Vincent AUCAGNE
4
Documents
Identifiants chercheurs
- vincent-aucagne
- 0000-0002-2647-0188
- IdRef : 077138120
Présentation
EDUCATION
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- 1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology
- 1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans
PROFESSIONAL EXPERIENCES
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- 2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins
- 2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures
- 2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities
- 1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions
- 1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates
RESEARCH INTERESTS
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- Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery.
- Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification
- Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry
- Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry.
- Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies
Publications
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Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probeBiochimie, 2019, 166, pp.84-93. ⟨10.1016/j.biochi.2019.03.013⟩
Article dans une revue
hal-02088627v1
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Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and SEuropean Journal of Medicinal Chemistry, 2018, 144, pp.201 - 210. ⟨10.1016/j.ejmech.2017.12.012⟩
Article dans une revue
hal-01702303v1
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Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations.Angewandte Chemie International Edition, 2012, 51 (3), pp.718-22. ⟨10.1002/anie.201107222⟩
Article dans une revue
hal-00726293v1
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Design of both pseudopeptide inhibitors and imaging probes derived from a unique substrate sequence: a versatile molecular toolbox for studying proteases21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès
hal-02892793v1
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