Vincent AUCAGNE
5
Documents
Identifiants chercheurs
- vincent-aucagne
- 0000-0002-2647-0188
- IdRef : 077138120
Présentation
EDUCATION
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- 1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology
- 1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans
PROFESSIONAL EXPERIENCES
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- 2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins
- 2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures
- 2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities
- 1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions
- 1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates
RESEARCH INTERESTS
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- Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery.
- Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification
- Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry
- Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry.
- Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies
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The Ancestral N-Terminal Domain of Big Defensins Drives Bacterially Triggered Assembly into Antimicrobial NanonetsmBio, 2019, 10 (5), pii: e01821-19. ⟨10.1128/mBio.01821-19⟩
Article dans une revue
hal-02328576v1
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Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus , improves sperm motility and fertilization in different mammalian speciesMolecular Human Reproduction, 2017, 23 (2), pp.116-131. ⟨10.1093/molehr/gaw075⟩
Article dans une revue
hal-01618630v1
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NCL-based total synthesis of spermaurin, a scorpion venom disulfide-rich miniprotein that improves sperm motility and fertilization in mammalsPoster de conférence hal-02453195v1 |
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NCL-based synthesis, 3D structure and first insight into antimicrobial properties of Cg-BigDef1, an oyster big defensin active at high salinityNMR: a tool for Biology Xth, Jan 2017, Paris, France
Poster de conférence
hal-02453460v1
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Laligation native simplifie l’étude de l’activité etdu mécanismed’action des peptides antimicrobiens à multiples domaines :cas des Big défensines d’huître.IIIèmes journées annuelles MuFoPAM « MultiFonction des Peptides AntiMicrobiens », Oct 2016, Tours, France
Poster de conférence
hal-02128427v1
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