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Keywords

Respiratory syncytial virus Poumon Asthma AGE-DEPENDENT DIFFERENCES DENDRITIC CELLS Lung Interferon REPONSE IMMUNE Aerosol Gut Flt3-L TLR9 Animal models Dendritic cells ADJUVANT Neonate VIROLOGIE Immunity DNA VACCINE
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Number of documents

94

Dr Sabine Riffault, DR INRAE

Neonatal sensitivity to respiratory viruses: how can we protect young animals against infections?

During the first months of life, acute lower respiratory tract infections are the major cause of morbidity and mortality among young mammals. The respiratory syncytial virus (RSV) is the main causative agent for broncho-pneumonia in calves (bovine RSV) and bronchiolitis in infants (human RSV). These viral infections have the particularity to cause severe acute lower respiratory disease in young animals whereas they are usually benign in adults, affecting only the upper respiratory tract. Thus, RSV infections are major health issues both for infants and calves. The neonatal period is characterized by immune responses quantitatively and qualitatively different from the adults one, issues that I have chosen to address through the following ongoing projects :

(a) To decipher the immunological and inflammatory mechanisms at stake in the lung upon respiratory infection of newborn.

(b) To elaborate new vaccine strategies against RSV using subunit vaccines: ring nanoparticles formed by the recombinant viral nucleoprotein and the pre-fusion form of the RSV fusion protein.

 

Journal articles43 documents

  • Sabine Riffault, Sara Hägglund, Efrain Guzman, Katarina Näslund, Luc Jouneau, et al.. A single shot pre-fusion-stabilized bovine rsv f vaccine is safe and effective in newborn calves with maternally derived antibodies. Vaccines, MDPI, 2020, 8 (2), ⟨10.3390/vaccines8020231⟩. ⟨hal-02677111⟩
  • Fabian Sesterhenn, Che Yang, Jaume Bonet, Johannes T. Cramer, Xiaolin Wen, et al.. De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, American Association for the Advancement of Science (AAAS), 2020, 368 (6492), ⟨10.1126/science.aay5051⟩. ⟨hal-02677103⟩
  • Delphyne Descamps, Irini Evnouchidou, Vivien Caillens, Carole Drajac, Sabine Riffault, et al.. The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells. Frontiers in Molecular Biosciences, Frontiers Media, 2020, 7, ⟨10.3389/fmolb.2020.583556⟩. ⟨hal-02972353⟩
  • Fabian Sesterhenn, Marie Galloux, Sabrina Vollers, Lucia Csepregi, Che Yang, et al.. Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen. PLoS Biology, Public Library of Science, 2019, 17 (2), pp.e3000164. ⟨10.1371/journal.pbio.3000164⟩. ⟨inserm-02138858⟩
  • Elliot Mathieu, Unai Escribano-Vazquez, Delphyne Descamps, Claire Cherbuy, Philippe Langella, et al.. Paradigms of Lung Microbiota Functions in Health and Disease, Particularly, in Asthma. Frontiers in Physiology, Frontiers, 2018, 9, pp.1-11. ⟨10.3389/fphys.2018.01168⟩. ⟨hal-02627730⟩
  • Carole Drajac, Daphnée Laubreton, Sabine Riffault, Delphyne Descamps. Pulmonary susceptibility of neonates to respiratory syncytial virus infection: a problem of innate immunity?. Journal of Immunology Research, Hindawi Publishing Corporation, 2017, ⟨10.1155/2017/8734504⟩. ⟨hal-02628884⟩
  • Sara Hagglund, Krister Blodorm, Katarina Naslund, Karin Vargmar, Sara Bergstrom Lind, et al.. Proteome analysis of bronchoalveolar lavage from calves infected with bovine respiratory syncytial virus-Insights in pathogenesis and perspectives for new treatments. PLoS ONE, Public Library of Science, 2017, 12 (10), pp.1-19. ⟨10.1371/journal.pone.0186594⟩. ⟨hal-02620701⟩
  • Dania Zhivaki, Sebastien Lemoine, Annick Lim, Ahsen Morva, Pierre-Olivier Vidalain, et al.. Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity. Immunity, Elsevier, 2017, 46 (2), pp.301-314. ⟨10.1016/j.immuni.2017.01.010⟩. ⟨hal-01604975⟩
  • Pierre Louis Hervé, Charlotte Deloizy, Delphyne Descamps, Marie-Anne Rameix Welti, Jenna Fix, et al.. RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine. Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2017, 13 (2), pp.411-420. ⟨10.1016/j.nano.2016.08.006⟩. ⟨hal-02628338⟩
  • Aude Remot-Brizion, Delphyne Descamps, Marie-Louise Noordine, Abdelhak Boukadiri, Elliot Mathieu, et al.. Bacteria isolated from lung modulate asthma susceptibility in mice. ISME Journal, Nature Publishing Group, 2017, pp.1-14. ⟨10.1038/ismej.2016.181⟩. ⟨hal-01595509⟩
  • Aude Remot-Brizion, Delphyne Descamps, Luc Jouneau, Daphnée Laubreton, Catherine Dubuquoy, et al.. Flt3 ligand improves the innate response to respiratory syncytial virus and limits lung disease upon RSV reexposure in neonate mice. European Journal of Immunology, Wiley-VCH Verlag, 2016, 46 (4), pp.874-884. ⟨10.1002/eji.201545929⟩. ⟨hal-01533877⟩
  • Pierre-Louis Hervé, Delphyne Descamps, Charlotte Deloizy, Véronique Dhelft, Daphné Laubreton, et al.. Non-invasive epicutaneous vaccine against Respiratory Syncytial Virus: Preclinical proof of concept. Journal of Controlled Release, Elsevier, 2016, 243, pp.146-159. ⟨10.1016/j.jconrel.2016.10.003⟩. ⟨hal-01425790⟩
  • Krister Blodorn, Sara Hagglund, Dolores Gavier-Widén, Jean Francois Eleouet, Sabine Riffault, et al.. A bovine respiratory syncytial virus model with high clinical expression in calves with specific passive immunity. BMC Veterinary Research, BioMed Central, 2015, 11, ⟨10.1186/s12917-015-0389-6⟩. ⟨hal-02640254⟩
  • Pierre-Louis Hervé, Mariam Raliou, Christiane Bourdieu, Catherine Dubuquoy, Agnes Petit-Camurdan, et al.. A Novel Subnucleocapsid Nanoplatform for Mucosal Vaccination against Influenza Virus That Targets the Ectodomain of Matrix Protein 2. Journal of Virology, American Society for Microbiology, 2014, 88 (1), pp.325-338. ⟨10.1128/JVI.01141-13⟩. ⟨hal-02637841⟩
  • Krister Blodorn, Sara Hagglund, Jenna Fix, Catherine Dubuquoy, Boby Makabi-Panzu, et al.. Vaccine Safety and Efficacy Evaluation of a Recombinant Bovine Respiratory Syncytial Virus (BRSV) with Deletion of the SH Gene and Subunit Vaccines Based On Recombinant Human RSV Proteins: N-nanorings, P and M2-1, in Calves with Maternal Antibodies. PLoS ONE, Public Library of Science, 2014, 9 (6), ⟨10.1371/journal.pone.0100392⟩. ⟨hal-02639198⟩
  • Marie-Anne Rameix-Welti, Ronan Le Goffic, Pierre-Louis Hervé, Julien Sourimant, Aude Remot, et al.. Visualizing the replication of respiratory syncytial virus in cells and in living mice. Nature Communications, Nature Publishing Group, 2014, 5, ⟨10.1038/ncomms6104⟩. ⟨hal-02633568⟩
  • Sara Hagglund, Kefei Hu, Krister Blodorn, Boby Makabi-Panzu, Anne-Laure Gaillard, et al.. Characterization of an experimental vaccine for bovine respiratory syncytial virus. Clinical and Vaccine Immunology, American Society for Microbiology, 2014, 21 (7), pp.997-1004. ⟨10.1128/CVI.00162-14⟩. ⟨hal-01204394⟩
  • Federico Sandoval, Magali Terme, Mevyn Nizard, Cecile Badoual, Michel-Francis Bureau, et al.. Mucosal Imprinting of Vaccine-Induced CD8(+) T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors. Science Translational Medicine, American Association for the Advancement of Science, 2013, 5 (172), ⟨10.1126/scitranslmed.3004888⟩. ⟨hal-02650685⟩
  • Aude Remot, Xavier Roux, Catherine Dubuquoy, Jenna Fix, Stephan Bouet, et al.. Nucleoprotein nanostructures combined with adjuvants adapted to the neonatal immune context: a candidate mucosal RSV vaccine. PLoS ONE, Public Library of Science, 2012, 7 (5), Non paginé. ⟨10.1371/journal.pone.0037722⟩. ⟨hal-01001405⟩
  • Xavier Roux, Aude Remot, Agnes Petit Camurdan, Marie-Anne Nahori, Helene Kiefer-Biasizzo, et al.. Neonatal lung immune responses show a shift of cytokines and transcription factors toward Th2 and a deficit in conventional and plasmacytoid dendritic cells. European Journal of Immunology, Wiley-VCH Verlag, 2011, 41, pp.2852-2861. ⟨10.1002/eji.201041224⟩. ⟨hal-02644846⟩
  • Sabine Riffault, Gilles Meyer, Martine Deplanche, Catherine Dubuquoy, Guillaume Durand, et al.. A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus. Vaccine, Elsevier, 2010, 28 (21), pp.3722-3734. ⟨10.1016/j.vaccine.2010.03.008⟩. ⟨hal-02658778⟩
  • Michelle Rémond, Bruno da Costa, Sabine Riffault, Satya Parida, Emmanuel Breard, et al.. Infectious bursal disease subviral particles displaying the foot-and-mouth disease virus major antigenic site. Vaccine, Elsevier, 2009, 27 (1), pp.93-98. ⟨10.1016/j.vaccine.2008.10.036⟩. ⟨hal-02664065⟩
  • Khaled Khoufache, Fanny Lebouder, Eric Morello, Fabrice Laurent, Sabine Riffault, et al.. Protective Role for Protease-Activated Receptor-2 against Influenza Virus Pathogenesis via an IFN-gamma-Dependent Pathway. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2009, 182 (12), pp.7795-7802. ⟨10.4049/jimmunol.0803743⟩. ⟨hal-02663202⟩
  • Xavier Roux, Catherine Dubuquoy, Guillaume Durand, Thi-Lan Tran-Tolla, Nathalie Castagné, et al.. Sub-nucleocapsid nanoparticles: a nasal vaccine against respiratory syncytial virus. PLoS ONE, Public Library of Science, 2008, 3 (3), pp.e1766. ⟨10.1371/journal.pone.0001766⟩. ⟨hal-02655935⟩
  • Florentina Pascale, Vanessa Contreras, Michel Bonneau, Alexandre Courbet, Stefan Chilmonczyk, et al.. Plasmacytoid dendritic cells migrate in afferent skin lymph. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 180 (9), pp.5963-5972. ⟨10.4049/jimmunol.180.9.5963⟩. ⟨hal-01193693⟩
  • Eric Soler, Nathalie Parez, Bruno Passet, Catherine Dubuquoy, Sabine Riffault, et al.. Recombinant rotavirus inner core proteins produced in the milk of transgenic rabbits confer a high level of protection after intrarectal delivery.. Vaccine, Elsevier, 2007, 25 ((34)), pp.6373-80. ⟨10.1016/j.vaccine.2007.06.011⟩. ⟨hal-00815843⟩
  • Eric Soler, Nathalie Parez, Bruno Passet, Catherine Dubuquoy, Sabine Riffault, et al.. Recombinant rotavirus inner core proteins produced in the milk of transgenic rabbits confer a high level of protection after intrarectal delivery. Vaccine, Elsevier, 2007, 25 (34), pp.6373-6380. ⟨hal-02656498⟩
  • Sabine Riffault, Catherine Dubuquoy, Nathalie Castagné, Eric Baranowski, Bernard Charley, et al.. Replication of Bovine respiratory syncytial virus in murine cells depends on type I interferon-receptor functionality. Journal of General Virology, Microbiology Society, 2006, 87 (8), pp.2145-2148. ⟨10.1099/vir.0.82091-0⟩. ⟨hal-02661692⟩
  • Bernard Charley, Sabine Riffault, Kristien van Reeth. Porcine innate and adaptative immune responses to influenza and coronavirus infections. Annals of the New York Academy of Sciences, Wiley, 2006, 1081 (1), pp.130-136. ⟨10.1196/annals.1373.014⟩. ⟨hal-02662172⟩
  • V. Niborski, Y. Li, Fiona Brennan, M. Lane, A.M. Torché, et al.. Efficacy of particle-based DNA delivery for vaccination of sheep against FMDV. Vaccine, Elsevier, 2006, 24 (49-50), pp.7204-7213. ⟨10.1016/j.vaccine.2006.06.048⟩. ⟨hal-02658133⟩
  • Michel Bonneau, Mathieu Epardaud, Fabrice Payot, Violeta Niborski, Marie Isabelle Thoulouze, et al.. Migratory monocytes and granulocytes are major lymphatic carriers of Salmonella from tissue to draining lymph node. Journal of Leukocyte Biology, Society for Leukocyte Biology, 2006, 79, pp.268-276. ⟨10.1189/jlb.0605288⟩. ⟨hal-02666924⟩
  • Karin Haverson, Sabine Riffault. Antigen presenting cells in mucosal sites of veterinary species. Veterinary Research, BioMed Central, 2006, 37 (3), pp.339-358. ⟨10.1051/vetres:2006005⟩. ⟨hal-00903028⟩
  • Daniela Tudor, Catherine Dubuquoy, Valérie Gaboriau, Francois Lefèvre, Bernard Charley, et al.. TLR9 pathway is involved in adjuvant effects of plasmid DNA-based vaccines. Vaccine, Elsevier, 2005, 23 (10), pp.1258-1264. ⟨10.1016/j.vaccine.2004.09.001⟩. ⟨hal-02680528⟩
  • Sabine Riffault, C. Carrat, K. van Reeth, M. Pensaert, Bernard Charley. Interferon-alpha-producing cells are localized in gut-associated lymphoid tissues in transmissible gastroenteritis virus (TGEV) infected piglets. Veterinary Research, BioMed Central, 2001, 32 (1), pp.71-79. ⟨hal-02681357⟩
  • D. Tudor, Sabine Riffault, C. Carrat, Francois Lefèvre, Marielle Bernoin, et al.. Type I IFN modulates the immune response induced by DNA vaccination to pseudorabies virus glycoprotein C. Virology, Elsevier, 2001, 286, pp.197-205. ⟨hal-02671713⟩
  • Sabine Riffault, Charles Carrat, Kristien van Reeth, Maurice Pensaert, Bernard Charley. Interferon-alpha-producing cells are localized in gut-associated lymphoid tissues in transmissible gastroenteritis virus (TGEV) infected piglets. Veterinary Research, BioMed Central, 2001, 32 (1), pp.71-79. ⟨10.1051/vetres:2001111⟩. ⟨hal-00902690⟩
  • Sabine Riffault, C. Carrat, G. Milon, Bernard Charley, J.H. Colle. Transient IFN-gamma synthesis in the lymph node draining a dermal site loaded with UV-irradiated herpes simplex virus type 1 : an NK- and CD3-dependent process regulated by IL-12 but not by IFN-alpha/beta. Journal of General Virology, Microbiology Society, 2000, 81, pp.2365-2373. ⟨hal-02692065⟩
  • Pierre Boudinot, Sabine Riffault, S. Salhi, C. Carrat, C. Sedlik, et al.. Vesicular stomatitis virus and pseudorabies virus induce a vig 1/cig5 homologue in mouse dendritic cells via different pathways. Journal of General Virology, Microbiology Society, 2000, 81, pp.2675-2682. ⟨hal-02695563⟩
  • Pierre Boudinot, Pascale Massin, Mar Blanco, Sabine Riffault, Abdenour Benmansour. vig-1, a new fish gene induced by the rhabdovirus glycoprotein, has a virus-induced homologue in humans and shares conserved motifs with the MoaA family. Journal of Virology, American Society for Microbiology, 1999, 73 (3), pp.1846-1852. ⟨hal-02697891⟩
  • Sabine Riffault, Jeanne Grosclaude, Muriel Vayssier, Hubert Laude, Bernard Charley. Reconstituted coronavirus TGEV virosomes lose the virus ability to induce porcine interferon-alpha production. Veterinary Research, BioMed Central, 1997, 28 (2), pp.105-114. ⟨hal-02685172⟩
  • Sabine Riffault, C. Carrat, Lydia Besnardeau, Claude La Bonnardière, Bernard Charley. In vivo induction of interferon-alpha in pig by non-infectious coronavirus: tissue localization and in situ phenotypic characterization of interferon-alpha-producing cells. Journal of General Virology, Microbiology Society, 1997, 78, pp.2483-2487. ⟨hal-02687594⟩
  • S Riffault, J Grosclaude, M Vayssier, H Laude, B Charley. Reconstituted coronavirus TGEV virosomes lose the virus ability to induce porcine interferon-alpha production. Veterinary Research, BioMed Central, 1997, 28 (1), pp.77-86. ⟨hal-00902460⟩
  • Sabine Riffault, M.L. Eloranta, C. Carrat, K. Sandberg, Bernard Charley, et al.. Herpes simplex virus induces appearance of interferon-alpha/bêta-producing cells and partially interferon-alpha/bêta-dependent accumulation of leukocytes in murine regional lymph nodes. Journal of Interferon and Cytokine Research, Mary Ann Liebert, 1996, pp.1007-1014. ⟨hal-02690475⟩

Conference papers31 documents

  • Aude Remot, Jennifer Palomo, Alexandre David-Hachette, Elliot Mathieu, Delphyne Descamps, et al.. Bacteria isolated from lung as biotherapeutics in asthma. ERS International Congress 2019 abstracts, Nov 2019, Madrid, Spain. pp.OA3593, ⟨10.1183/13993003.congress-2019.OA3593⟩. ⟨hal-02987807⟩
  • Fabian Sesterhenn, Che Yang, Jaume Bonet, Marie Galloux, Xiaolin Wen, et al.. Driving immune responses with synthetic proteins - development of de novo designed immunogens to elicit respiratory syncytial virus neutralizing antibodies. 32nd Annual Symposium of the Protein-Society, Protein Society. USA. Beckman Coulter Inc, USA. Pall ForteBio, USA. Bristol-Myers Squibb (BMS), USA., Jul 2018, Boston, United States. pp.2. ⟨hal-02734561⟩
  • Pierre-Louis Hervé, Delphyne Descamps, Charlotte Deloizy, Veronique Dhelft, Daphne Laubreton, et al.. Preclinicalevaluation of anovel non-Invasive epicutaneous vaccine against respiratory syncytial virus. Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology, Mar 2017, Atlanta, Georgia. pp.1. ⟨hal-01605167⟩
  • D. Zhivaki, S. Lemoine, M. -A Rameix-Welti, A. Lim, Delphyne Descamps, et al.. Respiratory syncytial virus targets a fetally developed B cell population with regulatory functions which predicts disease severity. International Congress of Immunology (ICI), Aug 2016, Melbourne, Australia. pp.1. ⟨hal-02742028⟩
  • Aude Remot, Marie-Louise Noordine, Chantal Bridonneau, Delphyne Descamps, Sabine Riffault, et al.. Impact of the development of the lung microbiota on neonatal immunity. 20. Colloque du Club des Bactéries Lactiques, Jun 2015, Lille, France. ⟨hal-02742693⟩
  • Pierre Louis Hervé, Charlotte Deloizy, Nicolas Bertho, Thierry Chaumeil, Maud Renouard, et al.. Preclinical Evaluation of a Novel Epicutaneous Vaccine against Respiratory Syncytial Virus. 10. World Processing Tomato Congress "Tomato Processing & Emerging Markets" and the 12. International Symposium on the Processing Tomato, Nov 2015, California, United States. ⟨hal-02742873⟩
  • Aude Remot, Luc Jouneau, Delphyne Descamps, Catherine Dubuquoy, Stephan Bouet, et al.. Lung neonatal responses to respiratory syncytial virus reveal deficiencies in dendritic cells and type I interferon in a mouse model of airway enhanced disease. 8. Word Immune Regulation Meeting, Mar 2014, Davos, Switzerland. ⟨hal-02740120⟩
  • Sabine Riffault. A novel proteic nano-platform for antigens: application to mucosal influenza vaccination.. 2eme séminaire du département de microbiologie de IRBA, 2012, Paris, France. ⟨hal-02744447⟩
  • Aude Remot, Xavier Roux, Catherine Dubuquoy, Julie Bernard, Mohammed Moudjou, et al.. Adapting vaccine formulation to the neonatal context is required to obtain safe protection against the respiratory syncytial virus. European Congress of Immunology, Sep 2012, Glasgow, Scotland, United Kingdom. pp.727. ⟨hal-01003266⟩
  • Aude Remot, Luc Jouneau, Catherine Dubuquoy, Stephan Bouet, Jérôme Lecardonnel, et al.. Transcriptomic analysis of neonatal vs. adult lung early responses to RSV reveals key roles for DC and type I IFN in controlling immunopathologic imprinting.. Diversity and plasticity of DCs, Dec 2012, Paris, France. ⟨hal-01191380⟩
  • Mariam Raliou, Pierre-Louis Hervé, Christophe Chevalier, Christiane Bourdieu, Catherine Dubuquoy, et al.. A novel proteic nano-platform for antigens: application to musocal influenza vaccination.. VIRUS-LIKE PARTICLE & NANO-PARTICLE VACCINES, Nov 2012, Cannes, France. ⟨hal-01191379⟩
  • Aude Remot, Agnes Petit Camurdan, Catherine Dubuquoy, Julie Bernard, Mohammed Moudjou, et al.. Newborns are particularly prone to respiratory syncytial virus infection: why ? How to protect them ?. Journées d'Animation Scientifique du Département Santé Animale, May 2011, Fréjus, France. 130 p. ⟨hal-02744806⟩
  • Aude Remot, Sabine Riffault. Which immune lung features relate to the higher severity of respiratory syncytial virus infection in newborns?. Séminaire, Institute for Virology, University of veterinary medicine, Sep 2010, Hannovre, Germany. ⟨hal-02813237⟩
  • Agnes Petit Camurdan, Catherine Dubuquoy, Julie Bernard, Jean Francois Eleouet, Sabine Riffault. Vaccination of newborn mice with the nucleoprotein of human RSV confers viral protection but enhances pulmonary inflammation after challenge. Journées d'Animation Scientifique du Département Santé Animale, May 2009, Port d'Albret, France. ⟨hal-02752386⟩
  • Sabine Riffault, Gilles Meyer, Guillaume Durand, Marion Soulestin, Catherine Dubuquoy, et al.. A New Subunit Vaccine Based on Nucleocapsid Protein Nanoparticles Confers Partial Protection in Calves Against Respiratory Syncytial Virus. 3. European Veterinary Immunology Workshop EVIW, Sep 2009, Berlin, Germany. n.p. ⟨hal-02824159⟩
  • Khaled Khoufache, Fanny Le Bouder, Eric Morello, Fabrice Laurent, Sabine Riffault, et al.. Protective role for Protease-Activated-Receptor-2 against Influenza virus Pathogenesis via an Interferon-Y dependent pathway. Journées d'animation scientifique du Département Santé Animale, May 2009, Port d'Albret, France. ⟨hal-02755857⟩
  • Gilles Meyer, Martine Deplanche, Catherine Dubuquoy, Marion Soulestin, Guillaume Durand, et al.. Evaluation of a new respiratory syncytial virus vaccine candidate. 25. World Buiatrics Congress, Jul 2008, Budapest, Hungary. n.p. ⟨hal-02822661⟩
  • Sabine Riffault, Agnes Petit Camurdan, Xavier Roux, Catherine Dubuquoy, Guillaume Durand, et al.. Une nouvelle stratégie vaccinale contre le virus respiratoire syncytial, basée sur des assemblages nanoparticulaires de la protéine de nucléocapside. 10. Journées Francophones de Virologie, Mar 2008, Paris, France. n.p. ⟨hal-02815443⟩
  • Sabine Riffault, Guillaume Durand, Marion Soulestin, Catherine Dubuquoy, Martine Deplanche, et al.. A New Subunit Vaccine Based on Nucleocapsid Protein Nanoparticles Confers Protection Against Respiratory Syncytial Virus. Réunion du Club de Vaccinologie de la Société Française d'Immunologie, Nov 2008, Paris, France. n.p. ⟨hal-02815657⟩
  • Florentina Pascale, Alexandre Courbet, Michel Bonneau, Violeta Niborski, Mathieu Epardaud, et al.. Plasmacytoid dendritic cells migrate in afferent skin and oro-nasal lymph. Réunion de la Société Française d'Immunologie et Club Francophone des Cellules Dendritiques, Jun 2008, Paris, France. n.p. ⟨hal-02818326⟩
  • Florentina Pascale, Alexandre Courbet, Michel Bonneau, Celine Urien, Catherine Dubuquoy, et al.. Plasmacytoid DC migrate in afferent lymph Club Francophone des cellules dendritiques. Congrès annuel de la Société Française d'Immunologie (SFI), Nov 2007, Lyon, France. n.p. ⟨hal-02819602⟩
  • Sabine Riffault, Guillaume Durand, Marion Soulestin, Catherine Dubuquoy, Nathalie Castagné, et al.. Evaluation dans l'espèce cible d'une nouvelle stratégie vaccinale contre le virus respiratoire syncytial bovin, basée sur des assemblages nanoparticulaires de la protéine de nucléocapside. Journée d'Animation du Réseau Immunologie des Animaux Domestiques (IAD), Nov 2007, Montpellier, France. n.p. ⟨hal-02823927⟩
  • Florentina Pascale, Vanessa Contreras, Alexandre Courbet, Michel Bonneau, Stefan Chilmonczyk, et al.. Type I interferon producing cells (ipc) can gain lymph nodes via the afferent lymphatic route. 13. International Congress of Immunology, Aug 2007, Rio de Janeiro, Brazil. 1 p. ⟨hal-01193698⟩
  • Xavier Roux, Agnes Petit Camurdan, Catherine Dubuquoy, Guillaume Durand, Nathalie Castagné, et al.. La vaccination nasale avec la nucléoprotéine du virus respiratoire syncytial confère une immunité protectrice contre une épreuve virale. Journées d'Animation Scientifique du Département de Santé Animale, Jun 2007, Tours, France. ⟨hal-02752791⟩
  • Xavier Roux, Catherine Dubuquoy, Nathalie Castagné, Julie Bernard, Jean Francois Eleouet, et al.. Mucosal vaccination with the nucleoprotein of respiratory syncytial virus confers protective immunity. Congrès Européen d'Immunologie des Muqueuses (EMIG), Oct 2006, Paris, France. n.p. ⟨hal-02814536⟩
  • Florentina Pascale, Alexandre Courbet, Michel Bonneau, Celine Urien, Catherine Dubuquoy, et al.. Natural Interferon (IFN) producing cells can reach lymph node via afferent lymph. 2. European Veterinary Immunology Workshop, Sep 2006, Paris, France. n.p. ⟨hal-02818733⟩
  • Xavier Roux, Catherine Dubuquoy, Bernard Charley, Sabine Riffault. Etude des cellules dendritiques et macrophages du poumon : comparaison adultes nouveaux-nés. Journées d'Animation Scientifique du Département de Santé Animale, May 2005, Batz-sur-Mer, France. ⟨hal-02759410⟩
  • Bernard Charley, Sabine Riffault, Kristien van Reeth. Porcine innate and adaptative immune responses to influenza and coronavirus infections. 8. Conference of the Society for Tropical Veterinary Medicine, Jun 2005, Hanoi, Vietnam. n.p. ⟨hal-02831435⟩
  • Violeta Niborski, Y. Li, C. Stirling, Fiona Brennan, A.M. Torché, et al.. Particle-based DNA vaccination against Foot-and-Mouth disease is efficient in sheep. Rencontres du Réseau français d'Immunologie des Animaux Domestiques (IAD), Oct 2005, Lyon, France. n.p. ⟨hal-02832501⟩
  • Jean Francois Eleouet, Nathalie Castagné, Eric Baranowski, Martine Deplanche, Gilles Meyer, et al.. Etude des bases moléculaires de la spécificité d’espèce du VRS et essais de développement d’un modèle murin pour le VRS bovin. Séminaire bilan du programme de recherche Zoonoses, Sep 2004, Nouzilly, France. n.p. ⟨hal-02832498⟩
  • Sabine Riffault, C. Carrat, M. Enache, K. van Reeth, M. Pensaert, et al.. Cellules sécrétrices d'IFN alpha dans le tissu lymphoïde associé à la muqueuse intestinale du porcelet infecté par le virus GET. Immunité muqueuse, Jun 1999, Toulouse, France. ⟨hal-02770429⟩

Poster communications20 documents

  • Carole Drajac, Daphnée Laubreton, Loredana Saveanu, Sabine Riffault, Delphyne Descamps. Control of nonatal type I interferon responses by IRAP upon RSV infection. IRAP 2017, 3rd international symposium, 2017, Paris, France. 2017. ⟨hal-01605602⟩
  • Aude Remot, Alix Penel, Mathilde Bauducel, Chantal Bridonneau, Delphyne Descamps, et al.. Impact of the development of the pulmonary microbiota on neonatal immunity. 8. Word Immune Regulation Meeting, Mar 2014, Davos, Switzerland. 2014. ⟨hal-02742629⟩
  • Aude Remot, Delphyne Descamps, Luc Jouneau, Catherine Dubuquoy, Stephan Bouet, et al.. Lung neonatal responses to respiratory syncytial virus reveal deficiencies in dendritic cells and type I interferon in a mouse model of airway enhanced disease. 13. International Symposium on Dendritic Cells, Sep 2014, Tours, France. 2014. ⟨hal-02739158⟩
  • Aude Remot, Alix Penel, Mathilde Bauducel, Chantal Bridonneau, Delphyne Descamps, et al.. Impact of the development of the pulmonary microbiota on neonatal immunity. AgreenSkills Annual Meeting 2013, Nov 2013, Louvain, Belgium. 87 p., 2013. ⟨hal-02748060⟩
  • Marie-Anne Rameix-Welti, Julien Sourimant, Jenna Fix, Aude Remot, Sabine Riffault, et al.. Recombinant hRSV expressing mCherry or luciferase without fitness alteration. 14. International Negative Strand Virus Meeting, Jun 2013, Granada, Spain. 2013. ⟨hal-02744494⟩
  • Aude Remot, Luc Jouneau, Catherine Dubuquoy, Stephan Bouet, Jerome Lecardonnel, et al.. Transcriptomic analysis of neonatal vs. adult lung early responses to RSV reveals key roles for DC and type I IFN in controlling immunopathologic imprinting. Diversity and plasticity of DCs, Club Francophone des Cellules Dendritiques, Dec 2012, Paris, France. ⟨hal-02935313⟩
  • Aude Remot, Azadeh Djavidi, Catherine Dubuquoy, Isabelle Schwartz-Cornil, Fabrice Laurent, et al.. Age-related differences in the lung tissue susceptibility to Respiratory Syncytial Virus. 4. European Veterinary Immunology Workshop (EVIW), Sep 2012, Edimbourg, United Kingdom. 2012. ⟨hal-02748020⟩
  • Aude Remot, Xavier Roux, Catherine Dubuquoy, Julie Bernard Theron, Jenna Fix, et al.. Nucleoprotein nanostructures: a mucosal subunit vaccine candidate for neonates protective against the respiratory syncytial virus. Journées de l’Ecole doctorale ABIES, Mar 2011, Paris, France. 2011. ⟨hal-02805147⟩
  • Aude Remot, Xavier Roux, Catherine Dubuquoy, Julie Bernard, Mohammed Moudjou, et al.. Neonatal Nasal Vaccination with the Nucleoprotein of the Respiratory Syncytial Virus Elicits Virus-protective but Airway-pathogenic Th2-biased Immunity that can be Modulated by the Choice of Adjuvants. 15. International Congress of Mucosal Immunology (ICMI 2011) "Peace and War at Mucosal Surfaces", Jul 2011, Paris, France. 2011. ⟨hal-02745248⟩
  • Aude Remot, Xavier Roux, Catherine Dubuquoy, Julie Bernard Theron, Jenna Fix, et al.. Nucleoprotein nanostructures: a mucosal subunit vaccine candidate for neonates protective against the respiratory syncytial virus. Cold spring Harbor meeting: Harnessing immunity to treat and prevent diseases, Nov 2011, New York, United States. 79 p., 2011. ⟨hal-02745116⟩
  • Aude Remot, Azadeh Djavidi, Agnes Petit-Camurdan, Catherine Dubuquoy, Isabelle Schwartz-Cornil, et al.. Rôle des récepteurs PAR et TLR pulmonaires dans les réponses néonatales aux infections virales respiratoires. 6. Colloque DOC’J 2010 "La biologie et les sciences qui gravitent autour d'elle", May 2010, Jouy-en-Josas, France. 2010. ⟨hal-02754675⟩
  • A Petit-Camurdan, Catherine Dubuquoy, Julie Bernard, Jf Eléouët, Sabine Riffault. Vaccination of newborn mice with the nucleoprotein of human RSV confers viral protection but enhances pulmonary inflammation after challenge. Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu, 2009. ⟨hal-02815224⟩
  • Khaled Khoufache, F Lebouder, Eric Morello, Fabrice Laurent, Sabine Riffault, et al.. Protective role for Protease-Activated-Receptor-2 against Influenza virus Pathogenesis via an Interferon-Y dependent pathway. Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu, 2009. ⟨hal-02815269⟩
  • Michelle Rémond, Bruno da Costa, Sabine Riffault, Jean Lepault, Catherine Dubuquoy, et al.. Pseudo-particules chimériques du virus de la bursite infectieuse aviaire (IBDV) exprimant le site antigénique majeur du virus de la fièvre aphteuse : études immunologiques. 10. Journées Francophones de Virologie, Mar 2008, Paris, France. 1 p., 2008. ⟨hal-02815198⟩
  • Michèle Remond, Bruno da Costa, Sabine Riffault, Satya Parida, Emmanuel Breard, et al.. Infectious bursal disease subviral particles displaying the foot-and-mouth disease virus major antigenic site. Open Session of the Research Group of the European Commission for the Control of Foot-and-Mouth Disease (EUFMD), Oct 2008, Erice, Italy. 1 p., 2008. ⟨hal-02816589⟩
  • Jean Francois Eleouet, Sabine Riffault. Evaluation of a new vaccine candidate. Colloque Eurobiotec, Oct 2008, Paris, France. 1 p., 2008. ⟨hal-02813299⟩
  • Sabine Riffault, Guillaume Durand, Marion Soulestin, Catherine Dubuquoy, Martine Deplanche, et al.. A new subunit vaccine based on nucleocapsid protein nanoparticles confers partial protection in calves against respiratory syncytial virus. 2. Vaccine Congress, Dec 2008, Boston, United States. 1 p., 2008. ⟨hal-02818104⟩
  • Xavier Roux, Catherine Dubuquoy, Bernard Charley, Sabine Riffault. CD11b- CD8α- F4/80lo cells are the dominant CD11c+ subset found in lung of neonates: potential interest for antiviral vaccination. Congrès Annuel de la Société Française d'Immunologie, Nov 2006, Paris, France. 1 p., 2006. ⟨hal-02816756⟩
  • Xavier Roux, Catherine Dubuquoy, Bernard Charley, Sabine Riffault. Etude des cellules dendritiques et macrophages du poumon : comparaison adultes nouveaux-nés. Journées d’Animation Scientifique du Département de Santé Animale, 2005, Batz-sur-Mer, France. pp.Inconnu, 2005. ⟨hal-02828241⟩
  • Xavier Roux, Catherine Dubuquoy, Bernard Charley, Sabine Riffault. CD11b- CD8α- CD11c+ dendritic cells are the dominant subset found in lung of neonates: potential interest for antiviral vaccination. 4. European mucosal immunology group meeting, Oct 2004, Lyon, France. 1 p., 2004. ⟨hal-02827063⟩