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48

Thomas Boraud, Md PhD


 

Thomas Boraud's research interest focused on the neural networks of decision making, skill and procedural learning and associated pathophysiology (Parkinson's disease, OCD, Dystonia, etc…). He tackles this topic with a phylogenetic approach in order to unravel how the system evolved in different taxa  (amphibians, birds, rodents and non-human primates) from an original blueprint.  

After a Marie Curie Fellowship at the Hebrew University of Jerusalem, he secured a tenured position (Charge de Recherche) in the CNRS in 2001 and became Directeur de Recherche in 2008. He took the head of the Institute of Neurodegenerative Diseases (IMN, UMR CNRS 5293) in September 2020.

Since 2010, his involvement in research brings him to develop a growing interest in the ethical responsibility of scientists toward society regarding scientific uncertainty and the development of  the Neuro-essentialism. He published a book toward general public called "Matière à decision" (CNRS editions, Paris, 2015; 2nd ed Biblis, Paris 2017), the second edition has been translated in English (How the Brain Makes Decisions, Oxford University Press, 2020).

Thomas Boraud has resumed a clinical activity in 2012 at the University Hospital of Bordeaux dedicated mainly to the follow up of patients included in clinical trials concerning Parkinson's syndromes and Alzheimer disease.

 

 

 


Journal articles47 documents

  • Aurélien Nioche, Nicolas Rougier, Marc Deffains, Sacha Bourgeois-Gironde, Sébastien Ballesta, et al.. The adaptive value of probability distortion and risk-seeking in macaques' decision-making. Philosophical Transactions of the Royal Society B: Biological Sciences, Royal Society, The, 2021, 376 (1819), pp.20190668. ⟨10.1098/rstb.2019.0668⟩. ⟨hal-03005035v2⟩
  • Dan Valsky, Shai Heiman Grosberg, Zvi Israel, Thomas Boraud, Hagai Bergman, et al.. What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?. eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.57445⟩. ⟨hal-02997422⟩
  • Brice de La Crompe, Asier Aristieta, Arthur Leblois, Salma Elsherbiny, Thomas Boraud, et al.. The globus pallidus orchestrates abnormal network dynamics in a model of Parkinsonism. Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-15352-3⟩. ⟨hal-03010083⟩
  • Thomas Boraud, Adrianus L.A.J. Hommel, Marjan Meinders, Nico Weerkamp, Carmen Richinger, et al.. Optimizing Treatment in Undertreated Late-Stage Parkinsonism: A Pragmatic Randomized Trial. Journal of Parkinson's disease, Amsterdam : b : IOS Press, 2020, 10 (3), pp.1171-1184. ⟨10.3233/JPD-202033⟩. ⟨hal-02997415⟩
  • Thomas Boraud, Marc Deffains, Tho Haï Nguyen, Hugues Orignac, Nathalie Biendon, et al.. In vivo electrophysiological validation of DREADD‐based modulation of pallidal neurons in the non‐human primate. European Journal of Neuroscience, Wiley, In press, ⟨10.1111/ejn.14746⟩. ⟨hal-02997440⟩
  • Thomas Boraud. Neurobiologie de l'éthique. Revue de Bioéthique de Nouvelle-Aquitaine, Espace de Réflexion Ethique Nouvelle-Aquitaine, 2020, p.19-25. ⟨hal-03272911⟩
  • Estelle Dumas-Mallet, Aran Tajika, Andy Smith, Thomas Boraud, Toshiaki Furukawa, et al.. Do newspapers preferentially cover biomedical studies involving national scientists?. Public Understanding of Science, SAGE Publications, 2019, 28 (2), pp.191-200. ⟨10.1177/0963662518809804⟩. ⟨halshs-01981421⟩
  • Thomas Boraud, Aurélien Nioche, Sacha Bourgeois-Gironde. An asymmetry of treatment between lotteries involving gains and losses in rhesus monkeys. Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-46975-2⟩. ⟨hal-02997460⟩
  • Aurélien Nioche, Basile Garcia, Germain Lefebvre, Thomas Boraud, Nicolas Rougier, et al.. Coordination over a unique medium of exchange under information scarcity. Palgrave Communications, Nature, In press. ⟨hal-02356248⟩
  • Aurélien Nioche, Basile Garcia, Thomas Boraud, Nicolas Rougier, Sacha Bourgeois-Gironde. Interaction effects between consumer information and firms' decision rules in a duopoly: how cognitive features can impact market dynamics. Palgrave Communications, Nature, 2019, 5 (1), ⟨10.1057/s41599-019-0241-x⟩. ⟨hal-02080610⟩
  • Jean-Christophe Corvol, Franck Durif, Wassilios Meissner, J.P. Azulay, Raphaël Haddad, et al.. Naftazone in advanced Parkinson's disease: An acute L-DOPA challenge randomized controlled trial. Parkinsonism and Related Disorders, Elsevier, 2018, 174 (9), pp.579 - 580. ⟨10.1016/j.parkreldis.2018.10.005⟩. ⟨hal-01912724⟩
  • Estelle Dumas-Mallet, Andy Smith, Thomas Boraud, François Gonon. Scientific Uncertainty in the Press: How Newspapers Describe Initial Biomedical Findings. Science Communication, SAGE Publications, 2018, 40 (1), pp.124-141. ⟨10.1177/1075547017752166⟩. ⟨halshs-01807150⟩
  • Meropi Topalidou, Daisuke Kase, Thomas Boraud, Nicolas Rougier. A Computational Model of Dual Competition between the Basal Ganglia and the Cortex. eNeuro, Society for Neuroscience, 2018, pp.ENEURO.0339--17.2018. ⟨hal-01925643⟩
  • Thomas Boraud, Arthur Leblois, Nicolas Rougier. A Natural History of Skills. Progress in Neurobiology, Elsevier, 2018, 171, pp.114-124. ⟨10.1016/j.pneurobio.2018.08.003⟩. ⟨hal-01874690⟩
  • Estelle Dumas-Mallet, Andy Smith, Thomas Boraud, François Gonon. Poor replication validity of biomedical association studies reported by newspapers. PLoS ONE, Public Library of Science, 2017, 12 (2), pp.[en ligne]. ⟨10.1371/journal.pone.0172650⟩. ⟨halshs-01807234⟩
  • Camille Piron, Daisuke Kase, Meropi Topalidou, Michel Goillandeau, Hugues Orignac, et al.. The Globus Pallidus Pars Interna in Goal-Oriented and Routine Behaviors: Resolving a Long-Standing Paradox. Movement Disorders, Wiley, 2016, ⟨10.1002/mds.26542⟩. ⟨hal-01317968⟩
  • Charlotte Héricé, Radwa Khalil, Marie Moftah, Thomas Boraud, Martin Guthrie, et al.. Decision making under uncertainty in a spiking neural network model of the basal ganglia. Journal of Integrative Neuroscience, World Scientific Publishing, 2016, 15 (3), pp.1-24. ⟨10.1142/S021963521650028X⟩. ⟨hal-01407859⟩
  • Mathieu Bourdenx, Sandra Dovero, Michel Engeln, Simone Bido, Matthieu Bastide, et al.. Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression. Acta Neuropathologica Communications, BioMed Central part of Springer Science, 2015, 3, pp.46. ⟨10.1186/s40478-015-0222-2⟩. ⟨inserm-02439376⟩
  • Mathieu Bourdenx, Sandra Dovero, Michel Engeln, Simone Bido, Matthieu Bastide, et al.. Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression. Acta Neuropathologica Communications, BioMed Central part of Springer Science, 2015, 3 (1), ⟨10.1186/s40478-015-0222-2⟩. ⟨hal-03130817⟩
  • Meropi Topalidou, Arthur Leblois, Thomas Boraud, Nicolas Rougier. A Long Journey into Reproducible Computational Neuroscience. Frontiers in Computational Neuroscience, Frontiers, 2015, pp.2. ⟨10.3389/fncom.2015.00030⟩. ⟨hal-01117873⟩
  • Aude Retailleau, Thomas Boraud. The Michelin red guide of the brain: role of dopamine in goal-oriented navigation.. Frontiers in Systems Neuroscience, Frontiers, 2014, http://journal.frontiersin.org/article/10.3389/fnsys.2014.00032/abstract. ⟨10.3389/fnsys.2014.00032⟩. ⟨hal-01160397⟩
  • Stéphanie Etienne, Martin Guthrie, Michel Goillandeau, Tho-Hai Nguyen, Hugues Orignac, et al.. Easy rider: monkeys learn to drive a wheelchair to navigate through a complex maze.. PLoS ONE, Public Library of Science, 2014, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096275. ⟨10.1371/journal.pone.0096275⟩. ⟨hal-01160393⟩
  • Matthieu F. Bastide, Brice de la Crompe, Evelyne Doudnikoff, Pierre Olivier Fernagut, Christian E Gross, et al.. Inhibiting Lateral Habenula Improves L-DOPA-induced Dyskinesia.. Biological Psychiatry, Elsevier, 2014. ⟨hal-01215529⟩
  • Cyril Dejean, Thomas Boraud, Catherine Le Moine. Opiate dependence induces network state shifts in the limbic system. Neurobiology of Disease, Elsevier, 2013, http://dx.doi.org/10.1016/j.nbd.2013.07.012. ⟨10.1016/j.nbd.2013.07.012⟩. ⟨hal-01160404⟩
  • Steeve Laquitaine, Camille Piron, David Abellanas, Yonatan Loewenstein, Thomas Boraud. Complex Population Response of Dorsal Putamen Neurons Predicts the Ability to Learn. PLoS ONE, Public Library of Science, 2013, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080683. ⟨10.1371/journal.pone.0080683⟩. ⟨hal-01160401⟩
  • Aude Retailleau, Cyril Dejean, Benjamin Fourneaux, Xavier Leinekugel, Thomas Boraud. Why am I lost without dopamine? Effects of 6-OHDA lesion on the encoding of reward and decision process in CA3. Neurobiology of Disease, Elsevier, 2013, http://dx.doi.org/10.1016/j.nbd.2013.07.014. ⟨10.1016/j.nbd.2013.07.014⟩. ⟨hal-01160385⟩
  • Martin Guthrie, Arthur Leblois, André Garenne, Thomas Boraud. Interaction Between Cognitive and Motor Cortico-Basal Ganglia Loops During Decision Making: A Computational Study. Journal of Neurophysiology, American Physiological Society, 2013. ⟨hal-00828004⟩
  • Thomas Boraud. Closed-loop stimulation: The future of surgical therapy of brain disorders?. Movement Disorders, Wiley, 2012, http://onlinelibrary.wiley.com.gate1.inist.fr/doi/10.1002/mds.24884/abstract. ⟨10.1002/mds.24884⟩. ⟨hal-01160425⟩
  • Peter Tass, Qin Li, Christian Hauptmann, Sandra Dovero, Erwan Bezard, et al.. Coordinated reset has sustained aftereffects in Parkinsonian monkeys. Annals of Neurology, Wiley, 2012, http://onlinelibrary.wiley.com.gate1.inist.fr/doi/10.1002/ana.23663/abstract. ⟨10.1002/ana.23663⟩. ⟨hal-01160410⟩
  • Aude Retailleau, Stéphanie Etienne, Martin Guthrie, Thomas Boraud. Where is my reward and how do I get it? Interaction between the hippocampus and the basal ganglia during spatial learning . Journal of Physiology - Paris, Elsevier, 2012, http://dx.doi.org/10.1016/j.jphysparis.2011.10.002. ⟨10.1016/j.jphysparis.2011.10.002⟩. ⟨hal-01160415⟩
  • Palma Pró-Sistiaga, Franck Lamberton, Thomas Boraud, Romaric Saulnier, Alan R Young, et al.. High resolution 3T fMRI in anesthetized monkeys.. Journal of Neuroscience Methods, Elsevier, 2012, 205 (1), pp.86-95. ⟨hal-01155568⟩
  • Palma Pró-Sistiaga, Franck Lamberton, Thomas Boraud, Romaric Saulnier, Alan R. Young, et al.. High resolution 3T fMRI in anesthetized monkeys. Journal of Neuroscience Methods, Elsevier, 2012, 205, pp.86-95. ⟨hal-01164693⟩
  • Cyril Déjean, Agnès Nadjar, Catherine Le Moine, Bernard Bioulac, Christian E. Gross, et al.. Evolution of the dynamic properties of the cortex–basal ganglia network after dopaminergic depletion in rats. Neurobiology of Disease, Elsevier, 2012, 46 (2), pp.402-413. ⟨10.1016/j.nbd.2012.02.004⟩. ⟨hal-02645123⟩
  • Cyril Dejean, Agnes Nadjar, Catherine Le Moine, Bernard Bioulac, Christian E Gross, et al.. Evolution of the dynamic properties of the cortex-basal ganglia network after dopaminergic depletion in rats.. Neurobiology of Disease, Elsevier, 2012, 46 (2), pp.402-13. ⟨hal-01155560⟩
  • Marianne Benoit-Marand, Bérangère Ballion, Emiliana Borrelli, Thomas Boraud, François Gonon. Inhibition of dopamine uptake by D2 antagonists: an in vivo study. Journal of Neurochemistry, Wiley, 2011, 116 (3), pp.449-458. ⟨10.1111/j.1471-4159.2010.07125.x⟩. ⟨hal-02484694⟩
  • François Gonon, Erwan Bezard, Thomas Boraud. Misrepresentation of Neuroscience Data Might Give Rise to Misleading Conclusions in the Media: The Case of Attention Deficit Hyperactivity Disorder. PLoS ONE, Public Library of Science, 2011, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014618. ⟨10.1371/journal.pone.0014618⟩. ⟨hal-01160423⟩
  • Cyril Dejean, Gordon Arbuthnott, Jeffrey Wickens, Catherine Le Moine, Thomas Boraud, et al.. Power Fluctuations in Beta and Gamma Frequencies in Rat Globus Pallidus: Association with Specific Phases of Slow Oscillations and Differential Modulation by Dopamine D-1 and D-2 Receptors. Journal of Neuroscience, Society for Neuroscience, 2011, http://www.jneurosci.org.gate1.inist.fr/content/31/16/6098. ⟨10.1523/JNEUROSCI.3311-09.2011⟩. ⟨hal-01160418⟩
  • François Gonon, Erwan Bezard, Thomas Boraud. What Should Be Said to the Lay Public Regarding ADHD Etiology. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Wiley, 2011, http://onlinelibrary.wiley.com.gate1.inist.fr/doi/10.1002/ajmg.b.31236/abstract. ⟨10.1002/ajmg.b.31236⟩. ⟨hal-01160417⟩
  • Marianne Benoit-Marand, Bérangère Ballion, Emiliana Borrelli, Thomas Boraud, François Gonon. Inhibition of dopamine uptake by D-2 antagonists: an in vivo study. Journal of Neurochemistry, Wiley, 2011, http://onlinelibrary.wiley.com.gate1.inist.fr/doi/10.1111/j.1471-4159.2010.07125.x/abstract. ⟨10.1111/j.1471-4159.2010.07125.x⟩. ⟨hal-01160422⟩
  • André Garenne, Benjamin Pasquereau, Martin Guthrie, Bernard Bioulac, Thomas Boraud. Basal Ganglia Preferentially Encode Context Dependent Choice in a Two-Armed Bandit Task. Frontiers in Systems Neuroscience, Frontiers, 2011, 5, ⟨10.3389/fnsys.2011.00023⟩. ⟨hal-03025204⟩
  • François Gonon, Jan Pieter Konsman, David Cohen, Thomas Boraud. Why Most Biomedical Findings Echoed by Newspapers Turn Out to be False: The Case of Attention Deficit Hyperactivity Disorder. PLoS ONE, Public Library of Science, 2011, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044275. ⟨10.1371/journal.pone.0044275⟩. ⟨hal-01160413⟩
  • Peter A Tass, Li Qin, Christian Hauptmann, Sandra Dovero, Erwan Bezard, et al.. The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research.. Conference proceedings : .. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, Institute of Electrical and Electronics Engineers (IEEE), 2010, 2011, pp.663-6. ⟨10.1109/IEMBS.2011.6090148⟩. ⟨hal-01290749⟩
  • André Garenne, Benjamin Pasquereau, Martin Guthrie, Bernard Bioulac, Thomas Boraud. Basal Ganglia preferentially encode context dependent choice in a two-armed bandit task.. Frontiers in Systems Neuroscience, Frontiers, 2010, 5, pp.23. ⟨hal-01155573⟩
  • Arthur Leblois, Wassilios Meissner, Bernard Bioulac, Christian E Gross, David Hansel, et al.. Late emergence of synchronized oscillatory activity in the pallidum during progressive parkinsonism.. European Journal of Neuroscience, Wiley, 2007, 26 (6), pp.1701-1713. ⟨10.1111/j.1460-9568.2007.05777.x⟩. ⟨hal-00174211⟩
  • Benjamin Pasquereau, Agnès Nadjar, David Arkadir, Erwan Bezard, Michel Goillandeau, et al.. Shaping of motor responses by incentive values through the basal ganglia. Journal of Neuroscience, Society for Neuroscience, 2007, 27 (5), pp.1176-1183. ⟨10.1523/JNEUROSCI.3745-06.2007⟩. ⟨hal-02658533⟩
  • Arthur Leblois, Thomas Boraud, Wassilios Meissner, Hagai Bergman, David Hansel. Competition between feedback loops underlies normal and pathological dynamics in the basal ganglia.. Journal of Neuroscience, Society for Neuroscience, 2006, 26 (13), pp.3567-83. ⟨10.1523/JNEUROSCI.5050-05.2006⟩. ⟨hal-00173766⟩
  • Wassilios Meissner, Arthur Leblois, David Hansel, Bernard Bioulac, Christian E Gross, et al.. Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations.. Brain - A Journal of Neurology , Oxford University Press (OUP), 2005, 128 (Pt 10), pp.2372-82. ⟨10.1093/brain/awh616⟩. ⟨hal-00173768⟩

Book sections1 document

  • A. Leblois, Thomas Boraud, H. Bergman, D. Hansel. Competition between feedback loops as the core of a computational model of the basal ganglia. E. Bezard. Recent breakthroughs in basal ganglia research, Nova Publishing, New York, pp.xxx-xxx, 2006. ⟨hal-00176394⟩