Nombre de documents

51

Sophie Payot-Lacroix


Biography:

I obtained my PhD in cellular, molecular and structural biology at Nancy University in 1999. My PhD work, carried under the supervision of H. Petitdemange, focused on cellobiose catabolism and sporulation of the anaerobic bacterium Clostridium cellulolyticum. After having insight on the green waste recycling potential of bacteria, I spent one year in England (team of D. O’Connor, University of Southampton) to explore stress response and virulence of Salmonella Typhimurium. In September 2000, I was appointed as permanent INRA research scientist in the UR086 INRA (Tours-Nouzilly) where I joined the antibioresistance team of E. Chaslus-Dancla to work on the mechanisms of antibiotic resistance in Campylobacter. In 2006, I moved to Nancy to work on gene transfers mediated by Integrative Conjugative Elements (ICEs) in streptococci in the UMR1128 UL/INRA DynAMic. In January 2017, I was promoted INRA Senior Researcher (Directeur de Recherches INRA).

Research topic:

Since more than 20 years now, my research work focuses on the fascinating power of bacteria to adapt to their environment: from flexibility of the catabolic pathways to sporulation for a cellulolytic anaerobic bacterium, host adaptation of the zoonotic pathogen Salmonella Typhimurium, antibiotic resistance of the zoonotic pathogen Campylobacter and adaptation of streptococci through horizontal gene transfers mediated by mobile conjugative elements. Keeping in mind the global bacterial physiology, I am interested in characterizing these mechanisms of adaptation at the molecular level. My current research project aims at determining biotic and abiotic factors (cell surface composition, stress, sub-lethal antibiotic concentrations, biofilm, conditions that mimic human digestive ecosystem) that promote conjugative transfer of ICEs of streptococci (in particular ICESt3 of Streptococcus thermophilus) and elucidating the underlying molecular mechanisms of regulation.

Responsabilities:

Member of the Scientific Committee of the French National Observatory for Epidemiology of Bacterial Resistance to Antimicrobials (www.onerba.org) (2003-2004) and of INRA Microbiology Department (2006-), team leader (2009-2015), Quality Manager (of INRA Microbiology Department 2008-2012 and of UMR1128 since 2007) and UMR1128 Deputy Director (2018-). Coordination of 7 regional projects, an INRA-Anses national project and a national project funded by the French National Research Agency (MATICE ANR-15-CE21-0007).

Contact:

E-mail: sophie.payot-lacroix@inra.fr

Tel : +33 3 72 74 56 81


Article dans une revue35 documents

  • Narimane Dahmane, Emilie Robert, Julien Deschamps, Thierry Meylheuc, Christine Delorme, et al.. Impact of cell surface molecules on conjugative transfer of the integrative and conjugative element ICESt3 of Streptococcus thermophilus. Applied and Environmental Microbiology, American Society for Microbiology, 2017, pp.AEM.02109-17. 〈10.1128/AEM.02109-17〉. 〈hal-01678088〉
  • Narimane Dahmane, Virginie Libante, Florence Charron-Bourgoin, Eric Guedon, Gérard Guédon, et al.. Diversity of Integrative and Conjugative Elements of Streptococcus salivarius and Their Intra- and Interspecies Transfer. Applied and Environmental Microbiology, American Society for Microbiology, 2017, 83 (13), pp.e00337-17. 〈10.1128/AEM.00337-17〉. 〈hal-01543490〉
  • Gérard Guédon, Virginie Libante, Charles Coluzzi, Sophie Payot-Lacroix, Nathalie Leblond-Bourget. The obscure world of integrative and mobilizable elements: Highly widespread elements that pirate bacterial conjugative systems. Genes, MDPI, 2017, 8 (11), pp.337. 〈10.3390/genes8110337〉. 〈hal-01686871〉
  • Charles Coluzzi, Gérard Guédon, Marie-Dominique Devignes, Chloé Ambroset, Valentin Loux, et al.. A Glimpse into the World of Integrative and Mobilizable Elements in Streptococci Reveals an Unexpected Diversity and Novel Families of Mobilization Proteins. Frontiers in Microbiology, Frontiers Media, 2017, 8, pp.16. 〈https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357655/〉. 〈10.3389/fmicb.2017.00443〉. 〈hal-01580789〉
  • Chloé Ambroset, Charles Coluzzi, Gérard Guédon, Marie-Dominique Devignes, Valentin Loux, et al.. New Insights into the Classification and Integration Specificity of Streptococcus Integrative Conjugative Elements through Extensive Genome Exploration. Frontiers in microbiology, Frontiers Research Foundation, 2016, 6, pp.1483. 〈http://journal.frontiersin.org/journal/microbiology#about〉. 〈10.3389/fmicb.2015.01483〉. 〈hal-01262284〉
  • Fanny Chaffanel, Florence Charron-Bourgoin, Virginie Libante, Nathalie Leblond-Bourget, Sophie Payot, et al.. Resistance Genes and Genetic Elements Associated with Antibiotic Resistance in Clinical and Commensal Isolates of Streptococcus salivarius. Applied and Environmental Microbiology, American Society for Microbiology, 2015, 81 (12), pp.4155 - 4163. 〈http://aem.asm.org/content/81/12/4155〉. 〈10.1128/AEM.00415-15〉. 〈hal-01475102〉
  • Aurore Puymège, Stéphane Bertin, Gérard Guédon, Sophie Payot. Analysis of Streptococcus agalactiae pan-genome for prevalence, diversity and functionality of integrative and conjugative or mobilizable elements integrated in the tRNALys CTT gene. Molecular Genetics and Genomics, Springer Verlag, 2015, 290 (5), pp.1727 - 1740. 〈http://link.springer.com/article/10.1007/s00438-015-1031-9〉. 〈10.1007/s00438-015-1031-9〉. 〈hal-01475226〉
  • Sarah Chuzeville, Shaynoor Dramsi, Jean-Yves Madec, Marisa Haenni, Sophie Payot. Antigen I/II encoded by integrative and conjugative elements of Streptococcus agalactiae and role in biofilm formation. Microbial Pathogenesis, Elsevier, 2015, 88, pp.1 - 9. 〈10.1016/j.micpath.2015.07.018〉. 〈hal-01475853〉
  • Abdur Rahman, Catherine Cailliez-Grimal, Cyril Bontemps, Sophie Payot-Lacroix, Stephane Chaillou, et al.. High genetic diversity among strains of the unindustrialized lactic acid bacterium carnobacterium maltaromaticum in dairy products as revealed by multilocus sequence typing. Applied and Environmental Microbiology, American Society for Microbiology, 2014, 80 (13), pp.3920-3929. 〈http://aem.asm.org/content/80/13/3920〉. 〈10.1128/AEM.00681-14〉. 〈hal-01190026〉
  • Xavier Bellanger, Sophie Payot, Nathalie Leblond-Bourget, Gérard Guédon. Conjugative and mobilizable genomic islands in bacteria: evolution and diversity. FEMS Microbiology Reviews, Wiley-Blackwell, 2014, 38 (4), pp.720 - 760. 〈https://academic-oup-com/femsre/article-lookup/doi/10.1111/1574-6976.12058〉. 〈10.1111/1574-6976.12058〉. 〈hal-01474898〉
  • Aurore Puymege, Stéphane Bertin, Sarah Chuzeville, G. Guedon, S. Payot. Conjugative Transfer and cis-Mobilization of a Genomic Island by an Integrative and Conjugative Element of Streptococcus agalactiae. Journal of Bacteriology, American Society for Microbiology, 2013, 195 (6), pp.1142 - 1151. 〈http://jb.asm.org/content/195/6/1142〉. 〈10.1128/JB.02199-12〉. 〈hal-01474816〉
  • Muhammad Inam Afzal, Citlalli Celeste Gonzalez Ariceaga, Emilie Lhomme, Nehal Kamel Ali, Sophie Payot, et al.. Characterization of Carnobacterium maltaromaticum LMA 28 for its positive technological role in soft cheese making. Food Microbiology, Elsevier, 2013, 36 (2), pp.223-230. 〈10.1016/j.fm.2013.05.008〉. 〈hal-01272773〉
  • Sarah Chuzeville, Aurore Puymege, Jean-Yves Madec, Marisa Haenni, Sophie Payot. Characterization of a new CAMP factor carried by an integrative and conjugative element in Streptococcus agalactiae and spreading in Streptococci. PLoS ONE, Public Library of Science, 2012, 7 (11), 〈10.1371/journal.pone.0048918〉. 〈hal-01637786〉
  • Marisa Haenni, Estelle Saras, Stephane Bertin, Pierre Leblond, Jean-Yves Madec, et al.. Diversity and Mobility of Integrative and Conjugative Elements in Bovine Isolates of Streptococcus agalactiae, S. dysgalactiae subsp dysgalactiae, and S. uberis. Applied and Environmental Microbiology, American Society for Microbiology, 2010, 76 (24), pp.7957 - 7965. 〈10.1128/AEM.00805-10〉. 〈hal-01637787〉
  • Mathieu Brochet, Elisabeth Couvé, Philippe Glaser, Gérard Guédon, Sophie Payot. Integrative conjugative elements and related elements are major contributors to the genome diversity of Streptococcus agalactiae. Journal of Bacteriology, American Society for Microbiology, 2008, 190 (20), pp.6913-6917. 〈10.1128/JB.00824-08〉. 〈hal-01637762〉
  • Cedric Cagliero, Marie-Christine Maurel, Axel Cloeckaert, Sophie Payot. Regulation of the expression of the CmeABC efflux pump in Campylobacter jejuni: identification of a point mutation abolishing the binding of the CmeR repressor in an in vitro-selected multidrug-resistant mutant. FEMS Microbiology Letters, Wiley-Blackwell, 2007, 267 (1), pp.89-94. 〈hal-01637761〉
  • Cedric Cagliero, Lucie Cloix, Axel Cloeckaert, Sophie Payot. High genetic variation in the multidrug transporter cmeB gene in Campylobacter jejuni and Campylobacter coli. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2006, 58 (1), pp.168-172. 〈10.1093/jac/dkl212〉. 〈hal-01637783〉
  • Cedric Cagliero, Christian Mouline, Axel Cloeckaert, Sophie Payot. Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2006, 50 (11), pp.3893-3896. 〈10.1128/AAC.00616-06〉. 〈hal-01637781〉
  • Sophie Payot, Jean-Michel Bolla, Deborah Corcoran, Séamus Fanning, Francis Mégraud, et al.. Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.. Microbes and Infection, Elsevier, 2006, 8 (7), pp.1967-1971. 〈10.1016/j.micinf.2005.12.032〉. 〈hal-01637759〉
  • Qijing Zhang, Orhan Sahin, Patrick F. Mcdermott, Sophie Payot. Fitness of antimicrobial-resistant Campylobacter and Salmonella. Microbes and Infection, Elsevier, 2006, 8 (7), pp.1972-1978. 〈10.1016/j.micinf.2005.12.031〉. 〈hal-01637760〉
  • J. Lin, C. Cagliero, B. Guo, Y.W. Barton, M.C. Maurel, et al.. Bile salts modulate expression of the CmeABC multidrug efflux pump in Campylobacter jejuni. Journal of Bacteriology, American Society for Microbiology, 2005, 187 (21), pp.7417-7424. 〈10.1128/JB.187.21.7417-7424.2005〉. 〈hal-01637779〉
  • C. Cagliero, C. Mouline, Sophie Payot, Axel Cloeckaert. Involvement of the CmeABC efflux pump in the macrolide resistance of Campylobacter coli. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2005, 56, pp.948-950. 〈hal-01637778〉
  • C. Cagliero, L. Cloix, Sophie Payot, Axel Cloeckaert. High genetic variation of the multidrug transporter gene cmeB in Campylobacter jejuni and Campylobacter coli. International Journal of Antimicrobial Agents, Elsevier, 2004, 24 (S2), pp.S107. 〈hal-01637771〉
  • Sophie Payot, S. Dridi, M. Laroche, M. Federighi, C. Magras. Prevalence and antimicrobial resistance of Campylobacter coli isolated from fattening pigs in France. Veterinary Microbiology, Elsevier, 2004, 101, pp.91-99. 〈hal-01637769〉
  • Sophie Payot, L. Avrain, C. Magras, K. Praud, Axel Cloeckaert, et al.. Relative contribution of target gene mutation and efflux to fluoroquinolone and erythromycin resistance, in French poultry and pig isolates of Campylobacter coli. International Journal of Antimicrobial Agents, Elsevier, 2004, 23, pp.468-472. 〈hal-01637767〉
  • Sophie Payot, I. Kempf, C. Magras, Axel Cloeckaert, E. Chaslus-Dancla. Involvement of a Phe-Arg-b-naphthylamide sensitive efflux mechanism in the intrinsic resistance to erythromycin in Campylobacter jejuni and coli. International Journal of Medical Microbiology, Elsevier, 2003, 293 (35), pp.47. 〈hal-01637770〉
  • Sophie Payot, Axel Cloeckaert, E. Chaslus-Dancla. Selection and characterization of fluoroquinolone-resistant mutants of Campylobacter jejuni using enrofloxacin. Microbial Drug Resistance, Mary Ann Liebert, 2002, 8 (4), pp.335-343. 〈hal-01637765〉
  • Sophie Payot, E. Guedon, M. Desvaux, H. Petitdemange. Relationships between cellobiose catabolism, enzyme levels, and metabolic intermediates inClostridium cellulolyticum grown in a synthetic medium. Biotechnology and Bioengineering, Wiley, 2000, 67 (3), pp.327 - 335. 〈10.1002/(SICI)1097-0290(20000205)67:3<327::AID-BIT9>3.0.CO;2-U〉. 〈hal-01787148〉
  • C. David O'Connor, Phillip Adams, Peter Alefounder, Michele Farris, Niamh Kinsella, et al.. The analysis of microbial proteomes: Strategies and data exploitation. ELECTROPHORESIS, Wiley-VCH Verlag, 2000, 21 (6), pp.1178 - 1186. 〈10.1002/(SICI)1522-2683(20000401)21:6<1178::AID-ELPS1178>3.0.CO;2-B〉. 〈hal-01787146〉
  • O. Mohand-Oussaid, S. Payot, E. Guedon, E. Gelhaye, A. Youyou, et al.. The Extracellular Xylan Degradative System in Clostridium cellulolyticum Cultivated on Xylan: Evidence for Cell-Free Cellulosome Production. Journal of Bacteriology, American Society for Microbiology, 1999, 181 (13). 〈hal-01787581〉
  • E. Guedon, S. Payot, M. Desvaux, H. Petitdemange. Carbon and Electron Flow in Clostridium cellulolyticum Grown in Chemostat Culture on Synthetic Medium. Journal of Bacteriology, American Society for Microbiology, 1999, 181 (10). 〈hal-01787604〉
  • S. Payot, E. Guedon, M. Desvaux, E. Gelhaye, E. Petitdemange. Effect of dilution rate, cellobiose and ammonium availabilities on Clostridium cellulolyticum sporulation. Applied Microbiology and Biotechnology, Springer Verlag, 1999, 52 (5), pp.670 - 674. 〈10.1007/s002530051577〉. 〈hal-01787601〉
  • E. Guedon, M. Desvaux, S. Payot, H. Petitdemange. Growth inhibition of Clostridium cellulolyticum by an inefficiently regulated carbon flow. Microbiology, Microbiology Society, 1999, 145 (8), pp.1831 - 1838. 〈10.1099/13500872-145-8-1831〉. 〈hal-01787598〉
  • Sophie Payot, Emmanuel Guedon, Eric Gelhaye, Henri Petitdemange. Induction of lactate production associated with a decrease in NADH cell content enables growth resumption of Clostridium cellulolyticum in batch cultures on cellobiose. Research in Microbiology, Elsevier, 1999, 150 (7), pp.465 - 473. 〈10.1016/S0923-2508(99)00110-2〉. 〈hal-01787587〉
  • S. Payot, E. Guedon, C. Cailliez, E. Gelhaye, H. Petitdemange. Metabolism of cellobiose by Clostridium cellulolyticum growing in continuous culture: evidence for decreased NADH reoxidation as a factor limiting growth. Microbiology, Microbiology Society, 1998, 144 (2), pp.375 - 384. 〈10.1099/00221287-144-2-375〉. 〈hal-01787609〉

Communication dans un congrès12 documents

  • Cedric Cagliero, Axel Cloeckaert, Sophie Payot. Mécanismes de résistance aux fluoroquinolones et aux macrolides chez Campylobacter jejuni et C coli. 7e Congrès National de la SFM - Voyage au centre de la Microbiologie, 2007, Nantes, France. pp.Inconnu, 2007. 〈hal-01637782〉
  • C. Cagliero, Sophie Payot, I. Kempf, C. Magras, Axel Cloeckaert. Relative contribution of target gene mutation and efflux to fluoroquinolone and erythromycin resistance in Campylobacter jejuni and C. coli. 1. Symposium ARAE - 2005, Feb 2005, Lyon, France. Antimicrobial resistance in animals and the environment, 2005. 〈hal-01637775〉
  • C. Cagliero, C. Mouline, Sophie Payot, Axel Cloeckaert. Role du système d'efflux multidrogues CmeABC dans la résistance aux macrolides chez Campylobacter coli. 25. Réunion interdisciplinaire de chimiothérapie anti-infectieuse, Dec 2005, Paris, France. RICAI 2005, 2005. 〈hal-01637780〉
  • J. Lin, C. Cagliero, B. Guo, E. Barton, M.C. Maurel, et al.. Bile salts modulate the expression of multidrug efflux pump CmeABC in Campylobacter jejuni. 13. International workshop CHRO, Sep 2005, Gold Coast, Australia. Campylobacter, Helicobacter and related organisms, 2005. 〈hal-01637776〉
  • C. Cagliero, L. Cloix, Sophie Payot, Axel Cloeckaert. High genetic variation of the multidrug transporter gene cmeB in Campylobacter jejuni and Campylobacter coli. 6. European Congress of Chemotherapy and Infection - 24 Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse, Dec 2004, Paris, France. 2004. 〈hal-01637785〉
  • C. Cagliero, Sophie Payot, M. Laroche, M. Federighi, C. Magras. Etude de l'épidémiologie et des mécanismes de résistance aux antibiotiques de souches de Campylobacter coli isolées en élevage porcin. 17. Colloque Biotechnocentre, 2004, Fondjouan, France. pp.13, 2004. 〈hal-01637772〉
  • Sophie Payot, S. Dridi, M. Laroche, M. Federighi, C. Magras. Prevalence and antimicrobial resistance of Campylobacter coli isolated from fattening pigs in France. Congress of the ISAH, Oct 2004, Saint-Malo, France. Animal productionin Europe: The way forward in a changing world, 2004. 〈hal-01637774〉
  • C. Cagliero, Sophie Payot, M.C. Maurel, Axel Cloeckaert. Régulation du système d'efflux multidrogues CmeABC chez Campylobacter jejuni : mise en évidence de la diminution d'affinité du répresseur CmeR chez une souche multirésistante aux antibiotiques. 17. Colloque Biotechnocentre, Nov 2004, Fondjuan, France. pp.14, 2004. 〈hal-01637773〉
  • S. Baucheron, C. Mouline, Sophie Payot, Axel Cloeckaert, E. Chaslus-Dancla. Mécanismes de résistance aux quinolones des Escherichia coli aviaires. 5. Journées de la Recherche Avicole, Mar 2003, Tours, France. Recherche avicole, 2003. 〈hal-01637766〉
  • Sophie Payot, I. Kempf, C. Magras, Axel Cloeckaert, E. Chaslus-Dancla. Involvement of a Phe-Arg-b-naphthylamide sensitive efflux mechanism in the intrinsic resistance to erythromycin in Campylobacter jejuni and coli. 12. International Workshop on Campylobacter, Helicobacter and Related Organisms, Sep 2003, Aarhus, Denmark. 2003. 〈hal-01637784〉
  • Sophie Payot, S. Dridri, M. Laroche, M. Federighi, C. Magras. Prévalence et résistance aux antibiotiques de souches de Campylobacter coli isolées de porcs charcutiers en France. 23. Réunion Interdisciplinaire de Chimiothérapie anti-infectieuse RICAI 2003, Dec 2003, PARIS, France. pp.118, 2003. 〈hal-01637768〉
  • Sophie Payot, Axel Cloeckaert, E. Chaslus-Dancla, . Société de Pathologie Infectieuse de Langue Française, . Section Des Agents Antimicrobiens. Chimiothérapie anti-Infectieuse. 22. Réunion Interdisciplinaire de Chimiothérapie Anti-infectieuse, Dec 2002, Paris, France. pp.189, 2002. 〈hal-01637764〉

Chapitre d'ouvrage2 documents

  • A. Garenaux, Céline Lucchetti-Miganeh, Frédérique Barloy-Hubler, Gwennola Ermel, M. Federighi, et al.. Better Understand the Campylobacter Conundrum : Parallel Between Campylobacter Jejuni Genome, Sequence Study and Physiology.. Michael C. Berger. New Developments in Food Microbiology Research, Nova Publishers, pp.1-90, 2007. 〈hal-00453220〉
  • E. Chaslus-Dancla, Axel Cloeckaert, Sophie Payot, S. Baucheron. Les multiples façons de faire de la résistance aux antibiotiques. Antibiothérapie bovine. Acquis et Consensus, Pfizer Santé Animale, 2002. 〈hal-01637763〉

Autre publication1 document

  • Sophie Payot. Habilitation à diriger des recherches. il s'agit d'un type de produit dont les métadonnées ne correspondent pas aux métadonnées atte.. 2005, 137 p. 〈hal-01637777〉

Thèse1 document

  • Sophie Payot-Lacroix. Etude des conditions physiologiques influançant [i.e. influençant] la croissance, le catabolisme du cellobiose et la sporulation de Clostridium Cellulolytycum ATCC 35319. Sciences agricoles. Université Henri Poincaré - Nancy 1, 1999. Français. 〈NNT : 1999NAN10266〉. 〈tel-01748147〉