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Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease

 François-Xavier Toublet , Cédric Lecoutey , Julien Lalut , Bérénice Hatat , Audrey Davis , et al.
Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩
Article dans une revue hal-02399906v1

Impact du microbiote intestinal dans un modèle murin de maladie d’Alzheimer.

 Patrizia Giannoni , Bérengère Coupé , Florence Gaven , Kévin Baranger , Santiago Rivera , et al.
Réunion francophone sur la maladie d’Alzheimer et les syndromes apparentés, Jun 2016, Lyon, France
Poster de conférence hal-02917762v1
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Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease

 Kévin Baranger , Patrizia Giannoni , Stéphane Girard , Sarah Girot , Florence Gaven , et al.
Neuropharmacology, 2017, 126, pp.128-141. ⟨10.1016/j.neuropharm.2017.08.031⟩
Article dans une revue hal-01799428v1
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Conformational Toggle Switches Implicated in Basal Constitutive and Agonist-Induced Activated States of 5-Hydroxytryptamine-4 Receptors

 Lucie P. Pellissier , Jessica Sallander , Mercedes Campillo , Florence Gaven , Emilie Queffeulou , et al.
Molecular Pharmacology, 2009, 75 (4), pp.982-990. ⟨10.1124/mol.108.053686⟩
Article dans une revue hal-02483472v1
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Longitudinal in vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

 Margarita Arango-Lievano , Patrizia Giannoni , Sylvie Claeysen , Nicola Marchi , Freddy Jeanneteau
Journal of visualized experiments : JoVE, 2016, ⟨10.3791/54796⟩
Article dans une revue hal-02368047v1

New insights in molecular aspects of Alzheimer’s disease. Conférencière invitée.

 Patrizia Giannoni , Florence Gaven , Kévin Baranger , Santiago Rivera , Philippe Marin , et al.
Sindem, Mar 2013, Perugia, Italy
Communication dans un congrès hal-02918588v1
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5-HT4 receptors

 Joël Bockaert , S. Claeysen , Valerie Compan , Aline Dumuis
Current Drug Targets -CNS and Neurological Disorders-, 2004, 3 (1), pp.39-51. ⟨10.2174/1568007043482615⟩
Article dans une revue hal-01667891v1
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Novel brain-specific 5-HT 4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain

 S. Claeysen , Michèle Sebben , C. Becamel , Joël Bockaert , Aline Dumuis
Molecular Pharmacology, 1999, 55 (5), pp.910-920
Article dans une revue hal-02487737v1
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Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease

 François-Xavier Toublet , Julien Lalut , Bérénice Hatat , Cédric Lecoutey , Audrey Davis , et al.
European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩
Article dans une revue hal-03082877v1
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Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease

 Julien Lalut , Hugo Payan , Audrey Davis , Cédric Lecoutey , Rémi Legay , et al.
Scientific Reports, 2020, 10, pp.3014. ⟨10.1038/s41598-020-59805-7⟩
Article dans une revue hal-02485740v1
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Primary culture of mouse dopaminergic neurons

 Florence Gaven , Philippe Marin , Sylvie Claeysen
Journal of visualized experiments : JoVE, 2014, 91, pp.e51751. ⟨10.3791/51751⟩
Article dans une revue hal-01943338v1
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Alzheimer culprits: cellular crossroads and interplay

 Sylvie Claeysen , Maud Cochet-Bissuel , Romain Donneger , Aline Dumuis , Joël Bockaert , et al.
Cellular Signalling, 2012, 24 (9), pp.1831-1840. ⟨10.1016/j.cellsig.2012.05.008⟩
Article dans une revue hal-01792371v1

Prodromal stimulation of 5-HT4 receptors reduces amyloid pathology in 5XFAD mice.

 Patrizia Giannoni , Florence Gaven , Kévin Baranger , Santiago Rivera , Philippe Marin , et al.
Club de neuroprotection, Nov 2012, Paris, France
Communication dans un congrès hal-02918562v1
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Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT 4 R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

 Cédric Lecoutey , Cédric Lecoutey , Florence Gaven , Patrizia Giannoni , Katia Hamidouche , et al.
Journal of Medicinal Chemistry, 2015, 58 (7), pp.3172-3187. ⟨10.1021/acs.jmedchem.5b00115⟩
Article dans une revue hal-02043873v1
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The 5×FAD mouse model of Alzheimer's disease

 Sylvie Claeysen , Patrizia Giannoni , Caroline Ismeurt
The Neuroscience of Dementia, 1 (Chapter 13), Academic Press, pp.207-221, 2020, Diagnosis and Management in Dementia, 9780128158548. ⟨10.1016/B978-0-12-815854-8.00013-6⟩
Chapitre d'ouvrage hal-02920524v1
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Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer’s disease

 Patrizia Giannoni , Florence Gaven , Dimitri de Bundel , Kévin Baranger , Evelyne Marchetti-Gauthier , et al.
Frontiers in Aging Neuroscience, 2013, 5, pp.96. ⟨10.3389/fnagi.2013.00096⟩
Article dans une revue hal-01703910v1
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Editorial: Identification of Multiple Targets in the Fight Against Alzheimer's Disease

 Patrizia Giannoni , Silvia Fossati , Elena Marcello , Sylvie Claeysen
Frontiers in Aging Neuroscience, 2020, 1, ⟨10.3389/fnagi.2020.00169⟩
Article dans une revue hal-02871844v1
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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

 Cédric Lecoutey , Damien Hedou , Thomas Freret , Patrizia Giannoni , Florence Gaven , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Article dans une revue hal-01800439v2
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5-HT4 Receptors: Cloning and Expression of New Splice Variants

 S. Claeysen , Patrick Faye , Michèle Sebben , Sylvie Taviaux , Joël Bockaert , et al.
Annals of the New York Academy of Sciences, 1998, 861 (1), pp.49-56. ⟨10.1111/j.1749-6632.1998.tb10172.x⟩
Article dans une revue hal-02489922v1
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A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist

 Sylvie Claeysen , Cédric Govaerts , Anne Lefort , Jacqueline Van Sande , Sabine Costagliola , et al.
FEBS Letters, 2002, 517 (1-3), pp.195-200. ⟨10.1016/s0014-5793(02)02620-0⟩
Article dans une revue hal-02486691v1
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Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase

 Sylvie Claeysen , Patrick Faye , Michèle Sebben , Stéphanie Barrère-Lemaire , Joël Bockaert , et al.
NeuroReport, 1997, 8 (15), pp.3189-3196. ⟨10.1097/00001756-199710200-00002⟩
Article dans une revue hal-02491123v1
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Pharmacological profile of engineered 5-HT4 receptors and identification of 5-HT4 receptor-biased ligands

 Florence Gaven , Lucie P. Pellissier , Emilie Queffeulou , Maud Cochet-Bissuel , Joël Bockaert , et al.
Brain Research, 2013, 1511, pp.65-72. ⟨10.1016/j.brainres.2012.11.005⟩
Article dans une revue hal-02482146v1
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5-HT4 Receptors: Gene, Transduction and Effects on Olfactory Memory

 Joël Bockaert , S. Claeysen , Michèle Sebben , Aline Dumuis
Annals of the New York Academy of Sciences, 1998, ADVANCES IN SEROTONIN RECEPTOR RESEARCH: MOLECULAR BIOLOGY, SIGNAL TRANSDUCTION, AND THERAPEUTICSa, 861 (1), pp.1-15. ⟨10.1111/j.1749-6632.1998.tb10167.x⟩
Article dans une revue istex hal-02490520v1
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Constitutively active mutants of 5‐HT 4 receptors are they in unique active states?

 Sylvie Claeysen , Michèle Sebben , Carine Becamel , Marie-Laure Parmentier , Aline Dumuis , et al.
EMBO Reports, 2001, 2 (1), pp.61-67. ⟨10.1093/embo-reports/kve003⟩
Article dans une revue hal-02486964v1
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A Single Mutation in the 5-HT 4 Receptor (5-HT4 -R D100(3.32)A) Generates a Gs-coupled Receptor Activated Exclusively by Synthetic Ligands (RASSL)

 Sylvie Claeysen , Lara Joubert , Michèle Sebben , Aline Dumuis , Joël Bockaert
Journal of Biological Chemistry, 2003, 278 (2), pp.699-702. ⟨10.1074/jbc.C200588200⟩
Article dans une revue hal-02486549v1

5 HT4 agonists: novel promising agents for AD prevention.

 Patrizia Giannoni , Florence Gaven , Kévin Baranger , Santiago Rivera , Philippe Marin , et al.
AD/PD 2013, Mar 2013, Florence, Italy
Poster de conférence hal-02918547v1

5 HT4 agonists: novel promising agents for AD prevention.

 Patrizia Giannoni , Florence Gaven , Kévin Baranger , Santiago Rivera , Philippe Marin , et al.
Congrès des Neurosciences Francaises, May 2013, Lyon, France
Poster de conférence hal-02918543v1
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Novel and atypical pathways for serotonin signaling

 Joël Bockaert , Carine Becamel , Séverine Chaumont-Dubel , Sylvie Claeysen , Franck Vandermoere , et al.
Faculty Reviews, 2021, 10, pp.52. ⟨10.12703/r/10-52⟩
Article dans une revue hal-03256253v1
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International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

 Nicholas M Barnes , Gerard P Ahern , Carine Becamel , Joël Bockaert , Michael Camilleri , et al.
Pharmacological Reviews, 2020, 73 (1), pp.310-520. ⟨10.1124/pr.118.015552⟩
Article dans une revue hal-03099832v1
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Serotonin type 4 receptor dimers

 Sylvie Claeysen , Romain Donneger , Patrizia Giannoni , Florence Gaven , Lucie P. Pellissier
Methods in Cell Biology - Receptor-Receptor Interactions, 117, Academic Press - Elsevier, pp.123-139, 2013, 117, 978-0-12-408143-7. ⟨10.1016/B978-0-12-408143-7.00007-4⟩
Chapitre d'ouvrage hal-01792387v1
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