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Thomas Boraud

49
Documents

Présentation

Thomas Boraud's research interest focused on the neural networks of decision making, skill and procedural learning and associated pathophysiology (Parkinson's disease, OCD, Dystonia, etc…). He tackles this topic with a phylogenetic approach in order to unravel how the system evolved in different taxa (amphibians, birds, rodents and non-human primates) from an original blueprint. After a Marie Curie Fellowship at the Hebrew University of Jerusalem, he secured a tenured position (Charge de Recherche) in the CNRS in 2001 and became Directeur de Recherche in 2008. He took the head of the Institute of Neurodegenerative Diseases (IMN, UMR CNRS 5293) in September 2020. Since 2010, his involvement in research brings him to develop a growing interest in the ethical responsibility of scientists toward society regarding scientific uncertainty and the development of the Neuro-essentialism. He published a book toward general public called "Matière à decision" (CNRS editions, Paris, 2015; 2nd ed Biblis, Paris 2017), the second edition has been translated in English (How the Brain Makes Decisions, Oxford University Press, 2020). Thomas Boraud has resumed a clinical activity in 2012 at the University Hospital of Bordeaux dedicated mainly to the follow up of patients included in clinical trials concerning Parkinson's syndromes and Alzheimer disease.

Publications

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The adaptive value of probability distortion and risk-seeking in macaques' decision-making

Aurélien Nioche , Nicolas P. Rougier , Marc Deffains , Sacha Bourgeois-Gironde , Sébastien Ballesta
Philosophical Transactions of the Royal Society B: Biological Sciences, 2021, 376 (1819), pp.20190668. ⟨10.1098/rstb.2019.0668⟩
Article dans une revue hal-03005035v2

Economic behaviours among non-human primates

Sacha Bourgeois-Gironde , Elsa Addessi , Thomas Boraud
Philosophical Transactions of the Royal Society B: Biological Sciences, 2021, 376 (1819), pp.20190676. ⟨10.1098/rstb.2019.0676⟩
Article dans une revue hal-03982979v1
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What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?

Dan Valsky , Shai Heiman Grosberg , Zvi Israel , Thomas Boraud , Hagai Bergman
Article dans une revue hal-02997422v1
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The globus pallidus orchestrates abnormal network dynamics in a model of Parkinsonism

Brice de La Crompe , Asier Aristieta , Arthur Leblois , Salma Elsherbiny , Thomas Boraud
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-15352-3⟩
Article dans une revue hal-03010083v1

In vivo electrophysiological validation of DREADD‐based modulation of pallidal neurons in the non‐human primate

Thomas Boraud , Marc Deffains , Tho Haï Nguyen , Hugues Orignac , Nathalie Biendon
European Journal of Neuroscience, inPress, ⟨10.1111/ejn.14746⟩
Article dans une revue hal-02997440v1
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Neurobiologie de l'éthique

Thomas Boraud
Revue de Bioéthique de Nouvelle-Aquitaine, 2020, 5, p.19-25
Article dans une revue hal-03272911v1

Optimizing Treatment in Undertreated Late-Stage Parkinsonism: A Pragmatic Randomized Trial

Thomas Boraud , Adrianus L.A.J. Hommel , Marjan Meinders , Nico Weerkamp , Carmen Richinger
Journal of Parkinson's disease, 2020, 10 (3), pp.1171-1184. ⟨10.3233/JPD-202033⟩
Article dans une revue hal-02997415v1
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Interaction effects between consumer information and firms' decision rules in a duopoly: how cognitive features can impact market dynamics

Aurélien Nioche , Basile Garcia , Thomas Boraud , Nicolas P. Rougier , Sacha Bourgeois-Gironde
Palgrave Communications, 2019, 5 (1), ⟨10.1057/s41599-019-0241-x⟩
Article dans une revue hal-02080610v1

Do newspapers preferentially cover biomedical studies involving national scientists?

Estelle Dumas-Mallet , Aran Tajika , Andy Smith , Thomas Boraud , Toshiaki Furukawa
Public Understanding of Science, 2019, 28 (2), pp.191-200. ⟨10.1177/0963662518809804⟩
Article dans une revue halshs-01981421v1
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An asymmetry of treatment between lotteries involving gains and losses in rhesus monkeys

Aurélien Nioche , Sacha Bourgeois-Gironde , Thomas Boraud
Scientific Reports, 2019, 9 (1), pp.10441. ⟨10.1038/s41598-019-46975-2⟩
Article dans une revue hal-02997460v1
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Coordination over a unique medium of exchange under information scarcity

Aurélien Nioche , Basile Garcia , Germain Lefebvre , Thomas Boraud , Nicolas P. Rougier
Palgrave Communications, 2019
Article dans une revue hal-02356248v1
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A Natural History of Skills

Thomas Boraud , Arthur Leblois , Nicolas P. Rougier
Progress in Neurobiology, 2018, 171, pp.114-124. ⟨10.1016/j.pneurobio.2018.08.003⟩
Article dans une revue hal-01874690v1

Scientific Uncertainty in the Press: How Newspapers Describe Initial Biomedical Findings

Andy Smith , Thomas Boraud , François Gonon , Estelle Dumas-Mallet
Science Communication, 2018, 40 (1), pp.124-141. ⟨10.1177/1075547017752166⟩
Article dans une revue halshs-01807150v1
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Naftazone in advanced Parkinson's disease: An acute L-DOPA challenge randomized controlled trial

Jean-Christophe Corvol , Franck Durif , Wassilios Meissner , J.P. Azulay , Raphaël Haddad
Parkinsonism & Related Disorders, 2018, 174 (9), pp.579 - 580. ⟨10.1016/j.parkreldis.2018.10.005⟩
Article dans une revue hal-01912724v1
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A Computational Model of Dual Competition between the Basal Ganglia and the Cortex

Meropi Topalidou , Daisuke Kase , Thomas Boraud , Nicolas P. Rougier
eNeuro, 2018, pp.ENEURO.0339--17.2018
Article dans une revue hal-01925643v1
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Poor replication validity of biomedical association studies reported by newspapers

Estelle Dumas-Mallet , Andy Smith , Thomas Boraud , François Gonon
PLoS ONE, 2017, 12 (2), pp.[en ligne]. ⟨10.1371/journal.pone.0172650⟩
Article dans une revue halshs-01807234v1
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The Globus Pallidus Pars Interna in Goal-Oriented and Routine Behaviors: Resolving a Long-Standing Paradox

Camille Piron , Daisuke Kase , Meropi Topalidou , Michel Goillandeau , Hugues Orignac
Movement Disorders, 2016, ⟨10.1002/mds.26542⟩
Article dans une revue hal-01317968v1
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Decision making under uncertainty in a spiking neural network model of the basal ganglia

Charlotte Héricé , Radwa Khalil , Marie E Moftah , Thomas Boraud , Martin Guthrie
Journal of Integrative Neuroscience, 2016, 15 (3), pp.1-24. ⟨10.1142/S021963521650028X⟩
Article dans une revue hal-01407859v1
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Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression

Mathieu Bourdenx , Sandra Dovero , Michel Engeln , Simone Bido , Matthieu Bastide
Acta Neuropathologica Communications, 2015, 3, pp.46. ⟨10.1186/s40478-015-0222-2⟩
Article dans une revue inserm-02439376v1
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Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression

Mathieu Bourdenx , Sandra Dovero , Michel Engeln , Simone Bido , Matthieu Bastide
Acta Neuropathologica Communications, 2015, 3 (1), ⟨10.1186/s40478-015-0222-2⟩
Article dans une revue hal-03130817v1
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A Long Journey into Reproducible Computational Neuroscience

Meropi Topalidou , Arthur Leblois , Thomas Boraud , Nicolas P. Rougier
Frontiers in Computational Neuroscience, 2015, pp.2. ⟨10.3389/fncom.2015.00030⟩
Article dans une revue hal-01117873v1

Inhibiting Lateral Habenula Improves L-DOPA-induced Dyskinesia.

Matthieu F. Bastide , Brice de La Crompe , Evelyne Doudnikoff , Pierre Olivier Fernagut , Christian E Gross
Biological Psychiatry, 2014
Article dans une revue hal-01215529v1

Easy rider: monkeys learn to drive a wheelchair to navigate through a complex maze.

Stéphanie Etienne , Martin Guthrie , Michel Goillandeau , Tho-Hai Nguyen , Hugues Orignac
PLoS ONE, 2014, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096275. ⟨10.1371/journal.pone.0096275⟩
Article dans une revue hal-01160393v1

The Michelin red guide of the brain: role of dopamine in goal-oriented navigation.

Aude Retailleau , Thomas Boraud
Frontiers in Systems Neuroscience, 2014, http://journal.frontiersin.org/article/10.3389/fnsys.2014.00032/abstract. ⟨10.3389/fnsys.2014.00032⟩
Article dans une revue hal-01160397v1

Why am I lost without dopamine? Effects of 6-OHDA lesion on the encoding of reward and decision process in CA3

Aude Retailleau , Cyril Dejean , Benjamin Fourneaux , Xavier Leinekugel , Thomas Boraud
Neurobiology of Disease, 2013, http://dx.doi.org/10.1016/j.nbd.2013.07.014. ⟨10.1016/j.nbd.2013.07.014⟩
Article dans une revue hal-01160385v1

Interaction Between Cognitive and Motor Cortico-Basal Ganglia Loops During Decision Making: A Computational Study

Martin Guthrie , Arthur Leblois , André Garenne , Thomas Boraud
Journal of Neurophysiology, 2013
Article dans une revue hal-00828004v1

Opiate dependence induces network state shifts in the limbic system

Cyril Dejean , Thomas Boraud , Catherine Le Moine
Neurobiology of Disease, 2013, http://dx.doi.org/10.1016/j.nbd.2013.07.012. ⟨10.1016/j.nbd.2013.07.012⟩
Article dans une revue hal-01160404v1

Complex Population Response of Dorsal Putamen Neurons Predicts the Ability to Learn

Steeve Laquitaine , Camille Piron , David Abellanas , Yonatan Loewenstein , Thomas Boraud
PLoS ONE, 2013, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080683. ⟨10.1371/journal.pone.0080683⟩
Article dans une revue hal-01160401v1

Closed-loop stimulation: The future of surgical therapy of brain disorders?

Thomas Boraud
Movement Disorders, 2012, http://onlinelibrary.wiley.com.gate1.inist.fr/doi/10.1002/mds.24884/abstract. ⟨10.1002/mds.24884⟩
Article dans une revue hal-01160425v1

High resolution 3T fMRI in anesthetized monkeys

Palma Pró-Sistiaga , Franck Lamberton , Thomas Boraud , Romaric Saulnier , Alan R. Young
Journal of Neuroscience Methods, 2012, 205, pp.86-95
Article dans une revue hal-01164693v1

High resolution 3T fMRI in anesthetized monkeys.

Palma Pró-Sistiaga , Franck Lamberton , Thomas Boraud , Romaric Saulnier , Alan R Young
Journal of Neuroscience Methods, 2012, 205 (1), pp.86-95
Article dans une revue hal-01155568v1

Where is my reward and how do I get it? Interaction between the hippocampus and the basal ganglia during spatial learning

Aude Retailleau , Stéphanie Etienne , Martin Guthrie , Thomas Boraud
Journal of Physiology - Paris, 2012, http://dx.doi.org/10.1016/j.jphysparis.2011.10.002. ⟨10.1016/j.jphysparis.2011.10.002⟩
Article dans une revue hal-01160415v1

Evolution of the dynamic properties of the cortex-basal ganglia network after dopaminergic depletion in rats.

Cyril Dejean , Agnes Nadjar , Catherine Le Moine , Bernard Bioulac , Christian E Gross
Neurobiology of Disease, 2012, 46 (2), pp.402-13
Article dans une revue hal-01155560v1

Evolution of the dynamic properties of the cortex–basal ganglia network after dopaminergic depletion in rats

Cyril Déjean , Agnès Nadjar , Catherine Le Moine , Bernard Bioulac , Christian E. Gross
Neurobiology of Disease, 2012, 46 (2), pp.402-413. ⟨10.1016/j.nbd.2012.02.004⟩
Article dans une revue hal-02645123v1

Coordinated reset has sustained aftereffects in Parkinsonian monkeys

Peter A. Tass , Qin Li , Christian Hauptmann , Sandra Dovero , Erwan Bezard
Annals of Neurology, 2012, http://onlinelibrary.wiley.com.gate1.inist.fr/doi/10.1002/ana.23663/abstract. ⟨10.1002/ana.23663⟩
Article dans une revue hal-01160410v1

What Should Be Said to the Lay Public Regarding ADHD Etiology

François Gonon , Erwan Bezard , Thomas Boraud
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2011, http://onlinelibrary.wiley.com.gate1.inist.fr/doi/10.1002/ajmg.b.31236/abstract. ⟨10.1002/ajmg.b.31236⟩
Article dans une revue hal-01160417v1

Why Most Biomedical Findings Echoed by Newspapers Turn Out to be False: The Case of Attention Deficit Hyperactivity Disorder

François Gonon , Jan Pieter J. P. Konsman , David Cohen , Thomas Boraud
PLoS ONE, 2011, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044275. ⟨10.1371/journal.pone.0044275⟩
Article dans une revue hal-01160413v1

Basal Ganglia Preferentially Encode Context Dependent Choice in a Two-Armed Bandit Task

André Garenne , Benjamin Pasquereau , Martin Guthrie , Bernard Bioulac , Thomas Boraud
Frontiers in Systems Neuroscience, 2011, 5, ⟨10.3389/fnsys.2011.00023⟩
Article dans une revue hal-03025204v1

Misrepresentation of Neuroscience Data Might Give Rise to Misleading Conclusions in the Media: The Case of Attention Deficit Hyperactivity Disorder

François Gonon , Erwan Bezard , Thomas Boraud
PLoS ONE, 2011, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014618. ⟨10.1371/journal.pone.0014618⟩
Article dans une revue hal-01160423v1

Inhibition of dopamine uptake by D2 antagonists: an in vivo study

Marianne Benoit-Marand , Bérangère Ballion , Emiliana Borrelli , Thomas Boraud , François Gonon
Journal of Neurochemistry, 2011, 116 (3), pp.449-458. ⟨10.1111/j.1471-4159.2010.07125.x⟩
Article dans une revue hal-02484694v1

Power Fluctuations in Beta and Gamma Frequencies in Rat Globus Pallidus: Association with Specific Phases of Slow Oscillations and Differential Modulation by Dopamine D-1 and D-2 Receptors

Cyril Dejean , Gordon Arbuthnott , Jeffrey Wickens , Catherine Le Moine , Thomas Boraud
Journal of Neuroscience, 2011, http://www.jneurosci.org.gate1.inist.fr/content/31/16/6098. ⟨10.1523/JNEUROSCI.3311-09.2011⟩
Article dans une revue hal-01160418v1

Inhibition of dopamine uptake by D-2 antagonists: an in vivo study

Marianne Benoit-Marand , Bérangère Ballion , Emiliana Borrelli , Thomas Boraud , François Gonon
Journal of Neurochemistry, 2011, http://onlinelibrary.wiley.com.gate1.inist.fr/doi/10.1111/j.1471-4159.2010.07125.x/abstract. ⟨10.1111/j.1471-4159.2010.07125.x⟩
Article dans une revue hal-01160422v1

The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research.

Peter A Tass , Li Qin , Christian Hauptmann , Sandra Dovero , Erwan Bezard
Conference proceedings : .. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2010, 2011, pp.663-6. ⟨10.1109/IEMBS.2011.6090148⟩
Article dans une revue hal-01290749v1

Basal Ganglia preferentially encode context dependent choice in a two-armed bandit task.

André Garenne , Benjamin Pasquereau , Martin Guthrie , Bernard Bioulac , Thomas Boraud
Frontiers in Systems Neuroscience, 2010, 5, pp.23
Article dans une revue hal-01155573v1

Late emergence of synchronized oscillatory activity in the pallidum during progressive parkinsonism.

Arthur Leblois , Wassilios Meissner , Bernard Bioulac , Christian E Gross , David Hansel
European Journal of Neuroscience, 2007, 26 (6), pp.1701-1713. ⟨10.1111/j.1460-9568.2007.05777.x⟩
Article dans une revue hal-00174211v1

Shaping of motor responses by incentive values through the basal ganglia

Benjamin Pasquereau , Agnès Nadjar , David Arkadir , Erwan Bezard , Michel Goillandeau
Journal of Neuroscience, 2007, 27 (5), pp.1176-1183. ⟨10.1523/JNEUROSCI.3745-06.2007⟩
Article dans une revue hal-02658533v1

Competition between feedback loops underlies normal and pathological dynamics in the basal ganglia.

Arthur Leblois , Thomas Boraud , Wassilios Meissner , Hagai Bergman , David Hansel
Journal of Neuroscience, 2006, 26 (13), pp.3567-83. ⟨10.1523/JNEUROSCI.5050-05.2006⟩
Article dans une revue hal-00173766v1

Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations.

Wassilios Meissner , Arthur Leblois , David Hansel , Bernard Bioulac , Christian E Gross
Brain - A Journal of Neurology , 2005, 128 (Pt 10), pp.2372-82. ⟨10.1093/brain/awh616⟩
Article dans une revue hal-00173768v1

Competition between feedback loops as the core of a computational model of the basal ganglia

A. Leblois , Thomas Boraud , H. Bergman , D. Hansel
E. Bezard. Recent breakthroughs in basal ganglia research, Nova Publishing, New York, pp.xxx-xxx, 2006
Chapitre d'ouvrage hal-00176394v1