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	Pour les 33 documents Envoyer sur ORCID RSS ATOM Exporter BibTeX XML-TEI CSV RTF EndNote PDF HTML Export avancé	Page : Page précédente 1 2 Page suivante	triés par Pertinence Auteur A→Z Auteur Z→A Titre A→Z Titre Z→A Date de publication croissante Date de publication décroissante Date de dépôt croissante Date de dépôt décroissante

		Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach Laurent Hoffer , Yuliia Voitovich , Brigitt Raux , Kendall Carrasco , Christophe Muller , et al. Journal of Medicinal Chemistry, 2018, 61 (13), pp.5719-5732. ⟨10.1021/acs.jmedchem.8b00653⟩ Article dans une revue hal-02067797v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Editorial. Françoise Ochsenbein , Xavier Morelli , Chandra Verma Progress in Biophysics and Molecular Biology, 2015, 119 (1), pp.1 Article dans une revue hal-01201641v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis Amandine Cartier-Michaud , Anne-Laure Bailly , Stéphane Betzi , Xiaoli Shi , Jean-Claude Lissitzky , et al. PLoS Genetics, 2017, 13 (6), ⟨10.1371/journal.pgen.1006803⟩ Article dans une revue hal-01542697v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor Jeremy Ariey‐bonnet , Kendall Carrasco , Marion Le Grand , Laurent Hoffer , Stéphane Betzi , et al. Molecular Oncology, 2020, 14, pp.3083 - 3099. ⟨10.1002/1878-0261.12810⟩ Article dans une revue hal-02989358v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer Laetitia Ganier , Stéphane Betzi , Carine Derviaux , Philippe Roche , Charlotte Dessaux , et al. ACS Chemical Biology, 2022, 17 (5), pp.1061-1072. ⟨10.1021/acschembio.1c00826⟩ Article dans une revue hal-03817750v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Rôle en cancérologie et ciblage du récepteur à activité tyrosine kinase PTK7 Laetitia Ganier , Xavier Morelli , Jean-Paul Borg Médecine/Sciences, 2020, ⟨10.1051/medsci/2020197⟩ Article dans une revue hal-03152194v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions Marie-Jeanne Basse , Stéphane Betzi , Xavier Morelli , Philippe Roche Database - The journal of Biological Databases and Curation, 2016, 2016, pp.6. ⟨10.1093/database/baw007⟩ Article dans une revue hal-01307114v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions Nicolas Bosc , Christophe Muller , Laurent Hoffer , David Lagorce , Stéphane Bourg , et al. ACS Chemical Biology, 2020, 15 (6), pp.1566-1574. ⟨10.1021/acschembio.0c00179⟩ Article dans une revue hal-02569625v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors Jessica Hernandez , Laurent Hoffer , Bruno Coutard , Gilles Quérat , Philippe Roche , et al. European Journal of Medicinal Chemistry, 2019, 161 (4), pp.323-333. ⟨10.1016/j.ejmech.2018.09.056⟩ Article dans une revue inserm-02378768v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase. Olivier Bornet , Matthieu Nouailler , Michaël Feracci , Corinne Sebban-Kreuzer , Deborah Byrne , et al. FEBS Letters, 2014, 588 (12), pp.2031--6. ⟨10.1016/j.febslet.2014.04.029⟩ Article dans une revue hal-01458194v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML). Emilie Coppin , Véronique Gelsi-Boyer , Xavier Morelli , Nathalie Cervera , Anne Murati , et al. Leukemia, 2014, 29 (2), pp.500-2. ⟨10.1038/leu.2014.288⟩ Article dans une revue inserm-01069773v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		The NANOTUMOR consortium - Towards the Tumor Cell Atlas Florent Colin , Kristine Schauer , Ali Hamiche , Pierre Martineau , Jean-Paul Borg , et al. Biology of the Cell, 2021, 113 (6), pp.272-280. ⟨10.1111/boc.202000135⟩ Article dans une revue hal-03169719v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR. Cedric Bernard , Stéphane Gely , Jean-Marie Bourhis , Xavier Morelli , Sonia Longhi , et al. FEBS Letters, 2009, 583 (7), pp.1084-9. ⟨10.1016/j.febslet.2009.03.004⟩ Article dans une revue hal-00473784v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Alteration of a Single Tryptophan Residue of the Cellulose-binding Domain Blocks Secretion of the Erwinia chrysanthemi Cel5 Cellulase (ex-EGZ) via the Type II System Virginie Chapon , Helen D Simpson , Xavier Morelli , Emmanuel Brun , Frederic Barras Journal of Molecular Biology, 2000, 303, pp.117-123. ⟨10.1006/jmbi.2000.4103⟩ Article dans une revue istex hal-01560905v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain Céline Contesto-Richefeu , Nicolas Tarbouriech , Xavier Brazzolotto , Stéphane Betzi , Xavier Morelli , et al. PLoS Pathogens, 2014, 10 (3), pp.e1003978. ⟨10.1371/journal.ppat.1003978⟩ Article dans une revue hal-01132360v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology Kahina Hammam , Magali Saez-Ayala , Etienne Rebuffet , Laurent Gros , Sophie Lopez , et al. Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-01582-5⟩ Article dans une revue hal-01643359v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides Pierre Stocker , Jean Michel Brunel , Leandro De Rezende , Antonia Tavares-Do Amaral , Xavier Morelli , et al. Biochimie, 2012, 94 (8), pp.1668-1675. ⟨10.1016/j.biochi.2012.01.006⟩ Article dans une revue istex hal-01460427v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step. Stéphane Betzi , Cécilia Eydoux , Cécile Bussetta , Marilyne Blemont , Pieter Leyssen , et al. Antiviral Research, 2009, 84 (1), pp.48-59. ⟨10.1016/j.antiviral.2009.06.009⟩ Article dans une revue istex hal-00418783v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		GFscore: a general nonlinear consensus scoring function for high-throughput docking. Stéphane Betzi , Karsten Suhre , Bernard Chétrit , Françoise Guerlesquin , Xavier Morelli Journal of Chemical Information and Modeling, 2006, 46 (4), pp.1704-12. ⟨10.1021/ci0600758⟩ Article dans une revue istex hal-00475665v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix) Xiaoli Shi , Stéphane Betzi , Adrien Lugari , Sandrine Opi , Audrey Restouin , et al. FEBS Letters, 2012, 586, pp.1759-1764. ⟨10.1016/j.febslet.2012.05.017⟩ Article dans une revue hal-00717171v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Stéphane Betzi , Audrey Restouin , Sandrine Opi , Stefan T Arold , Isabelle Parrot , et al. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (49), pp.19256-61. ⟨10.1073/pnas.0707130104⟩ Article dans une revue hal-00473817v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation Kendall Carrasco , Camille Montersino , Carine Derviaux , Magali Saez-Ayala , Laurent Hoffer , et al. Journal of Medicinal Chemistry, 2022, pp.acs.jmedchem.1c02168. ⟨10.1021/acs.jmedchem.1c02168⟩ Article dans une revue hal-03624836v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		A specific protein disorder catalyzer of HIV-1 Nef Adrien Lugari , Sebastian Breuer , Thibault Coursindel , Sandrine Opi , Audrey Restouin , et al. Bioorganic and Medicinal Chemistry, 2011, 19, pp.7401-7406. ⟨10.1016/j.bmc.2011.10.051⟩ Article dans une revue istex hal-00662295v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia Magali Saez-Ayala , Laurent Hoffer , Sébastien Abel , Khaoula Ben Yaala , Benoit Sicard , et al. Nature Communications, 2023, 14 (1), pp.3079. ⟨10.1038/s41467-023-38668-2⟩ Article dans une revue hal-04237671v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Identification and biophysical assessment of the molecular recognition mechanisms between the human hemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X Xiaoli Shi , Sandrine Opi , Adrien Lugari , Audrey Restouin , Thibault Coursindel , et al. Biochemical Journal, 2010, 431 (1), pp.93-102. ⟨10.1042/BJ20100314⟩ Article dans une revue hal-00517249v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Solution structure of HndAc: a thioredoxin-like domain involved in the NADP-reducing hydrogenase complex. Matthieu Nouailler , Xavier Morelli , Olivier Bornet , Bernard Chetrit , Zorah Dermoun , et al. Protein Science, 2006, 15 (6), pp.1369-78. ⟨10.1110/ps.051916606⟩ Article dans une revue hal-00475666v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Structural and Genetic Analyses Reveal a Key Role in Prophage Excision for the TorI Response Regulator Inhibitor Latifa Elantak , Mireille Ansaldi , Francoise Guerlesquin , Vincent Méjean , Xavier Morelli Journal of Biological Chemistry, 2005, 280 (44), pp.36802-36808. ⟨10.1074/jbc.m507409200⟩ Article dans une revue hal-02018141v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation Françoise Gondois-Rey , Thomas Miller , Vladimir Laletin , Xavier Morelli , Yves Collette , et al. Frontiers in Immunology, 2022, 13, pp.899068. ⟨10.3389/fimmu.2022.899068⟩ Article dans une revue hal-03857250v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach Laurent Hoffer , Manon Garcia , Raphael Leblanc , Mikael Feracci , Stéphane Betzi , et al. Journal of Medicinal Chemistry, 2023, ⟨10.1021/acs.jmedchem.2c01569⟩ Article dans une revue hal-04048842v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More
		Chemistry-driven Hit-to-lead Optimization Guided by Structure-based Approaches Laurent Hoffer , Christophe Muller , Philippe Roche , Xavier Morelli Molecular Informatics, 2018, 37 (9-10), pp.1800059. ⟨10.1002/minf.201800059⟩ Article dans une revue hal-02145522v1	Envoyer sur ORCID Exporter BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite Export avancé Partager Gmail Facebook X LinkedIn More

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Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

Editorial.

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis

In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer

Rôle en cancérologie et ciblage du récepteur à activité tyrosine kinase PTK7

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions

Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions

Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase.

Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML).

The NANOTUMOR consortium - Towards the Tumor Cell Atlas

Interaction between the C-terminal domains of N and P proteins of measles virus investigated by NMR.

Alteration of a Single Tryptophan Residue of the Cellulose-binding Domain Blocks Secretion of the Erwinia chrysanthemi Cel5 Cellulase (ex-EGZ) via the Type II System

Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit D4 in complex with the A20 N-terminal domain

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology

Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides

Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.

GFscore: a general nonlinear consensus scoring function for high-throughput docking.

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.

CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation

A specific protein disorder catalyzer of HIV-1 Nef

From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia

Identification and biophysical assessment of the molecular recognition mechanisms between the human hemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X

Solution structure of HndAc: a thioredoxin-like domain involved in the NADP-reducing hydrogenase complex.

Structural and Genetic Analyses Reveal a Key Role in Prophage Excision for the TorI Response Regulator Inhibitor

CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation

Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach

Chemistry-driven Hit-to-lead Optimization Guided by Structure-based Approaches