Vincent AUCAGNE
5
Documents
Identifiants chercheurs
- vincent-aucagne
- 0000-0002-2647-0188
- IdRef : 077138120
Présentation
EDUCATION
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- 1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology
- 1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans
PROFESSIONAL EXPERIENCES
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- 2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins
- 2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures
- 2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities
- 1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions
- 1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates
RESEARCH INTERESTS
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- Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery.
- Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification
- Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry
- Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry.
- Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies
Publications
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Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation4. GFPP Chemical Ligation Meeting (Ligation2020), Jan 2020, Orléans, France
Communication dans un congrès
hal-02892772v1
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Développement de bras enzymo-labiles pour la synthèse totale de protéines par ligations chimiques sur support solide32e Colloque Biotechnocentre, Oct 2019, Seillac, France
Communication dans un congrès
hal-02893386v1
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Synthesis of aryl-thioglycopeptides through chemoselective Pd-catalyzed conjugation26. American Peptide Symposium (APS 2019), Jun 2019, Monterey, Californie, United States
Poster de conférence
hal-02893419v1
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Synthesis of aryl-thioglycopeptides through chemoselective Pd-catalyzed conjugation21. Réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Poster de conférence
hal-02893488v1
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Development of chemo-enzymatic methodologies for the total synthesis of proteins through solid-supported chemical ligation31e Colloque Biotechnocentre, Oct 2018, Seillac, France
Poster de conférence
hal-02894152v1
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