquoy Gut, 2006, 55 (9), pp.1341-1349. ⟨10.1136/gut.2006.093484⟩ Article dans une revue hal-02873664v1
	Mu opioid receptor expression is increased in inflammatory bowel diseases: implications for homeostatic intestinal inflammation Xavier Thuru , D Philippe Gut, 2006, 55 (6), pp.815-823. ⟨10.1136/gut.2005.080887⟩ Article dans une revue hal-02873665v1
	Cannabis : des nouvelles fonctions anti-diarrhéiques et anti-cancéreuses Pierre Desreumaux , Xavier Thuru , David Philippe Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, 2004, 28 (1), pp.97. ⟨10.1016/s0399-8320(04)94859-2⟩ Article dans une revue hal-02873668v1

	Induction of mu opioid and cannabinoid receptors by probiotics: A new mechanism of regulation of visceral pain perception C. Rousseaux , Xavier Thuru , A. Gelot , N. Barnich , C. Neut 5. Annual Advances in the Inflammatory Bowel Diseases, Dec 2006, Miami (Florida), United States. 13 (Supplement 5), pp.652-653, 2007, Abstracts from the 2006 CCFA National Research and Clinical Conference, 5th Annual Advances in the Inflammatory Bowel Diseases, Dec. 1‐3, 2006, Miami, FL. ⟨10.1097/00054725-200705001-00035⟩ Poster de conférence hal-02873654v1

	NOVEL PYRAZOLE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS Xavier Thuru , Frédérique Klupsch , Christian Bailly , Régis Millet , Raphael Le Biannic France, Patent n° : EP23306103. 2023 Brevet inserm-04542066v1
	NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS Xavier Thuru , Bruno Quesnel , Romain Magnez , Régis Millet , Natascha Leleu-Chavain France, Patent n° : WO2021009384. 2021 Brevet inserm-04542080v1
	NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS Xavier Thuru , Bruno Quesnel , Magnez Romain , Régis Millet , Natascha Leleu-Chavain France, Patent n° : WO2021009384 (A1). 2021 Brevet hal-03857440v1

Xavier Thuru

Présentation

Publications

A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint Inhibition

Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties

Soluble TIM-3 as a biomarker of progression and therapeutic response in cancers and other of human diseases

Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction

Microscale Thermophoresis as a Tool to Study Protein Interactions and Their Implication in Human Diseases

Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors

Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease.

p65/RelA NF‐κB fragments generated by RIPK3 activity regulate tumorigenicity, cell metabolism, and stemness characteristics

A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

Mono- and bis-edaravone adducts formed in the presence of vanillin in an aqueous solution

Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents

Tau Stabilizes Chromatin Compaction

Soluble Programmed Death Ligand-1 (sPD-L1): A Pool of Circulating Proteins Implicated in Health and Diseases

Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors

The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis

Properties and reactivity of the folic acid and folate photoproduct 6-formylpterin

Modulation of the Gal-9/TIM-3 Immune Checkpoint with α-Lactose. Does Anomery of Lactose Matter?

Combined cytotoxic chemotherapy and immunotherapy of cancer: modern times

Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone

Measurement of Protein-Protein Interactions through Microscale Thermophoresis (MST)

Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands

Aggressiveness potential of spontaneous canine mucosal melanoma can dictate distinct cancer stem cell compartment behaviors in regard to their initial size and expansion abilities

Exploring isoxazoles and pyrrolidinones decorated with the 4,6‐dimethoxy‐1,3,5‐triazine unit as human farnesyltransferase inhibitors

MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis

Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface

Isolation and characterization of two canine melanoma cell lines new models for comparative oncology

PD-1/PD-L1 binding studies using microscale thermophoresis

Synthesis and Biological Evaluation of N -[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity

Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma

Synthesis and biological evaluation of phenstatin metabolites

Colonization of Mice by Candida albicans Is Promoted by Chemically Induced Colitis and Augments Inflammatory Responses through Galectin‐3

P176 C-Reactive Protein (crp), a novel adipocytokine overexpressed in Mesenteric fat in Crohn's disease

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

C-reactive protein (CRP), a novel adipocytokine overexpressed in mesenteric fat in Crohnʼs disease

C-reactive protein (CRP), a novel adipocytokine overexpressed in mesenteric fat in Crohnʼs disease

micro-Opioid receptor activation prevents acute hepatic inflammation and cell death.

Peroxisome Proliferator-Activated Receptor Gamma Functions As An Antibacterial Factor

PPAR as a new therapeutic target in inflammatory bowel diseases

Mu opioid receptor expression is increased in inflammatory bowel diseases: implications for homeostatic intestinal inflammation

Cannabis : des nouvelles fonctions anti-diarrhéiques et anti-cancéreuses

Induction of mu opioid and cannabinoid receptors by probiotics: A new mechanism of regulation of visceral pain perception

NOVEL PYRAZOLE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS

NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS

NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS