Sylvie BOUVIER

**Sylvie BOUVIER, age 40 (France) ** PharmD., Ph.D., University Associate Professor, Haematology, University of Montpellier, France Hospital Practitioner, Laboratory of Haematology, University Hospital, Nîmes, France Research Unit “ Institut Desbrest of Epidemiology and Santé Publique INSERM, University of Montpellier, France *Haemostasis, Thrombosis, Thrombophilia, Netosis, Venous thromboembolism, Vascular Biology, Pregnancy-related vascular complications.* Full professional adress: Consultations et Laboratoire d’Hématologie, Centre Hospitalier Universitaire, Groupe Hospitalo-Universitaire Caremeau, Place du Pr. Robert debré, F-30029 Nîmes cedex 9, France Phone number: +33 466 683 211 Fax number: +33 466 683 648 Email: sylvie.bouvier@chu-nimes.fr; sylvie.bouvier@umontpellier.fr **EDUCATION AND TRAINING ** - 2010: PharmD., Faculty of Pharmaceutical and Biological Science, University of Montpellier. - 2010: Diploma of Specialized Studies (DES), Medical Biology, University of Montpellier. - 2011: Master 2 graduate degree, academic area "Biology and Health", University of Montpellier. - 2014: Ph.D. degree, academic area "Biology and Health", University of Montpellier. - 2021: HDR “Habilitation à Diriger des Recherches”, University of Montpellier. **PROFESSIONAL EXPERIENCE** 2006-2010: Resident in Medical Biology, Montpellier University, Nîmes and Montpellier. 2010-2013: University Hospital Assistant (AHU), Haematology, Faculty of Pharmaceutical and Biological Science, University of Montpellier and Laboratory of Haematology, University Hospital, Nîmes. 2013-2014: Post-Doctoral degree, INSERM UMR-S1076, Vascular Research Center of Marseille (VRCM). Faculty of Pharmaceutical and Biological Science, Aix Marseille University. 2014-2015: Associate practitioner in Haematology, Laboratory of Haematology, University Hospital, Nîmes. 2015-present: University Associate Professor, Haematology, University of Montpellier and Hospital Practitioner (MCU-PH), Laboratory of Haematology, University Hospital, Nîmes. 2022-present: Co-coordinator of the Diploma of Specialized Studies (DES) in Medical Biology, University of Montpellier. **RESEARCH TOPICS:** Haemostasis, Thrombosis, Venous thromboembolism, Vascular Biology, Netosis, Pregnancy-related vascular complications. **GRANTS** Internal grants obtained from the University Hospital of Nîmes (NIMAO internal grant) : 258.6 k€ Grants obtained from the University Hospital of Nîmes and the University Hospital of Montpellier (GCS Meri) : 74.8 k€ **ACTIVITY OF COLLECTIVE INTEREST** Member of the Scientific Council on Clinical Research, University Hospital, Nîmes. Member of the “Conseil National des Universités” Section 82 (CNU 82). Member of the Association of Teachers of Haematology, Immunology and Biotherapy (AssHIB). Member of the International Society on Thrombosis and Haemostasis ISTH, of the French Society of Haematology SFH, of the French Society on Thrombosis and Haemostasis, SFTH, of the French National Association of Molecular Genetics Practitioners, ANPGM. **10 MAIN PUBLICATIONS** Guillotin F, Fortier M, Portes M, Demattei C, Cultrera L, Loyens M, Mousty E, Nouvellon E, Mercier E, Bourguignon C, Chea M, Letouzey V, Gris JC,** **Bouvier S****. Direct blood fluorescence signal intensity of neutrophils (NEU-SFL): A marker of NETosis in preeclampsia? Thromb Res. 2023 ;221:65-68. doi: 10.1016/j.thromres.2022.11.022. Guillotin F, Fortier M, Portes M, Demattei C, Mousty E, Nouvellon E, Mercier E, Chea M, Letouzey V, Gris JC, **Bouvier S.** Vital NETosis vs. suicidal NETosis during normal pregnancy and preeclampsia. Front Cell Dev Biol. 2023 ;10:1099038. doi: 10.3389/fcell.2022.1099038. Fortier M, Chea M, Aïn C, Loyens M, Boudemaghe T, Gris JC, **Bouvier S**. Direct blood fluorescence signal intensity of neutrophils (NEU-SFL): A predictive marker of death in hospitalized COVID-19 patients? Front Med (Lausanne). 2022:1;9:1062112. doi: 10.3389/fmed.2022.1062112. **Bouvier S**, Fortier M, Vincent L, Demattei C, Mousty E, Herzog M, Rommelaere G, Nouvellon E, Mercier E, Letouzey V, Gris JC. NETosis Markers in Pregnancy: Effects Differ According to Histone Subtypes. Thromb Haemost. 2021; 121(7):877-890. **Bouvier S**, Kaspi E, Joshkon A, Paulmyer-Lacroix O, Piercecchi-Marti MD, Sharma A, Leroyer AS, Bertaud A, Gris JC, Dignat-George F, Blot-Chabaud M, Bardin N. The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and Pregnancy. Front Immunol. 2021;12:711394. doi: 10.3389/fimmu.2021.711394. **Bouvier S,** Mousty E, Fortier M, Demattei C, Mercier E, Nouvellon E, Chea M, Grosjean F, Letouzey V, Gris JC. Placenta-mediated complications: Nucleosomes and free DNA concentrations differ depending on subtypes. J Thromb Haemost. 2020;18(12):3371-3380. **Bouvier S**, Paulmyer-Lacroix O, Molinari N, Bertaud A, Paci M, Leroyer A, Dignat George F, Blot-Chabaud M, Bardin N. Soluble CD146, an innovative and non-invasive biomarker of embryo selection for in vitro fertilization. Plos One 2017;12(3):e0173724. **Bouvier S**, Cochery-Nouvellon E, Lavigne-Lissalde G, Mercier E, Marchetti T, Balducchi JP, Marès P, Gris JC. Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study. Blood 2014; 123(3):404-413. **Bouvier S**, Cochery-Nouvellon E, Lavigne-Lissalde G, Mercier E, Fabbro-Peray P, Balducchi JP, Marès P, Gris JC. Comparative incidence of pregnancy outcomes in thrombophilia-positive women from the NOH-APS observational study. Blood 2014; 123(3):414-421. Gris JC, **Bouvier S**, Molinari N, Galanaud JP, Cochery-Nouvellon E, Mercier E, Fabbro-Peray P, Balducchi JP, Marès P, Quéré I, Dauzat M. Comparative incidence of a first thrombotic event in purely obstetric antiphospholipid syndrome with pregnancy loss: the NOH-APS observational study. Blood. 2012 Mar 15;119(11):2624-32. doi: 10.1182/blood-2011-09-381913.