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Vitamin K Epoxide Reductase Complex–Protein Disulphide Isomerase Assemblies in the Thiol–Disulphide Exchange Reactions: Portrayal of Precursor-to-Successor Complexes

Maxim Stolyarchuk , Marina Botnari , Luba Tchertanov
International Journal of Molecular Sciences, 2024, Special Issue Protein Folding 2.0, 25 (8), pp.4135. ⟨10.3390/ijms25084135⟩
Article dans une revue hal-04538503v1
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The Inherent Coupling of Intrinsically Disordered Regions in the Multidomain Receptor Tyrosine Kinase KIT

Julie Ledoux , Alain Trouvé , Luba Tchertanov
International Journal of Molecular Sciences, 2022, 23 (3), pp.1589. ⟨10.3390/ijms23031589⟩
Article dans une revue hal-03605085v1

Allosteric Communication across the Native and Mutated KIT Receptor Tyrosine Kinase

Elodie Laine , Christian Auclair , Luba Tchertanov , Ruth Nussinov
PLoS Computational Biology, 2012, 8 (8), ⟨10.1371/journal.pcbi.1002661⟩
Article dans une revue hal-01588576v1
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Receptor Tyrosine Kinase KIT: Mutation-Induced Conformational Shift Promotes Alternative Allosteric Pockets

Julie Ledoux , Marina Botnari , Luba Tchertanov
Kinases and Phosphatases, 2023, 1 (4), pp.220-250. ⟨10.3390/kinasesphosphatases1040014⟩
Article dans une revue hal-04216918v1
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The First 3D Model of the Full-Length KIT Cytoplasmic Domain Reveals a New Look for an Old Receptor

François Inizan , Myriam Hanna , Maxim Stolyarchuk , Isaure Chauvot de Beauchêne , Luba Tchertanov
Scientific Reports, 2020, ⟨10.1038/s41598-020-62460-7⟩
Article dans une revue hal-03000379v1
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Identification of the Primary Factors Determining the Specificity of the human VKORC1 Recognition by Thioredoxin-fold Proteins

Maxim Stolyarchuk , Julie Ledoux , Elodie Maignant , Alain Trouvé , Luba Tchertanov
International Journal of Molecular Sciences, 2021, 22 (2), pp.802. ⟨10.3390/ijms22020802⟩
Article dans une revue hal-03042382v2
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Human Vitamin K Epoxide Reductase as a Target of Its Redox Protein

Julie Ledoux , Maxim Stolyarchuk , Enki Bachelier , Alain Trouvé , Luba Tchertanov
International Journal of Molecular Sciences, 2022, 23 (7), pp.3899. ⟨10.3390/ijms23073899⟩
Article dans une revue hal-03809897v1
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Structures et rôles de l'intégrase du VIH dans le cycle viral

Jean-François Mouscadet , Luba Tchertanov , Eric Deprez
Virologie, 2007, 11 (35), pp.143-52
Article dans une revue hal-00220399v1

Raltegravir flexibility and its impact on recognition by the HIV-1 IN targets.

Rohit Arora , Isaure Chauvot de Beauchêne , Jaroslaw Polansky , Elodie Laine , Luba Tchertanov
Journal of Molecular Recognition, 2013, ⟨10.1002/jmr.2277⟩
Article dans une revue istex hal-01505872v1
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Novel insight on molecular dynamics trajectories : local equilibrium viewed by kappa-segmentation

Sharad Goulam , Luba Tchertanov , Alain Trouvé
JOBIM 2019, Jul 2019, Nantes, France
Communication dans un congrès hal-03318395v1
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Genetic Evidence of a Precisely Tuned Dysregulation in the Hypoxia Signaling Pathway during Oncogenesis

Sophie Couvé , Charline Ladroue , Elodie Laine , Karène Mahtouk , Justine Guégan , et al.
Cancer Research, 2014, 74 ((22)), pp.6554-64. ⟨10.1158/0008-5472.CAN-14-1161⟩
Article dans une revue inserm-01401701v1
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In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors

Xiaoju Ni , Safwat Abdel-Azeim , Elodie Laine , Rohit Arora , Osamuede Osemwota , et al.
Advances in Virology, 2012, 2012, pp.1-13. ⟨10.1155/2012/548657⟩
Article dans une revue hal-03906792v1

Allosteric pathway identification through network analysis: from molecular dynamics simulations to interactive 2d and 3d graphs

Arian Allain , Isaure Chauvot de Beauchêne , Florent Langenfeld , Yann Guarracino , Elodie Laine , et al.
Faraday Discussions, 2014, ⟨10.1039/c4fd00024b⟩
Article dans une revue hal-01505837v1
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Germline CDKN2A/P16INK4A mutations contribute to genetic determinism of sarcoma

Fanélie Jouenne , Isaure Chauvot de Beauchêne , Emeline Bollaert , Marie-Francoise Avril , Olivier Caron , et al.
Journal of Medical Genetics, 2017, 54 (9), pp.607-612. ⟨10.1136/jmedgenet-2016-104402⟩
Article dans une revue hal-01580787v1
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Insight on mutation-induced resistance from molecular dynamics simulations of the native and mutated CSF-1R and KIT

Priscilla da Silva Figueiredo Celestino Gomes , Isaure Chauvot de Beauchêne , Nicolas Panel , Sophie Lopes , Paulo de Sepulveda , et al.
PLoS ONE, 2016, 11 (7), ⟨10.1371/journal.pone.0160165⟩
Article dans une revue hal-01505869v1

How Missense Mutations in Receptors Tyrosine Kinases impact Constitutive Activity and alternate Drug Sensitivity: Insights from Molecular Dynamics Simulations

Isaure Chauvot de Beauchêne , Luba Tchertanov
Receptors & Clinical Investigation, 2016, ⟨10.14800/rci.1372⟩
Article dans une revue hal-01505870v1

Le premier modèle 3D du domaine cytoplasmique complet du récepteur d'activité tyrosine kinase KIT dévoile une nouvelle vision sur cette ancienne cible

Luba Tchertanov
Scooped by Life Sciences UPSaclay From www.nature.com/articles/s41598-020-62460-7. http://sco.lt/5Pyvei, 2020
Autre publication scientifique hal-03042368v1

Biomimetic catalysis of catechol cleavage by O2 in organic solvents - Role of accessibility of O2 to FeIII in 2,11-diaza[3,3](2,6)pyridinophane-type catalysts

N. Raffard , R. Carina , A.J. Simaan , J. Sainton , Eric Rivière , et al.
European Journal of Inorganic Chemistry, 2001, 2001 (9), pp.2249. ⟨10.1002/1099-0682(200109)2001:9<2249::AID-EJIC2249>3.0.CO;2-3⟩
Article dans une revue istex hal-00918614v1
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Human Vitamin K Epoxide Reductase as a Target of its Redox Protein

Julie Ledoux , Maxim Stolyarchuck , Luba Tchertanov
Ignacio Rojas, Olga Valenzuela, Fernando Rojas, Luis Javier Herrera, Francisco Ortuño. Book title Bioinformatics and Biomedical Engineering, Lecture Notes in Computer Science (LNCS, volume 13347), 2022, https://link.springer.com/book/10.1007/978-3-031-07802-6, ⟨10.1007/978-3-031-07802-6_12⟩
Chapitre d'ouvrage hal-03626866v1

Evidence of a target resistance to antivitamin K rodenticides in the roof rat Rattus rattus: identification and characterisation of a novel Y25F mutation in the Vkorc1 gene

Joffrey Goulois , Audrey Chapuzet , Véronique Lambert , Nolan Chatron , Luba Tchertanov , et al.
Pest Management Science, 2016, 72 (3), pp.544 - 550. ⟨10.1002/ps.4020⟩
Article dans une revue istex hal-02630922v1

Characterization of S628N: a novel KIT mutation found in a metastatic melanoma

Marina Vita , Julie C Tisserand , Isaure Chauvot de Beauchêne , Nicolas Panel , Luba Tchertanov , et al.
JAMA Dermatology, 2014, 150 (12), ⟨10.1001/jamadermatol.2014.1437⟩
Article dans une revue hal-01505849v1
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Hotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivity

Ariane Allain , Isaure Chauvot de Beauchêne , Nicolas Panel , Elodie Laine , Alain Trouvé , et al.
PLoS Computational Biology, 2014, 10 (7), pp.e1003749. ⟨10.1371/journal.pcbi.1003749⟩
Article dans une revue hal-01505833v1
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Differential Effects of CSF-1R D802V and KIT D816V Homologous Mutations on Receptor Tertiary Structure and Allosteric Communication

Priscila da Silva Figueiredo Celestino Gomes , Nicolas Panel , Elodie Laine , Pedro Geraldo Pascutti , Eric Solary , et al.
PLoS ONE, 2014, 9 (5), ⟨10.1371/journal.pone.0097519⟩
Article dans une revue hal-01588567v1
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A first comprehensive look at the order-disorder nature of RTK KIT native and carcinogenic targets

Tchertanov Luba , Julie Ledoux
Global Journal of Cancer Therapy, 2022, 8 (1), pp.036-039. ⟨10.17352/2581-5407.000046⟩
Article dans une revue hal-03893814v1

Synthesis and X-ray structure of the MnIICl2 and MnIIIF2 complexes of N,N'-dimethyl 2,11 diaza[3,3](2,6)pyridinophane. High-field electron paramagnetic resonance and density funtional theory studies of the Mn(III) complex. Evidence for a low-lying spin triplet state

Belen Albela , Riccardo Carina , Clotilde Policar , Sandrine Poussereau , Joan Cano , et al.
Inorganic Chemistry, 2005, 44 (20), pp.6959. ⟨10.1021/ic048302f⟩
Article dans une revue istex hal-00392238v1
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Identification of the functional states of human vitamin K epoxide reductase from molecular dynamics simulations

Nolan Chatron , B. Chalmond , A Trouvé , Etienne Benoit , H. Caruel , et al.
RSC Advances, 2017, 7 (82), pp.52071-52090. ⟨10.1039/c7ra07463h⟩
Article dans une revue hal-01634415v1
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Does Generic Cyclic Kinase Insert Domain of Receptor Tyrosine Kinase KIT Clone Its Native Homologue?

Julie Ledoux , Luba Tchertanov
International Journal of Molecular Sciences, 2022, 23 (21), pp.12898. ⟨10.3390/ijms232112898⟩
Article dans une revue hal-03829781v1
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Receptor Tyrosine Kinase KIT: A New Look for an Old Receptor

Tchertanov L & Ledoux , Julie Ledoux
The 3rd Struchkov Meeting (2021) – Struchkov Prize Society (struchkovprizeassociation.org), Nov 2021, Moscou, Russia
Communication dans un congrès hal-03452106v1
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Receptor Tyrosine Kinase KIT: A New Look for an Old Receptor

Julie Ledoux , Luba Tchertanov
Bioinformatics and Biomedical Engineering 2022, pp.133 - 137, 2022, ⟨10.1007/978-3-031-07802-6_11⟩
Chapitre d'ouvrage hal-03809900v1
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Folding and Intrinsic Disorder of the Receptor Tyrosine Kinase KIT Insert Domain Seen by Conventional Molecular Dynamics Simulations

Julie Ledoux , Alain Trouvé , Luba Tchertanov
International Journal of Molecular Sciences, 2021, 22 (14), pp.7375. ⟨10.3390/ijms22147375⟩
Article dans une revue hal-03451829v1