Vincent AUCAGNE
89
Documents
Identifiants chercheurs
- vincent-aucagne
- 0000-0002-2647-0188
- IdRef : 077138120
Présentation
EDUCATION
---------
- 1999-2002 - PhD in organic chemistry with higher honors, Université d'Orléans defended in 2003, grant from the French Ministry of Research and Technology
- 1998-1999 -Master in chemistry and physicochemistry of bioactive compounds with higher honors, Universités Paris V, Paris XI and Orléans
PROFESSIONAL EXPERIENCES
------------------------
- 2006 - CNRS Research manager, Centre de Biophysique Moléculaire, Orléans - Team of Dr A. Delmas, Development of new tools for the solid-phase total synthesis of native or modified proteins and glycoproteins
- 2004-2006 - Postdoctoral Research Associate, School of Chemistry, University of Edinburgh UK - Team of Prof. D. A. Leigh, Towards the total synthesis of the lasso peptide Microcin J25; Active template methodologies for the synthesis of mechanically-interlocked architectures
- 2002-2003 - Fixed-term Lecturer in organic chemistry (ATER, one year fellowship) Université d'Orléans - Institut de Chimie Organique et Analytique (I.C.O.A.), Team of Prof. L. A. Agrofoglio, synthesis of new nucleoside analogues with antiviral activities
- 1999-2002 - PhD in organic chemistry , I.C.O.A., team of Prof. P. Rollin Sulfur-containing phosphonium salts and anomeric Wittig reaction. Evaluation of vinylthio-functionalized alditols – new tools for stereocontrolled ring closure reactions
- 1998-1998 - Postgraduate research fellow , I.C.O.A.; team of Prof. P. Rollin Synthesis of C-glycosidic analogues of glucosinolates
RESEARCH INTERESTS
------------------
- Synthetic chemistry of biomacromolecules : Total synthesis of small proteins and glycoproteins. Click chemistry. Native chemical ligation Amino-acids, carbohydrates and nucleoside analogues. Modified or bioconjugated proteins. Synthetic vaccines. Drug-delivery.
- Solid-phase organic synthesis : Solid-phase peptide and bio-macromolecule ligation. Solid-phase purification
- Supramolecular Chemistry : Rotaxanes, Catenanes, Mechanically-interlocked architectures. Coordination chemistry
- Thiochemistry : Thioester and thioacid peptides. Sulfonylated strained aminoacids. Sulfur as a tool in organic and bioorganic chemistry.
- Referee for Letters in Organic Chemistry, the Journal of Organic Chemistry, the Journal of the American Chemical Society. Member of the French and American Chemical Societies
Publications
- 84
- 4
- 1
- 3
- 3
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 89
- 20
- 18
- 18
- 17
- 17
- 16
- 12
- 12
- 12
- 11
- 11
- 9
- 8
- 8
- 8
- 7
- 7
- 6
- 6
- 6
- 6
- 6
- 5
- 5
- 5
- 5
- 5
- 5
- 4
- 4
- 4
- 4
- 4
- 4
- 4
- 4
- 4
- 4
- 4
- 4
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 3
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 2
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 3
- 2
- 2
- 2
- 2
- 2
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
- 1
Peptides « Bacteriocyte-specific Cysteine Rich » (BCR) : un rôle dans le contrôle de la symbiose ? Focus sur BCR4 chez le puceron du pois12. Rencontre du Réseau Français de Biologie Adaptative des Pucerons et Organismes Associés (BAPOA), May 2022, Nice, France
Communication dans un congrès
hal-03741305v1
|
|
Functional DIversification of Big-Defensins and the shaping of oyster microbiotaAMP 2022 7th International Symposium on Antimicrobial Peptides, Nov 2022, Paris, France
Communication dans un congrès
hal-03976756v1
|
|
Enabling the synthesis of hydrophobic proteins using NCL-labile solubilizing tags: a case study of Crassostrea gigas big defensin 322nd GFPP / BPGM5 French-Belgian Joint Meeting, Groupe Français des Peptides et Protéines, May 2022, Port Leucate, France
Communication dans un congrès
hal-03976595v1
|
|
Design of both pseudopeptide inhibitors and imaging probes derived from a unique substrate sequence: a versatile molecular toolbox for studying proteases21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès
hal-02892793v1
|
|
Gga-AvBD11, the archetype of a new structural family of defensins21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès
hal-02892790v1
|
|
An improved synthesis of N-Hnb-Cys peptide crypto-thioesters ‒studies on the epimerization of cysteine during solid-phase reductive amination21e réunion du Groupe Français des Peptides et des Protéines (GFPP21), May 2019, Amboise, France
Communication dans un congrès
hal-02892784v1
|
|
Synthesis and structural characterization of naturally-occuring disulfide rich antimicrobial peptides Gyros Protein TechnologiesEuropean peptide symposium, Aug 2018, Dublin, Ireland
Communication dans un congrès
hal-02919154v1
|
|
Rational design of kisspeptin analogs for the control of reproduction4th Belgian Peptide Group Meeting, Feb 2018, Bruxelles, Belgium
Communication dans un congrès
hal-02892809v1
|
|
1ère structure 3D d’une défensine à double motif β-défensine, Gga-AvBD11 du poulet Gallus gallus, et explorations fonctionnelles5es Journées GDR MuFoPAM, Centre National de la Recherche Scientifique (CNRS). FRA., Oct 2018, Paris, France
Communication dans un congrès
hal-02788993v1
|
|
N-2-hydroxybenzyl-cysteine peptide crypto-thioesters for native chemical ligation35th European Peptide Symposium (EPS35), Aug 2018, Dublin, Ireland
Communication dans un congrès
hal-02892802v1
|
|
A non-chromatographic catch-and-release purification method to simplify the synthesis of cysteine-rich peptides20e réunion du Groupe Français des Peptides et des Protéines (GFPP 20), Mar 2017, Arcachon, France
Communication dans un congrès
hal-02893392v1
|
|
Native Chemical ligation simplifies the access of multidomain antimicrobial peptides: application to the study of big-defensinsInternational symposium on AntiMicrobial Peptides (AMP2016), Jun 2016, Montpellier, France
Communication dans un congrès
hal-02892834v1
|
|
New KISS1R agonists with potential for the treatment of reproductive disorder11. International Symposium on GnRH: The hypothalamic-pituitary-gonadal axis in cancer and reproduction, Kenes International. USA., Feb 2014, Salzburg, Austria
Communication dans un congrès
hal-02742248v1
|
|
Design and profiling of new selective KISS1R agonists that stimulate the reproductive system8. International Congress of Neuroendocrinology, Society for Behavioral Neuroendocrinology (SBN). USA., Aug 2014, Sydney, Australia
Communication dans un congrès
hal-02738894v1
|
|
Avian beta-defensins in the control of bacterial pathogens of chicken digestive tract2. International Symposium on Antimicrobial Peptides. Food Veterinary Medical and Novel Applications, Jun 2009, Saint-Malo, France
Communication dans un congrès
hal-02751627v1
|
|
First insights into the structure-activity relationships of avian beta-defensins.2nd International Symposium on Antimicrobial Peptides - Food Veterinary Medical and Novel Applications., 2009, Saint-Malo, France
Communication dans un congrès
hal-02753345v1
|
|
PA1b, un peptide à activité insecticide : relations structure/fonctionXVème Colloque de Physiologie de l'Insecte, 2007, Rennes (France), juillet 2007, France. pp.1-1
Communication dans un congrès
hal-00391295v1
|
Solid phase chemical ligationBrik Asharf, Dawson Philip, Liu Lei. Total Chemical Protein Synthesis, Wiley, 2021, 978-3-527-34660-8
Chapitre d'ouvrage
hal-02974365v1
|
Peptides dérivés d'une beta-défensine 11 aviaire et leurs utilisationsFrance, N° de brevet: WO 2020/030773 A1. AMV; SA, 3IMo, AIM. 2020
Brevet
hal-02595638v1
|
|
KISS1R receptor agonist compounds and use thereof for inducing ovulation in mammalsPatent n° : WO2014118318 (A1). 2014, 49 p. + 12 p. annexes
Brevet
hal-02793004v1
|
|
Composés agonistes du récepteur KISS1R et leur utilisation pour induire l’ovulation chez les mammiféresN° de brevet: FR3001455 (A1). 2013, 34 p. + 10 p. annexes
Brevet
hal-02808772v1
|