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Number of documents

47

CV William Raoul

Recrutement CR2 INSERM en CSS1 Neurosciences: 1er Octobre 2009 / Nomination CR1 INSERM en CSS6 Technologies pour la santé: 1er Janvier 2013 / Intégration de la CSS3 Physiologie et physiopathologie des grands systèmes: 1er Novembre 2019

 

Diplômes

2017 : Habilitation à Diriger des Recherches, Sciences de la Vie et de la Santé, Université François Rabelais de Tours.

2005 : Doctorat de Sciences de la Vie et de la Santé, Toxicologie, Université Paris XII-Créteil.

2001 : Diplôme d'études approfondies, Toxicologie, Université Paris V-Descartes.

2000 : Maîtrise de Biologie Cellulaire et Physiologie Animale, Université Paris XII-Créteil.

 

Laboratoires

2019 - : Inserm UMR 1069 N2C, Nutrition Croissance Cancer, Université de Tours

Directeur d’Unité : Christophe Vandier

2018 - 2019 : équipe PATCH, EA7501, Université de Tours

Directeur d’équipe : Gilles Paintaud / Directeur d’Unité : Gilles Thibault

 

2013 - 2017 : équipe A2RC, CNRS UMR 7292, Université François Rabelais, Tours

Directeur d’équipe : Gilles Paintaud / Directeur d’Unité : Gilles Paintaud

2012-2013 : équipe S14, INSERM UMR S 968, Institut de la Vision, Paris

Directeur d’équipe : Florian Sennlaub / Directeur de l’Institut : José-Alain Sahel 

2009-2011 : équipe 21, INSERM UMR S 872, Centre de Recherche des Cordeliers, Paris

Directeur d’équipe : Florian Sennlaub / Directeur du Centre : Wolf Hervé Fridman 

2006-2008 : équipe 17, INSERM UMR S 872, Centre de Recherche des Cordeliers, Paris

Directeur d’équipe : Francine Behar-Cohen / Directeur du Centre : Wolf Hervé Fridman

2001-2005 : INSERM U651 (ex-U492), Faculté de Médecine, Créteil

Directeur de Thèse : Bernard Maitre / Directeur d’Unité : Serge Adnot

Journal articles47 documents

  • Maxime Guéguinou, Sajida Ibrahim, Jérôme Bourgeais, Alison Robert, Trayambak Pathak, et al.. Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer. Cellular and Molecular Life Sciences, Springer Verlag, 2022, 79 (6), pp.article n° 284. ⟨10.1007/s00018-022-04311-4⟩. ⟨hal-03668944⟩
  • Bruno Oyallon, Marie Brachet-Botineau, Cédric Logé, Thomas Robert, Stéphane Bach, et al.. New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation. Molecules, MDPI, 2021, 26 (4), pp.867. ⟨10.3390/molecules26040867⟩. ⟨inserm-03272339⟩
  • Romain Chautard, Laetitia Corset, Sajida Ibrahim, Céline Desvignes, Gilles Paintaud, et al.. Panitumumab and cetuximab affect differently miRNA expression in colorectal cancer cells. Biomarkers in Medicine, Future Medicine, 2021, Online ahead of print. ⟨10.2217/bmm-2020-0520⟩. ⟨inserm-03272360⟩
  • Sajida Ibrahim, Justine Chaigne, Hassan Dakik, Yann Fourbon, Laetitia Corset, et al.. SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer. Cell Calcium, Elsevier, 2021, 96, pp.102384. ⟨10.1016/j.ceca.2021.102384⟩. ⟨inserm-03158756⟩
  • Maxime Guéguinou, Trayambak Pathak, Alison Robert, Christophe Vandier, Mohamed Trebak, et al.. NCLX exchanger: An ambivalent role in colorectal cancer timeline. médecine/sciences, EDP Sciences, 2021, 37 (2), pp.124-126. ⟨10.1051/medsci/2020274⟩. ⟨inserm-03144131⟩
  • Celine Desvignes, David Ternant, Thierry Lecomte, Astrid Lièvre, Marc Ohresser, et al.. A robust enzyme-linked immunosorbent assay to measure serum ramucirumab concentrations. Bioanalysis, Future Science, 2021, 13 (7), pp.565-574. ⟨10.4155/bio-2020-0199⟩. ⟨inserm-03186974⟩
  • Sophie Lavalette, Sara Touhami, Christophe Roubeix, Marianne Houssier, Sébastien Augustin, et al.. CD36 Deficiency Inhibits Retinal Inflammation and Retinal Degeneration in Cx3cr1 Knockout Mice. Frontiers in Immunology, Frontiers, 2020, 1, ⟨10.3389/fimmu.2019.03032⟩. ⟨hal-02438587⟩
  • Adeline Dolly, Thierry Lecomte, Olivier Bouché, Christophe Borg, Eric Terrebonne, et al.. Concurrent losses of skeletal muscle mass, adipose tissue and bone mineral density during bevacizumab / cytotoxic chemotherapy treatment for metastatic colorectal cancer. Clinical Nutrition, Elsevier, 2020, S0261-5614 (20), pp.30080-7. ⟨10.1016/j.clnu.2020.02.017⟩. ⟨inserm-02735513⟩
  • Marie Potier-Cartereau, William Raoul, Günther Weber, Karine Mahéo, Raphaël Rapetti-Mauss, et al.. Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research. Reviews of Physiology Biochemistry and Pharmacology, Springer Verlag, 2020, Epub 2020 - 08 August. ⟨10.1007/112_2020_24⟩. ⟨inserm-02921492⟩
  • Diane Bressand, Anthony Novell, Alban Girault, William Raoul, Gaëlle Fromont-Hankard, et al.. Enhancing Nab-Paclitaxel Delivery Using Microbubble-Assisted Ultrasound in a Pancreatic Cancer Model. Molecular Pharmaceutics, American Chemical Society, 2019, 16 (9), pp.3814-3822. ⟨10.1021/acs.molpharmaceut.9b00416⟩. ⟨hal-02301225⟩
  • Romain Chautard, Sajida Ibrahim, Maxime Gueguinou, Thierry Lecomte, William Raoul. micro-ARN et cancer colorectal. Hépato-Gastro & Oncologie Digestive, John Libbey Eurotext, 2019, ⟨10.1684/hpg.2019.1896⟩. ⟨hal-02438640⟩
  • Sajida Ibrahim, Hassan Dakik, Christophe Vandier, Romain Chautard, Gilles Paintaud, et al.. Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer. Cancers, MDPI, 2019, 11 (4), pp.561. ⟨10.3390/cancers11040561⟩. ⟨inserm-02152189⟩
  • Christophe Roubeix, Elisa Dominguez, William Raoul, Xavier Guillonneau, Michel Paques, et al.. Mo-derived perivascular macrophage recruitment protects against endothelial cell death in retinal vein occlusion. Journal of Neuroinflammation, BioMed Central, 2019, 16 (1), ⟨10.1186/s12974-019-1547-8⟩. ⟨inserm-02279956⟩
  • Sajida Ibrahim, William Raoul, Thierry Lecomte, Gilles Paintaud, David Ternant. Pharmacokinetics partly explains the relationship between carcinoembryonic antigen level and survival of colorectal cancer patients treated with ramucirumab. European Journal of Cancer, Elsevier, 2018, 92, pp.119 - 120. ⟨10.1016/j.ejca.2017.12.004⟩. ⟨inserm-01755511⟩
  • David Ternant, Nicolas Azzopardi, William Raoul, Theodora Bejan-Angoulvant, Gilles Paintaud. Influence of Antigen Mass on the Pharmacokinetics of Therapeutic Antibodies in Humans. Clinical Pharmacokinetics, Springer Verlag, In press, ⟨10.1007/s40262-018-0680-3⟩. ⟨hal-01821717⟩
  • Julie Auzoux, Gilles Boschetti, Widad Lahlou, Alexandre Aubourg, Alban Girault, et al.. Méthodes d'évaluation de la cicatrisation muqueuse des maladies inflammatoires chroniques de l'intestin (MICI). Hépato-Gastro & Oncologie Digestive, John Libbey Eurotext, 2017. ⟨hal-02438672⟩
  • Marzia Caldano, William Raoul, Theo Rispens, Antonio Bertolotto. Drug Efficacy Monitoring in Pharmacotherapy of Multiple Sclerosis with Biological Agents: Efficacy monitoring of biological agents in Multiple Sclerosis. Therapeutic Drug Monitoring, Lippincott, Williams & Wilkins, 2017, 39 (4), pp.350 - 355. ⟨10.1097/FTD.0000000000000393⟩. ⟨inserm-01755556⟩
  • Sajida Ibrahim, Alban Girault, Marc Ohresser, Emilie Lereclus, Gilles Paintaud, et al.. Monoclonal Antibodies Targeting the IL-17/IL-17RA Axis: An Opportunity to Improve the Efficiency of Anti-VEGF Therapy in Fighting Metastatic Colorectal Cancer?. Clinical Colorectal Cancer, Elsevier, 2017, ⟨10.1016/j.clcc.2017.10.003⟩. ⟨inserm-01661759⟩
  • Bertrand Calippe, Sébastien Augustin, Fanny Beguier, Hugo Charles-Messance, Lucie Poupel, et al.. Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. Immunity, Elsevier, 2017, 46 (2), pp.261 - 272. ⟨10.1016/j.immuni.2017.01.006⟩. ⟨inserm-01755551⟩
  • Serge Camelo, Sophie Lavalette, Xavier Guillonneau, William Raoul, Florian Sennlaub. Association of choroidal IL-17-producing T lymphocytes and macrophages with geographic atrophy. Ophthalmologica, Karger, 2016, 236 (1), pp.53-58. ⟨10.1159/000446587⟩. ⟨inserm-01499605⟩
  • Emilie Lereclus, Mira Tout, Alban Girault, Nadine Baroukh, Morgane Caulet, et al.. A possible association of baseline serum IL-17A concentrations with progression-free survival of metastatic colorectal cancer patients treated with a bevacizumab-based regimen. BMC Cancer, BioMed Central, 2016, 17 (1), pp.220. ⟨10.1186/s12885-017-3210-z⟩. ⟨inserm-01661765⟩
  • Sonia Selbonne, Deborah Francois, William Raoul, Yacine Boulaftali, Florian Sennlaub, et al.. Protease nexin-1 regulates retinal vascular development. Cellular and Molecular Life Sciences, Springer Verlag, 2015, 72 (20), pp.3999-4011. ⟨10.1007/s00018-015-1972-5⟩. ⟨inserm-01231082⟩
  • Olivier Levy, Bertrand Calippe, Sophie Lavalette, Shulong Hu, William Raoul, et al.. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration. EMBO Molecular Medicine, Wiley Open Access, 2015, 7 (2), pp.211-26. ⟨10.15252/emmm.201404524⟩. ⟨inserm-01231055⟩
  • Olivier Levy, Sophie Lavalette, Shulong Hu, Michael Housset, William Raoul, et al.. APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. Journal of Neuroscience, Society for Neuroscience, 2015, 35 (40), pp.13568-13576. ⟨10.1523/JNEUROSCI.2468-15.2015⟩. ⟨hal-02301206⟩
  • Elisa Dominguez, William Raoul, Bertrand Calippe, José-Alain Sahel, Xavier Guillonneau, et al.. Experimental Branch Retinal Vein Occlusion Induces Upstream Pericyte Loss and Vascular Destabilization. PLoS ONE, Public Library of Science, 2015, 10 (7), pp.e0132644. ⟨10.1371/journal.pone.0132644.g006⟩. ⟨inserm-01231103⟩
  • Serge Camelo, Bertrand Calippe, Sophie Lavalette, Elisa Dominguez, Justine Hur, et al.. Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice. Molecular Vision, Molecular Vision, 2015, 21, pp.1051-9. ⟨inserm-01231077⟩
  • Adeline Berger, Sophie Cavallero, Elisa Dominguez, Peggy Barbe, Manuel Simonutti, et al.. Spectral-domain optical coherence tomography of the rodent eye: highlighting layers of the outer retina using signal averaging and comparison with histology.. PLoS ONE, Public Library of Science, 2014, 9 (5), pp.e96494. ⟨10.1371/journal.pone.0096494⟩. ⟨hal-00990132⟩
  • Christophe Combadière, William Raoul, Xavier Guillonneau, Florian Sennlaub. Comment on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration" by Luhmann et al. (Exp. Eye Res. 2013; 107: 80.doi: 10.1016).. Experimental Eye Research, Elsevier, 2013, 111, pp.134-5. ⟨10.1016/j.exer.2013.02.002⟩. ⟨inserm-00990798⟩
  • Elsa Kermorvant-Duchemin, Alexis Christophe Pinel, Sophie Lavalette, Delphine Lenne, William Raoul, et al.. Neonatal Hyperglycemia Inhibits Angiogenesis and Induces Inflammation and Neuronal Degeneration in the Retina. PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e79545. ⟨10.1371/journal.pone.0079545⟩. ⟨hal-02301188⟩
  • Florian Sennlaub, Constance Auvynet, Bertrand Calippe, Sophie Lavalette, Lucie Poupel, et al.. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.. EMBO Molecular Medicine, Wiley Open Access, 2013, 5 (11), pp.1775-93. ⟨10.1002/emmm.201302692⟩. ⟨inserm-00912837⟩
  • Serge Camelo, William Raoul, Sophie Lavalette, Bertrand Calippe, Brunella Cristofaro, et al.. Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.: DLL4's opposing effects in choroidal neovascularization. Angiogenesis, Springer Verlag, 2012, 15 (4), pp.609-22. ⟨10.1007/s10456-012-9290-0⟩. ⟨inserm-00853034⟩
  • William Raoul, Lucie Poupel, David-Alexandre Tregouet, Sophie Lavalette, Serge Camelo, et al.. MFGE8 Does Not Influence Chorio-Retinal Homeostasis or Choroidal Neovascularization in vivo.. PLoS ONE, Public Library of Science, 2012, 7 (3), pp.e33244. ⟨10.1371/journal.pone.0033244⟩. ⟨inserm-00690728⟩
  • Sophie Lavalette, William Raoul, Marianne Houssier, Serge Camelo, Olivier Levy, et al.. Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration.. American Journal of Pathology, American Society for Investigative Pathology, 2011, 178 (5), pp.2416-23. ⟨10.1016/j.ajpath.2011.01.013⟩. ⟨inserm-00690746⟩
  • William Raoul, Elise Lelièvre, Constance Auvynet, Charles Feumi, Christophe Combadière, et al.. Rôles des chimiokines dans le développement de la dégénérescence maculaire liée à l’âge. Biologie Aujourd'hui, EDP sciences, 2010, 204 (4), pp.311-319. ⟨10.1051/jbio/2010024⟩. ⟨hal-02301154⟩
  • Patricia Escoffier, Jean-Claude Jeanny, Carine Marinach-Patrice, Laurent Jonet, William Raoul, et al.. Toxoplasma gondii: Flat-mounting of retina as a new tool for the observation of ocular infection in mice. Experimental Parasitology, Elsevier, 2010, pp.259-262. ⟨10.1016/j.exppara.2010.04.006⟩. ⟨inserm-01094666⟩
  • William Raoul, Constance Auvynet, Serge Camelo, Xavier Guillonneau, Charles Feumi, et al.. CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration.: chemokines in AMD. Journal of Neuroinflammation, BioMed Central, 2010, 7, pp.87. ⟨10.1186/1742-2094-7-87⟩. ⟨inserm-00610572v2⟩
  • Marianne Houssier, William Raoul, Sophie Lavalette, Nicole Keller, Xavier Guillonneau, et al.. CD36 Deficiency Leads to Choroidal Involution via COX2 Down-Regulation in Rodents.. PLoS Medicine, Public Library of Science, 2008, 5 (2), pp.e39. ⟨10.1371/journal.pmed.0050039⟩. ⟨inserm-00258554⟩
  • Esma Lejmi, Laurence Leconte, Sandrine Pédron-Mazoyer, Stanislas Ropert, William Raoul, et al.. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2008, 105 (34), pp.12491-6. ⟨10.1073/pnas.0804008105⟩. ⟨inserm-00315946⟩
  • Mathieu Rodéro, Yannick Marie, Mathieu Coudert, Emmeline Blondet, Karima Mokhtari, et al.. Polymorphism in the Microglial Cell-Mobilizing CX3CR1 Gene Is Associated With Survival in Patients With Glioblastoma. Journal of Clinical Oncology, American Society of Clinical Oncology, 2008, 26 (36), pp.5957-5964. ⟨10.1200/JCO.2008.17.2833⟩. ⟨hal-02301138⟩
  • William Raoul, Charles Feumi, Nicole Keller, Sophie Lavalette, Marianne Houssier, et al.. Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice.. Ophthalmic Research, Karger, 2008, 40 (3-4), pp.115-9. ⟨10.1159/000119860⟩. ⟨inserm-00315944⟩
  • William Raoul, Nicole Keller, Mathieu Rodéro, Francine Behar-Cohen, Florian Sennlaub, et al.. Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells.. Journal of Neuroimmunology, Elsevier, 2008, 198 (1-2), pp.56-61. ⟨10.1016/j.jneuroim.2008.04.014⟩. ⟨inserm-00311574⟩
  • William Raoul, Orianne Wagner-Ballon, Guitanouch Saber, Anne Hulin, Elisabeth Marcos, et al.. Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice.. Respiratory Research, BioMed Central, 2007, 8, pp.8. ⟨10.1186/1465-9921-8-8⟩. ⟨inserm-00130570⟩
  • Christophe Combadière, Charles Feumi, William Raoul, Nicole Keller, Mathieu Rodéro, et al.. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.. Journal of Clinical Investigation, American Society for Clinical Investigation, 2007, 117 (10), pp.2920-2928. ⟨10.1172/JCI31692⟩. ⟨inserm-00176389⟩
  • Christophe Guignabert, Bernadette Raffestin, Rima Benferhat, William Raoul, Patricia Zadigue, et al.. Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.: 5-HT Transporter Inhibition Prevents PH. Circulation, American Heart Association, 2005, 111 (21), pp.2812-9. ⟨10.1161/CIRCULATIONAHA.104.524926⟩. ⟨inserm-00499643⟩
  • William Raoul, Bernadette Chailley-Heu, Anne-Marie Barlier-Mur, Christophe Delacourt, Bernard Maitre, et al.. Effects of vascular endothelial growth factor on isolated fetal alveolar type II cells. American Journal of Physiology - Lung Cellular and Molecular Physiology, American Physiological Society, 2004, 286 (6), pp.L1293 - L1301. ⟨10.1152/ajplung.00157.2003⟩. ⟨inserm-01755344⟩
  • Vanessa Louzier, William Raoul, Aude Leroux, Didier Branellec, Jean-Michel Caillaud, et al.. Adenovirus-mediated fibroblast growth factor 1 expression in the lung induces epithelial cell proliferation: consequences to hyperoxic lung injury in rats.. Human Gene Therapy, Mary Ann Liebert, 2004, 15 (8), pp.793-804. ⟨10.1089/1043034041648390⟩. ⟨inserm-00990784⟩
  • Marie-Aude Pascaud, Frank Griscelli, William Raoul, Elisabeth Marcos, Paule Opolon, et al.. Lung Overexpression of Angiostatin Aggravates Pulmonary Hypertension in Chronically Hypoxic Mice. American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2003, 29, pp.449 - 457. ⟨10.1165/rcmb.2002-0120OC⟩. ⟨inserm-01094673⟩