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Vincent AUCAGNE

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EDUCATION --------- - 1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology - 1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans PROFESSIONAL EXPERIENCES ------------------------ - 2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins - 2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures - 2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities - 1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions - 1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates RESEARCH INTERESTS ------------------ - Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery. - Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification - Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry - Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry. - Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies

Publications

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Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights

Charlotte Rieux , Stéphane Goffinont , Franck Coste , Zahira Tber , Julien Cros
International Journal of Molecular Sciences, 2020, 21 (6), pp.2058. ⟨10.3390/ijms21062058⟩
Article dans une revue hal-03082414v1

Study of different copper(I) catalysts for the "click chemistry" approach to carbanucleosides

J. Broggi , N. Joubert , Vincent Aucagne , T. Zevaco , S. Berteina-Raboin
Nucleosides, Nucleotides and Nucleic Acids, 2007, 26, pp.779-783
Article dans une revue hal-00275217v1

Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis

Julie Broggi , Nicolas Joubert , Vincent Aucagne , Sabine Berteina-Raboin , S. Diez-Gonzalez
Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 (10-12), pp.1391-1394. ⟨10.1080/15257770701534139⟩
Article dans une revue hal-02086003v1

Highly Efficient AgNO3-Catalyzed Preparation of Substituted Furanopyrimidine Nucleosides [cf. (III)].

Vincent Aucagne , Franck Amblard , Luigi Agrofoglio
ChemInform, 2005, 36 (18), ⟨10.1002/chin.200518181⟩
Article dans une revue hal-02086027v1

Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series

Franck Amblard , Vincent Aucagne , Pierre Guenot , Raymond Schinazi , Luigi Agrofoglio
Bioorganic and Medicinal Chemistry, 2005, 13 (4), pp.1239-1248. ⟨10.1016/j.bmc.2004.11.057⟩
Article dans une revue hal-02086014v1

Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: Antiviral activity and cellular toxicity

Vanessa Escuret , Vincent Aucagne , Nicolas Joubert , David Durantel , Kimberly Rapp
Bioorganic and Medicinal Chemistry, 2005, 13 (21), pp.6015-6024. ⟨10.1016/j.bmc.2005.06.021⟩
Article dans une revue hal-02086013v1

Palladium-Catalyzed Synthesis of Uridines on Polystyrene-Based Solid Supports

Vincent Aucagne , Sabine Berteina-Raboin , Pierre Guenot , Luigi Agrofoglio
Journal of Combinatorial Chemistry, 2004, 6 (5), pp.717-723. ⟨10.1021/cc049976o⟩
Article dans une revue hal-02086022v1

Straightforward Synthesis of Labeled and Unlabeled Pyrimidine d4Ns via 2′,3′-Diyne seco Analogues through Olefin Metathesis Reactions

Isabelle Gillaizeau , Irene m. Lagoja , Steve p. Nolan , Vincent Aucagne , Jef Rozenski
European Journal of Organic Chemistry, 2003, 2003 (4), pp.666-671. ⟨10.1002/ejoc.200390107⟩
Article dans une revue hal-02086029v1