Recherche - Archive ouverte HAL Accéder directement au contenu

Filtrer vos résultats

45 résultats

Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.

Laurent Gavara , Virginie Suchaud , Lionel Nauton , Vincent Théry , Fabrice Anizon , et al.
Bioorganic and Medicinal Chemistry Letters, 2013, 23 (8), pp.2298-2301. ⟨10.1016/j.bmcl.2013.02.074⟩
Article dans une revue istex hal-01089114v1

12-Helix folding of cyclobutane beta-amino acid oligomers

Carlos Fernandes , Sophie Faure , Elisabeth Pereira , Vincent Thery , Valérie Declerck , et al.
Organic Letters, 2010, 12, pp.3606-3609. ⟨10.1021/ol101267u⟩
Article dans une revue hal-00530671v1

Water-Soluble Gold–N-Heterocyclic Carbene Complexes for the Catalytic Homogeneous Acid- and Silver-Free Hydration of Hydrophilic Alkynes.

Houssein Ibrahim , Pierre De frémont , Pierre Braunstein , Vincent Théry , Lionel Nauton , et al.
Advanced Synthesis and Catalysis, 2015, 357, pp.3893-3900. ⟨10.1002/adsc.201500729⟩
Article dans une revue istex hal-01264762v1

Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition

Virginie Suchaud , Laurent Gavara , Francis Giraud , Lionel Nauton , Vincent Théry , et al.
Bioorganic and Medicinal Chemistry, 2014, 22, pp.4704-4710. ⟨10.1016/j.bmc.2014.07.011⟩
Article dans une revue hal-01077451v1

Synthesis and Solution Conformation of Homo-β-peptides Consisting of N-Mannofuranosyl-3-ulosonic acids

Manuel Andreini , Claude Taillefumier , Francoise Chrétien , Vincent Thery , Yves Chapleur
Journal of Organic Chemistry, 2009, 74, pp.7651-7659
Article dans une revue hal-00435712v1

Study of Bruylants' reaction

Elisabeth Pereira , David J Aitken , Virginie Beaufort , Vincent Thery
Journées de Chimie Organique, Sep 2004, Palaiseau, France
Communication dans un congrès hal-00138706v1

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

Rufine Akué-Gédu , Lionel Nauton , Vincent Thery , Jenny Bain , Philip Cohen , et al.
Bioorganic and Medicinal Chemistry, 2010, 18, pp.6865-6873
Article dans une revue hal-00530591v1

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives.

Wael Zeinyeh , Yannick J. Esvan , Lionel Nauton , Nadège Loaëc , Laurent Meijer , et al.
Bioorganic and Medicinal Chemistry Letters, 2016, 26, pp.4327-4329. ⟨10.1016/j.bmcl.2016.07.032⟩
Article dans une revue hal-01367659v1

Palladium catalyzed intramolecular allylic amination: diastereoselective synthesis of 2,6-disubstituted 1,2,3,6-tetrahydropyridines.

A. Visseq , T. Boibessot , L. Nauton , V. Théry , F. Anizon , et al.
Congrès des jeunes Chercheurs de la Société de Chimie Thérapeutique, Feb 2019, Paris, France
Poster de conférence hal-02295647v1

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co–crystal structure.

Yannick J. Esvan , Wael Zeinyeh , Thibaut Boibessot , Lionel Nauton , Vincent Théry , et al.
European Journal of Medicinal Chemistry, 2016, 118, pp.170-177. ⟨10.1016/j.ejmech.2016.04.004⟩
Article dans une revue hal-01308803v1

Synthesis and molecular modelling study of new trimeric quinoline derivatives

Emmanuelle Saugues , Lionel Nauton , Vincent Thery , Fabrice Anizon , Pascale Moreau
Bioorganic Chemistry, 2011, 39, pp.143-150
Article dans une revue hal-00625030v1

Contribution à la modélisation de la réactivité dans les macromolécules biologiques

Vincent Thery
Autre. Université Henri Poincaré - Nancy 1, 1993. Français. ⟨NNT : 1993NAN10262⟩
Thèse tel-01753642v1

Insights into the Thiamine Diphosphate Enzyme Activation Mechanism: Computational Model for Transketolase Using a Quantum Mechanical/Molecular Mechanical Method.

Lionel Nauton , Virgil Hélaine , Vincent Théry , Laurence Hecquet
Biochemistry, 2016, 55, pp.2144-2152. ⟨10.1021/acs.biochem.5b00787⟩
Article dans une revue hal-01323789v1

Optimization of the synthesis of a key intermediate for the preparation of glucocorticoids

Romain Jouve , Vincent Thery , Sylvie Ducki , Julie Helfenbein , Christophe Thiery , et al.
Steroids, 2018, 137, pp.14 - 21. ⟨10.1016/j.steroids.2018.06.007⟩
Article dans une revue hal-01875170v1
Image document

Synthesis and glycosidase inhibitory study of new polyhydroxylated indolizidines

Delphine Baumann , Khalil Bennis , Isabelle Ripoche , Vincent Thery , Yves Troin
European Journal of Organic Chemistry, 2008, pp.5289-5300
Article dans une revue hal-00345106v1
Image document

QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle

Lionel Nauton , Laurence Hecquet , Vincent Théry
Journal of Chemical Information and Modeling, 2021, ⟨10.1021/acs.jcim.1c00190⟩
Article dans une revue hal-03286397v1

Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives.

Francis Giraud , Georges Alves , Eric Debiton , Lionel Nauton , Vincent Thery , et al.
Journal of Medicinal Chemistry, 2011, 54, pp.4474-4489
Article dans une revue hal-00609607v1
Image document

Cyclic b-peptoids

Olivier Roy , Sophie Faure , Vincent Thery , C. Didierjean , Claude Taillefumier
Organic Letters, 2008, 10, pp.921-924
Article dans une revue hal-00265039v1
Image document

Preparation of non-racemic single-stereocentre a-aminonitriles and a study of their fate in Bruylants reactions.

Virginie Beaufort-Droal , Elisabeth Pereira , Vincent Thery , David J Aitken
Tetrahedron, 2006, 62, pp.11948-11954. ⟨10.1016/j.tet.2006.09.087⟩
Article dans une revue hal-00118398v1

Micelle dynamic simulation and physicochemical characterization of biorelevant media to reflect gastrointestinal environment in fasted and fed states

Xiaoyu Xie , Jean-Michel Cardot , Ghislain Garrait , Vincent Thery , Mohamed El-Hajji , et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2014, 88, pp.565-573. ⟨10.1016/j.ejpb.2014.05.020⟩
Article dans une revue hal-01082838v1

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

Yannick J. Esvan , Francis Giraud , Elisabeth Pereira , Virginie Suchaud , Lionel Nauton , et al.
Bioorganic and Medicinal Chemistry, 2016, 24, pp.3116-3124. ⟨10.1016/j.bmc.2016.05.032⟩
Article dans une revue hal-01367761v1

Structure-Based Design of PDZ Ligands as Inhibitors of 5-HT2A Receptor/PSD-95 PDZ1 Domain Interaction Possessing Anti-hyperalgesic Activity

Alexandre Vogrig , Liam Dorr , Naoual Bouzidi , Benjamin Boucherle , Anne-Sophie Wattiez , et al.
ACS Chemical Biology, 2013, 8, pp.2209-2216. ⟨10.1021/cb400308u⟩
Article dans une revue hal-00948867v1

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles

Fabrice Anizon , Rufine Akué-Gédu , Lionel Nauton , Vincent Thery , J. Bain , et al.
17th European Symposium on Organic Chemistry, Hersonissos (Grèce), 10-15 juillet 2011, Jul 2011, Hersonissos, Greece
Communication dans un congrès hal-00609939v1

Synthesis, protein kinase inhibitory potencies and in vitro antiproliferative activities of meridianin derivatives

Pascale Moreau , Francis Giraud , Elisabeth Pereira , Fabrice Anizon , Georges Alves , et al.
17th European Symposium on Organic Chemistry, Jul 2011, Hersonissos, Greece
Communication dans un congrès hal-00609975v1

Fructose-1,6-bisphosphate aldolase-mediated synthesis of aminocyclitols (analogues of valiolamine) and their evaluation as glycosidase inhibitors

Lahssen El Blidi , Zeinab Assaf , Flora Camps Bres , Henri Veschambre , Vincent Thery , et al.
ChemCatChem, 2009, 1, pp.463-471
Article dans une revue hal-00438420v1
Image document

Pyridin-2(1H)one derivatives: A possible new class of therapeutics for mechanical allodynia

Alexia Visseq , Amélie Descheemaeker , Nicolas Pinto-Pardo , Lionel Nauton , Vincent Thery , et al.
European Journal of Medicinal Chemistry, 2020, 187, pp.111917. ⟨10.1016/j.ejmech.2019.111917⟩
Article dans une revue hal-02444268v1

New N-1,N-10 bridged pyrrolo[2,3-a]carbazole-3-carbaldehyde: synthesis and biological activities.

Francis Giraud , Marion Bourhis , Lionel Nauton , Vincent Théry , Lars Herfindal , et al.
Bioorganic Chemistry, 2014, 57, pp.108-115. ⟨10.1016/j.bioorg.2014.09.004⟩
Article dans une revue hal-01077457v1

Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

Francis Giraud , Rufine Akué-Gédu , Lionel Nauton , Nicolas Candelon , Eric Debiton , et al.
European Journal of Medicinal Chemistry, 2012, 56, pp.225-236
Article dans une revue hal-00786353v1
Image document

Enzymatic Synthesis of Aliphatic Acyloins through Thermostable Transketolase Catalyzed-Reaction

Hubert Casajus , Aurélie Lagarde , Martin Leremboure , Thomas De Dios Miguel , Lionel Nauton , et al.
ChemCatChem, 2020, ⟨10.1002/cctc.202001160⟩
Article dans une revue hal-02995504v1
Image document

Mechanism of photochemical degradation of Fe(III)-EDDS complex

S. Jaber , M. Leremboure , V. Théry , A.-M. Delort , G. Mailhot
Journal of Photochemistry and Photobiology A: Chemistry, 2020, 399, pp.112646. ⟨10.1016/j.jphotochem.2020.112646⟩
Article dans une revue hal-02769495v1