Nombre de documents


CV William Raoul

Recrutement CR2 INSERM : 1er Octobre 2009 - Nomination CR1 INSERM : 1er Janvier 2013



2017 : Habilitation à Diriger des Recherches, Sciences de la Vie et de la Santé, Université François Rabelais de Tours.


2005 : Doctorat de Sciences de la Vie et de la Santé, Toxicologie, Université Paris XII-Créteil.


2001 : Diplôme d'études approfondies, Toxicologie, Université Paris V-Descartes.


2000 : Maîtrise de Biologie Cellulaire et Physiologie Animale, Université Paris XII-Créteil.



2013 - 2017 : équipe A2RC, CNRS UMR 7292, Université François Rabelais, Tours

Directeur d’équipe : Gilles Paintaud / Directeur d’Unité : Gilles Paintaud


2012-2013 : équipe S14, INSERM UMR S 968, Institut de la Vision, Paris

Directeur d’équipe : Florian Sennlaub / Directeur de l’Institut : José-Alain Sahel 


2009-2011 : équipe 21, INSERM UMR S 872, Centre de Recherche des Cordeliers, Paris

Directeur d’équipe : Florian Sennlaub / Directeur du Centre : Wolf Hervé Fridman 


2006-2008 : équipe 17, INSERM UMR S 872, Centre de Recherche des Cordeliers, Paris

Directeur d’équipe : Francine Behar-Cohen / Directeur du Centre : Wolf Hervé Fridman


2001-2005 : INSERM U651 (ex-U492), Faculté de Médecine, Créteil

Directeur de Thèse : Bernard Maitre / Directeur d’Unité : Serge Adnot

Article dans une revue30 documents

  • Sajida Ibrahim, William Raoul, Thierry Lecomte, Gilles Paintaud, David Ternant. Pharmacokinetics partly explains the relationship between carcinoembryonic antigen level and survival of colorectal cancer patients treated with ramucirumab. European Journal of Cancer, Elsevier, 2018, 92, pp.119 - 120. 〈10.1016/j.ejca.2017.12.004〉. 〈inserm-01755511〉
  • David Ternant, Nicolas Azzopardi, William Raoul, Theodora Bejan-Angoulvant, Gilles Paintaud. Influence of Antigen Mass on the Pharmacokinetics of Therapeutic Antibodies in Humans. Clinical Pharmacokinetics, Springer Verlag, In press, 〈10.1007/s40262-018-0680-3〉. 〈hal-01821717〉
  • Sajida Ibrahim, Alban Girault, Marc Ohresser, Emilie Lereclus, Gilles Paintaud, et al.. Monoclonal Antibodies Targeting the IL-17/IL-17RA Axis: An Opportunity to Improve the Efficiency of Anti-VEGF Therapy in Fighting Metastatic Colorectal Cancer?. Clinical Colorectal Cancer, Elsevier, 2017, 〈10.1016/j.clcc.2017.10.003〉. 〈inserm-01661759〉
  • Bertrand Calippe, Sébastien Augustin, Fanny Beguier, Hugo Charles-Messance, Lucie Poupel, et al.. Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. Immunity, Elsevier, 2017, 46 (2), pp.261 - 272. 〈10.1016/j.immuni.2017.01.006〉. 〈inserm-01755551〉
  • Marzia Caldano, William Raoul, Theo Rispens, Antonio Bertolotto. Drug Efficacy Monitoring in Pharmacotherapy of Multiple Sclerosis with Biological Agents: Efficacy monitoring of biological agents in Multiple Sclerosis. Therapeutic Drug Monitoring, Lippincott, Williams & Wilkins, 2017, 39 (4), pp.350 - 355. 〈10.1097/FTD.0000000000000393〉. 〈inserm-01755556〉
  • Emilie Lereclus, Mira Tout, Alban Girault, Nadine Baroukh, Morgane Caulet, et al.. A possible association of baseline serum IL-17A concentrations with progression-free survival of metastatic colorectal cancer patients treated with a bevacizumab-based regimen. BMC Cancer, BioMed Central, 2016, 17 (1), pp.220. 〈10.1186/s12885-017-3210-z〉. 〈inserm-01661765〉
  • Serge Camelo, Sophie Lavalette, Xavier Guillonneau, William Raoul, Florian Sennlaub. Association of choroidal IL-17-producing T lymphocytes and macrophages with geographic atrophy. Ophthalmologica, Karger, 2016, 236 (1), pp.53-58. 〈10.1159/000446587〉. 〈inserm-01499605〉
  • Julie Auzoux, Gilles Boschetti, Widad Lahlou, Alexandre Aubourg, Alban Girault, et al.. Assessment of Mucosal Healing in Inflammatory Bowel Disease. Journal of Clinical Gastroenterology and Hepatology, iMedPub Journals, 2016, 1 (1), Epub ahead of print. 〈10.21767/2575-7733.1000002〉. 〈inserm-01755525〉
  • Elisa Dominguez, William Raoul, Bertrand Calippe, José-Alain Sahel, Xavier Guillonneau, et al.. Experimental Branch Retinal Vein Occlusion Induces Upstream Pericyte Loss and Vascular Destabilization. PLoS ONE, Public Library of Science, 2015, 10 (7), pp.e0132644. 〈10.1371/journal.pone.0132644.g006〉. 〈inserm-01231103〉
  • Olivier Levy, Bertrand Calippe, Sophie Lavalette, Shulong Hu, William Raoul, et al.. Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration. EMBO Molecular Medicine, Wiley Open Access, 2015, 7 (2), pp.211-26. 〈10.15252/emmm.201404524〉. 〈inserm-01231055〉
  • Serge Camelo, Bertrand Calippe, Sophie Lavalette, Elisa Dominguez, Justine Hur, et al.. Thinning of the RPE and choroid associated with T lymphocyte recruitment in aged and light-challenged mice. Molecular Vision, Molecular Vision, 2015, 21, pp.1051-9. 〈inserm-01231077〉
  • Sonia Selbonne, Deborah Francois, William Raoul, Yacine Boulaftali, Florian Sennlaub, et al.. Protease nexin-1 regulates retinal vascular development. Cellular and Molecular Life Sciences, Springer Verlag, 2015, 72 (20), pp.3999-4011. 〈10.1007/s00018-015-1972-5〉. 〈inserm-01231082〉
  • Adeline Berger, Sophie Cavallero, Elisa Dominguez, Peggy Barbe, Manuel Simonutti, et al.. Spectral-domain optical coherence tomography of the rodent eye: highlighting layers of the outer retina using signal averaging and comparison with histology.. PLoS ONE, Public Library of Science, 2014, 9 (5), pp.e96494. 〈10.1371/journal.pone.0096494〉. 〈hal-00990132〉
  • Christophe Combadière, William Raoul, Xavier Guillonneau, Florian Sennlaub. Comment on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration" by Luhmann et al. (Exp. Eye Res. 2013; 107: 80.doi: 10.1016).. Experimental Eye Research, Elsevier, 2013, 111, pp.134-5. 〈10.1016/j.exer.2013.02.002〉. 〈inserm-00990798〉
  • Florian Sennlaub, Constance Auvynet, Bertrand Calippe, Sophie Lavalette, Lucie Poupel, et al.. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice.. EMBO Molecular Medicine, Wiley Open Access, 2013, 5 (11), pp.1775-93. 〈10.1002/emmm.201302692〉. 〈inserm-00912837〉
  • William Raoul, Lucie Poupel, David-Alexandre Tregouet, Sophie Lavalette, Serge Camelo, et al.. MFGE8 Does Not Influence Chorio-Retinal Homeostasis or Choroidal Neovascularization in vivo.. PLoS ONE, Public Library of Science, 2012, 7 (3), pp.e33244. 〈10.1371/journal.pone.0033244〉. 〈inserm-00690728〉
  • Serge Camelo, William Raoul, Sophie Lavalette, Bertrand Calippe, Brunella Cristofaro, et al.. Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.: DLL4's opposing effects in choroidal neovascularization. Angiogenesis, Springer Verlag, 2012, 15 (4), pp.609-22. 〈10.1007/s10456-012-9290-0〉. 〈inserm-00853034〉
  • Sophie Lavalette, William Raoul, Marianne Houssier, Serge Camelo, Olivier Levy, et al.. Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration.. American Journal of Pathology, American Society for Investigative Pathology, 2011, 178 (5), pp.2416-23. 〈10.1016/j.ajpath.2011.01.013〉. 〈inserm-00690746〉
  • William Raoul, Constance Auvynet, Serge Camelo, Xavier Guillonneau, Charles Feumi, et al.. CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration.: chemokines in AMD. Journal of Neuroinflammation, BioMed Central, 2010, 7, pp.87. 〈10.1186/1742-2094-7-87〉. 〈inserm-00610572v2〉
  • Patricia Escoffier, Jean-Claude Jeanny, Carine Marinach-Patrice, Laurent Jonet, William Raoul, et al.. Toxoplasma gondii: Flat-mounting of retina as a new tool for the observation of ocular infection in mice. Experimental Parasitology, Elsevier, 2010, pp.259-262. 〈10.1016/j.exppara.2010.04.006〉. 〈inserm-01094666〉
  • William Raoul, Nicole Keller, Mathieu Rodéro, Francine Behar-Cohen, Florian Sennlaub, et al.. Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells.. Journal of Neuroimmunology, Elsevier, 2008, 198 (1-2), pp.56-61. 〈10.1016/j.jneuroim.2008.04.014〉. 〈inserm-00311574〉
  • Marianne Houssier, William Raoul, Sophie Lavalette, Nicole Keller, Xavier Guillonneau, et al.. CD36 Deficiency Leads to Choroidal Involution via COX2 Down-Regulation in Rodents.. PLoS Medicine, Public Library of Science, 2008, 5 (2), pp.e39. 〈10.1371/journal.pmed.0050039〉. 〈inserm-00258554〉
  • William Raoul, Charles Feumi, Nicole Keller, Sophie Lavalette, Marianne Houssier, et al.. Lipid-bloated subretinal microglial cells are at the origin of drusen appearance in CX3CR1-deficient mice.. Ophthalmic Research, Karger, 2008, 40 (3-4), pp.115-9. 〈10.1159/000119860〉. 〈inserm-00315944〉
  • Esma Lejmi, Laurence Leconte, Sandrine Pédron-Mazoyer, Stanislas Ropert, William Raoul, et al.. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2008, 105 (34), pp.12491-6. 〈10.1073/pnas.0804008105〉. 〈inserm-00315946〉
  • William Raoul, Orianne Wagner-Ballon, Guitanouch Saber, Anne Hulin, Elisabeth Marcos, et al.. Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice.. Respir Res, 2007, 8, pp.8. 〈10.1186/1465-9921-8-8〉. 〈inserm-00130570〉
  • Christophe Combadière, Charles Feumi, William Raoul, Nicole Keller, Mathieu Rodéro, et al.. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.. Journal of Clinical Investigation, American Society for Clinical Investigation, 2007, 117 (10), pp.2920-2928. 〈10.1172/JCI31692〉. 〈inserm-00176389〉
  • Christophe Guignabert, Bernadette Raffestin, Rima Benferhat, William Raoul, Patricia Zadigue, et al.. Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats.: 5-HT Transporter Inhibition Prevents PH. Circulation, American Heart Association, 2005, 111 (21), pp.2812-9. 〈10.1161/CIRCULATIONAHA.104.524926〉. 〈inserm-00499643〉
  • Vanessa Louzier, William Raoul, Aude Leroux, Didier Branellec, Jean-Michel Caillaud, et al.. Adenovirus-mediated fibroblast growth factor 1 expression in the lung induces epithelial cell proliferation: consequences to hyperoxic lung injury in rats.. Human Gene Therapy, Mary Ann Liebert, 2004, 15 (8), pp.793-804. 〈10.1089/1043034041648390〉. 〈inserm-00990784〉
  • William Raoul, Bernadette Chailley-Heu, Anne-Marie Barlier-Mur, Christophe Delacourt, Bernard Maitre, et al.. Effects of vascular endothelial growth factor on isolated fetal alveolar type II cells. American Journal of Physiology - Lung Cellular and Molecular Physiology, American Physiological Society, 2004, 286 (6), pp.L1293 - L1301. 〈10.1152/ajplung.00157.2003〉. 〈inserm-01755344〉
  • Marie-Aude Pascaud, Frank Griscelli, William Raoul, Elisabeth Marcos, Paule Opolon, et al.. Lung Overexpression of Angiostatin Aggravates Pulmonary Hypertension in Chronically Hypoxic Mice. American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2003, 29, pp.449 - 457. 〈10.1165/rcmb.2002-0120OC〉. 〈inserm-01094673〉