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    Curriculum vitae - Sara LACERDA


    • 2009 – PhD. in Inorganic Chemistry. Final classification: “summa cum laude”.

    Title: "Copper Samarium and Holmium complexes with tetraazamacrocyles potentially interesting for Nuclear Medicine", Faculdade de Ciências da Universidade de Lisboa / Instituto Tecnológico e Nuclear, Lisboa, Portugal. Supervisor: Dr. Isabel Rego dos Santos.

    •  2000 - Graduate in Chemistry, Faculdade de Ciências of the Universidade de Lisboa, Lisboa, Portugal.

    Current Position

    • From Jan 2016 – Researcher 1st Grade (CR1): Centre de Biophysique Moléculaire, CNRS, Orléans, France

     Previous Positions

    • Jan 2013 – Dec 2015 – Research Associate: “Molecular Imaging of Dysfunctional Matrix Remodelling in Arterial Disease” at Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, UK
    • Jan 2010 – Dec 2012 – Post-Doc fellowship: “Development of new lipoparticles as bimodal MRI/Optics imaging probes”, at Centre de Biophysique Moléculaire/CNRS, Orléans, France
    • Apr 2009 – Dec 2009 – Post-Doc fellowship: “Fragment-Based Drug Discovery approach to find antiviral compounds against virus proteases”, at Institute für Biochemie, Universität zu Lübeck, Lübeck, Germany
    • Oct 2001 – Apr 2002 – Technician for advise and council for Generic Medicines for National Portuguese Authority for the Evaluation of Medicinal Products (INFARMED).

    Fellowships / Short Scientific Missions and Training

    • Nov 2004 – Nov 2008 – FCT/PhD fellowship, at Instituto Tecnológico e Nuclear, (Portugal) and Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf (Germany).

    • 2007 – 2008 – Several Short Scientific Missions at the Institute of Radiopharmacy, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

    • 2006 - 2007 – Several Short Scientific Missions at the Group of Coordination and Bioinorganic Chemistry, Charles University, Prague, Czech Republic.

    • May 2002 – Oct 2004 – FCT fellowship (BIC), Instituto Tecnológico e Nuclear, Sacavem, Portugal.

    • Jan 2001 – Set2001 – Research Trainee: “Interaction and Partition of flavonoids with SDS Micelles”, at Faculdade de Ciências da Universidade de Lisboa.

    • Oct 1999 - Dec 2000 – Undergraduate Trainning at Faculdade de Ciências da Universidade de Lisboa.

    Main Scientific Areas of Research

    • Molecular Imaging

    • Targeted Contrast Agents

    • Bimodal Imaging Agents: MR/OI and MR/PET or MR/SPECT

    • Theranostic Agents

    • Nanoparticles

    • Fragment-Based Drug Design

    • Medicinal Chemistry

    • Radiopharmaceuticals Development

    Other Qualifications

    • Associate Fellow of the Higher Education Academy in UK, since January 2015.

    • Chair of Cardiovascular Imaging Session at the 9th European Molecular Imaging Meeting, June 2014; sub-chair “New Probes, MRI & Multimodal” Session at the 13th European Molecular Imaging Meeting, March 2018.

    • Qualified for Maître de Conférences in section 85 – Sc. Physicochimie et Ingénierie Appliquée à la Santé, since February 2013.


    • Portuguese: native language.

    • English: fluent.

    • French: fluent.

    Other Interests

    • Travelling, cinema, music

    • Member of the Students Association at the Faculty of Sciences of the University of Lisboa (1998-1999) and at the High School (1993-1994)

    • Participation on the organization of several National and International conferences - March 2019


    Journal articles22 documents

    • Kyangwi Malikidogo, Isidro da Silva, Jean-François Morfin, Sara Lacerda, Laurent Barantin, et al.. A cocktail of 165 Er( iii ) and Gd( iii ) complexes for quantitative detection of zinc using SPECT and MRI. Chemical Communications, Royal Society of Chemistry, 2018, 54 (55), pp.7597 - 7600. ⟨10.1039/c8cc03407a⟩. ⟨hal-01904447⟩
    • Eva Toth, Sara Lacerda. Theranostics and Image Guided Drug Delivery. Edited by Maya Thanou. ChemMedChem, Wiley-VCH Verlag, 2018, 13 (17), pp.1851-1852. ⟨hal-01966410⟩
    • Sara Lacerda. Targeted Contrast Agents for Molecular MRI. Inorganics, MDPI AG, 2018, 6 (4), pp.129. ⟨10.3390/inorganics6040129⟩. ⟨hal-02068580⟩
    • Alkystis Phinikaridou, Sara Lacerda, Begoña Lavin, Marcelo Andia, Alberto Smith, et al.. Tropoelastin: A novel marker for plaque progression and instability.. Circulation: Cardiovascular Imaging, American Heart Association, 2018, 11 (8), ⟨10.1161/CIRCIMAGING.117.007303⟩. ⟨hal-02079426⟩
    • Hongguang Li, Bethany Harriss, Alkystis Phinikaridou, Sara Lacerda, Gregory Ramniceanu, et al.. Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging. Nanotheranostics, 2017, 1 (2), pp.186-195. ⟨10.7150/ntno.18619⟩. ⟨hal-02079515⟩
    • Sara Lacerda, Éva Tóth. Lanthanide Complexes in Molecular Magnetic Resonance Imaging and Theranostics. ChemMedChem, Wiley-VCH Verlag, 2017, 12 (12), pp.883 - 894. ⟨10.1002/cmdc.201700210⟩. ⟨hal-01618333⟩
    • S. Lacerda, J.-F. Morfin, C. Geraldes, É. Tóth. Metal complexes for multimodal imaging of misfolded protein-related diseases. Dalton Transactions, Royal Society of Chemistry, 2017, 46 (42), pp.14461-14474. ⟨10.1039/C7DT02371E⟩. ⟨hal-02068723⟩
    • Jiefang He, Célia S. Bonnet, Svetlana V. Eliseeva, Sara Lacerda, Thomas Chauvin, et al.. Prototypes of Lanthanide(III) Agents Responsive to Enzymatic Activities in Three Complementary Imaging Modalities: Visible/Near-Infrared Luminescence, PARACEST-, and T 1 -MRI. Journal of the American Chemical Society, American Chemical Society, 2016, 138 (9), pp.2913 - 2916. ⟨10.1021/jacs.5b12084⟩. ⟨hal-01407004⟩
    • Slávka Kaščáková, Alexandre Giuliani, Sara Lacerda, Agnès Pallier, Pascal Mercère, et al.. X-ray-induced radiophotodynamic therapy (RPDT) using lanthanide micelles: Beyond depth limitations. Nano Research, Springer, 2015, 8, pp.2373 - 2379. ⟨⟩. ⟨10.1007/s12274-015-0747-5⟩. ⟨hal-01479428⟩
    • André F. Martins, David M. Dias, Jean-François Morfin, Sara Lacerda, Douglas V. Laurents, et al.. Interaction of PiB-Derivative Metal Complexes with Beta-Amyloid Peptides: Selective Recognition of the Aggregated Forms. Chemistry - A European Journal, Wiley-VCH Verlag, 2015, 21 (14), pp.5413-5422. ⟨10.1002/chem.201406152⟩. ⟨hal-01171718⟩
    • René Botnar, Andrea Wiethoff, Ullrich Ebersberger, Sara Lacerda, Ulrike Blume, et al.. In Vivo Assessment of Aortic Aneurysm Wall Integrity Using Elastin-Specific Molecular Magnetic Resonance Imaging. Circulation: Cardiovascular Imaging, American Heart Association, 2014, 7 (4), pp.679-689. ⟨10.1161/CIRCIMAGING.113.001131⟩. ⟨hal-02079499⟩
    • Alkystis Phinikaridou, Marcelo Andia, Sara Lacerda, Silvia Lorrio, Marcus Makowski, et al.. Molecular MRI of Atherosclerosis. Molecules, MDPI, 2013, 18 (11), pp.14042-14069. ⟨10.3390/molecules181114042⟩. ⟨hal-02079495⟩
    • Sara Lacerda, Célia S Bonnet, Agnès Pallier, Sandrine Villette, Frédéric Foucher, et al.. Lanthanide-Based, Near-Infrared Luminescent and Magnetic Lipoparticles: Monitoring Particle Integrity.. Small, Wiley-VCH Verlag, 2013, 9 (16), pp.2662-2666. ⟨10.1002/smll.201201923⟩. ⟨hal-00817465⟩
    • Sara Lacerda, Fernanda Marques, Paula Campello, Lurdes Gano, Vojtěch Kubíček, et al.. Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/phosphinic acid pendant arm. Journal of Labelled Compounds and Radiopharmaceuticals, Wiley-Blackwell, 2010, 53 (1), pp.36-43. ⟨10.1002/jlcr.1697⟩. ⟨hal-02079486⟩
    • Paula c. M. Campello, Sara Lacerda, Isabel c. Santos, Giovannia a. Pereira, Carlos F. G. C. Geraldes, et al.. Lanthanide(III) complexes of 4,10-bis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (trans-H6do2a2p) in solution and in the solid state: structural studies along the series. Chemistry - A European Journal, Wiley-VCH Verlag, 2010, 16 (28), pp.8446-8465. ⟨10.1002/chem.201000320⟩. ⟨hal-00529313⟩
    • Sara Lacerda, M. Paula Campello, Fernanda Marques, Lurdes Gano,, Vojtech Kubicek, et al.. A novel tetraazamacrocycle bearing a thiol pendant arm for labeling biomolecules with radiolanthanides. Dalton Transactions, Royal Society of Chemistry, 2009, pp.4509-4518. ⟨10.1039/b820375j⟩. ⟨hal-00525104⟩
    • M. Paula Campello, Fernanda Marques, Lurdes Gano, Sara Lacerda, Isabel Santos. Radiochemical and biological behaviour of 153Sm and 166Ho complexes anchored by a novel bis(methylphosphonate) tetraazamacrocycle. Radiochimica Acta, R Oldenbourg Verlag GMBH, 2007, 95 (6), ⟨10.1524/ract.2007.95.6.329⟩. ⟨hal-02079464⟩
    • I Gano, M. Marques, M Campello, M Balbina, S. Lacerda, et al.. Radiolanthanide complexes with tetraazamacrocycles bearing methylphosphonate pendant arms as bone seeking agents.. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutic, 2007, 51 (1), pp.6-15. ⟨hal-02079469⟩
    • Fernanda Marques, Lurdes Gano, M. Paula Campello, Sara Lacerda, Isabel Santos. Biological evaluation of 153Sm and 166Ho complexes with tetraazamacrocycles containing methylcarboxylate and/or methylphosphonate pendant arms. Radiochimica Acta, R Oldenbourg Verlag GMBH, 2007, 95 (6), ⟨10.1524/ract.2007.95.6.335⟩. ⟨hal-02079460⟩
    • Sara Lacerda, Maria Paula Campello, Isabel Santos, Rita Delgado. Study of the cyclen derivative 2-[1,4,7,10-tetraazacyclododecan-1-yl]-ethanethiol and its complexation behaviour towards d-transition metal ions. Polyhedron, Elsevier, 2007, 26 (14), pp.3763-3773. ⟨10.1016/j.poly.2007.04.037⟩. ⟨hal-02079478⟩
    • M. Marques, Lurdes Gano, M. Paula Campello, Sara Lacerda, Isabel Santos, et al.. 13- and 14-membered macrocyclic ligands containing methylcarboxylate or methylphosphonate pendant arms: Chemical and biological evaluation of their 153Sm and 166Ho complexes as potential agents for therapy or bone pain palliation. Journal of Inorganic Biochemistry, Elsevier, 2006, 100 (2), pp.270-280. ⟨10.1016/j.jinorgbio.2005.11.011⟩. ⟨hal-02079453⟩
    • Sara Lacerda, Maria Paula Campello, Isabel Santos, Rita Delgado. A N,N′-diacetate benzodioxotetraazamacrocycle and its transition metal complexes. Polyhedron, Elsevier, 2005, 24 (3), pp.451-461. ⟨10.1016/j.poly.2004.12.008⟩. ⟨hal-02079449⟩

    Book sections3 documents

    • Begoña Lavin-Plaza, Alkystis Phinikaridou, Marcelo Andia, Sara Lacerda, Markus Henningsson, et al.. Atherosclerotic Plaque Imaging. Cardiovascular magnetic resonance imaging, pp.229-248, 2019, 978-1-4939-8841-9. ⟨10.1007/978-1-4939-8841-9_14⟩. ⟨hal-02080780⟩
    • Carlos F.G.C. Geraldes, Sara Lacerda, Eva Toth. Molecular Probes for Magnetic Resonance Imaging of Amyloid β Peptides. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier, 2018, 9780124095472. ⟨10.1016/B978-0-12-409547-2.13926-5⟩. ⟨hal-02080790⟩
    • M. Soledade C. S. Santos, Sara Lacerda, Ester Barbosa. Interactions of selected flavonoids with NaDS micelles. Progress in Colloid and Polymer Science, Springer Berlin Heidelberg, pp.73-77, 2004, ⟨10.1007/b11645⟩. ⟨hal-02081118⟩

    Directions of work or proceedings3 documents

    • Alkystis Phinikaridou, Sara Lacerda, Marcelo Andia, Rene Botnar. Development of a tropoelastin-binding MR contrast agent for in vivo imaging of impaired elastogenesis in atherosclerosis. Journal of Cardiovascular Magnetic Resonance, 17 (S1), 2015, ⟨10.1186/1532-429X-17-S1-O102⟩. ⟨hal-02081119⟩
    • Rolf Hilgenfeld, Lili Zhu, Ksenia Pumpor, Yuri Kusov, Shyla George, et al.. Structure-based discovery of antivirals targeting the proteases of RNA viruses. Acta Crystallographica Section a Foundations of Crystallography, 66 (a1), pp.s33-s33, 2010, ⟨10.1107/S0108767310099253⟩. ⟨hal-02095727⟩
    • Fernanda Marques, António Paulo, Maria Paula Campello, Sara Lacerda, Rute Filipe Vitor, et al.. Radiopharmaceuticals for targeted radiotherapy.. Radiation Protection Dosimetry, 116 (1-4), pp.601-4, 2005. ⟨hal-02081130⟩

    Patents1 document

    • Éva Tóth, Stephane Petoud, Célia Bonnet, S. Lacerda. Particles Comprising Luminescent Lanthanide Complexes. France, Patent n° : 13305291.0. 2014. ⟨hal-02081138⟩