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Brucella Carbonic Anhydrases: New Targets for Designing Anti-Infective Agents

Jean-Yves Winum , Claudiu T. Supuran , Stephan Köhler
Current Pharmaceutical Design, 2010, 16 (29), pp.3310-3316. ⟨10.2174/138161210793429850⟩
Article dans une revue hal-02424984v1

Glutamate decarboxylase-dependent acid resistance in Brucella spp.: distribution and contribution to fitness under extremely acidic conditions

Maria Alessandra Damiano , Daniela Bastianelli , Sascha Al Dahouk , Stephan Köhler , Axel Cloeckaert , et al.
Applied and Environmental Microbiology, 2015, 81 (2), pp.578-586. ⟨10.1128/AEM.02928-14⟩
Article dans une revue hal-01142767v1

The intramacrophagic environment of Brucella suis and bacterial response

Stephan Köhler , Françoise Porte , Véronique Jubier-Maurin , Safia Ouahrani-Bettache , Jacques Teyssier , et al.
Veterinary Microbiology, 2002, 90 (1-4), pp.299-309. ⟨10.1016/S0378-1135(02)00215-8⟩
Article dans une revue istex hal-02167195v1

Antimicrobials: targeting virulence genes necessary for intracellular multiplication

Jean-Pierre Liautard , Véronique Jubier-Maurin , Rose-Anne Boigegrain , Stephan Köhler
Trends in Microbiology, 2006, 14 (3), pp.109-113. ⟨10.1016/j.tim.2006.01.005⟩
Article dans une revue istex hal-02165771v1
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RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity

Elias Abdou , María Jiménez de Bagüés , Ignacio Martínez-Abadía , Safia Ouahrani-Bettache , Véronique Pantesco , et al.
Frontiers in Cellular and Infection Microbiology, 2017, 7, pp.186. ⟨10.3389/fcimb.2017.00186⟩
Article dans une revue hal-02425105v1
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Brucella suis histidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide

Marie-Rose Abdo , Pascale Joseph , Rose-Anne Boigegrain , Jean-Louis Montero , Stephan Köhler , et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 23 (3), pp.357-361. ⟨10.1080/14756360701617107⟩
Article dans une revue hal-02424977v1

Zinc metalloenzymes as new targets against the bacterial pathogen Brucella

Marie Lopez , Stephan Köhler , Jean-Yves Winum
Journal of Inorganic Biochemistry, 2012, 111, pp.138-145. ⟨10.1016/j.jinorgbio.2011.10.019⟩
Article dans une revue istex hal-02424989v1

Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions

Alfonso Maresca , Andrea Scozzafava , Stephan Köhler , Jean-Yves Winum , Claudiu T. Supuran
Journal of Inorganic Biochemistry, 2012, 110, pp.36-39. ⟨10.1016/j.jinorgbio.2012.02.009⟩
Article dans une revue istex hal-02424990v1

Absence of evidence for the participation of the macrophage cellular prion protein in infection with Brucella suis.

Pascaline Fontes , Maria-Teresa Alvarez-Martinez , Antoine Gross , Claude Carnaud , Stephan Köhler , et al.
Infection and Immunity, 2005, 73 (10), pp.6229-36. ⟨10.1128/IAI.73.10.6229-6236.2005⟩
Article dans une revue hal-00194015v1

L’image sans qualités

Tania Vladova , Nora Labo , Maddalena Parise , Jacques Leenhardt , Diane Watteau , et al.
Radial, 2, 2020
N°spécial de revue/special issue hal-02612420v1

A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth

Pascale Joseph , S. Bettache , Jean-Louis Montero , Isao Nishimori , Tomoko Minakuchi , et al.
Bioorganic and Medicinal Chemistry, 2011, 19, pp.1172-1178. ⟨10.1016/j.bmc.2010.12.048⟩
Article dans une revue istex hal-00675825v1

Identification of the nik Gene Cluster of Brucella suis: Regulation and Contribution to Urease Activity

Véronique Jubier-Maurin , Agnès Rodrigue , Safia Ouahrani-Bettache , Marion Layssac , Marie-Andrée Mandrand Berthelot , et al.
Journal of Bacteriology, 2001
Article dans une revue hal-03034033v1
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From the discovery of the Malta fever's agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis

Jacques Godfroid , Axel Cloeckaert , Jean-Pierre Liautard , Stephan Kohler , David Fretin , et al.
Veterinary Research, 2005, 36 (3), pp.313-326. ⟨10.1051/vetres:2005003⟩
Article dans une revue hal-00902972v1
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From the discovery of the Malta fever's agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis

Jacques Godfroid , Axel Cloeckaert , Jean-Pierre Liautard , Stephan Köhler , David Fretin , et al.
Veterinary Research, 2005, 36, pp.313-326
Article dans une revue hal-02675437v1

The new species Brucella microti replicates in macrophages and causes death in murine models of infection

María P Jiménez de Bagüés , Safia Ouahrani-Bettache , Juan F Quintana , Olga Mitjana , Nabil Hanna , et al.
Journal of Infectious Diseases, 2010, 202 (1), pp.3-10. ⟨10.1086/653084⟩
Article dans une revue hal-00509064v1

Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis

Katia d'Ambrosio , Marie Lopez , Nina Dathan , Safia Ouahrani-Bettache , Stephan Köhler , et al.
Biochimie, 2014, 97, pp.114-120. ⟨10.1016/j.biochi.2013.09.028⟩
Article dans une revue hal-02425093v1
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N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases

Joanna Ombouma , Daniela Vullo , Stephan Köhler , Pascal Dumy , Claudiu T. Supuran , et al.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2014, 30 (6), pp.1010-1012. ⟨10.3109/14756366.2014.986119⟩
Article dans une revue hal-02425102v1

Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.

Pascale Joseph , François Turtaut , Safia Ouahrani-Bettache , Jean-Louis Montero , Isao Nishimori , et al.
Journal of Medicinal Chemistry, 2010, 53 (5), pp.2277-85. ⟨10.1021/jm901855h⟩
Article dans une revue hal-00509065v1
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Global Rsh-dependent transcription profile of Brucella suis during stringent response unravels adaptation to nutrient starvation and cross-talk with other stress responses

Nabil Hanna , Safia Ouahrani-Bettache , Kenneth Drake , L Garry Adams , Stephan Köhler , et al.
BMC Genomics, 2013, 14, pp.459. ⟨10.1186/1471-2164-14-459⟩
Article dans une revue hal-02352345v1

RegA, the transcriptional regulator of the two-component system RegB/RegA of Brucella suis is a controller of both oxidative respiration and denitrification, required for chronic infection in mice.

Amélie Deredjian , María Pilar Jiménez de Bagüés , Séverine Loisel-Meyer , Stephan Köhler , Véronique Jubier-Maurin
The 62nd Brucellosis Research Conference, Dec 2009, Chicago, United States
Communication dans un congrès hal-02327000v1

RegA, the Regulator of the Two-Component System RegB/RegA of Brucella suis, Is a Controller of Both Oxidative Respiration and Denitrification Required for Chronic Infection in Mice

Elias Abdou , Amélie Deredjian , Maria Pilar Jiménez de Bagüés , Stephan Köhler , Véronique Jubier-Maurin
Infection and Immunity, 2013, 81 (6), pp.2053-2061. ⟨10.1128/IAI.00063-13⟩
Article dans une revue hal-02165165v1

Does oxygen tension modulate gene expression during growth of Brucella inside its replicative niche?

Séverine Loisel , Stephan Köhler , Jean-Pierre Liautard , Véronique Jubier-Maurin
The 56th Brucellosis Research Conference, Sep 2003, Pampelune, Spain
Communication dans un congrès hal-02326600v1

The Intramacrophagic Environment of Brucella spp. and Their Replicative Niche I. Lopez-Goni and I. Moriyon, eds. Horizon Scientific Press

Véronique Jubier-Maurin , Séverine Loisel , Jean-Pierre Liautard , Stephan Köhler.
Brucella : molecular and cellular biology,, 2004
Chapitre d'ouvrage hal-02167127v1

RegA, of the redox-sensing system RegB/A, is a key regulator in oxygen-dependent establishment of Brucella suis persistence.

Elias Abdou , María Pilar Jiménez de Bagüés , Ignacio Martínez-Abadía , Safia Ouahrani-Bettache , Véronique Pantesco , et al.
9th meeting on Bacterial Electron Transfer Processes and their Regulation, Mar 2018, Saint Tropez, France
Communication dans un congrès hal-02329110v1
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The glutamic acid decarboxylase system of the new species Brucella microti contributes to its acid resistance and to oral infection of mice.

Alessandra Occhialini , Maria Pilar Jiménez de Bagüés , Bashir Saadeh , Daniela Bastianelli , Nabil Hanna , et al.
Journal of Infectious Diseases, 2012, 206 (9), pp.1424-32. ⟨10.1093/infdis/jis522⟩
Article dans une revue pasteur-00952116v1
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Brucella suis carbonic anhydrases and their inhibitors: Towards alternative antibiotics?

Stephan Köhler , Safia Ouahrani-Bettache , Jean-Yves Winum
Journal of Enzyme Inhibition and Medicinal Chemistry, 2017, 32 (1), pp.683-687. ⟨10.1080/14756366.2017.1295451⟩
Article dans une revue hal-02425103v1

Quantitative analysis of the intramacrophagic Brucella suis proteome reveals metabolic adaptation to late stage of cellular infection.

Sascha Al Dahouk , Véronique Jubier-Maurin , Holger C Scholz , Herbert Tomaso , Wolfram Karges , et al.
Proteomics, 2008, 8 (18), pp.3862-3870. ⟨10.1002/pmic.200800026⟩
Article dans une revue hal-00311701v1
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Lethality of Brucella microti in a murine model of infection depends on the wbkE gene involved in O-polysaccharide synthesis

Safia Ouahrani-Bettache , María Jiménez de Bagüés , Jorge de La Garza , Luca Freddi , Juan Bueso , et al.
Virulence, 2019, 10 (1), pp.868-878. ⟨10.1080/21505594.2019.1682762⟩
Article dans une revue hal-02352287v1

Role of the transcriptional regulator RegA in establishment of Brucella suis persistence in an original in vitro model.

Elias Abdou , Ignacio Martínez-Abadía , Véronique Pantesco , María Pilar Jiménez de Bagüés , Sascha Al Dahouk , et al.
Brucellosis 2014 International Research Conference, Sep 2014, Berlin, Germany
Communication dans un congrès hal-02327142v1

Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.

Pascale Joseph , Marie-Rose Abdo , Rose-Anne Boigegrain , Jean-Louis Montero , Jean-Yves Winum , et al.
Antimicrobial Agents and Chemotherapy, 2007, 51 (10), pp.3752-5. ⟨10.1128/AAC.00572-07⟩
Article dans une revue hal-00258959v1