Thomas Secher

Documents

Publications

	The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies Timothée Blin , Christelle Parent , Gabrielle Pichon , Antoine Guillon , Youenn Jouan European Journal of Pharmaceutics and Biopharmaceutics, 2024, 195, pp.114163. ⟨10.1016/j.ejpb.2023.12.003⟩ Article dans une revue hal-04484465v1
	Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects Thomas Sécher , Elsa Bodier-Montagutelli , Christelle Parent , Laura Bouvart , Mélanie Cortes Pharmaceutics, 2022, 14 (3), pp.671. ⟨10.3390/pharmaceutics14030671⟩ Article dans une revue hal-03687448v1
	Therapeutic antibodies – natural and pathological barriers and strategies to overcome them Yara Al Ojaimi , Timothée Blin , Juliette Lamamy , Matthieu Gracia , Aubin Pitiot Pharmacology and Therapeutics, 2021, pp.108022. ⟨10.1016/j.pharmthera.2021.108022⟩ Article dans une revue hal-03531953v1
	Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling Claire Mackowiak , Tiffany Marchiol , Hana Cipcic Paljetak , Louis Fauconnier , Jennifer Palomo ImmunoHorizons , 2021, 5 (5), pp.273 - 283. ⟨10.4049/immunohorizons.2000095⟩ Article dans une revue hal-03429701v1
	Therapeutic Antibodies for the Treatment of Respiratory Tract Infections—Current Overview and Perspectives Alexie Mayor , Adélaïde Chesnay , Guillaume Desoubeaux , David Ternant , Nathalie Heuzé-Vourc'H Vaccines, 2021, 9 (2), pp.151. ⟨10.3390/vaccines9020151⟩ Article dans une revue hal-03485350v1
	Immune Checkpoint and Anti-Angiogenic Antibodies for the Treatment of Non-Small Cell Lung Cancer in the European Union and United States Marion Ferreira , Thomas Secher , Nathalie Heuzé-Vourc'H , Karen Reckamp Pharmaceutics, 2021, 13 (6), pp.912. ⟨10.3390/pharmaceutics13060912⟩ Article dans une revue hal-03382451v1
	Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling Claire Mackowiak , Tiffany Marchiol , Hana Cipcic Paljetak , Louis Fauconnier , Jennifer Palomo ImmunoHorizons , 2021, 5 (5), pp.273-283. ⟨10.4049/immunohorizons.2000095⟩ Article dans une revue hal-03258180v1
	MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands Marion Pavlovic , Christelle Gross , Chahinaize Chili , Thomas Secher , Emmanuel Treiner Frontiers in Immunology, 2020, 11 (article 2097), pp.1-16. ⟨10.3389/fimmu.2020.02097⟩ Article dans une revue hal-03154944v1
	Inhalation of Immuno-Therapeutics/- Prophylactics to Fight Respiratory Tract Infections: An Appropriate Drug at the Right Place! Thomas Secher , Alexie Mayor , Nathalie Heuzé-Vourc'H Frontiers in Immunology, 2019, 1, ⟨10.3389/fimmu.2019.02760⟩ Article dans une revue hal-02439828v1
	The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure Nadine Waldschmitt , Sho Kitamoto , Thomas Secher , Vassiliki Zacharioudaki , Olivier Boulard Gut, 2019, 68 (7), pp.1190-1199. ⟨10.1136/gutjnl-2018-316757⟩ Article dans une revue hal-02126570v1
	Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917 Clémence Massip , Priscilla Branchu , Nadège Bossuet-Greif , Camille V Chagneau , Déborah Gaillard PLoS Pathogens, 2019, 15 (9), pp.e1008029. ⟨10.1371/journal.ppat.1008029⟩ Article dans une revue inserm-02320208v1
	In a murine model of acute lung infection, airway administration of a therapeutic antibody confers greater protection than parenteral administration Thomas Secher , Emilie Dalonneau , Marion Ferreira , Christelle Parent , Nicolas Azzopardi Journal of Controlled Release, 2019, 303, pp.24-33. ⟨10.1016/j.jconrel.2019.04.005⟩ Article dans une revue hal-02179896v1
	Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics A. Guillon , Thomas Secher , L.A. Dailey , L. Vecellio , M. de Monte International Journal of Pharmaceutics, 2018, 536 (1), pp.116-126. ⟨10.1016/j.ijpharm.2017.11.049⟩ Article dans une revue hal-02439838v1
	Therapeutic antibodies: A new era in the treatment of respiratory diseases? Thomas Secher , L. Guilleminault , K. Reckamp , I. Amanam , L. Plantier Pharmacology and Therapeutics, 2018, 189, pp.149-172. ⟨10.1016/j.pharmthera.2018.05.003⟩ Article dans une revue hal-02439820v1
	The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice Thomas Secher , Isabelle Maillet , Claire Mackowiak , Jessica Le Bérichel , Amandine Philippeau Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-29689-9⟩ Article dans une revue hal-02126575v1
	Mu and delta opioid receptor knockout mice show increased colonic sensitivity David Reiss , R.A. Ceredig , Thomas Secher , J. Boué , Frédérick Barreau European Journal of Pain, 2017, 21 (4), pp.623-634. ⟨10.1002/ejp.965⟩ Article dans une revue hal-01607491v1
	The food contaminant deoxynivalenol exacerbates the genotoxicity of gut microbiota Delphine Payros , Ulrich Dobrindt , Patricia Martin-Bizon , Thomas Secher , Ana-Paula Loureiro-Bracarense mBio, 2017, 8 (2), 11 p. ⟨10.1128/mBio.00007-17⟩ Article dans une revue hal-01608529v1
	Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction Thomas Secher , Sahar Kassem , Mehdi Benamar , Isabelle Bernard-Cadenat , Michèle Boury Frontiers in Immunology, 2017, 8, ⟨10.3389/fimmu.2017.01096⟩ Article dans une revue hal-02624001v1
	DNA Inversion Regulates Outer Membrane Vesicle Production in Bacteroides fragilis Haruyuki Nakayama-Imaohji , Katsuhiko Hirota , Hisashi Yamasaki , Saori Yoneda , Hirofumi Nariya PLoS ONE, 2016, 11 (2), pp.1-21. ⟨10.1371/journal.pone.0148887⟩ Article dans une revue hal-02632202v1
	Early settlers: which E. coli strains do you not want at birth? Thomas Secher , Camille Brehin , Eric Oswald AJP - Gastrointestinal and Liver Physiology, 2016, 311 (1), pp.G123 - G129. ⟨10.1152/ajpgi.00091.2016⟩ Article dans une revue hal-01602829v1
	Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin Thomas Secher , Delphine Payros , Camille Brehin , Michèle Boury , Claude Watrin Infection and Immunity, 2015, 83 (6), pp.2420-2429. ⟨10.1128/IAI.00064-15⟩ Article dans une revue hal-02634629v1
	Retrograde trafficking inhibitor of Shiga toxins reduces morbidity and mortality of mice infected with enterohemorrhagic Escherichia coli Thomas Secher , Ayaka Shima , Karen Hinsinger , Jean Christophe Cintrat , Ludger Johannes Antimicrobial Agents and Chemotherapy, 2015, 59 (8), pp.5010-5013. ⟨10.1128/AAC.00455-15⟩ Article dans une revue hal-02640796v1
	Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis Delphine Payros , Thomas Secher , Michèle Boury , Camille Brehin , Sandrine Ménard Gut Microbes, 2014, 5 (3), pp.313-325. ⟨10.4161/gmic.28932⟩ Article dans une revue hal-01859355v2
	IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice Rodrigo Guabiraba , Anne-Gaëlle Besnard , Gustavo Batista Menezes , Thomas Secher , M. S. Jabir Mucosal Immunology, 2014, 7 (5), pp.1079-1093. ⟨10.1038/mi.2013.124⟩ Article dans une revue hal-02633989v1
	Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells Thomas Secher , Ascel Samba Louaka , Eric Oswald , Jean-Philippe Nougayrède PLoS ONE, 2013, 8 (10), ⟨10.1371/journal.pone.0077157⟩ Article dans une revue hal-02646496v1
	Dysbiosis, a new medical concept Sylvain Normand , Thomas Secher , Mathias Chamaillard Médecine/Sciences, 2013, 29 (6-7), pp.586-589. ⟨10.1051/medsci/2013296011⟩ Article dans une revue hal-02180092v1
	Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice Bérengère Villeret , Lea Brault , Aurélie Couturier-Maillard , Pauline Robinet , Virginie Vasseur American journal of Clinical and Experimental Immunology, 2013, 2 (1), pp.107-116 Article dans une revue hal-02651056v1
	NOD2 prevents emergence of disease-predisposing microbiota Thomas Secher , Sylvain Normand , Mathias Chamaillard Gut microbes, 2013, 4 (4), pp.353-356. ⟨10.4161/gmic.25275⟩ Article dans une revue hal-02180087v1
	NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. Aurélie Couturier-Maillard , Thomas Secher , Ateequr Rehman , Sylvain Normand , Adèle de Arcangelis Journal of Clinical Investigation, 2013, 123 (2), pp.700-11. ⟨10.1172/JCI62236⟩ Article dans une revue hal-00944194v1
	Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity Maïwenn Olier , Ingrid Marcq , Christel Cartier , Thomas Secher , Ulrich Dobrindt Gut microbes, 2012, 3 (6), pp.501-509. ⟨10.4161/gutmicrobes.21737⟩ Article dans une revue hal-02935516v1
	Local and remote tissue injury upon intestinal ischemia and reperfusion depends on the TLR/MyD88 signaling pathway. Tatiana Victoni , Fernando Rodrigues Coelho , Alexandre Learth Soares , Andressa de Freitas , Thomas Secher Medical Microbiology and Immunology, 2010, 199 (1), pp.35-42. ⟨10.1007/s00430-009-0134-5⟩ Article dans une revue hal-00591521v1
	Remote control of intestinal tumorigenesis by innate immunity. Thomas Secher , Olivier Gaillot , Bernhard Ryffel , Mathias Chamaillard Cancer Research, 2010, 70 (5), pp.1749-52. ⟨10.1158/0008-5472.CAN-09-3401⟩ Article dans une revue hal-00591500v1
	Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation. Kevin N Couper , Tom Barnes , Julius C R Hafalla , Valery Combes , Bernhard Ryffel PLoS Pathogens, 2010, 6 (1), pp.e1000744. ⟨10.1371/journal.ppat.1000744⟩ Article dans une revue hal-00591502v1
	Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis. Thomas Secher , Virginie Vasseur , Didier Marc Poisson , Jane A Mitchell , Fernando Q Cunha Journal of Immunology, 2009, 182 (12), pp.7855-64. ⟨10.4049/jimmunol.0804008⟩ Article dans une revue hal-00404907v1
	Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin. Laure Janot , Jean-Claude Sirard , Thomas Secher , Nicolas Noulin , Lizette Fick European Journal of Immunology, 2009, 39 (6), pp.1587-96. ⟨10.1002/eji.200838907⟩ Article dans une revue inserm-00385299v1
	Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis. R. Dessein , M. Gironella , Clémentine Vignal , L. Peyrin-Biroulet , H. Sokol Gut, 2009, 58 (6), pp.771-6. ⟨10.1136/gut.2008.168443⟩ Article dans une revue hal-00404858v1
	IL-17 receptor signaling is required to control polymicrobial sepsis. Andressa Freitas , José C Alves-Filho , Tatiana Victoni , Thomas Secher , Henrique P Lemos Journal of Immunology, 2009, 182 (12), pp.7846-54. ⟨10.4049/jimmunol.0803039⟩ Article dans une revue hal-00404905v1
	CD14 works with toll-like receptor 2 to contribute to recognition and control of Listeria monocytogenes infection. Laure Janot , Thomas Secher , David Torres , Isabelle Maillet , Josef Pfeilschifter Journal of Infectious Diseases, 2008, 198 (1), pp.115-24. ⟨10.1086/588815⟩ Article dans une revue hal-00318570v1
	Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection. Jonathan Zalevsky , Thomas Secher , Sergei A Ezhevsky , Laure Janot , Paul M Steed Journal of Immunology, 2007, 179 (3), pp.1872-83 Article dans une revue hal-00318488v1
	Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury. Dieudonnée Togbe , Silvia Schnyder-Candrian , Bruno Schnyder , Emilie Doz , Nicolas Noulin International Journal of Experimental Pathology, 2007, 88 (6), pp.387-91. ⟨10.1111/j.1365-2613.2007.00566.x⟩ Article dans une revue hal-00318537v1

	Mucosal administration of anti-bacterial antibody (Ab) provides long-term cross-protection against Pseudomonas aeruginosa respiratory infection Aubin Pitiot , Marion Ferreira , Christelle Parent , Chloé Boisseau , Mélanie Cortes Journées d'Animation Scientifique de la FéRI 2022 - FéRi Scientific Days 2022, Fédération de Recherche en Infectiologie (FéRI), Centre Val de Loire, Jul 2022, Joué-Lès-Tours, France Communication dans un congrès hal-03735460v1
	A c-type lectin triggers immune surveillance by innate lymphoid cells for eradication of attaching-and-effacing bacteria Bruno Lamas , Nadine Waldschmitt , Sho Kitamoto , Thomas Secher , Vassiliki Zacharioudaki 25. United European Gastroenterology: Week, Oct 2017, Barcelone, Spain Communication dans un congrès hal-02786603v1

	Combination of inhaled antibodies and immunomodulatory agents for the treatment or prevention of respiratory infections Muriel Thomas , Nathalie Heuzé-Vourc’h , Thomas Secher France, Patent n° : FR2010296. 2020 Brevet hal-04292601v1

	Réponses de suspensions cellulaires de pommier (Malus domestica) cultivées en présence d'Erwinia amylovora ou de differents eliciteurs Thomas Secher [Stage] U.F.R. Sciences de la Vie. Université Pierre et Marie Curie - Paris 6 (UPMC), Paris, FRA. 1999, 20 p Rapport hal-02841036v1

Thomas Secher

Publications

The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies

Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects

Therapeutic antibodies – natural and pathological barriers and strategies to overcome them

Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling

Therapeutic Antibodies for the Treatment of Respiratory Tract Infections—Current Overview and Perspectives

Immune Checkpoint and Anti-Angiogenic Antibodies for the Treatment of Non-Small Cell Lung Cancer in the European Union and United States

Chronic Pseudomonas aeruginosa Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling

MAIT Cells Display a Specific Response to Type 1 IFN Underlying the Adjuvant Effect of TLR7/8 Ligands

Inhalation of Immuno-Therapeutics/- Prophylactics to Fight Respiratory Tract Infections: An Appropriate Drug at the Right Place!

The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure

Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917

In a murine model of acute lung infection, airway administration of a therapeutic antibody confers greater protection than parenteral administration

Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics

Therapeutic antibodies: A new era in the treatment of respiratory diseases?

The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice

Mu and delta opioid receptor knockout mice show increased colonic sensitivity

The food contaminant deoxynivalenol exacerbates the genotoxicity of gut microbiota

Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction

DNA Inversion Regulates Outer Membrane Vesicle Production in Bacteroides fragilis

Early settlers: which E. coli strains do you not want at birth?

Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin

Retrograde trafficking inhibitor of Shiga toxins reduces morbidity and mortality of mice infected with enterohemorrhagic Escherichia coli

Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis

IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice

Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells

Dysbiosis, a new medical concept

Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice

NOD2 prevents emergence of disease-predisposing microbiota

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.

Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity

Local and remote tissue injury upon intestinal ischemia and reperfusion depends on the TLR/MyD88 signaling pathway.

Remote control of intestinal tumorigenesis by innate immunity.

Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation.

Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis.

Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.

Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.

IL-17 receptor signaling is required to control polymicrobial sepsis.

CD14 works with toll-like receptor 2 to contribute to recognition and control of Listeria monocytogenes infection.

Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection.

Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury.

Mucosal administration of anti-bacterial antibody (Ab) provides long-term cross-protection against Pseudomonas aeruginosa respiratory infection

A c-type lectin triggers immune surveillance by innate lymphoid cells for eradication of attaching-and-effacing bacteria

Combination of inhaled antibodies and immunomodulatory agents for the treatment or prevention of respiratory infections

Réponses de suspensions cellulaires de pommier (Malus domestica) cultivées en présence d'Erwinia amylovora ou de differents eliciteurs