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Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

 Madeleine Bossaert , Angélique Pipier , Jean-Francois Riou , Céline Noirot , Linh-Trang Nguyên , et al.
eLife, 2021, 10 (1), pp.13469. ⟨10.7554/eLife.65184⟩
Article dans une revue hal-04478256v1
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Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids

 Margaux Bossuat , Pauline Rullière , Nadège Preuilh , Antonio Peixoto , Etienne Joly , et al.
Journal of Medicinal Chemistry, 2023, 66 (20), pp.13918-13945. ⟨10.1021/acs.jmedchem.3c00859⟩
Article dans une revue hal-04274040v1
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Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

 Agnese Cristini , Giulia Ricci , Sébastien Britton , Simona Salimbeni , Shar-Yin Naomi Huang , et al.
Cell Reports, 2019, 28 (12), pp.3167 - 3181. ⟨10.1016/j.celrep.2019.08.041⟩
Article dans une revue hal-02378250v1

Séparation chirale par chromatographie liquide et par fluide supercritique des analogues cliquables de Jaspine B

 Cécile Santos , Isabelle Fabing , Stéphanie Ballereau , Yves Génisson , A. Rozie , et al.
33e journée Chimie-Biologie-Santé, Apr 2019, Toulouse, France
Poster de conférence hal-02338505v1

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

 Jing Ye , Christelle Lenain , Serge Bauwens , Angela Rizzo , Adelaïde Saint-Léger , et al.
Cell, 2010, 142 (2), pp.230-242. ⟨10.1016/j.cell.2010.05.032⟩
Article dans une revue ensl-00817706v1
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Alkyne-Tagged Analogue of Jaspine B: New Tool for Identifying Jaspine B Mode of Action

 Alexandrine Rozié , Cécile Santos , Isabelle Fabing , Patrick Calsou , Sébastien Britton , et al.
ChemBioChem, 2018, 19 (23), pp.2438-2442. ⟨10.1002/cbic.201800496⟩
Article dans une revue hal-02059233v1

Development of Bioinspired Lipidic Alcynylcarbinol Prodrugs for Targeted Anticancer Therapy.

 Margaux Bossuat , Nadège Preuilh , Stéphanie Ballereau , V. Bernades-Génisson , Valérie Maraval , et al.
Journée Chimie et Cancer du Cancéropole Grand Sud-Ouest, Jun 2023, Toulouse, France
Poster de conférence hal-04198422v1
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SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

 Pascal Demange , Etienne Joly , Julien Marcoux , Patrick Ra Zanon , Dymytrii Listunov , et al.
eLife, 2022, 11, pp.e73913. ⟨10.7554/eLife.73913⟩
Article dans une revue hal-03719267v2
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ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks

 Sébastien Britton , Pauline Chanut , Christine Delteil , Nadia Barboule , Philippe Frit , et al.
Nucleic Acids Research, 2020, 48, pp.9710 - 9723. ⟨10.1093/nar/gkaa723⟩
Article dans une revue hal-02989041v1
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Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays

 Katerina Duskova , Jérémy Lamarche , Souheila Amor , Coralie Caron , Nicolas Queyriaux , et al.
Journal of Medicinal Chemistry, 2019, 62 (9), pp.4456-4466. ⟨10.1021/acs.jmedchem.8b01978⟩
Article dans une revue hal-02121543v3
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SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

 Pascal Demange , Etienne Joly , Julien Marcoux , Patrick R A Zanon , Dymytrii Listunov , et al.
2021
Pré-publication, Document de travail hal-03370122v1
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Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

 Madeleine Bossaert , Angélique Pipier , Jean-Francois Riou , Céline Noirot , Linh-Trang Nguyên , et al.
eLife, 2021, 10, ⟨10.7554/eLife.65184⟩
Article dans une revue hal-03369757v1

Séparation chirale par chromatographie liquide et par fluide supercritique des analogues cliquables de Jaspine B

 Isabelle Fabing , Stéphanie Ballereau , Yves Génisson , Cécile Santos , A. Rozie , et al.
14ème Congrès de l'Association Francophone des Sciences Séparatives, Mar 2019, PARIS, France
Poster de conférence hal-02333453v1
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DNA folds threaten genetic stability and can be leveraged for chemotherapy

 Joanna Zell , Francesco Rota Sperti , Sébastien Britton , David Monchaud
RSC Chemical Biology, 2021, 2 (1), pp.47-76. ⟨10.1039/d0cb00151a⟩
Article dans une revue hal-02953870v1

Bioactive lipids

 Stéphanie Ballereau , Yves Génisson , Patrick Calsou , Sébastien Britton
1er workshop du Groupe de travail « Chimie et Cancer » du Cancéropôle Grand Sud-Ouest, Jun 2023, Toulouse, France
Communication dans un congrès hal-04402254v1

2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology

 Marco Lucchino , Anne Billet , Antoine Versini , Harikrishna Bavireddi , Bhanu-Das Dasari , et al.
ChemBioChem, 2019, 20 (7), pp.968-973. ⟨10.1002/cbic.201900092⟩
Article dans une revue hal-02324665v1

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

 Kyle Miller , Jorrit Tjeertes , Julia Coates , Gaëlle Legube , Sophie Polo , et al.
Nature Structural and Molecular Biology, 2010, 17 (9), pp.1144-1151. ⟨10.1038/nsmb.1899⟩
Article dans une revue hal-03082153v1
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DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

 Sébastien Britton , Emma Dernoncourt , Christine Delteil , Carine Froment , Odile Schiltz , et al.
Nucleic Acids Research, 2014, 42 (14), pp.9047-9062. ⟨10.1093/nar/gku601⟩
Article dans une revue hal-01191434v1

New tool for identification of jaspine B pharmacological target

 Stéphanie Ballereau , Yves Génisson , P. Calsou , S. Britton
9ème Ecole Thématique de Criblage, Oct 2018, Carry-Le-Rouet, France
Poster de conférence hal-02337302v1

Bio-inspired antitumor acetylenic lipids bearing alkynylcarbinol pharmacophores

 Pauline Rullière , Maroua Bourkhis , Dymytrii Listunov , Hafida Gaspard , Valérie Maraval , et al.
Flash communication, Congrès SCF18, Jul 2018, Montpellier, France
Communication dans un congrès hal-02335955v1
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Constrained G4 structures unveil topology specificity of known and new G4 binding proteins

 A. Pipier , A. Devaux , T. Lavergne , A. Adrait , Y. Couté , et al.
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-92806-8⟩
Article dans une revue hal-03369749v1
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Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction

 Antonia Kefala Stavridi , Amandine Gontier , Vincent Morin , Philippe Frit , Virginie Ropars , et al.
Nucleic Acids Research, 2023, ⟨10.1093/nar/gkad863⟩
Article dans une revue hal-04284601v1

Bioinspired lipidic alkynylcarbinols as anticancer agents

 Margaux Bossuat , Sébastien Britton , Remi Chauvin , Yves Génisson
Journées Jeunes Chercheurs SCT, Feb 2023, Paris, France
Poster de conférence hal-04402496v1
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Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligands

 A Pipier , M Bossaert , J F Riou , C Noirot , L-T Nguyễn , et al.
2020
Pré-publication, Document de travail hal-02989065v1

Alkyne-tagged analogue of jaspine B: new tool for identifying jaspine B mode of action

 Stéphanie Ballereau , Yves Génisson , Patrick Calsou , Sébastien Britton
10th International Chemistry Conference Toulouse-Kiev (ICTK-10), Jun 2019, TOULOUSE, France
Communication dans un congrès hal-02333441v1
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DNA junction ligands trigger DNA damage and are synthetic lethal with DNA repair inhibitors in cancer cells

 Katerina Duskova , Pauline Lejault , Élie Benchimol , Régis Guillot , Sébastien Britton , et al.
Journal of the American Chemical Society, 2019, ⟨10.1021/jacs.9b11150⟩
Article dans une revue hal-02412757v1
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XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase

 Abhishek Bharadwaj Sharma , Hélène Erasimus , Lia Pinto , Marie-Christine Caron , Diyavarshini Gopaul , et al.
Nucleic Acids Research, 2021, 49 (17), pp.9906-9925. ⟨10.1093/nar/gkab785⟩
Article dans une revue hal-03371180v1
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BRCA1 prevents R-loop-associated centromeric instability

 Carine Racca , Sébastien Britton , Sabrine Hédouin , Claire Francastel , Patrick Calsou , et al.
Cell Death and Disease, 2021, 12 (10), ⟨10.1038/s41419-021-04189-3⟩
Article dans une revue hal-03371200v1
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XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition

 Abhishek B Sharma , Hélène Erasimus , Lia Pinto , Marie-Christine Caron , Katrin Neumann , et al.
2020
Pré-publication, Document de travail hal-02989098v1

Biased and unbiased strategies to identify biologically active small molecules.

 Valentina Abet , Angelica Mariani , Fiona R Truscott , Sébastien Britton , Raphaël Rodriguez
Bioorganic and Medicinal Chemistry, 2014, 22 (16), pp.4474-4489. ⟨10.1016/j.bmc.2014.04.019⟩
Article dans une revue hal-01067769v1
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