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The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (“squelching”) SRC-1 coactivator

Lucie Hyrsova , Tomas Smutny , Alejandro Carazo , Stefan Moravcik , Jana Mandikova , et al.
British Journal of Pharmacology, 2016, 173 (10), pp.1703 - 1715. ⟨10.1111/bph.13472⟩
Article dans une revue hal-01837977v1
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The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor

Nicolas Creusot , Matthieu Gassiot , Elina Alaterre , Barbara Chiavarina , Marina Grimaldi , et al.
Cells, 2020, 9 (7), pp.1641. ⟨10.3390/cells9071641⟩
Article dans une revue hal-02899508v1
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Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way

Alice Marmugi , Céline Lukowicz , Frédéric Lasserre , Alexandra Montagner , Arnaud Polizzi , et al.
Toxicology and Applied Pharmacology, 2016, 303, pp.90 - 100. ⟨10.1016/j.taap.2016.05.006⟩
Article dans une revue hal-01837194v1

On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids

Sébastien Deshayes , Sabine Gerbal-Chaloin , May Morris , Gudrun Aldrian-Herrada , Pierre Charnet , et al.
Biochimica et Biophysica Acta:Biomembranes, 2004, 1667 (2), pp.141-147. ⟨10.1016/j.bbamem.2004.09.010⟩
Article dans une revue hal-03128831v1
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MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

Brice Nzigou Mombo , Sabine Gerbal-Chaloin , Aleksandra Bokus , Martine Daujat-Chavanieu , Christian Jorgensen , et al.
Journal of visualized experiments : JoVE, 2017, 120, pp.e55245. ⟨10.3791/55245⟩
Article dans une revue hal-01777706v1
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Human induced pluripotent stem cells in hepatology: beyond the proof of concept.

Sabine Gerbal-Chaloin , Natalie Funakoshi , Amandine Caillaud , Claire Gondeau , Benoite Champon , et al.
American Journal of Pathology, 2014, 184 (2), pp.332-47. ⟨10.1016/j.ajpath.2013.09.026⟩
Article dans une revue inserm-00921587v1
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Dissecting the first transcriptional divergence during human embryonic development.

Qiang Bai , Said Assou , Delphine Haouzi , Jean-Marie Ramirez , Cécile Monzo , et al.
Stem Cell Reviews and Reports, 2012, 8 (1), pp.150-62. ⟨10.1007/s12015-011-9301-3⟩
Article dans une revue inserm-00664573v1
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Mitochondrial Complex I activity signals antioxidant response through ERK5

Abrar Ul Haq Khan , Nerea Allende-Vega , Delphine Gitenay , Johan Garaude , Dang-Nghiem Vo , et al.
Scientific Reports, 2018, 8 (1), pp.7420. ⟨10.1038/s41598-018-23884-4⟩
Article dans une revue hal-01835615v1
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Glucose Starvation or Pyruvate Dehydrogenase Activation Induce a Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation

Abrar Ul Haq Khan , Hamideh Salehi , Catherine Alexia , Jose M Valdivielso , Milica Bozic , et al.
Cells, 2022, 11 (9), pp.1392. ⟨10.3390/cells11091392⟩
Article dans une revue hal-03757316v1

Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor

Hugues de Boussac , Claire Gondeau , Philippe Briolotti , Cédric Duret , Fridolin Treindl , et al.
Drug Metabolism and Disposition, 2018, 46 (3), pp.223 - 236. ⟨10.1124/dmd.117.078683⟩
Article dans une revue hal-01731561v1

Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding

Franck Da-Silva , Xavier Boulenc , Hélène Vermet , Pauline Compigne , Sabine Gerbal-Chaloin , et al.
Journal of Pharmaceutical Sciences, 2018, 107 (7), pp.1957 - 1972. ⟨10.1016/j.xphs.2018.03.001⟩
Article dans une revue hal-01837119v1
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ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

Rozenn Riou , Meriem Ladli , Sabine Gerbal-Chaloin , Pascale Bossard , Angélique Gougelet , et al.
eLife, 2020
Article dans une revue hal-03024026v1
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Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes

Martin Krøyer Rasmussen , Patrick Balaguer , Bo Ekstrand , Martine Daujat-Chavanieu , Sabine Gerbal-Chaloin
PLoS ONE, 2016, 11 (5), pp.e0154629. ⟨10.1371/journal.pone.0154629⟩
Article dans une revue hal-01837192v1

The WNT/ β -Catenin Pathway Is a Transcriptional Regulator of CYP2E1, CYP1A2, and Aryl Hydrocarbon Receptor Gene Expression in Primary Human Hepatocytes

Sabine Gerbal-Chaloin , Anne-Sophie Dumé , Philippe Briolotti , Sylvie Klieber , Edith Raulet , et al.
Molecular Pharmacology, 2014, 86 (6), pp.624-634. ⟨10.1124/mol.114.094797⟩
Article dans une revue hal-03116200v1

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling

Philippe Briolotti , Laurent Chaloin , Patrick Balaguer , Franck da Silva , Veronika Tománková , et al.
Toxicological Sciences, 2015, 148 (1), pp.261 - 275. ⟨10.1093/toxsci/kfv177⟩
Article dans une revue hal-01838127v1

Skeletal Muscle Interleukin-6 Regulates Hepatic Cytochrome P450 Expression: Effects of 16-Week High-Fat Diet and Exercise

Jakob Knudsen , Lærke Bertholdt , Anders Gudiksen , Sabine Gerbal-Chaloin , Martin Krøyer Rasmussen
Toxicological Sciences, 2018, 162 (1), pp.309 - 317. ⟨10.1093/toxsci/kfx258⟩
Article dans une revue hal-01837113v1
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Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

Cedric Duret , Martine Daujat-Chavanieu , Jean-Marc Pascussi , Lydiane Pichard-Garcia , Patrick Balaguer , et al.
Molecular Pharmacology, 2006, 70, pp.329-39. ⟨10.1124/mol.105.022046⟩
Article dans une revue inserm-00086861v1
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Cold Preservation of Human Adult Hepatocytes for Liver Cell Therapy

Cédric Duret , Daniel Moreno , Anangi Balasiddaiah , Solene Roux , Phillipe Briolotti , et al.
Cell Transplantation, 2015, 24 (12), pp.2541 - 2555. ⟨10.3727/096368915X687020⟩
Article dans une revue hal-01838017v1
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Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

Vanessa Delfosse , Beatrice Dendelé , Tiphaine Huet , Marina Grimaldi , Abdelhay Boulahtouf , et al.
Nature Communications, 2015, 6 (1), ⟨10.1038/ncomms9089⟩
Article dans une revue hal-01838034v1
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Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring

Jean Nakhle , Khattar Khattar , Tülin Özkan , Adel Boughlita , Daouda Abba Moussa , et al.
Cancer Research Communications, 2023, 3 (6), pp.1041 - 1056. ⟨10.1158/2767-9764.crc-23-0144⟩
Article dans une revue hal-04156158v1

PBPK modeling of irbesartan: incorporation of hepatic uptake

Hélène Chapy , Sylvie Klieber , Priscilla Brun , Sabine Gerbal-Chaloin , Xavier Boulenc , et al.
Biopharmaceutics and Drug Disposition, 2015, 36 (8), pp.491 - 506. ⟨10.1002/bdd.1961⟩
Article dans une revue istex hal-01838123v1
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ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

Rozenn Riou , Meriem Ladli , Sabine Gerbal-Chaloin , Pascale Bossard , Angélique Gougelet , et al.
eLife, 2020, 9, pp.e53550. ⟨10.7554/elife.53550⟩
Article dans une revue hal-03010546v1

Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Göttingen minipigs

Martin Krøyer Rasmussen , Carsten Scavenius , Sabine Gerbal-Chaloin , Jan Enghild
Toxicology Letters, 2019, 314, pp.181-186. ⟨10.1016/j.toxlet.2019.08.008⟩
Article dans une revue hal-02414371v1

Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG

Martin Krøyer Rasmussen , Martine Daujat-Chavanieu , Sabine Gerbal-Chaloin
Toxicology Letters, 2017, 277, pp.1 - 8. ⟨10.1016/j.toxlet.2017.05.029⟩
Article dans une revue hal-01837154v1
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Design of a Novel Class of Peptide Inhibitors of Cyclin-dependent Kinase/Cyclin Activation

Claire Gondeau , Sabine Gerbal-Chaloin , Paul Bello , Gudrun Aldrian-Herrada , May Morris , et al.
Journal of Biological Chemistry, 2005, 280 (14), pp.13793-13800. ⟨10.1074/jbc.M413690200⟩
Article dans une revue hal-03117951v1
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The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

Abrar Ul Haq Khan , Nerea Allende-Vega , Delphine Gitenay , Sabine Gerbal-Chaloin , Claire Gondeau , et al.
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-10339-5⟩
Article dans une revue hal-01835605v1
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The Tangle of Nuclear Receptors that Controls Xenobiotic Metabolism and Transport: Crosstalk and Consequences.

Jean-Marc Pascussi , Sabine Gerbal-Chaloin , Cédric Duret , Martine Daujat-Chavanieu , Marie-José Vilarem , et al.
Annual Review of Pharmacology, 2008, 48, pp.1-32. ⟨10.1146/annurev.pharmtox.47.120505.105349⟩
Article dans une revue inserm-00162144v1
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A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

Alison Iroz , Alexandra Montagner , Fadila Benhamed , Françoise Levavasseur , Arnaud Polizzi , et al.
Cell Reports, 2017, 21 (2), pp.403 - 416. ⟨10.1016/j.celrep.2017.09.065⟩
Article dans une revue hal-01837159v1
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Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

Amar Abderrahmani , Loïc Yengo , Robert Caiazzo , Mickael Canouil , Stéphane Cauchi , et al.
Diabetes, 2018, 67 (7), pp.1310 - 1321. ⟨10.2337/db17-1539⟩
Article dans une revue hal-01837153v1