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62

Epigenetics, Proteomics and Stem cells


Journal articles44 documents

  • Emmanuelle Salort-Campana, Farzad Fatehi, Sadia Beloribi-Djefaflia, Stéphane Roche, Karine Nguyen, et al.. Type 1 FSHD with 6–10 Repeated Units: Factors Underlying Severity in Index Cases and Disease Penetrance in Their Relatives Attention. International Journal of Molecular Sciences, MDPI, 2020, 21 (6), pp.2221. ⟨10.3390/ijms21062221⟩. ⟨hal-02533845⟩
  • Karine Nguyen, Natacha Broucqsault, Charlene Chaix, Stéphane Roche, Jérôme Robin, et al.. Deciphering the complexity of the 4q and 10q subtelomeres by molecular combing in healthy individuals and patients with facioscapulohumeral dystrophy. Journal of Medical Genetics, BMJ Publishing Group, In press, ⟨10.1136/jmedgenet-2018-105949⟩. ⟨hal-02140159⟩
  • Stéphane Roche, Camille Dion, Natacha Broucqsault, Camille Laberthonnière, Marie-Cécile Gaillard, et al.. Methylation hotspots evidenced by deep sequencing in patients with facioscapulohumeral dystrophy and mosaicism. Neurology Genetics, American Academy of Neurology, 2019, 5 (6), pp.e372. ⟨10.1212/NXG.0000000000000372⟩. ⟨hal-02406985⟩
  • Karine Nguyen, Stéphane Roche, Erwan Donal, Sylvie Odent, Jean-Christophe Eicher, et al.. Whole Exome Sequencing Reveals a Large Genetic Heterogeneity and Revisits the Causes of Hypertrophic Cardiomyopathy. Circulation: Genomic and Precision Medicine, American Heart Association, 2019, 12 (5), pp.e002500. ⟨10.1161/CIRCGEN.119.002500⟩. ⟨hal-02140150⟩
  • Chiara Uboldi, Marcos Sanles Sobrido, Elodie Bernard, Virginie Tassistro, Nathalie Herlin-Boime, et al.. In Vitro Analysis of the Effects of ITER-Like Tungsten Nanoparticles: Cytotoxicity and Epigenotoxicity in BEAS-2B Cells. Nanomaterials, MDPI, 2019, From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials, 9 (9), pp.1233. ⟨10.3390/nano9091233⟩. ⟨hal-02352628⟩
  • Camille Dion, Stéphane Roche, Camille Laberthonnière, Natacha Broucqsault, Virginie Mariot, et al.. SMCHD1 is involved in de novo methylation of the DUX4-encoding D4Z4 macrosatellite. Nucleic Acids Research, Oxford University Press, 2019, ⟨10.1093/nar/gkz005⟩. ⟨hal-02002680⟩
  • Marie-Cécile Gaillard, Natacha Broucqsault, Julia Morere, Camille Laberthonnière, Camille Dion, et al.. Analysis of the 4q35 chromatin organization reveals distinct long-range interactions in patients affected with Facio-Scapulo-Humeral Dystrophy.. Scientific Reports, Nature Publishing Group, 2019, ⟨10.1038/s41598-019-46861-x⟩. ⟨hal-01951503v2⟩
  • Nicolas Molinari, Stéphane Roche, Katell Peoc’h, Laurent Tiers, Martial Seveno, et al.. Sample Pooling and Inflammation Linked to the False Selection of Biomarkers for Neurodegenerative Diseases in Top–Down Proteomics: A Pilot Study. Frontiers in Molecular Neuroscience, Frontiers Media, 2018, 11, pp.477. ⟨10.3389/fnmol.2018.00477⟩. ⟨hal-02061536⟩
  • P. Merviel, S. Bouée, Mathieu Menard, M. Le Martelot, S. Roche, et al.. Quelles stimulations pour quelles femmes : le syndrome des ovaires polykystiques (SOPK). Gynécologie Obstétrique Fertilité & Sénologie, Elsevier, 2017, 45 (11), pp.623-631. ⟨hal-02050695⟩
  • Karine Nguyen, Francesca Puppo, Stéphane Roche, Marie-Cécile Gaillard, Charlene Chaix, et al.. Molecular combing reveals complex 4q35 rearrangements in Facioscapulohumeral dystrophy. Human Mutation, Wiley, 2017, 38 (10), pp.1432 - 1441. ⟨10.1002/humu.23304⟩. ⟨hal-01614514⟩
  • Marie-Cécile Gaillard, Francesca Puppo, Stéphane Roche, Camille Dion, Emmanuelle Campana Salort, et al.. Segregation between SMCHD1 mutation, D4Z4 hypomethylation and Facio-Scapulo-Humeral Dystrophy: a case report. BMC Medical Genetics, BioMed Central, 2016, 17, pp.66. ⟨10.1186/s12881-016-0328-9⟩. ⟨hal-01378417⟩
  • Virginie Mariot, S. Roche, Débora Portilho, Sabrina Sacconi, Francesca Puppo, et al.. Correlation between low FAT1 expression and early affected muscle in facioscapulohumeral muscular dystrophy. Annals of Neurology, Wiley, 2015, 78 (3), pp.387-400. ⟨10.1002/ana.24446⟩. ⟨hal-01431338⟩
  • Débora Portilho, Marcelo Ribeiro Alves, Gueorgui Kratassiouk, Stéphane Roche, Frédérique Magdinier, et al.. miRNA Expression in Control and FSHD Fetal Human Muscle Biopsies. PLoS ONE, Public Library of Science, 2015, 10 (2), pp.e0116853. ⟨10.1371/journal.pone.0116853⟩. ⟨hal-01219803⟩
  • A. Sirvent, S. Urbach, S. Roche. Analyse in vivo de la signalisation tumorale induite par les tyrosinekinases par protéomique quantitative. médecine/sciences, EDP Sciences, 2014, 30 (5), pp.558--566. ⟨10.1051/medsci/20143005020⟩. ⟨hal-01942937⟩
  • Marie-Cécile Gaillard, Stéphane Roche, Camille Dion, Armand Tasmadjian, Gwenaelle Bouget, et al.. Differential DNA methylation of the D4Z4 repeat in patients with FSHD and asymptomatic carriers. Neurology, American Academy of Neurology, 2014, 83 (8), pp.733-742. ⟨10.1212/WNL.0000000000000708⟩. ⟨hal-01610019⟩
  • Nathalie Caruso, Balàzs Herberth, Marc Bartoli, Francesca Puppo, Julie Dumonceaux, et al.. Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy.. PLoS Genetics, Public Library of Science, 2013, 9 (6), pp.e1003550. ⟨10.1371/journal.pgen.1003550⟩. ⟨hal-00862092⟩
  • Natacha Broucqsault, Julia Morere, Marie-Cécile Gaillard, Julie Dumonceaux, Julia Torrents, et al.. Dysregulation of 4q35- and muscle-specific genes in fetuses with a short D4Z4 array linked to facio-scapulo-humeral dystrophy. Human Molecular Genetics, Oxford University Press (OUP), 2013, 22 (20), pp.4206 - 4214. ⟨10.1093/hmg/ddt272⟩. ⟨hal-01662672⟩
  • A. L. Chesnais, E. Niaf, F. Bratan, F. Mège-Lechevallier, S. Roche, et al.. Differentiation of transitional zone prostate cancer from benign hyperplasia nodules: evaluation of discriminant criteria at multiparametric MRI. Clinical Radiology, WB Saunders, 2013, 68, pp.e323-30. ⟨10.1016/j.crad.2013.01.018⟩. ⟨hal-02168098⟩
  • Stephane Roche, Gianluca d'Ippolito, Adriana Gomez, Thomas Bouckenooghe, Sylvain Lehmann, et al.. Comparative analysis of protein expression of three stem cell populations: models of cytokine delivery system in vivo.. International Journal of Pharmaceutics, Elsevier, 2013, 440 (1), pp.72-82. ⟨10.1016/j.ijpharm.2011.12.041⟩. ⟨inserm-00802595v2⟩
  • Maxime Ferreboeuf, Virginie Mariot, Bettina Bessières, Alexandre Vasiljevic, Tania Attié-Bitach, et al.. DUX4 and DUX4 downstream target genes are expressed in fetal FSHD muscles.. Human Molecular Genetics, Oxford University Press (OUP), 2013, 23 (1), epub ahead of print. ⟨10.1093/hmg/ddt409⟩. ⟨hal-00868855⟩
  • Somayyeh Fahiminiya, S. Roche, Nadine Gérard. Improvement of 2D-PAGE resolution of human, porcine and canine follicular fluid: comparison of two immunodepletion columns. Reproduction in Domestic Animals, Wiley, 2012, 47 (5), pp.e67-e70. ⟨10.1111/j.1439-0531.2011.01939.x⟩. ⟨hal-01129661⟩
  • Stéphane Roche, Boris Mericskay, Wided Batita, Matthieu Bach, Mathieu Rondeau. WikiGIS Basic Concepts: Web 2.0 for Geospatial Collaboration. Future internet, MDPI, 2012, 4 (1), pp.265-284. ⟨10.3390/fi4010265⟩. ⟨halshs-02309571⟩
  • Somayyeh Fahiminiya, Valérie Labas, S. Roche, Jean-Louis Dacheux, Nadine Gérard. Proteomic analysis of mare follicular fluid during late follicle development. Proteome Science, BioMed Central, 2011, 9:54, pp.1-19. ⟨10.1186/1477-5956-9-54⟩. ⟨hal-01129526⟩
  • Audrey Gabelle, S. Roche, C. Geny, K. Bennys, P. Labauge, et al.. Decreased sAβPPβ, Aβ38, and Aβ40 Cerebrospinal Fluid Levels in Frontotemporal Dementia.. Journal of Alzheimer's Disease, IOS Press, 2011, 26 (3), pp.553-563. ⟨10.3233/JAD-2011-110515⟩. ⟨hal-00635931⟩
  • Audrey Gabelle, S. Roche, Christian Geny, Karim Bennys, Pierre Labauge, et al.. Correlations between soluble alpha/beta forms of amyloid precursor protein and Abeta38, 40 and 42 in human cerebrospinal fluid. Brain Research, Elsevier, 2010, 1357, pp.175-183. ⟨10.1016/j.brainres.2010.08.022⟩. ⟨hal-00527806⟩
  • Monique Provansal, S. Roche, M. Pastore, D. Casanova, M. Belondrade, et al.. Proteomic consequences of expression and pathological conversion of the prion protein in inducible neuroblastoma N2a cells. Prion, Taylor & Francis, 2010, 4 (4), pp.4, 4. ⟨10.4161/pri.4.4.13435⟩. ⟨hal-00529322⟩
  • Stéphane Roche, Laurent Tiers, Monique Provansal, Martial Seveno, Marie-Thérèse Piva, et al.. Depletion of one, six, twelve or twenty major blood proteins before proteomic analysis: the more the better?. Journal of Proteomics, Elsevier, 2009, 72 (6), pp.945-951. ⟨10.1016/j.jprot.2009.03.008⟩. ⟨hal-00410072⟩
  • Stéphane Roche, B. Delorme, R. Oostendorp, R. Barbet, C. Caton, et al.. Comparative proteomic analysis of human mesenchymal and embryonic stem cells: towards the definition of a mesenchymal stem cell proteomic signature. Proteomics, Wiley-VCH Verlag, 2009, 9 (2), pp.223-232. ⟨10.1002/pmic.200800035⟩. ⟨hal-00357170⟩
  • Audrey Gabelle, S. Roche, Sylvain Lehmann. Les marqueurs biologiques protéiques du liquide céphalorachidien : caractéristiques et implications cliniques dans les démences. Revue Neurologique, Elsevier Masson, 2009, 165 (3), pp.213-222. ⟨10.1016/j.neurol.2008.05.004⟩. ⟨hal-00409885⟩
  • Sylvain Lehmann, S. Roche, Y. Allory, A. Barthelaix, J.-L. Beaudeux, et al.. Preanalytical guidelines for clinical proteomics investigation of biological fluids. Annales de Biologie Clinique, John Libbey Eurotext, 2009, 67 (6), pp.629-639. ⟨10.1684/abc.2009.0374⟩. ⟨hal-00444355⟩
  • Sonia Molina, Dorothée Missé, Stéphane Roche, Stéphanie Badiou, Jean-Paul Cristol, et al.. Identification of apolipoprotein C-III as a potential plasmatic biomarker associated with the resolution of hepatitis C virus infection. PROTEOMICS - Clinical Applications, Wiley-VCH Verlag, 2008, 2 (5), pp.751 - 761. ⟨10.1002/prca.200800020⟩. ⟨hal-01662783⟩
  • Stéphane Roche, Audrey Gabelle, Sylvain Lehmann. Clinical proteomics of the cerebrospinal fluid: Towards the discovery of new biomarkers. PROTEOMICS - Clinical Applications, Wiley-VCH Verlag, 2008, 2 (3), pp.428 - 436. ⟨10.1002/prca.200780040⟩. ⟨hal-01662796⟩
  • Danièle Noël, David Caton, S. Roche, Claire Bony, Sylvain Lehmann, et al.. Cell specific differences between human adipose derived- and mesenchymal- stromal cells despite similar differentiation potentials.. Experimental Cell Research, Elsevier, 2008, 314 (7), pp.1575-1584. ⟨10.1016/j.yexcr.2007.12.022⟩. ⟨hal-00275173⟩
  • Yannick Saintigny, Stéphane Roche, Delphine Meynard, Bernard S Lopez. Homologous Recombination is Involved in the Repair Response of Mammalian Cells to Low Doses of Tritium. Radiation Research, Radiation Research Society, 2008, 170 (2), pp.172-183. ⟨10.1667/RR1089.1⟩. ⟨hal-01621200⟩
  • Stéphane Roche, Yves Dauvilliers, Laurent Tiers, Carine Couderc, Marie-Thérèse Piva, et al.. Auto-antibody profiling on high-density protein microarrays for biomarker discovery in the cerebrospinal-fluid.. Journal of Immunological Methods, Elsevier, 2008, 338 (1-2), pp.75-78. ⟨10.1016/j.jim.2008.07.002⟩. ⟨hal-00323778⟩
  • M. Kastrinaki, P. Sidiropoulos, S. Roche, J. Ringe, Sylvain Lehmann, et al.. Functional, Molecular and Proteomic Characterization of Bone Marrow Mesenchymal Stem Cells in Rheumatoid Arthritis. Annals of the Rheumatic Diseases, BMJ Publishing Group, 2008, 67 (6), pp.741-749. ⟨10.1136/ard.2007.076174⟩. ⟨hal-00287919⟩
  • C. Reynes, Stephane Roche, Laurent Tiers, R. Sabatier, P. Jouin, et al.. Comparison between surface and bead based MALDI profiling technologies using a single bioinformatics algorithm. Clinical Proteomics, BioMed Central, 2007, 2, pp.145-152. ⟨10.1007/BF02752497⟩. ⟨hal-00291842⟩
  • Stéphane Roche, Marie-Jeanne Richard, Marie-Christine Favrot. Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression.. Journal of Cellular Biochemistry, Wiley, 2007, 101 (2), pp.271-80. ⟨10.1002/jcb.21185⟩. ⟨inserm-00312819⟩
  • Sylvain Lehmann, A. Dupuy, K. Peoc'H, Stephane Roche, B. Baudin, et al.. Présent et futur de la Protéomique clinique. Annales de Biologie Clinique, John Libbey Eurotext, 2007, 65 (5), pp.463-471. ⟨10.1684/abc.2007.0149⟩. ⟨hal-00179241⟩
  • Stéphane Roche, M. Provansal, L. Tiers, C. Jorgensen, S. Lehmann. Proteomics of primary mesenchymal stem cells. Regenerative Medicine, Future Medicine, 2006, 1 (4), pp.511 - 517. ⟨10.2217/17460751.1.4.511⟩. ⟨hal-01919376⟩
  • S. Roche, Laurent Tiers, Monique Provansal, Marie-Thérèse Piva, Sylvain Lehmann. Interest of major serum protein removal for Surface-Enhanced Laser Desorption/Ionization - Time Of Flight (SELDI-TOF) proteomic blood profiling.. Proteome Science, BioMed Central, 2006, 4 (1), pp.20. ⟨10.1186/1477-5956-4-20⟩. ⟨hal-00113437⟩
  • Marie-Claire Ronzière, Stéphane Roche, Jérome Gouttenoire, Olivier Demarteau, Daniel Herbage, et al.. Ascorbate modulation of bovine chondrocyte growth, matrix protein gene expression and synthesis in three-dimensional collagen sponges.. Biomaterials, Elsevier, 2003, 24, pp.851-861. ⟨10.1016/S0142-9612(02)00418-0⟩. ⟨hal-00313309⟩
  • Stéphane Roche, Marie-Claire Ronzière, Daniel Herbage, Anne-Marie Freyria. Native and DPPA cross-linked collagen sponges seeded with fetal bovine epiphyseal chondrocytes used for cartilage tissue engineering.. Biomaterials, Elsevier, 2001, 22, pp.9-18. ⟨10.1016/S0142-9612(00)00084-3⟩. ⟨hal-00313313⟩
  • Anne-Marie Freyria, Marie-Claire Ronzière, S. Roche, Cécile F. Rousseau, Daniel Herbage. Regulation of growth, protein synthesis, and maturation of fetal bovine epiphyseal chondrocytes grown in high-density culture in the presence of ascorbic acid, retinoic acid, and dihydrocytochalasin B.. Journal of Cellular Biochemistry, Wiley, 1999, 76 (1), pp.84-98. ⟨10.1002/(SICI)1097-4644(20000101)76:1<84::AID-JCB9>3.0.CO;2-Z⟩. ⟨hal-00313321⟩

Conference papers5 documents

  • M Ferreboeuf, V. Mariot, B. Bessières, A Vasiljevic, Tania Attié-Bitach, et al.. DUX 4 and DUX4 downstream target genes are expressed in fetal FSHD muscles. 18th International Congress of The World Muscle Society, Oct 2013, Pacific Grove, CA, United States. pp.823, ⟨10.1016/j.nmd.2013.06.640⟩. ⟨hal-01907613⟩
  • Natacha Broucqsault, Stéphane Roche, Julia Morere, Marie-Cécile Gaillard, Nicolas Levy, et al.. Modification of 4q35 and muscular gene expression in fetuses carrying a shortened D4Z4 array linked to FSHD. 18th International Congress of The World Muscle Society, Oct 2013, Pacific Grove, CA, United States. pp.824, ⟨10.1016/j.nmd.2013.06.643⟩. ⟨hal-01907599⟩
  • S Lehmann, A Gabelle, Stéphane Roche, E Thouvenot, K Peoc'h, et al.. Apport de la tomographie par émission monophotonique de perfusion dans le diagnostic étiologique des démences : Confrontations cliniques, tomographiques et neuropathologiques. 10e Réunion Francophone sur la Maladie d'Alzheimer et les syndromes apparentés, Oct 2009, Nantes, France. pp.70-71. ⟨hal-01908628⟩
  • A. Gabelle, Stéphane Roche, C. Gény, J. Touchon, S. Lehmann. les corrélats neuronaux de l'acquisition et de la consolidation dans la maladie d'alzheimer et l'altération cognitive légère. 10e Réunion francophone sur la maladie d’Alzheimer et les syndromes apparentés, Oct 2009, Nantes, France. pp.65 - 75. ⟨hal-01908635⟩
  • Audrey Gabelle, Stéphane Roche, C. Gény, F. Portet, J. Touchon, et al.. INTEREST OF CSF ABETA/TAU INDEX IN ALZHEIMER’S POSITIVE DIAGNOSIS.. 1st Conference Clinical Trials on Alzheimer’s Disease, Sep 2008, Montpellier, France. pp.531. ⟨hal-01907406⟩

Poster communications7 documents

  • Karine Nguyen, Stéphane Roche, C Lavoute, P Reant, E Donal, et al.. Genetic spectrum of hypertrophic cardiomyopathy revisited. Whole Exome Sequencing reveals extreme genetic heterogeneity and new gene mutations in a multicenter series of 200 patients. ESC Congress 2018, Aug 2018, Munich, Germany. Oxford University Press, 39 (suppl_1), 2018, European Heart Journal. ⟨hal-01908612⟩
  • Karine Nguyen, Francesca Puppo, Natacha Broucqsault, Stéphane Roche, Charlene Chaix, et al.. L’apport du peignage moléculaire pour révéler la variabilité génétique et la complexité du diagnostic moléculaire dans la dystrophie Facio-Scapulo Humérale.. 9ème édition des Assises de Génétique Humaine et Médicale, Jan 2018, Nante, France. 2018. ⟨hal-01695264⟩
  • Camille Dion, Marie-Cécile Gaillard, Arnaud Lagarde, Cherif Badja, Armand Tasmadjian, et al.. 3D nuclear topology dynamics of the 4q35 subtelomeric region linked to Facio-Scapulo-Humeral Dystrophy in skeletal muscle cells and hiPSC. EMBO Conference - Chromatin and Epigenetics, May 2015, Heidelberg, Germany. ⟨hal-01675614⟩
  • Marie-Cécile Gaillard, Camille Dion, Francesca Puppo, Marc Bartoli, Karine N'Guyen, et al.. DNA Methylation-based diagnosis of Facio Scapulo Humeral Dystrophy. EMBO Conference - Chromatine and Epigenetics, May 2015, Heidelberg, Germany. ⟨hal-01676426⟩
  • Marie-Cécile Gaillard, Francesca Puppo, Stéphane Roche, Camille Dion, Emmanuelle Salort-Campana, et al.. Segregation between a frameshift SMCHD1 mutation, D4Z4 hypomethylation and Facio-Scapulo-Humeral Dystrophy. 13e Journée de la Société Française de Myologie, Nov 2015, Lyon, France. 2015. ⟨hal-01688694⟩
  • Cherif Badja, Marie-Cécile Gaillard, Claire El-Yazidi, Marc Bartoli, Stéphane Roche, et al.. DIRECT AND EFFICIENT DERIVATION OF SKELETAL MUSCLE CELLS FROM HUMAN INDUCED PLURIPOTENT STEM CELLS. International Society For Stem Cell Research - Annual Meeting, Jun 2015, Stockholm, Sweden. ⟨hal-01676453⟩
  • Marie-Cécile Gaillard, Natacha Broucqsault, C Chaix, C Vovan, Stéphane Roche, et al.. Analyses de profils épigénétiques dans la dystrophie facio-scapulo-humérale : de la méthylation de l’ADN vers des corrélations génotype-phénotype. Xeme Journées Annuelles de la Société Francaise de Myologie & Colloque de Myogenèse, Nov 2012, Grenoble, France. 2012. ⟨hal-01688662⟩

Books1 document

  • Olivier Galland, Jean-Hugues Déchaux, A. Degenne, J.M. Donegani, M. Forse, et al.. La nouvelle société française. Trente années de mutation.. Armand Colin, 1998. ⟨hal-02171309⟩

Book sections4 documents

  • Teriitutea Quesnot, Stéphane Roche. Explorer les mobilités partagées à l'ère des Technologies de Géolocalisation. Médias situés et mobilités partagées, Hermann, pp.55-75, 2020, 9791037003508. ⟨hal-02141723v2⟩
  • Monique Provansal, Christian Jorgensen, Sylvain Lehmann, S. Roche. Two Dimensional Gel Electrophoresis Analysis of Mesenchymal Stem Cells. Mesenchymal Stem Cell Assays and Applications, 698, pp.431-442, 2011, Methods in Molecular Biology ⟨10.1007/978-1-60761-999-4_31⟩. ⟨hal-00616455⟩
  • Sylvain Lehmann, Stéphane Roche, Anne-Marie Dupuy. Analyses multiples des protéines : multiplexages en phase solide (puces à protéines) ou liquide; applications en biologie médicales et perspectives. Protéomique, spectrométrie de masse et analyses multiples, 2010, Cahier de formation biologie médicale. ⟨hal-01900150⟩
  • Stéphane Roche, Benoît Raveleau. Social Use and Adoption Models of GIS. Roche Stéphane; Caron Claude. Organizational Facets of GIS, Wiley-ISTE, pp.121-145, 2009, 978-1-84821-085-1. ⟨hal-02495089⟩

Patents1 document

  • Sylvain Lehmann, Stéphane Roche, Jacques Ducos, Laurent Tiers. Method for predicting the response to a treatment against hepatitis c. United States, Patent n° : US 2014/0051079 A1. 2014. ⟨hal-01899413⟩