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75

Professor of Biochemistry and Toxicology - University of Paris - Team leader INSERM Metatox - T3S


Mes activités de recherche portent essentiellement sur la caractérisation des effets de polluants variés et en mélange sur le phénotype tumoral, l'évolution des maladies chroniques du foie, et l'apparition de maladies neurodégénératives.

L'équipe que je dirige possède une expertise importante en biologie moléculaire, cellulaire, biochimie et métabolisme et aborde ces thématiques à l'aide de modèles in vitro, in vivo, cliniques et plus récemment computationnels.

Nous recevons un soutien important d'agences nationales (ANR, ANSES..) ou internationales (projets européens) pour la réalisation de nos recherches qui sont adossées à l'enseignement en licence (biochimie, métabolisme) et master (notamment de toxicologie que je dirige), pour lesquels les enseignants-chercheurs de l'équipe essaient d'implémenter des méthodologies innovantes et interactives.

Une part importante de mon activité et de celle de l'équipe est dédiée à la valorisation (pour partie à destination du grand public), à la réalisation d'expertises ainsi qu'à la formation d'étudiants.


Journal articles67 documents

  • Lucie Larigot, Linh-Chi Bui, Marine de Bouvier, Ophélie Pierre, Grégory Pinon, et al.. Identification of Modulators of the C. elegans Aryl Hydrocarbon Receptor and Characterization of Transcriptomic and Metabolic AhR-1 Profiles. Antioxidants , MDPI, 2022, 11 (5), pp.1030. ⟨10.3390/antiox11051030⟩. ⟨hal-03745310⟩
  • Lucie Larigot, Daniel Mansuy, Ilona Borowski, Xavier Coumoul, Julien Dairou. Cytochromes P450 of Caenorhabditis elegans: Implication in Biological Functions and Metabolism of Xenobiotics. Biomolecules, MDPI, 2022, 12 (3), pp.342. ⟨10.3390/biom12030342⟩. ⟨hal-03745295⟩
  • Vanessa Brinkmann, Margherita Romeo, Lucie Larigot, Anne Hemmers, Lisa Tschage, et al.. Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects. Antioxidants , MDPI, 2022, 11 (4), pp.613. ⟨10.3390/antiox11040613⟩. ⟨hal-03745302⟩
  • Jerrold J Heindel, Sarah Howard, Keren Agay-Shay, Juan P Arrebola, Karine Audouze, et al.. Obesity II: Establishing causal links between chemical exposures and obesity. Biochemical Pharmacology, Elsevier, 2022, 199, pp.115015. ⟨10.1016/j.bcp.2022.115015⟩. ⟨hal-03705630⟩
  • Isabelle Hernandez, Audrey Chissey, Jean Guibourdenche, Roger Atasoy, Xavier Coumoul, et al.. Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways. Antioxidants , MDPI, 2021, 10 (2), pp.281. ⟨10.3390/antiox10020281⟩. ⟨hal-03741281⟩
  • Meriem Koual, Céline Tomkiewicz, Ida Chiara Guerrera, David Sherr, Robert Barouki, et al.. Aggressiveness and Metastatic Potential of Breast Cancer Cells Co-Cultured with Preadipocytes and Exposed to an Environmental Pollutant Dioxin: An in Vitro and in Vivo Zebrafish Study. Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (3), ⟨10.1289/ehp7102⟩. ⟨hal-03741287⟩
  • Maria João Correia, António Pimpão, Filipa Lopes-Coelho, Catarina Sequeira, Nuno Coelho, et al.. Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex. Antioxidants , MDPI, 2021, 10 (9), pp.1484. ⟨10.3390/antiox10091484⟩. ⟨hal-03744708⟩
  • Eloi Chazelas, Nathalie Druesne-Pecollo, Younes Esseddik, Fabien Szabo de Edelenyi, Cédric Agaesse, et al.. Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort. Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-98496-6⟩. ⟨hal-03376892⟩
  • Carolina Duarte-Hospital, Arnaud Tête, François Brial, Louise Benoit, Meriem Koual, et al.. Mitochondrial Dysfunction as a Hallmark of Environmental Injury. Cells, MDPI, 2021, 11 (1), pp.110. ⟨10.3390/cells11010110⟩. ⟨hal-03744739⟩
  • Robert Barouki, Karine Audouze, Xavier Coumoul. Perturbateurs endocriniens : de quoi parle-t-on, et quels nouveaux mécanismes de toxicité mettent-ils en jeu ? : Effets différés, à faible dose ou en cocktail : de nouveaux enjeux pour la toxicologie. La Revue du Praticien Médecine Générale, Global Média Santé, 2021, 71 (7), pp.723-726. ⟨hal-03744691⟩
  • Xavier Coumoul. Les effets des co-expositions du BaP avec des nanoparticules : Effets du B(a)P seul ou en co-exposition avec des nanoparticules et implication du récepteur Ah (ou AhR) dans l’intégrité et la fonction de deux barrières physiologiques : broncho-pulmonaire et placentaire. Les cahiers de la Recherche. Santé, Environnement, Travail, ANSES, 2021, Microplastiques et nanomatériaux, pp.14-16. ⟨anses-03348846⟩
  • Meriem Koual, Céline Tomkiewicz, German Cano-Sancho, Jean-Philippe Antignac, Anne-Sophie Bats, et al.. Environmental chemicals, breast cancer progression and drug resistance. Environmental Health, BioMed Central, 2020, 19 (1), ⟨10.1186/s12940-020-00670-2⟩. ⟨hal-03182397⟩
  • Sylvie Babajko, Géraldine Lescaille, Loredana Radoi, Ai Thu Bui, Vanessa Baaroun, et al.. La sphère orale, cible et marqueur de l’exposition environnementaleII. Maladies diagnostiquées chez l'adulte. médecine/sciences, EDP Sciences, 2020, 36 (3), pp.231-234. ⟨10.1051/medsci/2020025⟩. ⟨hal-02559671⟩
  • Sylvie Babajko, Véronique V. Gayrard-Troy, Sophia Houari, Ai Thu Bui, Robert Barouki, et al.. La sphère orale, cible et marqueur de l’exposition environnementale : I. Défauts du développement dentaire. médecine/sciences, EDP Sciences, 2020, 36 (3), pp.225-230. ⟨10.1051/medsci/2020024⟩. ⟨hal-02617147⟩
  • Quentin Vicens, Xavier Coumoul, Jean‐luc Souciet. A forum where french‐speaking faculty can exchange research on teaching. Biochemistry and Molecular Biology Education, Wiley, 2019, ⟨10.1002/bmb.21258⟩. ⟨hal-02171219⟩
  • Carolina Duarte-Hospital, Laurence Huc, Sylvie Bortoli, Xavier Coumoul. Les xénobiotiques, quel impact sur les maladies métaboliques ?. Cahiers de Nutrition et de Diététique, Elsevier Masson, 2019, 54 (5), pp.286-293. ⟨10.1016/j.cnd.2019.07.002⟩. ⟨hal-02618196⟩
  • Barbara Allen, Xavier Coumoul, Silvia Lacorte. Microplastic freshwater contamination: an issue advanced by science with public engagement. Environmental Science and Pollution Research, Springer Verlag, 2019, ⟨10.1007/s11356-019-05300-0⟩. ⟨hal-02122843⟩
  • Xavier Coumoul, Rémi Servien, Ludmila Juricek, Yael Kaddouch-Amar, Yannick Lippi, et al.. The GMO90+ Project: Absence of Evidence for Biologically Meaningful Effects of Genetically Modified Maize-based Diets on Wistar Rats After 6-Months Feeding Comparative Trial. Toxicological Sciences, Oxford University Press (OUP), 2019, 168 (2), pp.315-338. ⟨10.1093/toxsci/kfy298⟩. ⟨hal-02196332⟩
  • Komodo Matta, Stéphane Ploteau, Xavier Coumoul, Meriem Koual, Bruno Le Bizec, et al.. Associations between exposure to organochlorine chemicals and endometriosis in experimental studies: A systematic review protocol. Environment International, Elsevier, 2019, 124, pp.400-407. ⟨10.1016/j.envint.2018.12.063⟩. ⟨hal-02196329⟩
  • Jean-Charles Carvaillo, Robert Barouki, Xavier Coumoul, Karine Audouze. Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach. Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2019, 127 (4), pp.047005. ⟨10.1289/ehp4200⟩. ⟨hal-02196330⟩
  • Expédite Yen-Pon, Bo Li, Marta Acebrón-Garcia-De-Eulate, Céline Tomkiewicz-Raulet, John Dawson, et al.. Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase. ACS Chemical Biology, American Chemical Society, 2018, 13 (8), pp.2067-2073. ⟨10.1021/acschembio.8b00250⟩. ⟨hal-02196326⟩
  • Sylvie Bortoli, Xavier Coumoul. Impact des pesticides sur la santé humaine. Pratiques en Nutrition : santé et alimentation, Elsevier-Masson, 2018, 14 (53), pp.18-24. ⟨10.1016/j.pranut.2017.12.005⟩. ⟨hal-02282362⟩
  • Charlotte Esser, B. Paige Lawrence, David H Sherr, Gary H Perdew, Alvaro Puga, et al.. Old Receptor, New Tricks—The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29–31 August 2018 in Paris, France. International Journal of Molecular Sciences, MDPI, 2018, 19 (11), pp.3603. ⟨10.3390/ijms19113603⟩. ⟨hal-01955760⟩
  • Nolwenn Joffin, Philippe Noirez, Jean-Philippe Antignac, Min-Ji Kim, Philippe Marchand, et al.. Release and toxicity of adipose tissue-stored TCDD: Direct evidence from a xenografted fat model. Environment International, Elsevier, 2018, 121, pp.1113-1120. ⟨10.1016/j.envint.2018.10.027⟩. ⟨hal-01922515⟩
  • Caroline Duval, Etienne Blanc, Xavier Coumoul. Aryl hydrocarbon receptor and liver fibrosis. Current Opinion in Toxicology, 2018, 8, pp.8-13. ⟨10.1016/j.cotox.2017.11.010⟩. ⟨hal-02196325⟩
  • Robert Barouki, Karine Audouze, Xavier Coumoul, Florence Demenais, Dominique Gauguier. Integration of the human exposome with the human genome to advance medicine. Biochimie, Elsevier, 2018, 152, pp.155-158. ⟨10.1016/j.biochi.2018.06.023⟩. ⟨hal-02196327⟩
  • Lucie Larigot, Ludmila Juricek, Julien Dairou, Xavier Coumoul. AhR signaling pathways and regulatory functions. Biochimie Open, Elsevier, 2018, 7, pp.1-9. ⟨10.1016/j.biopen.2018.05.001⟩. ⟨hal-02196328⟩
  • Anaïs Wakx, Margaux Nedder, Céline Tomkiewicz-Raulet, Jessica Dalmasso, Audrey Chissey, et al.. Expression, Localization, and Activity of the Aryl Hydrocarbon Receptor in the Human Placenta. International Journal of Molecular Sciences, MDPI, 2018, 19 (12), pp.3762. ⟨10.3390/ijms19123762⟩. ⟨hal-01955802⟩
  • Ghjuvan Ghjacumu Shackleford, Nirmal Kumar Sampathkumar, Mehdi Hichor, Laure Weill, Delphine Meffre, et al.. The Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (6), pp.E1319-E1328. ⟨10.1073/pnas.1715999115⟩. ⟨hal-02110942⟩
  • Ludmila Juricek, Xavier Coumoul. The Aryl Hydrocarbon Receptor and the Nervous System. International Journal of Molecular Sciences, MDPI, 2018, 19 (9), pp.2504. ⟨10.3390/ijms19092504⟩. ⟨hal-03741246⟩
  • Marie Verbanck, Mickaël Canouil, Audrey Leloire, Véronique Dhennin, Xavier Coumoul, et al.. Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles. PLoS ONE, Public Library of Science, 2017, 12 (6), pp.e0179583. ⟨10.1371/journal.pone.0179583⟩. ⟨hal-02196318⟩
  • Aude Jacob, Céline Tomkiewicz-Raulet, Charlotte Jamet, Reina Bendayan, France Massicot, et al.. Aryl hydrocarbon receptor upregulates IL-1β expression in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure. Toxicology in Vitro, Elsevier, 2017, 41, pp.200-204. ⟨10.1016/j.tiv.2017.03.001⟩. ⟨hal-02196316⟩
  • Elise Saunier, Samantha Antonio, Anne Regazzetti, Nicolas Auzeil, Olivier Laprévote, et al.. Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells. Scientific Reports, Nature Publishing Group, 2017, 7 (1), 16 p. ⟨10.1038/s41598-017-07006-0⟩. ⟨hal-01603368⟩
  • Ludmila Juricek, Julie Carcaud, Alice Pelhaître, Thorfinn T Riday, Aline Chevallier, et al.. AhR-deficiency as a cause of demyelinating disease and inflammation. Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-09621-3⟩. ⟨hal-02110960⟩
  • Mirlande Présumé, Angélique Simon-Deckers, Céline Tomkiewicz-Raulet, Béatrice Le Grand, Jean Tran van Nhieu, et al.. Exposure to metal oxide nanoparticles administered at occupationally relevant doses induces pulmonary effects in mice. Nanotoxicology, Taylor & Francis, 2016, 10 (10), pp.1535-1544. ⟨10.1080/17435390.2016.1242797⟩. ⟨hal-01496265⟩
  • Caroline Duval, Fatima Teixeira-Clerc, Alix F. Leblanc, Sothea Touch, Claude Emond, et al.. Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model. Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2016, 125 (3), ⟨10.1289/ehp316⟩. ⟨hal-02196317⟩
  • Linh-Chi Bui, Céline Tomkiewicz, Stephane Pierre, Aline Chevallier, Robert Barouki, et al.. Regulation of Aquaporin 3 Expression by the AhR Pathway Is Critical to Cell Migration. TOXICOLOGICAL SCIENCES, 2015, 149 (1), pp.158-166. ⟨10.1093/toxsci/kfv221⟩. ⟨hal-02196308⟩
  • Erwan Guyot, Yevgeniya Solovyova, Céline Tomkiewicz, Alix Leblanc, Stéphane Pierre, et al.. Determination of Heavy Metal Concentrations in Normal and Pathological Human Endometrial Biopsies and In Vitro Regulation of Gene Expression by Metals in the Ishikawa and Hec-1b Endometrial Cell Line. PLoS ONE, Public Library of Science, 2015, 10 (11), pp.e0142590. ⟨10.1371/journal.pone.0142590⟩. ⟨hal-02196310⟩
  • Xavier Coumoul. Editorial. Biochimie Open, Elsevier, 2015, 1, pp.60. ⟨10.1016/j.biopen.2015.11.002⟩. ⟨hal-02195702⟩
  • Elise Emeville, Arnaud Giusti, Xavier Coumoul, Jean-Pierre Thome, Pascal Blanchet, et al.. Associations of Plasma Concentrations of Dichlorodiphenyldichloroethylene and Polychlorinated Biphenyls with Prostate Cancer: A Case–Control Study in Guadeloupe (French West Indies). Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2015, 123 (4), pp.317-323. ⟨10.1289/ehp.1408407⟩. ⟨hal-02195806⟩
  • Ludmila Juricek, Linh-Chi Bui, Florent Busi, Stéphane Pierre, Erwan Guyot, et al.. Activation of the aryl hydrocarbon receptor by carcinogenic aromatic amines and modulatory effects of their N-acetylated metabolites. Archives of Toxicology, Springer Verlag, 2014, 89 (12), pp.2403-2412. ⟨10.1007/s00204-014-1367-7⟩. ⟨hal-02195701⟩
  • Nolwenn Joffin, Anne-Marie Jaubert, Sylvie Durant, Jean Bastin, Jean de Bandt, et al.. Citrulline reduces glyceroneogenesis and induces fatty acid release in visceral adipose tissue from overweight rats. Molecular Nutrition & Food Research, 2014, 58 (12), pp.2320-2330. ⟨10.1002/mnfr.201400507⟩. ⟨hal-01957294⟩
  • Ludmila Juricek, Xavier Coumoul. Alimentation, pesticides et pathologies neurologiques. Cahiers de Nutrition et de Diététique, Elsevier Masson, 2014, 49 (2), pp.74-80. ⟨10.1016/j.cnd.2014.02.002⟩. ⟨hal-02195654⟩
  • Stéphane Pierre, Aline Chevallier, Fatima Teixeira-Cler, Ariane Ambolet-Camoit, Linh-Chi Bui, et al.. Aryl Hydrocarbon Receptor-Dependent Induction of Liver Fibrosis by Dioxin. TOXICOLOGICAL SCIENCES, 2013, 137 (1), pp.114-124. ⟨10.1093/toxsci/kft236⟩. ⟨hal-02195641⟩
  • Erwan Guyot, Aline Chevallier, Robert Barouki, Xavier Coumoul. The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications. Drug Discovery Today, Elsevier, 2013, 18 (9-10), pp.479-486. ⟨10.1016/j.drudis.2012.11.014⟩. ⟨hal-02190808⟩
  • Aline Chevallier, Antoine Mialot, Jean-Maurice Petit, Pedro Fernandez-Salguero, Robert Barouki, et al.. Oculomotor Deficits in Aryl Hydrocarbon Receptor Null Mouse. PLoS ONE, Public Library of Science, 2013, 8 (1), pp.e53520. ⟨10.1371/journal.pone.0053520⟩. ⟨hal-02190806⟩
  • Erwan Guyot, Xavier Coumoul, Jean-François Chassé, Farid Khallouki, Jean François Savouret, et al.. Identification of a new stilbene-derived inducer of paraoxonase 1 and ligand of the Aryl hydrocarbon Receptor.. Biochemical Pharmacology, Elsevier, 2012, 83 (5), pp.627-632. ⟨10.1016/j.bcp.2011.12.013⟩. ⟨inserm-00743456⟩
  • Robert Barouki, Martine Aggerbeck, Lawrence Aggerbeck, Xavier Coumoul. The aryl hydrocarbon receptor system. Drug Metabolism and Drug Interactions, 2012, 27 (1), ⟨10.1515/dmdi-2011-0035⟩. ⟨hal-02190803⟩
  • Aude Jacob, Anika Hartz, Sophie Potin, Xavier Coumoul, Salah Yousif, et al.. Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels.. Fluids and Barriers of the CNS, BioMed Central, 2011, 8 (1), pp.23. ⟨10.1186/2045-8118-8-23⟩. ⟨inserm-00626715⟩
  • Aude Jacob, Anika Ms Hartz, Sophie Potin, Xavier Coumoul, Salah Yousif, et al.. Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels. Fluids and Barriers of the CNS, BioMed Central, 2011, 8 (1), pp.23. ⟨10.1186/2045-8118-8-23⟩. ⟨hal-02190081⟩
  • Stéphane Pierre, Anne-Sophie Bats, Aline Chevallier, Linh-Chi Bui, Ariane Ambolet-Camoit, et al.. INDUCTION OF THE RAS ACTIVATOR SON OF SEVENLESS 1 BY ENVIRONMENTAL POLLUTANTS MEDIATES THEIR EFFECTS ON CELLULAR PROLIFERATION. Biochemical Pharmacology, Elsevier, 2011, 81 (2), pp.304-313. ⟨10.1016/j.bcp.2010.10.003⟩. ⟨hal-02190082⟩
  • Stéphane Pierre, Anne-Sophie Bats, Xavier Coumoul. Understanding SOS (Son of Sevenless). Biochemical Pharmacology, Elsevier, 2011, 82 (9), pp.1049-1056. ⟨10.1016/j.bcp.2011.07.072⟩. ⟨hal-02190799⟩
  • Aline Chevallier, Linh-Chi Bui, Xavier Coumoul. Le récepteur de la dioxine : rôle endogène et médiateur de la toxicité de la dioxine. Cahiers de Nutrition et de Diététique, Elsevier Masson, 2011, 46 (2), pp.67-74. ⟨10.1016/j.cnd.2011.01.002⟩. ⟨hal-02190797⟩
  • Yannick Simoni, Anne-Sophie Gautron, Lucie Beaudoin, Linh-Chi Bui, Marie-Laure Michel, et al.. NOD mice contain an elevated frequency of iNKT17 cells: implications in type 1 diabetes. European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (12), pp.3574-3585. ⟨10.1002/eji.201141751⟩. ⟨hal-02190801⟩
  • Stéphane Pierre, Anne-Sophie Bats, Aline Chevallier, Linh-Chi Bui, Ariane Ambolet-Camoit, et al.. Induction Of The Ras Activator Son Of Sevenless 1 By Environmental Pollutants Mediates Their Effects On Cellular Proliferation. Biochemical Pharmacology, Elsevier, 2010, 81 (2), pp.304. ⟨10.1016/j.bcp.2010.10.003⟩. ⟨hal-00649887⟩
  • Robert Barouki, Xavier Coumoul. Cell migration and metastasis markers as targets of environmental pollutants and the Aryl hydrocarbon receptor. Cell Adhesion & Migration, 2010, 4 (1), pp.72-76. ⟨10.4161/cam.4.1.10313⟩. ⟨hal-02190044⟩
  • Ariane Ambolet-Camoit, Linh Chi Bui, Stéphane Pierre, Aline Chevallier, Alexandre Marchand, et al.. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Counteracts the p53 Response to a Genotoxicant by Upregulating Expression of the Metastasis Marker AGR2 in the Hepatocarcinoma Cell Line HepG2. Toxicological Sciences, Oxford University Press (OUP), 2010, 115 (2), pp.501-512. ⟨10.1093/toxsci/kfq082⟩. ⟨hal-02190079⟩
  • Vivek Shukla, Xavier Coumoul, Athanassios Vassilopoulos, Chu-Xia Deng. IGF Signaling Pathway as a Selective Target of Familial Breast Cancer Therapy. CMM, 2008, 8 (8), pp.727-740. ⟨10.2174/156652408786733694⟩. ⟨hal-02190041⟩
  • Pedro M. Fernandez Salguero, Xavier Coumoul, Robert Barouki. The Aryl Hydrocarbon Receptor, More than a Xenobiotic-Interacting Protein. FEBS Letters, Wiley, 2007, 581 (19), pp.3608-3615. ⟨10.1016/j.febslet.2007.03.046⟩. ⟨hal-02175734⟩
  • Xavier Coumoul. Dioxine et œstradiol: L’amour vache ou une histoire de « complexes ». médecine/sciences, EDP Sciences, 2007, 23 (8-9), pp.701-702. ⟨10.1051/medsci/20072389701⟩. ⟨hal-02175735⟩
  • Xavier Coumoul, Vivek Shukla, Chu-Xia Deng. RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector. International Journal of Biological Sciences, Ivyspring International Publisher, 2007, pp.91-99. ⟨10.7150/ijbs.3.91⟩. ⟨hal-02175719⟩
  • Xavier Coumoul, Chu-Xia Deng. RNAi in mice: a promising approach to decipher gene functions in vivo. Biochimie, Elsevier, 2006, 88 (6), pp.637-643. ⟨10.1016/j.biochi.2005.11.010⟩. ⟨hal-02174003⟩
  • M. Diry, C. Tomkiewicz, C. Koehle, Xavier Coumoul, K. Walter Bock, et al.. Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism. Oncogene, Nature Publishing Group, 2006, 25 (40), pp.5570-5574. ⟨10.1038/sj.onc.1209553⟩. ⟨hal-02173983⟩
  • Xavier Coumoul, Vivek Shukla, Cuiling Liu, Rui-Hong Wang, Chu-Xia Deng. Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Research, Oxford University Press, 2005, 33 (11), pp.e102-e102. ⟨10.1093/nar/gni100⟩. ⟨hal-02173980⟩
  • Xavier Coumoul, Wenmei Li, Rui-Hong Wang, Chuxia Deng. Inducible suppression of Fgfr2 and Survivin in ES cells using a combination of the RNA interference (RNAi) and the Cre–LoxP system. Nucleic Acids Research, Oxford University Press, 2004, 32 (10), pp.e85-e85. ⟨10.1093/nar/gnh083⟩. ⟨hal-02173975⟩
  • Xavier Coumoul, Chu-Xia Deng. Roles of FGF Receptors in Mammalian Development and Congenital Diseases. Birth Defects Research Part C: Embryo Today: Reviews, Wiley, 2003, 69 (4), pp.286-304. ⟨10.1002/bdrc.10025⟩. ⟨hal-02171887⟩
  • Xavier Coumoul, Robert Barouki. Génotoxicité des métabolites des œstrogènes et cancers. Med Sci (Paris), 2002, 18 (1), pp.86-90. ⟨10.1051/medsci/200218186⟩. ⟨hal-02173818⟩

Conference papers3 documents

  • Boris Barbour, Xavier Coumoul, Hélène Skrzypniak, Rémi Thomasson, Jacques Walter. Table ronde sur l’intégrité scientifique dans les revues dans le cadre de la Journée d'étude L'intégrité scientifique au prisme de l'IST. Journée d'étude L'intégrité scientifique au prisme de l'IST. 7e journée nationale d’étude du Réseau des Urfist, Réseau des Urfist, Dec 2018, Nanterre, France. ⟨hal-01989746⟩
  • Bernard Salles, Peter Rogowsky, Florence Forget, Annick Moing, Rémi Servien, et al.. Large scale studies of the influence of GMO-based corn diet after 6 months of consumption in Wistar rats. 53. Congress of the European Societies of Toxicology (EUROTOX), Sep 2017, Bratislava, Slovakia. ⟨10.1016/j.toxlet.2017.07.297⟩. ⟨hal-01603238⟩
  • Ph Detilleux, L Vallier, C Legallais, E Leclerc, M Prot J, et al.. Toxicologie predictive: les voies du futur. Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France. ⟨hal-01122677⟩

Poster communications1 document

  • Stéphane Bernillon, Mickael Maucourt, Sylvain Chéreau, Catherine Deborde, Daniel Jacob, et al.. Characterization of GMO or glyphosate effects on the composition of maize grain and maize-based diet for rat feeding. 12. Journées Scientifiques du RFMF, May 2019, Clermont-Ferrand, France. pp.109 /P30, 2019, 12. Journées Scientifiques du RFMF. ⟨hal-02556668⟩

Other publications1 document

  • Thierry Koscielniak, Sonia Badeau, Xavier Coumoul. Interactive BYOD Sessions with Moodle during Lectures EDUCAUSE 2014. 2014. ⟨hal-02190809⟩

Reports3 documents

  • Isabelle Baldi, Botton Jérémie, Cécile Chevrier, Xavier Coumoul, Alexis Elbaz, et al.. Pesticides et effets sur la santé : Nouvelles données. [Rapport de recherche] Inserm (dir.). Pesticides et effets sur la santé - Nouvelles données. Collection Expertise collective. Montrouge : EDP Sciences, 2021., Institut national de la santé et de la recherche médicale (INSERM). 2021, Paris : Inserm : Éditions EDP Sciences (ISSN : 0990-7440) / XIX - 1009 p. ⟨inserm-03384960⟩
  • Nathalie Bonvallot, Sara Brimo, Philippe Boudes, Xavier Coumoul, Soraya Duboc, et al.. Pour une gestion alerte du risque chimique - Risques (éco)toxicologiques pour les êtres humains et l’environnement dans une logique de biodiversité. [Autre] Commission nationale de la déontologie et des alertes en matière de santé publique et d’environnement (cnDAspe). 2021, 129 p. ⟨hal-03418000⟩
  • Isabelle Baldi, Sylvaine Cordier, Xavier Coumoul, Alexis Elbaz, Laurence Gamet-Payrastre, et al.. Pesticides : Effets sur la santé. [Rapport de recherche] Institut national de la santé et de la recherche médicale(INSERM). 2013, Paris : Inserm : Éditions EDP Sciences (ISSN : 1264-1782) / 1014 p. ⟨inserm-02102981⟩