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HUIN Vincent, M.D., Ph.D.


HUIN Vincent, M.D., Ph.D.






Associate professor in Biochemistry and Molecular Biology, University of Lille, France


Univ. Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S1172, Team "Alzheimer & Tauopathies" /


Tel: +33 359 899 605 / Fax: +33 320 538 562


French citizen








University of Lille, Faculty of Medicine, Bachelor of Medicine                                                           2007


University of Lille, B.Sc. (Master 1), Research in Biology-Health                                                         2005


University of Rouen, B.Sc. (Master 1), Medical/Pharmaceutical Sciences & Biology-Health         2009


University of Lille, M.Sc. (Master 2), Research in Biology-Health                                                         2011


University of Rouen and University Hospital of Rouen, M.D. Medical biology & genetics              2012


University of Paris Descartes, Paris (DIU), Diploma of Inborn errors of metabolism                         2013


National examination for the position of hospital doctor,Medical biology                                       2016


University of Lille, Ph.D in Neurosciences                                                                                                2016


University of Pierre et Marie Curie, Paris (DIU), Diploma of medical pedagogy                                 2019






University Hospital of Lille, Professional practice and internship                                                      2003-2007


University Hospital of Rouen, Postgraduate experience as Medical Intern                                      2007-2012


University Hospital of Lille, Specialty Registrar                                                                                     2012-2017


Institut du Cerveau et de la moelle épinière (ICM), Paris, PostPh.D.                                                   2017-2018


University of Lille and University Hospital of Lille, Associate professor                                           2018-present






Speech Therapy School of Lille, Head teacher in Biochemistry and Molecular Biology             2013-2016






Societies: Society for Neuroscience France; Association Nationale des Praticiens de Génétique Moléculaire (ANPGM); Société Française de Biochimie et Biologie Moléculaire; Collège national des Biochimistes et Biologistes Moléculaires Médicaux (CBBMM)


• Networks: Member of the clinical and genetics analysis of Spastic paraplegia and Ataxia network (European Spatax network); "BRAIN-TEAM": Filière de Santé Maladies Rares


Conference as invited speaker:


National scientific symposium of the charity « connaître les syndromes cérébelleux », France      2016


Reviewer for the journal “Orphanet Journal of Rare Diseases”, "Scientific Reports" and "Neurology: Genetics"


Journal articles15 documents

  • Ilda Coku, Eugénie Mutez, Sabiha Eddarkaoui, Sébastien Carrier, Antoine Marchand, et al.. Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease.. Movement disorders : official journal of the Movement Disorder Society, 2022, ⟨10.1002/mds.29124⟩. ⟨hal-03703786⟩
  • Vincent Huin, Mathieu Barbier, Alexandra Durr, Isabelle Le Ber. Reply: Two heterozygous Progranulin mutations in progressive supranuclear palsy. Brain - A Journal of Neurology , Oxford University Press (OUP), 2021, ⟨10.1093/brain/awaa456⟩. ⟨hal-03113276⟩
  • Vincent Huin, Giulia Coarelli, Clément Guemy, Susana Boluda, Rabab Debs, et al.. Motor neuron pathology in CANVAS due to RFC1 expansions. Brain - A Journal of Neurology , Oxford University Press (OUP), 2021, pp.awab449. ⟨10.1093/brain/awab449⟩. ⟨hal-03540380⟩
  • Mégane Homa, Anne Loyens, Sabiha Eddarkaoui, Emilie Faivre, Vincent Deramecourt, et al.. The TMEM240 Protein, Mutated in SCA21, Is Expressed in Purkinje Cells and Synaptic Terminals: TMEM240 localization in the cerebellum. The Cerebellum, Springer, In press, Ahead of print. ⟨10.1007/s12311-020-01112-y⟩. ⟨inserm-02463227v2⟩
  • Vincent Huin, Mathieu Barbier, Alexandra Durr, Isabelle Le Ber. Reply: Early-onset phenotype of bi-allelic GRN mutations. Brain - A Journal of Neurology , Oxford University Press (OUP), 2020, ⟨10.1093/brain/awaa415⟩. ⟨hal-03113239⟩
  • Vincent Huin, Mathieu Barbier, Armand Bottani, Johannes Alexander Lobrinus, Fabienne Clot, et al.. Homozygous GRN mutations: unexpected phenotypes and new insights into pathological and molecular mechanisms: New insights in homozygous GRN mutations. Brain - A Journal of Neurology , Oxford University Press (OUP), 2020, 143 (1), pp.303-319. ⟨10.1093/brain/awz377⟩. ⟨inserm-03014481v2⟩
  • Fábio Carneiro, Dario Saracino, Vincent Huin, Fabienne Clot, Cécile Delorme, et al.. Isolated parkinsonism is an atypical presentation of GRN and C9orf72 gene mutations Authors. Parkinsonism and Related Disorders, Elsevier, 2020, 80, pp.73-81. ⟨10.1016/j.parkreldis.2020.09.019⟩. ⟨hal-03146705⟩
  • Vincent Huin, Claire-Marie Dhaenens, Mégane Homa, Kévin Carvalho, Luc Buée, et al.. Neurogenetics of the Human Adenosine Receptor Genes: Genetic Structures and Involvement in Brain Diseases. Journal of Caffeine and Adenosine Research, New Rochelle, N.Y. : Mary Ann Liebert, Inc., [2018]-, 2019, 9 (3), pp.73-88. ⟨10.1089/caff.2019.0011⟩. ⟨inserm-02460598⟩
  • Kevin Carvalho, Emilie Faivre, Marie Pietrowski, Xavier Marques, Victoria Gomez-Murcia, et al.. Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor. Brain - A Journal of Neurology , Oxford University Press (OUP), 2019, 142 (11), pp.3636-3654. ⟨10.1093/brain/awz288⟩. ⟨inserm-02350065⟩
  • Vincent Huin, Isabelle Strubi-Vuillaume, Kathy Dujardin, Marine Brion, Marie Delliaux, et al.. Expanding the phenotype of SCA19/22: Parkinsonism, cognitive impairment and epilepsy. Parkinsonism and Related Disorders, Elsevier, 2017, Parkinsonism & related disorders, 45, pp.85-89. ⟨10.1016/j.parkreldis.2017.09.014⟩. ⟨hal-02467104v2⟩
  • Vincent Huin, Vincent Deramecourt, Dominique Caparros-Lefebvre, Claude Alain Maurage, Charles Duyckaerts, et al.. Alternative promoter usage generates novel shorter MAPT mRNA transcripts in Alzheimer’s disease and progressive supranuclear palsy brains. Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.12589. ⟨10.1038/s41598-017-12955-7⟩. ⟨inserm-02460428⟩
  • Vincent Huin, Vincent Deramecourt, Dominique Caparros-Lefebvre, Claude-Alain Maurage, Charles Duyckaerts, et al.. The MAPT gene is differentially methylated in the progressive supranuclear palsy brain: Hypomethylation of MAPT in PSP brain. Movement Disorders, Wiley, 2016, 31 (12), pp.1883-1890. ⟨10.1002/mds.26820⟩. ⟨hal-03015965v2⟩
  • Dominique Caparros-Lefebvre, Lawrence I Golbe, Vincent Deramecourt, Claude-Alain Maurage, Vincent Huin, et al.. A geographical cluster of progressive supranuclear palsy in northern France. Neurology, American Academy of Neurology, 2015, 85 (15), pp.1293-1300. ⟨10.1212/WNL.0000000000001997⟩. ⟨inserm-02460488⟩
  • Jérôme Delplanque, David Devos, Vincent Huin, Alexandre Genet, Olivier Sand, et al.. TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment. Brain - A Journal of Neurology , Oxford University Press (OUP), 2014, 137 (10), pp.2657-2663. ⟨10.1093/brain/awu202⟩. ⟨inserm-03017555⟩
  • Vincent Huin, Francis Vasseur, Susanna Schraen-Maschke, Claire-Marie Dhaenens, Patrick Devos, et al.. MBNL1 gene variants as modifiers of disease severity in myotonic dystrophy type 1. Journal of Neurology, Springer Verlag, 2013, 260 (4), pp.998-1003. ⟨10.1007/s00415-012-6740-y⟩. ⟨hal-03555357⟩

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