Number of documents



Journal articles30 documents

  • Benjamin Schneider, Arnaud Boyer, Joseph Ciccolini, Fabrice Barlési, Kenneth Wang, et al.. Optimal Scheduling of Bevacizumab and Pemetrexed/cisplatin Dosing in Non‐Small Cell Lung Cancer. CPT: Pharmacometrics and Systems Pharmacology, American Society for Clinical Pharmacology and Therapeutics ; International Society of Pharmacometrics, 2019, ⟨10.1002/psp4.12415⟩. ⟨hal-02109335⟩
  • Jonathan Mochel, Stephen Ekker, Chad Johannes, Albert Jergens, Karin Allenspach, et al.. CAR T-Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies. AAPS Journal, American Association of Pharmaceutical Scientists, 2019, 21 (3), ⟨10.1208/s12248-019-0322-1⟩. ⟨hal-02099159⟩
  • Diane-Charlotte Imbs, Raouf El Cheikh, Arnaud Boyer, Joseph Ciccolini, Celine Mascaux, et al.. Revisiting bevacizumab + cytotoxics scheduling using mathematical modeling: proof of concept study in experimental non-small cell lung carcinoma. CPT: Pharmacometrics and Systems Pharmacology, American Society for Clinical Pharmacology and Therapeutics ; International Society of Pharmacometrics, 2018, pp.1-9. ⟨10.1002/psp4.12265⟩. ⟨hal-01624423v2⟩
  • Anne Rodallec, Guillaume Sicard, Raphaelle Fanciullino, Sébastien Benzekry, Bruno Lacarelle, et al.. Turning cold tumors into hot tumors: harnessing the potential of tumor immunity using nanoparticles. Expert Opinion on Drug Metabolism and Toxicology, Taylor & Francis, 2018, 14 (11), pp.1-9. ⟨10.1080/17425255.2018.1540588⟩. ⟨hal-01958583⟩
  • Anne Rodallec, Sébastien Benzekry, Bruno Lacarelle, Joseph Ciccolini, Raphaelle Fanciullino. Pharmacokinetics variability: why nanoparticles are not magic bullets in oncology. Critical Reviews in Oncology/Hematology, Elsevier, 2018, 129, pp.1 - 12. ⟨10.1016/j.critrevonc.2018.06.008⟩. ⟨hal-01821678⟩
  • Araceli Henares-Molina, Sébastien Benzekry, Pedro Lara, Marcial García-Rojo, Víctor Pérez-García, et al.. Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas. PLoS ONE, Public Library of Science, 2017, ⟨10.1371/journal.pone.0178552.t001⟩. ⟨hal-01532505⟩
  • Arnaud Boyer, Joseph Ciccolini, Céline Mascaux, Diane-Charlotte Imbs, Raouf El Cheikh, et al.. Etude de l'effet séquence bevacizumab/pemetrexed/cisplatine chez la souris porteuse de cancer du poumon non à petites cellules. Revue des Maladies Respiratoires, Elsevier Masson, 2017, 34, ⟨10.1016/j.rmr.2016.10.110⟩. ⟨hal-01540322⟩
  • Severine Mollard, Joseph Ciccolini, Diane-Charlotte Imbs, Raouf El Cheikh, Dominique Barbolosi, et al.. Model-driven optimization of antiangiogenics + cytotoxics combination: application to breast cancer mice treated with bevacizumab + paclitaxel doublet leads to reduced tumor growth and fewer metastasis. Oncotarget, Impact journals, 2017, ⟨10.18632/oncotarget.15484⟩. ⟨hal-01474679⟩
  • Madeleine Benguigui, Dror Alishekevitz, Michael Timaner, Dvir Shechter, Ziv Raviv, et al.. Dose- and time-dependence of the host-mediated response to paclitaxel therapy: a mathematical modeling approach. Oncotarget, Impact journals, 2017, 9 (2), pp.2574-2590. ⟨10.18632/oncotarget.23514⟩. ⟨hal-01672568⟩
  • Sébastien Benzekry, Clare Lamont, Dominique Barbolosi, Lynn Hlatky, Philip Hahnfeldt. Mathematical modeling of tumor-tumor distant interactions supports a systemic control of tumor growth. Cancer Research, American Association for Cancer Research, 2017, ⟨10.1158/0008-5472.CAN-17-0564⟩. ⟨hal-01566947⟩
  • Sébastien Benzekry. Les lois de la croissance tumorale. Bibliothèque Tangente, Editions Pôle Paris, 2016. ⟨hal-01418295⟩
  • Pan Pantziarka, Lisa Hutchinson, Nicolas André, Sébastien Benzekry, Francesco Bertolini, et al.. Next generation metronomic chemotherapy - report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6 - 8 May 2016, Mumbai. Ecancermedicalscience, 2016, 10, ⟨10.3332/ecancer.2016.689⟩. ⟨hal-01392473⟩
  • Séverine Mollard, Raphaelle Fanciullino, Sarah Giacometti, Cindy Serdjebi, Sebastien Benzekry, et al.. In Vivo Bioluminescence Tomography for Monitoring Breast Tumor Growth and Metastatic Spreading: Comparative Study and Mathematical Modeling. Scientific Reports, Nature Publishing Group, 2016, 6, pp.10. ⟨10.1038/srep36173⟩. ⟨hal-01392861⟩
  • Sébastien Benzekry, A. Tracz, M. Mastri, R. Corbelli, D. Barbolosi, et al.. Modeling Spontaneous Metastasis following Surgery: An In Vivo-In Silico Approach. Cancer Research, American Association for Cancer Research, 2016, 76 (3), pp.535 - 547. ⟨10.1158/0008-5472.CAN-15-1389⟩. ⟨hal-01222046v2⟩
  • R. Serre, Sébastien Benzekry, Laetitia Padovani, C. Meille, N. Andre, et al.. Mathematical modeling of cancer immunotherapy and its synergy with radiotherapy. Cancer Research, American Association for Cancer Research, 2016, ⟨10.1158/0008-5472.CAN-15-3567⟩. ⟨hal-01336779⟩
  • Sebastien Benzekry, Jack A Tuszynski, Edward Rietman, Giannoula Lakka Klement. Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks. Biology Direct, BioMed Central, 2015, pp.14. ⟨10.1186/s13062-015-0058-5⟩. ⟨hal-01158313⟩
  • Etienne Baratchart, Sébastien Benzekry, Andreas Bikfalvi, Thierry Colin, Lindsay S. Cooley, et al.. Computational Modelling of Metastasis Development in Renal Cell Carcinoma. PLoS Computational Biology, Public Library of Science, 2015, 11 (11), ⟨10.1371/journal.pcbi.1004626⟩. ⟨hal-01164834v2⟩
  • Sébastien Benzekry, Eddy Pasquier, Dominique Barbolosi, Bruno Lacarelle, Fabrice Barlési, et al.. Metronomic Reloaded: Theoretical Models Bringing Chemotherapy into the Era of Precision Medicine. Seminars in Cancer Biology, Elsevier, 2015, pp.23. ⟨10.1016/j.semcancer.2015.09.002⟩. ⟨hal-01195547⟩
  • Joseph Ciccolini, Sébastien Benzekry, Bruno Lacarelle, Dominique Barbolosi, Fabrice Barlési. Improving efficacy of the combination between antiangiogenic and chemotherapy: Time for mathematical modeling support. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2015, pp.1. ⟨10.1073/pnas.1506689112⟩. ⟨hal-01168635⟩
  • Sebastien Benzekry, Afshin Beheshti, Philip Hahnfeldt, Lynn Hlatky. Capturing the Driving Role of Tumor-Host Crosstalk in a Dynamical Model of Tumor Growth. Bio-protocol , Bio-protocol LCC, 2015, 5 (21), ⟨⟩. ⟨hal-01222068⟩
  • Afshin Beheshti, Sebastien Benzekry, J. Tyson Mcdonald, Lili Ma, Michael Peluso, et al.. Host Age Is a Systemic Regulator of Gene Expression Impacting Cancer Progression. Cancer Research, American Association for Cancer Research, 2015, 75 (6), pp.10. ⟨10.1158/0008-5472.CAN-14-1053⟩. ⟨hal-01132048⟩
  • Sebastien Benzekry, Alberto Gandolfi, Philip Hahnfeldt. Global Dormancy of Metastases due to Systemic Inhibition of Angiogenesis. PLoS ONE, Public Library of Science, 2014, 9 (1), pp.e84249. ⟨10.1371/journal.pone.0084249⟩. ⟨hal-00868592v3⟩
  • Sebastien Benzekry, Clare Lamont, Afshin Beheshti, Amanda Tracz, John M. Ebos, et al.. Classical Mathematical Models for Description and Forecast of Experimental Tumor Growth. PLoS Computational Biology, Public Library of Science, 2014, 10 (8), pp.e1003800. ⟨10.1371/journal.pcbi.1003800⟩. ⟨hal-00922553v6⟩
  • Floriane Lignet, Sébastien Benzekry, Shelby Wilson, Frédérique Billy, Olivier Saut, et al.. Theoretical investigation of the efficacy of antiangiogenic drugs combined to chemotherapy in xenografted mice.. Journal of Theoretical Biology, Elsevier, 2013, 320, pp.86-99. ⟨10.1016/j.jtbi.2012.12.013⟩. ⟨hal-00785876⟩
  • Sebastien Benzekry, Philip Hahnfeldt. Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers.. Journal of Theoretical Biology, Elsevier, 2013, 335, pp.235-44. ⟨10.1016/j.jtbi.2013.06.036⟩. ⟨hal-00836032⟩
  • Sébastien Benzekry, Nicolas André, Assia Benabdallah, Joseph Ciccolini, Christian Faivre, et al.. Modeling the impact of anticancer agents on metastatic spreading. Mathematical Model Natural Phenomenon, 2012, 7 (1), pp 306--336. ⟨10.1051/mmnp/20127114⟩. ⟨hal-00657724⟩
  • Sebastien Benzekry. Mathematical and numerical analysis of a model for anti-angiogenic therapy in metastatic cancers. ESAIM: Mathematical Modelling and Numerical Analysis, EDP Sciences, 2012, 46 (2), pp.207-237. ⟨hal-00518110⟩
  • Sébastien Benzekry, Guillemette Chapuisat, Joseph Ciccolini, Alice Erlinger, Florence Hubert. A new mathematical model for optimizing the combination between antiangiogenic and cytotoxic drugs in oncology. Comptes rendus de l'Académie des sciences. Série I, Mathématique, Elsevier, 2012, 350, pp.23-28. ⟨10.1016/j.crma.2011.11.019⟩. ⟨hal-00641476v2⟩
  • Sebastien Benzekry. Mathematical analysis of a two-dimensional population model of metastatic growth including angiogenesis. Journal of Evolution Equations, Springer Verlag, 2011, 11 (1), pp.187-213. ⟨hal-00516693⟩
  • Sebastien Benzekry. Passing to the limit 2D-1D in a model for metastatic growth. Journal of Biological Dynamics, Taylor & Francis Open, 2011, pp.10.1080/17513758.2011.568071. ⟨10.1080/17513758.2011.568071⟩. ⟨hal-00521968⟩

Conference papers10 documents

  • Sébastien Benzekry. Optimization of sequential administration of bevacizumab plus cytotoxics in non-small cell lung cancer by combining in vivo experiments and mathematical modeling. Mathematical perspectives in the biology and therapeutics of cancer, Jul 2018, Marseille, France. ⟨hal-01969142⟩
  • Sébastien Benzekry. Mechanistic modeling of metastasis: cancer at the organism scale. Mathematical Models in Cancer, Jul 2018, Vienna, Austria. ⟨hal-01969104⟩
  • Sébastien Benzekry. Mathematical Modeling and Prediction of Clinical Metastasis. Mathematical Challenges in the Analysis of Continuum Models for Cancer Growth, Evolution and Therapy, Nov 2018, Oaxaca, Mexico. ⟨hal-01969108⟩
  • Sébastien Benzekry. Mathematical Modeling of Tumor-Tumor Distant Interactions Supports a Systemic Control of Tumor Growth. 3rd Mathematical Biology Modeling days of Besançon, Jun 2018, Besançon, France. ⟨hal-01969102⟩
  • Araceli Henares-Molina, Sébastien Benzekry, Pedro Lara, Marcial García-Rojo, Victor Pérez-García, et al.. Optimized radiotherapy protocols delay the malignant transformation of low-grade gliomas in-silico. 5th Quadrennial Meeting of the World Federation of Neuro-Oncology Societies, May 2017, Zurich, Switzerland. pp.iii12 - iii12, ⟨10.1093/neuonc/nox036.040⟩. ⟨hal-01517899⟩
  • Joseph Ciccolini, Sebastien Benzekry, Sarah Giacometti, Fabrice Barlesi, Dominique Barbolosi. Abstract 2099: Model-driven optimization of anti-angiogenics combined with chemotherapy: application to bevacizumab + pemetrexed/cisplatin doublet in NSCLC-bearing mice. 107th Annual Meeting of the American Association for Cancer Research, 2016, New Orleans, France. pp.20, ⟨10.1158/1538-7445.AM2016-2099⟩. ⟨hal-01404637⟩
  • Sébastien Benzekry, John Ebos. On the growth and dissemination laws in a mathematical model of metastatic growth. Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, Mar 2015, Paris, France. ⟨10.1051/itmconf/20150500007⟩. ⟨hal-01222088⟩
  • Séverine Mollard, Sébastien Benzekry, Giacometti Sarah, Christian Faivre, Florence Hubert, et al.. Model-based optimization of combined antiangiogenic + cytotoxics modalities: application to the bevacizumab-paclitaxel association in breast cancer models. AACR Annual Meeting 2014, Apr 2014, San Diego, United States. ⟨10.1158/1538-7445.AM2014-3677⟩. ⟨hal-01090883⟩
  • Sebastien Benzekry, Alberto Gandolfi, Philip Hahnfeldt. A mathematical model of systemic inhibition of angiogenesis in metastatic development. Congres SMAI 2013, May 2013, Seignosse, France. pp.75-87, ⟨10.1051.201445008⟩. ⟨hal-00867992⟩
  • Sebastien Benzekry, Nicolas André, Assia Benabdallah, J. Ciccolini, Christian Faivre, et al.. A mathematical mode for growing metastases on oncologist's service. 3rd Annual International Conference in Computational Surgery, Jan 2011, houston, United States. ⟨hal-00839331⟩

Poster communications4 documents

  • Benjamin Schneider, Arnaud Boyer, Joseph Ciccolini, Kenneth Wang, Martin E Fernandez-Zapico, et al.. Modeling Primary Tumor Dynamics of Human-to-Mouse Xenografted Non-Small Cell Lung Cancer in Response to Administration of Bevacizumab and Pemetrexed-Cisplatin. Population Approach Group in Europe (PAGE) Meeting 2018, May 2018, Montreux, Switzerland. 2018. ⟨hal-01968942⟩
  • Cristina Vaghi, Anne Rodallec, Raphaelle Fanciullino, Joseph Ciccolini, Clair Poignard, et al.. Improving the efficacy of anti-cancer nanoparticles with data-driven mathematical modeling. Data Science Summer School, Jun 2018, Palaiseau, France. ⟨hal-01968959⟩
  • Michalis Mastri, Cynthia Perier, Gaetan Macgrogan, John Ebos, Sébastien Benzekry. A biologically-based mathematical model for prediction of metastatic relapse. 17th Biennial Congress of the Metastasis Research Society, Aug 2018, Princeton, United States. ⟨hal-01968980⟩
  • Chiara Nicolò, Michalis Mastri, Amanda Tracz, John Ebos, Sébastien Benzekry. Mathematical modeling of differential effects of neo-adjuvant Sunitinib on primary tumor and metastatic growth. AACR Annual Meeting 2018, Apr 2018, Chicago, United States. 78 (13 Supplement), pp.4264, 2018, ⟨10.1158/1538-7445.AM2018-4264⟩. ⟨hal-01968917⟩

Book sections1 document

  • Dominique Barbolosi, Assia Benabdallah, Sébastien Benzekry, Joseph Ciccolini, Christian Faivre, et al.. A Mathematical Model for Growing Metastases on Oncologists’s Service. Computational Surgery and Dual Training, Springer, pp.331 - 338, 2014, ⟨10.1007/978-1-4614-8648-0_21⟩. ⟨hal-01087708⟩

Preprints, Working Papers, ...3 documents

  • M Bilous, C Serdjebi, Arnaud Boyer, P. Tomasini, C Pouypoudat, et al.. Computational modeling reveals dynamics of brain metastasis in non-small cell lung cancer and provides a tool for personalized therapy. 2018. ⟨hal-01928442⟩
  • Sebastien Benzekry, Dominique Barbolosi, Assia Benabdallah, Florence Hubert, Philip Hahnfeldt. Quantitative Analysis of the Tumor/Metastasis System and its Optimal Therapeutic Control. 2012. ⟨hal-00836023⟩
  • Nina Aguillon, Sebastien Benzekry, Jérémie Bettinelli, Pierre Bochard, Nicolas Bonnotte, et al.. Semaine d'Etude Mathématiques et Entreprises 1 : Deux problèmes sur les parcs solaires.. 2011. ⟨hal-00710024⟩

Reports2 documents

  • Laura Lumale, Sébastien Benzekry. Around a mathematical model of the concomitant tumor resistance phenomenon . [Research Report] INRIA Bordeaux; Equipe MONC; INSA Toulouse. 2016. ⟨hal-01420449⟩
  • Simon Evain, Sebastien Benzekry. Mathematical modeling of tumor and metastatic growth when treated with sunitinib. [Research Report] Inria Bordeaux Sud-Ouest. 2016. ⟨hal-01377994⟩

Theses1 document

  • Sébastien Benzekry. Modeling, mathematical and numerical analysis of anti-cancerous therapies for metastatic cancers . Analysis of PDEs [math.AP]. Université Aix-Marseille 1 – Université de Provence, 2011. English. ⟨tel-01658210⟩

Habilitation à diriger des recherches1 document

  • Sébastien Benzekry. Contributions in Mathematical Oncology: When Theory Meets Reality. Mathematics [math]. Université de Bordeaux, 2017. ⟨tel-01658070⟩