Séverine MORISSET-LOPEZ

Documents

Publications

	An adult Drosophila glioma model to highlight metabolic dysfunctions and evaluate the role of the serotonin 5‐HT 7 receptor as a potential therapeutic target Marylène Bertrand , Frédéric Szeremeta , Nadège Hervouet-Coste , Vincent Sarou-Kanian , Céline Landon FASEB Journal, 2023, 37 (11), ⟨10.1096/fj.202300783RR⟩ Article dans une revue hal-04301912v1
	An efficient site-selective, dual bioconjugation approach exploiting N-terminal cysteines as minimalistic handles to engineer tailored anti-HER2 affibody conjugates Ana Novak , Florian Kersaudy , Sylvie Berger , Séverine Morisset-Lopez , François Lefoulon European Journal of Medicinal Chemistry, 2023, 260, pp.115747. ⟨10.1016/j.ejmech.2023.115747⟩ Article dans une revue hal-04222710v1
	Expression of the Human Serotonin 5-HT7 Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a Drosophila melanogaster Glioma Model Florestan Courant , Marion Maravat , Wanyin Chen , David Gosset , Lauren Blot Cells, 2022, 11 (8), pp.1281. ⟨10.3390/cells11081281⟩ Article dans une revue hal-03846028v1
	T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients Flora Reverchon , Colleen Guillard , Lucile Mollet , Pascal Auzou , David Gosset Biomedicines, 2022, 10 (10), pp.2418. ⟨10.3390/biomedicines10102418⟩ Article dans une revue hal-03806213v1
	T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients Flora Reverchon , Colleen Guillard , Lucile Mollet , Pascal Auzou , David Gosset Biomedicines, 2022, 10 (10), pp.2418. ⟨10.3390/biomedicines10102418⟩ Article dans une revue hal-03846032v1
	Complementary Nuclear Magnetic Resonance-Based Metabolomics Approaches for Glioma Biomarker Identification in a Drosophila melanogaster Model Marion Maravat , Marylène Bertrand , Céline Landon , Franck Fayon , Séverine Morisset-Lopez Journal of Proteome Research, 2021, 20 (8), pp.3977-3991. ⟨10.1021/acs.jproteome.1c00304⟩ Article dans une revue hal-03335927v1
	Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite Nayara Braga Emidio , Rajeshwari Meli , Hue Tran , Hayeon Baik , Séverine Morisset-Lopez Journal of Medicinal Chemistry, 2021, 64 (13), pp.9484-9495. ⟨10.1021/acs.jmedchem.1c00767⟩ Article dans une revue hal-03335490v1
	Defective Oligodendroglial Lineage and Demyelination in Amyotrophic Lateral Sclerosis Elisabeth Traiffort , Séverine Morisset-Lopez , Mireille Moussaed , Amina Zahaf International Journal of Molecular Sciences, 2021, 22 (7), pp.3426. ⟨10.3390/ijms22073426⟩ Article dans une revue hal-03436366v1
	The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes Wissem Deraredj Nadim , Shalina Hassanaly , Hélène Bénédetti , Claudine Kieda , Catherine Grillon Biochemical and Biophysical Research Communications, 2021, 534, pp.758-764. ⟨10.1016/j.bbrc.2020.11.003⟩ Article dans une revue hal-03007433v1
	BRET Analysis of GPCR Dimers in Neurons and Non-Neuronal Cells: Evidence for Inactive, Agonist, and Constitutive Conformations Chayma El Khamlichi , Laetitia Cobret , Jean-Michel Arrang , Séverine Morisset-Lopez International Journal of Molecular Sciences, 2021, 22 (19), pp.10638. ⟨10.3390/ijms221910638⟩ Article dans une revue hal-03436322v1
	LINGO family receptors are differentially expressed in the mouse brain and form native multimeric complexes Anthony Guillemain , Yousra Laouarem , Laetitia Cobret , Dora Štefok , Wanyin Chen FASEB Journal, 2020, pp.1-13. ⟨10.1096/fj.202000826R⟩ Article dans une revue hal-02943248v1
	Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology Chayma El Khamlichi , Flora Reverchon-Assadi , Nadège Hervouet-Coste , Lauren Blot , Eric Reiter Molecules, 2019, 24 (3), pp.537. ⟨10.3390/molecules24030537⟩ Article dans une revue hal-02067271v1
	Votre cerveau est-il grignoté par les neuromythes ? Céline Dubourg , Flora Reverchon-Assadi , Maryvonne Ardourel , Olivier Richard , Séverine Morisset-Lopez The Conversation France, 2018, https://bit.ly/2CBaykM Article dans une revue hal-02972757v1
	Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities Viorel Simion , Wissem Deraredj Nadim , Hélène Bénédetti , Chantal Pichon , Séverine Morisset-Lopez Current Neuropharmacology, 2017, 15 (2), pp.276 - 290. ⟨10.2174/1570159X14666160630210422⟩ Article dans une revue hal-01618771v1
	MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments? Wissem Deraredj Nadim , Simion Viorel , Hélène Bénédetti , Chantal Pichon , Patrick Baril Current Neuropharmacology, 2017, 15 (2), pp.260 - 275. ⟨10.2174/1570159X14666160709001441⟩ Article dans une revue hal-01618199v1
	Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity Wissem Deraredj Nadim , Séverine Chaumont-Dubel , Fahima Madouri , Laetitia Cobret , Marie-Ludivine de Tauzia Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (43), pp.12310 - 12315. ⟨10.1073/pnas.1600914113⟩ Article dans une revue hal-01407899v1
	Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite Yacine Chebani , Candice Marion , Philippe Zizzari , Khadidja Chettab , Marie Pastor Science Signaling, 2016, 9 (424), pp.ra39. ⟨10.1126/scisignal.aae0374⟩ Article dans une revue inserm-01463897v1
	Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT 7 )/5-Hydroxytryptamine 2A (5-HT 2A ) Receptor Antagonists and Evaluation by [ 18 F]-PET Imaging in a Primate Brain Emmanuel Deau , Elodie Robin , Raluca Voinea , Nathalie Percina , Grzegorz Satała Journal of Medicinal Chemistry, 2015, 58 (20), pp.8066-8096. ⟨10.1021/acs.jmedchem.5b00874⟩ Article dans une revue hal-03082898v1
	Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling L Cobret , M L de Tauzia , J Ferent , E Traiffort , I Hénaoui British Journal of Clinical Pharmacology, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩ Article dans une revue hal-01170735v1
	Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth Fanny Duhr , Paul Déléris , F. Raynaud , Martial Séveno , Séverine Morisset-Lopez Nature Chemical Biology, 2014, 10 (7), pp.590-597. ⟨10.1038/nchembio.1547⟩ Article dans une revue hal-01178901v1
	A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line. Fabienne Godin , Sandrine Villette , Béatrice Vallée , Michel Doudeau , Séverine Morisset-Lopez Biochemical and Biophysical Research Communications, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩ Article dans une revue hal-00721861v1
	Le système histaminergique : une cible pour de nouveaux traitements des deficits cognitifs Mouhammad Motawaj , Aude Burban , Elisabeth Davenas , Florence Gbahou , Raphaël Faucard Thérapie, 2010, 65 (5), pp.415-422. ⟨10.2515/therapie/2010058⟩ Article dans une revue hal-02071208v1
	Pharmacological, neurochemical, and behavioral profile of JB-788, a new 5-HT1A agonist M. Picard , S. Morisset , J.F. Cloix , J.C. Bizot , M. Guerin Neuroscience, 2010, 169 (3), pp.1337-1346. ⟨10.1016/j.neuroscience.2010.05.040⟩ Article dans une revue hal-02071835v1
	Effects of Betahistine at Histamine H3 Receptors: Mixed Inverse Agonism/Agonism In Vitro and Partial Inverse Agonism In Vivo F. Gbahou , E. Davenas , S. Morisset , J.- Arrang Journal of Pharmacology and Experimental Therapeutics, 2010, 334 (3), pp.945-954. ⟨10.1124/jpet.110.168633⟩ Article dans une revue hal-02071192v1
	Histamine H3 receptor-mediated signaling protects mice from cerebral malaria. W. Beghdadi , A. Porcherie , Schneider B.S. , S. Morisset , D. Dubayle PLoS ONE, 2009, 4, pp.e6004 Article dans une revue hal-00397938v1
	Recessive Isolated Growth Hormone Deficiency and Mutations in the Ghrelin Receptor Jacques Pantel , Marie Legendre , Sylvie Nivot , Séverine Morisset , Marie Vie-Luton Journal of Clinical Endocrinology and Metabolism, 2009, 94 (11), pp.4334-4341. ⟨10.1210/jc.2009-1327⟩ Article dans une revue hal-02081574v1
	Autoregulation of McA-RH7777 Hepatoma Cell Proliferation by Histamine H3 Receptors E. Davenas , A. Rouleau , S. Morisset , J. Arrang Journal of Pharmacology and Experimental Therapeutics, 2008, 326 (2), pp.406-413. ⟨10.1124/jpet.107.135368⟩ Article dans une revue hal-02081595v1
	Constitutive activity of the histamine H3 receptor Jean-Michel Arrang , Séverine Morisset , Florence Gbahou Trends in Pharmacological Sciences, 2007, 28 (7), pp.350-357. ⟨10.1016/j.tips.2007.05.002⟩ Article dans une revue hal-02081603v1
	Histamine H3 and dopamine D2 receptor-mediated [35S]GTPγ[S] binding in rat striatum: Evidence for additive effects but lack of interactions Marie Humbert-Claude , Séverine Morisset , Florence Gbahou , Jean-Michel Arrang Biochemical Pharmacology, 2007, 73 (8), pp.1172-1181. ⟨10.1016/j.bcp.2007.01.006⟩ Article dans une revue hal-02081605v1
	Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649. Xavier Ligneau , Laurent Landais , David Perrin , Johanne Piriou , Marilyne Uguen Biochemical Pharmacology, 2007, 73 (8), pp.1215-24. ⟨10.1016/j.bcp.2007.01.023⟩ Article dans une revue inserm-00150117v1
	Potential molecular interactions between the histamine H3 receptor and the dopamine D2 receptor in the rat striatum M. Humbert-Claude , S Morisset-Lopez , F. Gbahou , M. Arrang European Neuropsychopharmacology, 2006, 16, pp.S16-S17. ⟨10.1016/s0924-977x(06)80021-0⟩ Article dans une revue hal-02082149v1
	Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature J. Pantel , Marie Legendre , Sylvie Cabrol , Latifa Hilal , Yassir Hajaji Journal of Clinical Investigation, 2006, 116 (3), pp.760-768. ⟨10.1172/JCI25303⟩ Article dans une revue hal-02082146v1
	P.1.31 Constitutive dimerization of the histamineH3 receptor in living cells S Morisset-Lopez , C. Chabret , J.M. Arrang European Neuropsychopharmacology, 2005, 15, pp.S25-S26. ⟨10.1016/s0924-977x(05)80136-1⟩ Article dans une revue hal-02082151v1
	P.1.03 Constitutive activity of the recombinant and native histamine H3 receptor: effects of inverse agonists and protean agonists F. Gbahou , A. Rouleau , S Morisset-Lopez , X. Ligneau , J. Tardivel-Lacombe European Neuropsychopharmacology, 2004, 14, pp.S4-S5. ⟨10.1016/s0924-977x(04)90004-1⟩ Article dans une revue hal-02081569v1
	Fluorescence resonance energy transfer to probe human M1 muscarinic receptor structure and drug binding properties. Brigitte Ilien , Christelle Franchet , Philippe Bernard , Séverine Morisset , Claire Odile Weill Journal of Neurochemistry, 2003, 85 (3), pp.768-78 Article dans une revue hal-02081577v1
	S.16.04 Histamine H3-receptor ligands: Effects of inverse agonists and protean ligands J.M. Arrang , S Morisset-Lopez , A. Rouleau , F. Gbahou , X. Ligneau European Neuropsychopharmacology, 2003, 13, pp.S141. ⟨10.1016/s0924-977x(03)91663-4⟩ Article dans une revue hal-02081585v1
	Constitutive activity of the recombinant and native histamine H3 receptor J.M. Arrang , S. Morisset , A. Rouleau , F. Gbahou , X. Ligneau International Congress Series, 2003, 1249, pp.139-151. ⟨10.1016/S0531-5131(03)00617-4⟩ Article dans une revue hal-02081573v1
	Protean agonism at histamine H3 receptors in vitro and in vivo F. Gbahou , A. Rouleau , S Morisset-Lopez , R. Parmentier , S. Crochet Proceedings of the National Academy of Sciences of the United States of America, 2003, 100 (19), pp.11086-11091. ⟨10.1073/pnas.1932276100⟩ Article dans une revue hal-02081588v1
	Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor. J. C. Schwartz , S Morisset-Lopez , A. Rouleau , X. Ligneau , F. Gbahou Journal of Neural Transmission Supplementum, 2003, 64, pp.1-16 Article dans une revue hal-02081590v1
	Ciproxifan, a Histamine H 3 -Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of Haloperidol in the Rat Catherine Pillot , Jordi Ortiz , Anne Héron , Sophie Ridray , Jean-Charles Schwartz Journal of Neuroscience, 2002, 22 (16), pp.7272-7280 Article dans une revue hal-01490023v1
	Acute and chronic effects of methamphetamine on tele-methylhistamine levels in mouse brain: selective involvement of the D(2) and not D(3) receptor. Séverine Morisset-Lopez , Catherine Pilon , Joël Tardivel-Lacombe , D Weinstein , William Rostene Journal of Pharmacology and Experimental Therapeutics, 2002, 300 (2), pp.621-8. ⟨10.1124/jpet.300.2.621⟩ Article dans une revue hal-02082246v1
	Effects of histamine H 3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain C. Chotard , T. Ouimet , S. Morisset , U. Sahm , C. Schwartz Journal of Neural Transmission, 2002, 109 (3), pp.293-306. ⟨10.1007/s007020200024⟩ Article dans une revue hal-02081594v1
	Histamine H 3 -receptor-mediated [ 35 S]GTPγ[S] binding: evidence for constitutive activity of the recombinant and native rat and human H 3 receptors A. Rouleau , X Ligneau , J. Tardivel-Lacombe , S Morisset-Lopez , F Gbahou British Journal of Pharmacology, 2002, 135 (2), pp.383-392. ⟨10.1038/sj.bjp.0704490⟩ Article dans une revue hal-02082155v1
	The Rat H3 Receptor: Gene Organization and Multiple Isoforms Séverine Morisset , Astrid Sasse , Florence Gbahou , Anne Héron , Xavier Ligneau Biochemical and Biophysical Research Communications, 2001, 280 (1), pp.75-80. ⟨10.1006/bbrc.2000.4073⟩ Article dans une revue hal-02082164v1
	Application of genomics to drug design: the example of the histamine H3 receptor Jean-Charles Schwartz , Séverine Morisset , Agnès Rouleau , Joël Tardivel-Lacombe , Florence Gbahou European Neuropsychopharmacology, 2001, 11 (6), pp.441-448. ⟨10.1016/s0924-977x(01)00121-3⟩ Article dans une revue hal-02129745v1
	Chromosomal mapping and organization of the human histamine H3 receptor gene Joël Tardivel-Lacombe , Séverine Morisset , Florence Gbahou , Jean-Charles Schwartz , Jean-Michel Arrang NeuroReport, 2001, 12 (2), pp.321-324. ⟨10.1097/00001756-200102120-00028⟩ Article dans une revue hal-02082162v1
	Histamine H2 receptor gene variants: lack of association with schizophrenia C Ito , S Morisset-Lopez , J-P Olié , H Lôo , M-F Poirier Molecular Psychiatry, 2000, 5 (2), pp.159-164. ⟨10.1038/sj.mp.4000664⟩ Article dans une revue hal-02082207v1
	Cloning and cerebral expression of the guinea pig histamine H3 receptor S Morisset-Lopez , Agnés Rouleau , Anne Héron , Joël Tardivel-Lacombe , Séverine Morisset NeuroReport, 2000, 11 (4), pp.755-759. ⟨10.1097/00001756-200003200-00020⟩ Article dans une revue hal-02082171v1
	Changes in histamine H3 receptor responsiveness in mouse brain. S. Morisset , E. Traiffort , J. M. Arrang , J. C. Schwartz Journal of Neurochemistry, 2000, 74 (1), pp.339-46 Article dans une revue hal-00347608v1
	Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. X. Ligneau , S Morisset-Lopez , J. Tardivel-Lacombe , F Gbahou , C Ganellin British Journal of Pharmacology, 2000, 131 (7), pp.1247-50. ⟨10.1038/sj.bjp.0703712⟩ Article dans une revue hal-02081534v1
	High constitutive activity of native H3 receptors regulates histamine neurons in brain. S. Morisset , A. Rouleau , X Ligneau , F Gbahou , J. Tardivel-Lacombe Nature, 2000, 408 (6814), pp.860-4. ⟨10.1038/35048583⟩ Article dans une revue hal-02081523v1
	Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade. S. Morisset , U. G. Sahm , E. Traiffort , J. Tardivel-Lacombe , J. M. Arrang Journal of Pharmacology and Experimental Therapeutics, 1999, 288 (2), pp.590-6 Article dans une revue hal-00347619v1
	Cloning and Selective Expression in Brain and Kidney of ARNT2 Homologous to the Ah Receptor Nuclear Translocator (ARNT) Guillaume Drutel , Markus Kathmann , Anne Héron , Jean-Charles Schwartz , Jean-Michel Arrang Biochemical and Biophysical Research Communications, 1996, 225, pp.333-339. ⟨10.1006/bbrc.1996.1176⟩ Article dans une revue hal-01560437v1
	Inhibition of histamine versus acetylcholine metabolism as a mechanism of tacrine activity Séverine Morisset , Elisabeth Traiffort , Jean-Charles Schwartz European Journal of Pharmacology, 1996, 315 (1), pp.R1-R2. ⟨10.1016/s0014-2999(96)00738-8⟩ Article dans une revue hal-02081407v1
	Molecular and Functional Diversity of Histamine Receptor Subtypes Jean-Michel Arrang , Guillaume Drutel , Monique Garbarg , Martial Ruat , Elisabeth Traiffort Annals of the New York Academy of Sciences, 1995, 757 (1), pp.314-323. ⟨10.1111/j.1749-6632.1995.tb17489.x⟩ Article dans une revue hal-03534121v1
	Chromosomal localization of the human histamine H1-receptor gene Maryvonne Le Coniat , Elisabeth Traiffort , Martial Ruat , Jean-Michel Arrang , Roland Berger Human Genetics, 1994, 94 (2), pp.186-188. ⟨10.1007/BF00202867⟩ Article dans une revue hal-03535137v1
	Histaminergic transmission in the mammalian brain Jean-Charles Schwartz , Jean-Michel Arrang , Monique Garbarg , Hélène Pollard , Martial Ruat Physiological Reviews, 1991, 71 (1), pp.1-51. ⟨10.1152/physrev.1991.71.1.1⟩ Article dans une revue hal-03536845v1
	Cloning and tissue expression of a rat histamine H2-receptor gene Martial Ruat , Elisabeth Traiffort , Jean-Michel Arrang , Rob Leurs , Jean-Charles Schwartz Biochemical and Biophysical Research Communications, 1991, 179 (3), pp.1470-1478. ⟨10.1016/0006-291x(91)91738-x⟩ Article dans une revue hal-03536798v1
	Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates M.I. Martinez-Mir , H. Pollard , J. Moreau , Jean-Michel Arrang , Martial Ruat Brain Research, inPress, 526 (2), pp.322-327. ⟨10.1016/0006-8993(90)91240-h⟩ Article dans une revue hal-03536911v1

	Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas Wanyin Chen , Anthony Guillemain , Lauren Blot , Fabienne Fasani , Esther Kellenberger Colloque Niche et épigénétique des tumeurs, Jul 2020, Online, France Communication dans un congrès hal-03686680v1
	Innovations pharmacologiques pour l'étude des neurorécepteurs : intérêt du BRET et de la technologie AlphaScreen Séverine Morisset-Lopez Journée scientifique de l’axe protéomique des plateformes de Biogenouest, Feb 2020, Roscoff, France Communication dans un congrès hal-02973392v1
	Séminaire invité : Ligands biaisés du récepteur 5-HT7: outils pharmacologiques, d'imagerie et applications thérapeutiques Séverine Morisset-Lopez PRC INRA, Nouzilly, Apr 2019, Nouzilly, France Communication dans un congrès hal-02974178v1
	The research of new therapeutic targets and small chemical molecules for glioblastoma therapies W. Chen , A. Guillemain , L. Blot , Fabienne Fasani , E. Kellenberger Central South University in HuNan, Dec 2019, Changsha, China Communication dans un congrès hal-03686683v1
	Utilisation de la technologie Alpha Screen pour étudier les neurorécepteurs : du binding à la signalisation Séverine Morisset-Lopez Séminaire technologique organisé par Perkin Elmer, Sep 2019, Paris, France Communication dans un congrès hal-02973431v1
	Les neurorécepteurs : Bases moléculaires de leur activation et intérêts physiopathologiques, Séverine Morisset-Lopez Journée de la SFR Neuroimagerie, May 2018, La Riche, France Communication dans un congrès hal-02973456v1
	Le récepteur 5-HT7 de la sérotonine : de la pharmacologie moléculaire vers la physiopathologie Séverine Morisset-Lopez ESBS, Apr 2018, Strasbourg, France Communication dans un congrès hal-03331436v1
	Le récepteur 5-HT7 de la sérotonine : de la pharmacologie moléculaire vers la physiopathologie Séverine Morisset-Lopez ESBS, Apr 2018, Strasbourg, France Communication dans un congrès hal-02974183v1
	Le récepteur 5-HT7 de la sérotonine, un acteur dans les neuropathologies: signalisation cellulaire et modèles animaux Séverine Morisset-Lopez INEM, Jul 2017, Orléans, France Communication dans un congrès hal-03331443v1
	Modèles pour l’étude de la pigmentation Shalina Hassanaly , Alexia Perrin , Séverine Morisset-Lopez , Catherine Grillon 1er atelier thématique du GDR Cosm’actifs Quel modèle pour tester l’activité d’un composé : de la molécule à l’homme, Mar 2016, Lyon, France Communication dans un congrès hal-03668561v1

	Rôle différentiel de Lingo1 et Lingo3 dans la prolifération et la migration des cellules de glioblastome Khadidja Sidelarbi , Fabienne Fasani , Séverine Morisset-Lopez , Catherine Grillon 16èmes journées du Cancéropôle Grand Ouest, Jun 2021, Angers, France Poster de conférence hal-03838122v1
	Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas Wanyin Chen , Anthony Guillemain , Lauren Blot , Fabienne Fasani , Esther Kellenberger Colloque Niche et épigénétique des tumeurs, Jul 2020, Online, France. Poster de conférence hal-03686675v1
	Biomarkers involved in glioma development in Drosophila melanogaster model Marion Maravat , Marylène Bertrand , M. Decoville , C. Landon , Séverine Morisset-Lopez European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France Poster de conférence hal-02919170v1
	Etude de l’activité anti-tumorale de nouveaux ligands ciblant LINGO-1 pour le traitement des glioblastomes Wanyin Chen , Anthony Guillemain , Lauren Blot , Fabienne Fasani , Esther Kellenberger Journée Fédération FR2708 Physique et Chimie du Vivant, Apr 2019, Orléans, France Poster de conférence hal-03625295v1
	Nouvelles molécules chimiques anti-tumorales pour le traitement du glioblastomes W. Chen , A. Guillemain , L. Blot , F. Fasani , E. Kellenberger 13es journées du Cancéropôle Grand Ouest, Jul 2019, Tours, France Poster de conférence hal-02973622v1
	NMR-based metabolomics for glioma biomarker discovery in a Drosophila melanogaster model Marion Maravat , Martine Decoville , Marylène Bertrand , Celine Landon , Séverine Morisset-Lopez 3rd edition Metabolism & Cancer, Apr 2019, Marseille, France Poster de conférence hal-02986792v1
	Etude d’une nouvelle cible thérapeutique dans un modèle de gliome chez Drosophila melanogaster F. Courant , Marion Maravat , L. Blot , David Gosset , Séverine Morisset-Lopez 13es journées du cancéropôle Grand Ouest, Jul 2019, Tours, France Poster de conférence hal-02973627v1
	Etude de l’activité anti-tumorale de nouveaux ligands ciblant LINGO-1 pour le traitement des glioblastomes Wanyin Chen , Anthony Guillemain , Lauren Blot , Fabienne Fasani , Esther Kellenberger Colloque de l’ADOC, Jul 2019, Orléans, France Poster de conférence hal-03686230v1
	Serotonin 5-HT7 receptor: characterization of new potent ligands with therapeutical properties C. El Khamlichi , Flora Reverchon , Eric Robin , Arnaud Menuet , N. Chopin 31e colloque Biotechnocentre, Oct 2018, Seillac, France Poster de conférence hal-02973722v1
	Identification of biased ligands of 5-HT7 receptor: Molecular bases of their action C. El Khamlichi , Flora Reverchon , Eric Robin , N. Chopin , E. Deau 7th Annual meeting GDR 3545, Oct 2018, Strasbourg, France Poster de conférence hal-02973734v1
	Identification of new partner of EGF receptor: functional interaction and interest for the treatment of glioma Séverine Morisset-Lopez , L. Blot , A. Guillemain , C. Grillon , D. Decoville Studium conference Stem cells and cancer stem cells, Jun 2018, Orléans, France Poster de conférence hal-02973700v1
	Développement des gliomes chez Drosophila Melanogaster: rôle du récepteur 5-HT7 de la sérotonine L. Blot , Y. Makhloufi , V. Sarou-Kainian , A. Guillemain , C. Grillon Journée Scientifique de la fédération de Recherche FR 2708, Jan 2018, Orléans, France Poster de conférence hal-02973683v1
	Identification d’un nouveau partenaire de l’EGFR : interaction fonctionnelle et intérêt pour le traitement des tumeurs cérébrales L. Blot , A. Guillemain , C. Grillon , D. Decoville , Séverine Morisset-Lopez 12es journées du cancéropôle Grand Ouest, Jul 2018, Vannes, France Poster de conférence hal-02973707v1
	Neurofibromin 1 promotes constitutive activity of native 5−HT6 receptors expressed in mouse prefrontal cortex Séverine Morisset-Lopez , W. Deraredj Nadim , S. Chaumont−dubel , F. Madouri , L. Cobret Neurofrance, May 2017, Bordeaux, France Poster de conférence hal-02973767v1
	Rôle du récepteur 5-HT7 de la sérotonine dans le développement des gliomes chez Drosophila Melanogaster L. Blot , Y. Makhloufi , A. Guillemain , C. Grillon , Séverine Morisset-Lopez 11es journées du Cancéropôle Grand Ouest, Jun 2017, Vannes, France Poster de conférence hal-02973773v1
	LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications Hélène Bénédetti , Fabienne Godin , Michel Doudeau , Béatrice Vallée , Marie-Ludivine De Tauzia 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark Poster de conférence hal-02453487v1
	A Physical Interaction between Neurofibromin and Serotonin 5-HT6 Receptor Promotes Receptor Constitutive Activity W. Deraredj Nadim , S. Chaumont-Dubel , F. Madouri , L. Cobret , M.-L. de Tauzia 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France Poster de conférence hal-02973912v1
	Etude d’une nouvelle cible thérapeutique LINGO-1 pour le traitement des tumeurs cérébrales A. Guillemain , L. Blot , L. Cobret , M. Decoville , Séverine Morisset-Lopez 10es Journées du Cancéropôle Grand Ouest, Jun 2016, Les-Sables-d'Olonne, France Poster de conférence hal-02973806v1
	Regulation of MC1R-mediated pigmentation by the GRD domain of neurofibromin in human melanocytes Shalina Hassanaly , Wissem Deraredj Nadim , Claudine Kieda , Séverine Morisset , Catherine Grillon 20th ESPCR Meeting, Sep 2016, Milan, Italy Poster de conférence hal-02453404v1
	Effect of the serotonin 5-HT7 recepteur on cellular proliferation in Drosophila melanogaster Martine Decoville , Anthony Guillemain , Catherine Grillon , Séverine Morisset 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France Poster de conférence hal-02453412v1
	Regulation of MC1R-mediated pigmentation in human melanocytes by the GRD domain of neurofibromin Shalina Hassanaly , Wissem Deraredj Nadim , Claudine Kieda , Séverine Morisset , Catherine Grillon 5th annual meeting of the GDR 3545 RCPG-PhysioMed 2016, Nov 2016, Tours, France Poster de conférence hal-02453410v1
	Etude de l'histamine au cours du développement des lesions consecutives à une ischémie cérébrale néonatale Anne Héron , Véronique Cochois , Valérie Biran , Jean-Michel Arrang , Christiane Charriaut-Marlangue 7e colloque de la Société des neurosciences, 2005, Lille, France Poster de conférence hal-01610437v1

	Voyage au centre du cerveau avec le Professeur Ciboulot Séverine Morisset-Lopez édité dans le cadre du Labo Tour’80. 100 p., 2019 Ouvrages hal-02973919v1

	Applications of biased ligands of the serotonin 5-HT7 receptor for the treatment of pain, multiple sclerosis and the control of thermoregulation Séverine Morisset-Lopez , F. Suzenet , G. Guillaumet , E. Deau , E. Robin France, Patent n° : Patent BET 20P3848 (STL-SED) - EUROPE 21315045.1. BCT. 2021 Brevet hal-03668557v1
	Tools for the identification od LINGO-1, LINGO-2, LINGO-3 and LINGO-4, ligands, and uses thereof Séverine Morisset-Lopez , Hélène Bénédetti France, Patent n° : WO2011121257. BCT. 2011 Brevet hal-02130935v1

Séverine MORISSET-LOPEZ

Publications

An adult Drosophila glioma model to highlight metabolic dysfunctions and evaluate the role of the serotonin 5‐HT 7 receptor as a potential therapeutic target

An efficient site-selective, dual bioconjugation approach exploiting N-terminal cysteines as minimalistic handles to engineer tailored anti-HER2 affibody conjugates

Expression of the Human Serotonin 5-HT7 Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a Drosophila melanogaster Glioma Model

T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients

T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients

Complementary Nuclear Magnetic Resonance-Based Metabolomics Approaches for Glioma Biomarker Identification in a Drosophila melanogaster Model

Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite

Defective Oligodendroglial Lineage and Demyelination in Amyotrophic Lateral Sclerosis

The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes

BRET Analysis of GPCR Dimers in Neurons and Non-Neuronal Cells: Evidence for Inactive, Agonist, and Constitutive Conformations

LINGO family receptors are differentially expressed in the mouse brain and form native multimeric complexes

Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology

Votre cerveau est-il grignoté par les neuromythes ?

Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities

MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?

Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity

Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite

Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT 7 )/5-Hydroxytryptamine 2A (5-HT 2A ) Receptor Antagonists and Evaluation by [ 18 F]-PET Imaging in a Primate Brain

Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling

Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth

A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.

Le système histaminergique : une cible pour de nouveaux traitements des deficits cognitifs

Pharmacological, neurochemical, and behavioral profile of JB-788, a new 5-HT1A agonist

Effects of Betahistine at Histamine H3 Receptors: Mixed Inverse Agonism/Agonism In Vitro and Partial Inverse Agonism In Vivo

Histamine H3 receptor-mediated signaling protects mice from cerebral malaria.

Recessive Isolated Growth Hormone Deficiency and Mutations in the Ghrelin Receptor

Autoregulation of McA-RH7777 Hepatoma Cell Proliferation by Histamine H3 Receptors

Constitutive activity of the histamine H3 receptor

Histamine H3 and dopamine D2 receptor-mediated [35S]GTPγ[S] binding in rat striatum: Evidence for additive effects but lack of interactions

Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.

Potential molecular interactions between the histamine H3 receptor and the dopamine D2 receptor in the rat striatum

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

P.1.31 Constitutive dimerization of the histamineH3 receptor in living cells

P.1.03 Constitutive activity of the recombinant and native histamine H3 receptor: effects of inverse agonists and protean agonists

Fluorescence resonance energy transfer to probe human M1 muscarinic receptor structure and drug binding properties.

S.16.04 Histamine H3-receptor ligands: Effects of inverse agonists and protean ligands

Constitutive activity of the recombinant and native histamine H3 receptor

Protean agonism at histamine H3 receptors in vitro and in vivo

Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor.

Ciproxifan, a Histamine H 3 -Receptor Antagonist/Inverse Agonist, Potentiates Neurochemical and Behavioral Effects of Haloperidol in the Rat

Acute and chronic effects of methamphetamine on tele-methylhistamine levels in mouse brain: selective involvement of the D(2) and not D(3) receptor.

Effects of histamine H 3 receptor agonist and antagonist on histamine co-transmitter expression in rat brain

Histamine H 3 -receptor-mediated [ 35 S]GTPγ[S] binding: evidence for constitutive activity of the recombinant and native rat and human H 3 receptors

The Rat H3 Receptor: Gene Organization and Multiple Isoforms

Application of genomics to drug design: the example of the histamine H3 receptor

Chromosomal mapping and organization of the human histamine H3 receptor gene

Histamine H2 receptor gene variants: lack of association with schizophrenia

Cloning and cerebral expression of the guinea pig histamine H3 receptor

Changes in histamine H3 receptor responsiveness in mouse brain.

Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain.

High constitutive activity of native H3 receptors regulates histamine neurons in brain.

Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade.

Cloning and Selective Expression in Brain and Kidney of ARNT2 Homologous to the Ah Receptor Nuclear Translocator (ARNT)

Inhibition of histamine versus acetylcholine metabolism as a mechanism of tacrine activity

Molecular and Functional Diversity of Histamine Receptor Subtypes

Chromosomal localization of the human histamine H1-receptor gene

Histaminergic transmission in the mammalian brain

Cloning and tissue expression of a rat histamine H2-receptor gene

Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates

Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas

Innovations pharmacologiques pour l'étude des neurorécepteurs : intérêt du BRET et de la technologie AlphaScreen

Séminaire invité : Ligands biaisés du récepteur 5-HT7: outils pharmacologiques, d'imagerie et applications thérapeutiques

The research of new therapeutic targets and small chemical molecules for glioblastoma therapies

Utilisation de la technologie Alpha Screen pour étudier les neurorécepteurs : du binding à la signalisation

Les neurorécepteurs : Bases moléculaires de leur activation et intérêts physiopathologiques,

Le récepteur 5-HT7 de la sérotonine : de la pharmacologie moléculaire vers la physiopathologie

Le récepteur 5-HT7 de la sérotonine : de la pharmacologie moléculaire vers la physiopathologie

Le récepteur 5-HT7 de la sérotonine, un acteur dans les neuropathologies: signalisation cellulaire et modèles animaux

Modèles pour l’étude de la pigmentation

Rôle différentiel de Lingo1 et Lingo3 dans la prolifération et la migration des cellules de glioblastome

Anti-tumor activity of new ligands targeting LINGO1- a protein primarily expressed in CNS for the treatment of glioblastomas

Biomarkers involved in glioma development in Drosophila melanogaster model

Etude de l’activité anti-tumorale de nouveaux ligands ciblant LINGO-1 pour le traitement des glioblastomes

Nouvelles molécules chimiques anti-tumorales pour le traitement du glioblastomes

NMR-based metabolomics for glioma biomarker discovery in a Drosophila melanogaster model

Etude d’une nouvelle cible thérapeutique dans un modèle de gliome chez Drosophila melanogaster

Etude de l’activité anti-tumorale de nouveaux ligands ciblant LINGO-1 pour le traitement des glioblastomes

Serotonin 5-HT7 receptor: characterization of new potent ligands with therapeutical properties