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Professeur de Biochimie et de Toxicologie à l'Université de Paris et Directeur de l'équipe de recherche INSERM Metatox - T3S


Mes activités de recherche portent essentiellement sur la caractérisation des effets de polluants variés et en mélange sur le phénotype tumoral, l'évolution des maladies chroniques du foie, et l'apparition de maladies neurodégénératives.

L'équipe que je dirige possède une expertise importante en biologie moléculaire, cellulaire, biochimie et métabolisme et aborde ces thématiques à l'aide de modèles in vitro, in vivo, cliniques et plus récemment computationnels.

Nous recevons un soutien important d'agences nationales (ANR, ANSES..) ou internationales (projets européens) pour la réalisation de nos recherches qui sont adossées à l'enseignement en licence (biochimie, métabolisme) et master (notamment de toxicologie que je dirige), pour lesquels les enseignants-chercheurs de l'équipe essaient d'implémenter des méthodologies innovantes et interactives.

Une part importante de mon activité et de celle de l'équipe est dédiée à la valorisation (pour partie à destination du grand public), à la réalisation d'expertises ainsi qu'à la formation d'étudiants.


Article dans une revue56 documents

  • Sylvie Babajko, Véronique Gayrard, Sophia Houari, Ai Thu Bui, Robert Barouki, et al.. La sphère orale, cible et marqueur de l’exposition environnementale : I. Défauts du développement dentaire. médecine/sciences, EDP Sciences, 2020, 36 (3), pp.225-230. ⟨10.1051/medsci/2020024⟩. ⟨hal-02617147⟩
  • Sylvie Babajko, Géraldine Lescaille, Loredana Radoi, Ai Thu Bui, Vanessa Baaroun, et al.. Oral cavity as a target and a marker of environmental exposures: diseases diagnosed during adulthood.. médecine/sciences, EDP Sciences, 2020, 36 (3), pp.231-234. ⟨10.1051/medsci/2020025⟩. ⟨hal-02559671⟩
  • Quentin Vicens, Xavier Coumoul, Jean‐luc Souciet. A forum where french‐speaking faculty can exchange research on teaching. Biochemistry and Molecular Biology Education, Wiley, 2019, ⟨10.1002/bmb.21258⟩. ⟨hal-02171219⟩
  • Xavier Coumoul, Rémi Servien, Ludmila Juricek, Yael Kaddouch-Amar, Yannick Lippi, et al.. The GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial. Toxicological Sciences, Oxford University Press (OUP), 2019, 168 (2), pp.315-338. ⟨10.1093/toxsci/kfy298⟩. ⟨hal-02196332⟩
  • Barbara Allen, Xavier Coumoul, Silvia Lacorte. Microplastic freshwater contamination: an issue advanced by science with public engagement. Environmental Science and Pollution Research, Springer Verlag, 2019, ⟨10.1007/s11356-019-05300-0⟩. ⟨hal-02122843⟩
  • Jean-Charles Carvaillo, Robert Barouki, Xavier Coumoul, Karine Audouze. Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach. Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2019, 127 (4), pp.047005. ⟨10.1289/ehp4200⟩. ⟨hal-02196330⟩
  • Carolina Duarte-Hospital, Laurence Huc, Sylvie Bortoli, Xavier Coumoul. Xenobiotics and their impact on metabolic diseases. Cahiers de Nutrition et de Diététique, Elsevier Masson, 2019, 54 (5), pp.286-293. ⟨10.1016/j.cnd.2019.07.002⟩. ⟨hal-02618196⟩
  • Meriem Koual, German Cano-Sancho, Anne-Sophie Bats, Céline Tomkiewicz, Yael Kaddouch-Amar, et al.. Associations between persistent organic pollutants and risk of breast cancer metastasis. Environment International, Elsevier, 2019, 132, pp.105028. ⟨10.1016/j.envint.2019.105028⟩. ⟨hal-02263282⟩
  • Komodo Matta, Stéphane Ploteau, Xavier Coumoul, Meriem Koual, Bruno Le Bizec, et al.. Associations between exposure to organochlorine chemicals and endometriosis in experimental studies: A systematic review protocol. Environment International, Elsevier, 2019, 124, pp.400-407. ⟨10.1016/j.envint.2018.12.063⟩. ⟨hal-02196329⟩
  • Caroline Duval, Etienne Blanc, Xavier Coumoul. Aryl hydrocarbon receptor and liver fibrosis. Current Opinion in Toxicology, 2018, 8, pp.8-13. ⟨10.1016/j.cotox.2017.11.010⟩. ⟨hal-02196325⟩
  • Ghjuvan Ghjacumu Shackleford, Nirmal Kumar Sampathkumar, Mehdi Hichor, Laure Weill, Delphine Meffre, et al.. The Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2018, 115 (6), pp.E1319-E1328. ⟨10.1073/pnas.1715999115⟩. ⟨hal-02110942⟩
  • Expédite Yen-Pon, Bo Li, Marta Acebrón-Garcia-De-Eulate, Céline Tomkiewicz-Raulet, John Dawson, et al.. Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. ACS Chemical Biology, American Chemical Society, 2018, 13 (8), pp.2067-2073. ⟨10.1021/acschembio.8b00250⟩. ⟨hal-02196326⟩
  • Lucie Larigot, Ludmila Juricek, Julien Dairou, Xavier Coumoul. AhR signaling pathways and regulatory functions. Biochimie Open, Elsevier, 2018, 7, pp.1-9. ⟨10.1016/j.biopen.2018.05.001⟩. ⟨hal-02196328⟩
  • Robert Barouki, Karine Audouze, Xavier Coumoul, Florence Demenais, Dominique Gauguier. Integration of the human exposome with the human genome to advance medicine. Biochimie, Elsevier, 2018, 152, pp.155-158. ⟨10.1016/j.biochi.2018.06.023⟩. ⟨hal-02196327⟩
  • Nolwenn Joffin, Philippe Noirez, Jean-Philippe Antignac, Min-Ji Kim, Philippe Marchand, et al.. Release and toxicity of adipose tissue-stored TCDD: Direct evidence from a xenografted fat model. Environment International, Elsevier, 2018, 121, pp.1113-1120. ⟨10.1016/j.envint.2018.10.027⟩. ⟨hal-01922515⟩
  • Ludmila Juricek, Xavier Coumoul. The Aryl Hydrocarbon Receptor and the Nervous System. International Journal of Molecular Sciences, MDPI, 2018, 19 (9), pp.2504. ⟨10.3390/ijms19092504⟩. ⟨hal-01955890⟩
  • Charlotte Esser, B. Paige Lawrence, David Sherr, Gary Perdew, Alvaro Puga, et al.. Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France. International Journal of Molecular Sciences, MDPI, 2018, 19 (11), pp.3603. ⟨10.3390/ijms19113603⟩. ⟨hal-01955760⟩
  • Anaïs Wakx, Margaux Nedder, Céline Tomkiewicz-Raulet, Jessica Dalmasso, Audrey Chissey, et al.. Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta. International Journal of Molecular Sciences, MDPI, 2018, 19 (12), pp.3762. ⟨10.3390/ijms19123762⟩. ⟨hal-01955802⟩
  • Aude Jacob, Céline Tomkiewicz-Raulet, Charlotte Jamet, Reina Bendayan, France Massicot, et al.. Aryl hydrocarbon receptor upregulates IL-1β expression in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure. Toxicology in Vitro, Elsevier, 2017, 41, pp.200-204. ⟨10.1016/j.tiv.2017.03.001⟩. ⟨hal-02196316⟩
  • Elise Saunier, Samantha Antonio, Anne Regazzetti, Nicolas Auzeil, Olivier Laprévote, et al.. Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells. Scientific Reports, Nature Publishing Group, 2017, 7 (1), 16 p. ⟨10.1038/s41598-017-07006-0⟩. ⟨hal-01603368⟩
  • Marie Verbanck, Mickaël Canouil, Audrey Leloire, Véronique Dhennin, Xavier Coumoul, et al.. Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles. PLoS ONE, Public Library of Science, 2017, 12 (6), pp.e0179583. ⟨10.1371/journal.pone.0179583⟩. ⟨hal-02196318⟩
  • Ludmila Juricek, Julie Carcaud, Alice Pelhaître, Thorfinn Riday, Aline Chevallier, et al.. AhR-deficiency as a cause of demyelinating disease and inflammation. Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-09621-3⟩. ⟨hal-02110960⟩
  • Mirlande Présumé, Angélique Simon-Deckers, Céline Tomkiewicz-Raulet, Béatrice Le Grand, Jean Tran van Nhieu, et al.. Exposure to metal oxide nanoparticles administered at occupationally relevant doses induces pulmonary effects in mice. Nanotoxicology, Taylor & Francis, 2016, 10 (10), pp.1535-1544. ⟨10.1080/17435390.2016.1242797⟩. ⟨hal-01496265⟩
  • Caroline Duval, Fatima Teixeira-Clerc, Alix Leblanc, Sothea Touch, Claude Emond, et al.. Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model. Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2016, 125 (3), ⟨10.1289/ehp316⟩. ⟨hal-02196317⟩
  • Linh-Chi Bui, Céline Tomkiewicz, Stephane Pierre, Aline Chevallier, Robert Barouki, et al.. Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration. TOXICOLOGICAL SCIENCES, 2015, 149 (1), pp.158-166. ⟨10.1093/toxsci/kfv221⟩. ⟨hal-02196308⟩
  • Elise Emeville, Arnaud Giusti, Xavier Coumoul, Jean-Pierre Thome, Pascal Blanchet, et al.. Associations of Plasma Concentrations of Dichlorodiphenyldichloroethylene and Polychlorinated Biphenyls with Prostate Cancer: A Case–Control Study in Guadeloupe (French West Indies). Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2015, 123 (4), pp.317-323. ⟨10.1289/ehp.1408407⟩. ⟨hal-02195806⟩
  • Erwan Guyot, Yevgeniya Solovyova, Céline Tomkiewicz, Alix Leblanc, Stéphane Pierre, et al.. Determination of Heavy Metal Concentrations in Normal and Pathological Human Endometrial Biopsies and In Vitro Regulation of Gene Expression by Metals in the Ishikawa and Hec-1b Endometrial Cell Line. PLoS ONE, Public Library of Science, 2015, 10 (11), pp.e0142590. ⟨10.1371/journal.pone.0142590⟩. ⟨hal-02196310⟩
  • Xavier Coumoul. Editorial. Biochimie Open, Elsevier, 2015, 1, pp.60. ⟨10.1016/j.biopen.2015.11.002⟩. ⟨hal-02195702⟩
  • Ludmila Juricek, Xavier Coumoul. Alimentation, pesticides et pathologies neurologiques. Cahiers de Nutrition et de Diététique, Elsevier Masson, 2014, 49 (2), pp.74-80. ⟨10.1016/j.cnd.2014.02.002⟩. ⟨hal-02195654⟩
  • Ludmila Juricek, Linh-Chi Bui, Florent Busi, Stéphane Pierre, Erwan Guyot, et al.. Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites. Archives of Toxicology, Springer Verlag, 2014, 89 (12), pp.2403-2412. ⟨10.1007/s00204-014-1367-7⟩. ⟨hal-02195701⟩
  • Nolwenn Joffin, Anne-Marie Jaubert, Sylvie Durant, Jean Bastin, Jean de Bandt, et al.. Citrulline reduces glyceroneogenesis and induces fatty acid release in visceral adipose tissue from overweight rats. Molecular Nutrition & Food Research, 2014, 58 (12), pp.2320-2330. ⟨10.1002/mnfr.201400507⟩. ⟨hal-01957294⟩
  • Erwan Guyot, Aline Chevallier, Robert Barouki, Xavier Coumoul. The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications. Drug Discovery Today, Elsevier, 2013, 18 (9-10), pp.479-486. ⟨10.1016/j.drudis.2012.11.014⟩. ⟨hal-02190808⟩
  • Stéphane Pierre, Aline Chevallier, Fatima Teixeira-Cler, Ariane Ambolet-Camoit, Linh-Chi Bui, et al.. Aryl Hydrocarbon Receptor-Dependent Induction of Liver Fibrosis by Dioxin. TOXICOLOGICAL SCIENCES, 2013, 137 (1), pp.114-124. ⟨10.1093/toxsci/kft236⟩. ⟨hal-02195641⟩
  • Aline Chevallier, Antoine Mialot, Jean-Maurice Petit, Pedro Fernandez-Salguero, Robert Barouki, et al.. Oculomotor Deficits in Aryl Hydrocarbon Receptor Null Mouse. PLoS ONE, Public Library of Science, 2013, 8 (1), pp.e53520. ⟨10.1371/journal.pone.0053520⟩. ⟨hal-02190806⟩
  • Robert Barouki, Martine Aggerbeck, Lawrence Aggerbeck, Xavier Coumoul. The aryl hydrocarbon receptor system. Drug Metabolism and Drug Interactions, 2012, 27 (1), ⟨10.1515/dmdi-2011-0035⟩. ⟨hal-02190803⟩
  • Erwan Guyot, Xavier Coumoul, Jean-François Chassé, Farid Khallouki, Jean François Savouret, et al.. Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.. Biochemical Pharmacology, Elsevier, 2012, 83 (5), pp.627-632. ⟨10.1016/j.bcp.2011.12.013⟩. ⟨inserm-00743456⟩
  • Aline Chevallier, Linh-Chi Bui, Xavier Coumoul. Le récepteur de la dioxine : rôle endogène et médiateur de la toxicité de la dioxine. Cahiers de Nutrition et de Diététique, Elsevier Masson, 2011, 46 (2), pp.67-74. ⟨10.1016/j.cnd.2011.01.002⟩. ⟨hal-02190797⟩
  • Y. Simoni, A.S. Gautron, L. Beaudoin, Bui L.-C., Michel M.L., et al.. NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes. European Journal of Immunology, Wiley-VCH Verlag, 2011, 41, pp.3574-3584. ⟨hal-00655397⟩
  • Stéphane Pierre, Anne-Sophie Bats, Xavier Coumoul. Understanding SOS (Son of Sevenless). Biochemical Pharmacology, Elsevier, 2011, 82 (9), pp.1049-1056. ⟨10.1016/j.bcp.2011.07.072⟩. ⟨hal-02190799⟩
  • Stéphane Pierre, Anne-Sophie Bats, Aline Chevallier, Linh-Chi Bui, Ariane Ambolet-Camoit, et al.. INDUCTION OF THE RAS ACTIVATOR SON OF SEVENLESS 1 BY ENVIRONMENTAL POLLUTANTS MEDIATES THEIR EFFECTS ON CELLULAR PROLIFERATION. Biochemical Pharmacology, Elsevier, 2011, 81 (2), pp.304-313. ⟨10.1016/j.bcp.2010.10.003⟩. ⟨hal-02190082⟩
  • Aude Jacob, Anika Ms Hartz, Sophie Potin, Xavier Coumoul, Salah Yousif, et al.. Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels. Fluids and Barriers of the CNS, BioMed Central, 2011, 8 (1), pp.23. ⟨10.1186/2045-8118-8-23⟩. ⟨hal-02190081⟩
  • Aude Jacob, Anika Hartz, Sophie Potin, Xavier Coumoul, Salah Yousif, et al.. Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels.. Fluids and Barriers of the CNS, BioMed Central, 2011, 8 (1), pp.23. ⟨10.1186/2045-8118-8-23⟩. ⟨inserm-00626715⟩
  • Yannick Simoni, Anne-Sophie Gautron, Lucie Beaudoin, Linh-Chi Bui, Marie-Laure Michel, et al.. NOD mice contain an elevated frequency of iNKT17 cells: implications in type 1 diabetes. European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (12), pp.3574-3585. ⟨10.1002/eji.201141751⟩. ⟨hal-02190801⟩
  • Robert Barouki, Xavier Coumoul. Cell migration and metastasis markers as targets of environmental pollutants and the Aryl hydrocarbon receptor. Cell Adhesion & Migration, 2010, 4 (1), pp.72-76. ⟨10.4161/cam.4.1.10313⟩. ⟨hal-02190044⟩
  • Ariane Ambolet-Camoit, Linh Bui, Stéphane Pierre, Aline Chevallier, Alexandre Marchand, et al.. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Counteracts the p53 Response to a Genotoxicant by Upregulating Expression of the Metastasis Marker AGR2 in the Hepatocarcinoma Cell Line HepG2. Toxicological Sciences, Oxford University Press (OUP), 2010, 115 (2), pp.501-512. ⟨10.1093/toxsci/kfq082⟩. ⟨hal-02190079⟩
  • Stéphane Pierre, Anne-Sophie Bats, Aline Chevallier, Linh-Chi Bui, Ariane Ambolet-Camoit, et al.. Induction Of The Ras Activator Son Of Sevenless 1 By Environmental Pollutants Mediates Their Effects On Cellular Proliferation. Biochemical Pharmacology, Elsevier, 2010, 81 (2), pp.304. ⟨10.1016/j.bcp.2010.10.003⟩. ⟨hal-00649887⟩
  • Vivek Shukla, Xavier Coumoul, Athanassios Vassilopoulos, Chu-Xia Deng. IGF Signaling Pathway as a Selective Target of Familial Breast Cancer Therapy. CMM, 2008, 8 (8), pp.727-740. ⟨10.2174/156652408786733694⟩. ⟨hal-02190041⟩
  • Xavier Coumoul. Dioxine et œstradiol: L’amour vache ou une histoire de « complexes ». médecine/sciences, EDP Sciences, 2007, 23 (8-9), pp.701-702. ⟨10.1051/medsci/20072389701⟩. ⟨hal-02175735⟩
  • Pedro Fernandez Salguero, Xavier Coumoul, Robert Barouki. The Aryl Hydrocarbon Receptor, More than a Xenobiotic-Interacting Protein. FEBS Letters, Wiley, 2007, 581 (19), pp.3608-3615. ⟨10.1016/j.febslet.2007.03.046⟩. ⟨hal-02175734⟩
  • Xavier Coumoul, Vivek Shukla, Chu-Xia Deng. RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector. International Journal of Biological Sciences, Ivyspring International Publisher, 2007, pp.91-99. ⟨10.7150/ijbs.3.91⟩. ⟨hal-02175719⟩
  • M. Diry, C. Tomkiewicz, C. Koehle, Xavier Coumoul, K. Walter Bock, et al.. Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism. Oncogene, Nature Publishing Group, 2006, 25 (40), pp.5570-5574. ⟨10.1038/sj.onc.1209553⟩. ⟨hal-02173983⟩
  • Xavier Coumoul, Chu-Xia Deng. RNAi in mice: a promising approach to decipher gene functions in vivo. Biochimie, Elsevier, 2006, 88 (6), pp.637-643. ⟨10.1016/j.biochi.2005.11.010⟩. ⟨hal-02174003⟩
  • Xavier Coumoul, Vivek Shukla, Cuiling Liu, Rui-Hong Wang, Chu-Xia Deng. Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Research, Oxford University Press, 2005, 33 (11), pp.e102-e102. ⟨10.1093/nar/gni100⟩. ⟨hal-02173980⟩
  • Xavier Coumoul, Wenmei Li, Rui-Hong Wang, Chuxia Deng. Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre–LoxP system. Nucleic Acids Research, Oxford University Press, 2004, 32 (10), pp.e85-e85. ⟨10.1093/nar/gnh083⟩. ⟨hal-02173975⟩
  • Xavier Coumoul, Chu-Xia Deng. Roles of FGF Receptors in Mammalian Development and Congenital Diseases. Birth Defects Research Part C: Embryo Today: Reviews, Wiley, 2003, 69 (4), pp.286-304. ⟨10.1002/bdrc.10025⟩. ⟨hal-02171887⟩
  • Xavier Coumoul, Robert Barouki. Génotoxicité des métabolites des œstrogènes et cancers. Med Sci (Paris), 2002, 18 (1), pp.86-90. ⟨10.1051/medsci/200218186⟩. ⟨hal-02173818⟩

Communication dans un congrès3 documents

  • Boris Barbour, Xavier Coumoul, Hélène Skrzypniak, Rémi Thomasson, Jacques Walter. Table ronde sur l’intégrité scientifique dans les revues. Journée d'étude L'intégrité scientifique au prisme de l'IST. 7e journée nationale d’étude du Réseau des Urfist, Réseau des Urfist, Dec 2018, Nanterre, France. ⟨hal-01989746⟩
  • Bernard Salles, Peter Rogowsky, Florence Forget, Annick Moing, Remi Servien, et al.. Large scale studies of the influence of GMO-based corn diet after 6 months of consumption in Wistar rats. 53. Congress of the European Societies of Toxicology (EUROTOX), Sep 2017, Bratislava, Slovakia. ⟨10.1016/j.toxlet.2017.07.297⟩. ⟨hal-01603238⟩
  • Ph Detilleux, L Vallier, C Legallais, E Leclerc, M Prot J, et al.. Toxicologie predictive: les voies du futur. Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France. ⟨hal-01122677⟩

Poster1 document

  • Stéphane Bernillon, Mickael Maucourt, Sylvain Chereau, Catherine Deborde, Daniel Jacob, et al.. Characterization of GMO or glyphosate effects on the composition of maize grain and maize-based diet for rat feeding. 12. Journées Scientifiques du RFMF, May 2019, Clermont-Ferrand, France. pp.109 /P30, 2019, 12. Journées Scientifiques du RFMF. ⟨hal-02556668⟩

Autre publication1 document

  • Thierry Koscielniak, Sonia Badeau, Xavier Coumoul. Interactive BYOD Sessions with Moodle during Lectures EDUCAUSE 2014. 2014. ⟨hal-02190809⟩

Rapport1 document

  • Isabelle Baldi, Sylvaine Cordier, Xavier Coumoul, Alexis Elbaz, Laurence Gamet-Payrastre, et al.. Pesticides : Effets sur la santé. [Rapport de recherche] Institut national de la santé et de la recherche médicale(INSERM). 2013, Paris : Inserm : Éditions EDP Sciences (ISSN : 1264-1782) / 1014 p. ⟨inserm-02102981⟩