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Vincent AUCAGNE

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Identifiants chercheurs

Présentation

EDUCATION --------- - 1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology - 1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans PROFESSIONAL EXPERIENCES ------------------------ - 2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins - 2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures - 2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities - 1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions - 1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates RESEARCH INTERESTS ------------------ - Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery. - Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification - Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry - Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry. - Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies

Publications

jean-baptiste-madinier
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Real-Time Fluorescence Microscopy on Living E. coli Sheds New Light on the Antibacterial Effects of the King Penguin beta-Defensin AvBD103b

Céline Landon , Yanyu Zhu , Mainak Mustafi , Jean-Baptiste Madinier , Dominique Lelièvre
International Journal of Molecular Sciences, 2022, This article belongs to the Special Issue Antimicrobial Peptides: Structure and Mechanism of Biological Activity, 23 (2057), pp.2057. ⟨10.3390/ijms23042057⟩
Article dans une revue hal-03860107v1
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Monitoring Human Neutrophil Activation by a Proteinase 3 Near-Infrared Fluorescence Substrate-Based Probe

Ahlame Saidi , Mylène Wartenberg , J.B Madinier , Guy Ilango , Seda Seren
Bioconjugate Chemistry, 2021, 32 (8), pp.1782-1790. ⟨10.1021/acs.bioconjchem.1c00267⟩
Article dans une revue hal-03525228v1
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Enzyme‐Cleavable Linkers for Protein Chemical Synthesis through Solid‐Phase Ligations

Skander A Abboud , Mehdi Amoura , J.B Madinier , Brigitte Renoux , Sébastien Papot
Angewandte Chemie International Edition, 2021, 60 (34), pp.18612-18618. ⟨10.1002/anie.202103768⟩
Article dans une revue hal-03335485v1
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A synthetic kisspeptin analog that triggers ovulation and advances puberty

Caroline Decourt , Vincent Robert , Karine Anger , Mathieu Galibert , Jean-Baptiste Madinier
Scientific Reports, 2016, 6 (1), pp.26908. ⟨10.1038/srep26908⟩
Article dans une revue hal-01406943v1

Rational Design of Triazololipopeptides Analogs of Kisspeptin Inducing a Long-Lasting Increase of Gonadotropins

Massimiliano Beltramo , Vincent Robert , Mathieu Galibert , Jean-Baptiste Madinier , Philippe Marceau
Journal of Medicinal Chemistry, 2015, 58 (8), pp.3459-3470. ⟨10.1021/jm5019675⟩
Article dans une revue hal-01170460v1

Rational design of kisspeptin analogs for the control of reproduction

T.M. Vishwanatha , C. Decourt , V.P. Terrier , V. Robert , M. Galibert
4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium
Communication dans un congrès hal-02892809v1

New KISS1R agonists with potential for the treatment of reproductive disorder

Massimiliano Beltramo , Vincent Aucagne , Vincent Robert , Mathieu Galibert , Jean-Baptiste Madinier
11. International Symposium on GnRH: The hypothalamic-pituitary-gonadal axis in cancer and reproduction, Kenes International. USA., Feb 2014, Salzburg, Austria
Communication dans un congrès hal-02742248v1

Design and profiling of new selective KISS1R agonists that stimulate the reproductive system

Massimiliano Beltramo , Vincent Aucagne , Vincent Robert , Mathieu Galibert , Jean-Baptiste Madinier
8. International Congress of Neuroendocrinology, Society for Behavioral Neuroendocrinology (SBN). USA., Aug 2014, Sydney, Australia
Communication dans un congrès hal-02738894v1

Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity

F. Coste , G. Chaume , J.-B. Madinier , I. Rahioui , B. Castaing
21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Poster de conférence hal-02893471v1

Long-lasting increase of gonadotropins by rational design of lipophilic kisspeptin analogs

T.M. Vishwanatha , C. Decourt C , V. Robert , M. Galibert , J.-B. Madinier
2018 International Symposium on Chemical Biology, Jan 2018, Genève, Switzerland
Poster de conférence hal-02894282v1

Incorporation of trifluoromethylated pseudoproline in an entomotoxic knottin: effects on oxidative folding, 3D structure and biological activity

F. Coste , G. Chaume , J.-B. Madinier , I. Rahioui , B. Castaing
35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland
Poster de conférence hal-02894161v1

Rational design of kisspeptin analogs for the control of the reproductive system

T.M. Vishwanatha , C. Decourt , V.P. Terrier , V. Robert , J.-B. Madinier
25th SCT Young Research Fellows meeting, Mar 2018, Orléans, France
Poster de conférence hal-02894277v1

Induction of fertile ovulation and puberty advancement by a new kisspeptin analog

Caroline Decourt , Vincent Robert , Didier Lomet , Karine Anger , M. Galibert
18th International Congress on Animal Reproduction (ICAR), Jun 2016, Tours, France. 676 p., 2016, 18th International Congress on Animal Reproduction (ICAR)
Poster de conférence hal-01604087v1

A new selective kisspeptin analog, C6, that advance puberty in mice and stimulate fertile ovulation in ewe

M. Beltramo , V. Robert , D. Lomet , K. Anger , M. Galibert
British Society for Neuroendocrinology Annual Meeting, Sep 2016, Glasgow, United Kingdom
Poster de conférence hal-02453336v1

Induction of synchronized fertile ovulation by a new selective agonist of kisspeptin receptor

Caroline Decourt , Vincent Robert , Didier Lomet , Karine Anger , Mathieu Galibert
1 Journées du GdR 3606 Repro, Apr 2015, Rennes, France. 105 p., 2015, 1ères Journées Scientifiques du GdR Repro
Poster de conférence hal-02742326v1

Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotropins

Vincent Aucagne , Vincent Robert , Mathieu Galibert , Jean-Baptiste Madinier , P. Marceau
24. Meeting of the American Peptide Society, Jun 2015, Orlando, United States. 2015, 24th Meeting of the American Peptide Society
Poster de conférence hal-02741835v1

Rational design of triazolo-lipopeptides analogs of kisspeptin inducing a long-lasting increase of gonadotrophins

Vincent Aucagne , Vincent Robert , Mathieu Galibert , Jean-Baptiste Madinier , P. Marceau
19. Congrès du Groupe Français des Peptides et des Protéines, May 2015, Port-Bail, United States. 2015
Poster de conférence hal-02793091v1

Development of new kisspeptin analogs to stimulate the reproductive system

Caroline Decourt , Karine Anger , Vincent Robert , Vincent Aucagne , Mathieu Galibert
International Conference on Gonadotropins & Receptors, Sep 2014, Tours, France. , 2014, ICGRIII International Conference on Gonadotropins & Receptors
Poster de conférence hal-02744014v1
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Design and functional profiling of new KISS1R agonists

Massimiliano Beltramo , V. Aucagne , Vincent Robert , M. Galibert , J.B. Madinier
2. Annual Meeting of the GDR RCPG-PhysioMed, Oct 2013, Illkirch, France. 2013, 2nd Annual Meeting of the GDR RCPG-PhysioMed
Poster de conférence hal-02745908v1
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La kisspeptine : une nouvelle voie pour maitriser l’ovulation chez les petits ruminants ?

Massimiliano Beltramo , V. Aucagne , R. Vincent , M. Galibert , J.B. Madinier
5. Journées d'Animation Scientifique du département Phase (JAS Phase 2013), Oct 2013, Paris, France. 2013
Poster de conférence hal-02805330v1