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Nuclear Magnetic Resonance Spectroscopy Insights into Tau Structure in Solution: Impact of Post-translational Modifications

Clément Danis , Elian Dupré , Xavier Hanoulle , Isabelle Landrieu , Alessia Lasorsa , et al.
Advanced in Experimental Medical Biology, pp.35-45, 2019, ⟨10.1007/978-981-32-9358-8_3⟩
Chapitre d'ouvrage hal-02506938v1
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Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies

Elian Dupré , Clément Danis , Alexis Arrial , Xavier Hanoulle , Mégane Homa , et al.
ACS Chemical Neuroscience, 2019, 10 (9), pp.3997-4006. ⟨10.1021/acschemneuro.9b00217⟩
Article dans une revue hal-02337161v1

X-ray structure of alisporivir in complex with cyclophilin A at 1.5 Å resolution

Marie Dujardin , Julie Bouckaert , Prakash Rucktooa , Xavier Hanoulle
Acta crystallographica Section F : Structural biology communications [2014-..], 2018, 74 (9), pp.583 - 592. ⟨10.1107/S2053230X18010415⟩
Article dans une revue hal-01925054v1
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Hepatitis E Virus RNA‐Dependent RNA Polymerase is Involved in RNA Replication and Infectious Particle Production

Noémie Oechslin , Nathalie da Silva , Dagmara Szkolnicka , François‐xavier Cantrelle , Xavier Hanoulle , et al.
Hepatology, 2021, ⟨10.1002/hep.32100⟩
Article dans une revue hal-03326608v1
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Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening

Léo Faion , Kamel Djaout , Rosangela Frita , Catalin Pintiala , Francois-Xavier Cantrelle , et al.
European Journal of Medicinal Chemistry, 2020, 200, pp.112440. ⟨10.1016/j.ejmech.2020.112440⟩
Article dans une revue hal-02988077v1

Interaction study between HCV NS5A-D2 and NS5B using 19F NMR

Marie Dujardin , François-Xavier Cantrelle , Guy Lippens , Xavier Hanoulle
Journal of Biomolecular NMR, 2018, 70 (1), pp.67-76. ⟨10.1007/s10858-017-0159-9⟩
Article dans une revue hal-01886452v1
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NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B

Luiza Bessa , Hélène Launay , Marie Dujardin , Xavier Cantrelle , Guy Lippens , et al.
Journal of Biological Chemistry, In press, 292 (44), pp.18024-18043. ⟨10.1074/jbc.M117.813766⟩
Article dans une revue hal-01620117v1

Tau aggregation in Alzheimer's disease : what role for phosphorylation ?

Guy Lippens , Alain Sillen , Isabelle Landrieu , Laziza Amniai , Nathalie Sibille , et al.
Prion, 2007, 1 (1), pp.21-25
Article dans une revue hal-00161158v1

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A.

Lotte Coelmont , Xavier Hanoulle , Udayan Chatterji , Carola Berger , Joke Snoeck , et al.
PLoS ONE, 2010, 5 (10), pp.e13687. ⟨10.1371/journal.pone.0013687⟩
Article dans une revue hal-00586948v1

Proline Conformation in a Functional Tau Fragment

Puneet Ahuja , Xavier Cantrelle , Isabelle Huvent , Xavier Hanoulle , Juan Lopez , et al.
Journal of Molecular Biology, 2016, 428 (1), pp.79 - 91. ⟨10.1016/j.jmb.2015.11.023⟩
Article dans une revue hal-01389832v1

Ranking High Affinity Ligands of Low Solubility by NMR Spectroscopy

Isabelle Landrieu , Xavier Hanoulle , Bernd Fritzinger , Dragos Horvath , Jean-Michel Wieruszeski , et al.
ACS Medicinal Chemistry Letters, 2011, 2 (6), pp.485-487. ⟨10.1021/ml200039u⟩
Article dans une revue hal-00618277v1

Set-up and screening of a fragment library targeting the 14-3-3 protein interface

Dario Valenti , João Filipe Neves , Francois-Xavier Cantrelle , Stanimira Hristeva , Domenico Lentini Santo , et al.
MedChemComm, 2019, 10 (10), pp.1796-1802. ⟨10.1039/c9md00215d⟩
Article dans une revue hal-02353610v1
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Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

Clément Danis , Elian Dupré , Orgeta Zejneli , Raphaëlle Caillierez , Alexis Arrial , et al.
2021
Pré-publication, Document de travail hal-03428993v1
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Backbone chemical shift assignments of human 14-3-3σ

João Filipe Neves , Isabelle Landrieu , Hamida Merzougui , Emmanuelle Boll , Xavier Hanoulle , et al.
Biomolecular NMR Assignments, 2019, 13 (1), pp.103-107. ⟨10.1007/s12104-018-9860-1⟩
Article dans une revue hal-02107858v1

Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A

Aurélie Badillo , Véronique Receveur-Brechot , Stéphane Sarrazin , François-Xavier Cantrelle , Frédéric Delolme , et al.
Biochemistry, 2017, 56 (24), pp.3029 - 3048. ⟨10.1021/acs.biochem.7b00212⟩
Article dans une revue hal-01785410v1
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NMR spectroscopy of the main protease of SARS‐CoV‐2 and fragment‐based screening identify three protein hotspots and an antiviral fragment

François-Xavier Cantrelle , Emmanuelle Boll , Lucile Brier , Danai Moschidi , Sandrine Belouzard , et al.
Angewandte Chemie International Edition, In press, 60 (48), pp.25428-25435. ⟨10.1002/anie.202109965⟩
Article dans une revue hal-03363607v1

Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025.

Isabelle Landrieu , Xavier Hanoulle , Fanny Bonachera , Arnaud Hamel , Nathalie Sibille , et al.
Biochemistry, 2010, 49 (22), pp.4679-86. ⟨10.1021/bi1003266⟩
Article dans une revue hal-00508817v1

Domain 3 of NS5A protein from the hepatitis C virus has intrinsic {alpha}-helical propensity and is a substrate of Cyclophilin A.

Dries Verdegem , Aurelie Badillo , Jean-Michel Wieruszeski , Isabelle Landrieu , Arnaud Leroy , et al.
Journal of Biological Chemistry, 2011, epub ahead of print. ⟨10.1074/jbc.M110.182436⟩
Article dans une revue hal-00586923v1

Hepatitis C Virus NS5B and Host Cyclophilin A share a common binding site on NS5A.

Claire Rosnoblet , Bernd Fritzinger , Dominique Legrand , Hélène Launay , Jean-Michel Wieruszeski , et al.
Journal of Biological Chemistry, 2012, epub ahead of print. ⟨10.1074/jbc.M112.392209⟩
Article dans une revue hal-00765873v1

Premier spectromètre RMN 1,2 GHz français : quelles nouvelles possibilités pour l’analyse ?

Fabien Ferrage , Pierre Florian , Guy Lippens , Emmanuel Maes , Guido Pintacuda , et al.
Réunion des utilisateurs RMN de Bruker France, Nov 2023, Lille, France
Communication dans un congrès hal-04470791v1
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Phosphorylated full-length Tau interacts with 14-3-3 proteins via two short phosphorylated sequences, each occupying a binding groove of 14-3-3 dimer

João Filipe Neves , Olivia Petrvalská , Francesco Bosica , François‐xavier Cantrelle , Hamida Merzougui , et al.
FEBS Journal, 2021, 288 (6), pp.1918-1934. ⟨10.1111/febs.15574⟩
Article dans une revue hal-02989190v1
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Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies

Muriel Lavie , Xavier Hanoulle , Jean Dubuisson
Frontiers in Immunology, 2018, 9, pp.910. ⟨10.3389/fimmu.2018.00910⟩
Article dans une revue hal-02112360v1

Sandwich-ELISE NMR: reducing the sample volume of NMR samples.

Jean-Michel Wieruszeski , Bernd Fritzinger , Xavier Hanoulle , José C Martins , Guy Lippens
Journal of Magnetic Resonance, 2008, 193 (1), pp.37-40. ⟨10.1016/j.jmr.2008.04.006⟩
Article dans une revue istex hal-00293593v1

Selective backbone labelling of ILV methyl labelled proteins.

Nathalie Sibille , Xavier Hanoulle , Fanny Bonachera , Dries Verdegem , Isabelle Landrieu , et al.
Journal of Biomolecular NMR, 2009, 43 (4), pp.219-27. ⟨10.1007/s10858-009-9307-1⟩
Article dans une revue istex hal-00373458v1

NMR and circular dichroism data for domain 2 of the HCV NS5A protein phosphorylated by the Casein Kinase II

Luiza Bessa , Robert Schneider , Xavier Hanoulle
Data in Brief, 2018, 17, pp.325-333. ⟨10.1016/j.dib.2018.01.038⟩
Article dans une revue hal-02354950v1
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Identification of a Potential Inhibitor of the FIV p24 Capsid Protein and Characterization of Its Binding Site

Mathieu Long , François-Xavier Cantrelle , Xavier Robert , Emmanuelle Boll , Natalia Sierra , et al.
Biochemistry, 2021, 60 (24), pp.1896-1908. ⟨10.1021/acs.biochem.1c00228⟩
Article dans une revue hal-03280829v1

Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria.

Xavier Hanoulle , Jean-Michel Wieruszeski , Pierre Rousselot-Pailley , Isabelle Landrieu , Camille Locht , et al.
Journal of Antimicrobial Chemotherapy, 2006, 58 (4), pp.768. ⟨10.1093/jac/dkl332⟩
Article dans une revue hal-00103724v1

Hepatitis C virus NS5A protein is a substrate for the Peptidyl-Prolyl cis/trans isomerase activity of Cyclophilins A and B.

Xavier Hanoulle , Aurélie Badillo , Jean-Michel Wieruszeski , Dries Verdegem , Isabelle Landrieu , et al.
Journal of Biological Chemistry, 2009, epub ahead of print. ⟨10.1074/jbc.M809244200⟩
Article dans une revue hal-00373457v1

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation.

Caroline Smet-Nocca , Malgorzata Broncel , Jean-Michel Wieruszeski , Caroline Tokarski , Xavier Hanoulle , et al.
Molecular BioSystems, 2011, 7 (5), pp.1420-9. ⟨10.1039/c0mb00337a⟩
Article dans une revue hal-00586849v1
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Cyclophilin A allows the allosteric regulation of a structural motif in the disordered domain 2 of NS5A and thereby fine-tunes HCV RNA replication

Marie Dujardin , Vanesa Madan , Neha S Gandhi , François-Xavier Cantrelle , Hélène Launay , et al.
Journal of Biological Chemistry, 2019, 294 (35), pp.13171-13185. ⟨10.1074/jbc.RA119.009537⟩
Article dans une revue hal-02998113v1