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Romain Yvinec


I am a permanent INRAE researcher since 2013 in the team Biology of Signalling Systems (BIOS) within the laboratory Physiologie de la Reproduction et des Comportements (PRC). The BIOS team is an interdisciplinary team composed of biologists, informaticians and mathematicians. Our main research area is the study of the dynamics of cellular signalling networks induced by G protein coupled receptors (GPCR), using a system biology approach.  We particularly focus on GPCR signaling systems involved in reproductive biology and social behavior.

I'm mathematician by training. My works deals with deterministic and stochastic models in biology, particulary from cellular and molecular biology (including signalling systems, reaction networks, gene expression, protein aggregation and structured population dynamics). I'm interested in hybrid modelling, and study stochastic processes, limit theorem, asymptotic properties. I'm also interested in parameter estimation for the dynamic model we study. The main applications I'm interested in concern reproductive biology.


Preprints, Working Papers, ...1 document

  • Erwan Hingant, Romain Yvinec. Quasi-stationary distribution and metastability for the stochastic Becker-Döring model. 2021. ⟨hal-03110670⟩

Journal articles20 documents

  • Juan Calvo, Erwan Hingant, Romain Yvinec. THE INITIAL-BOUNDARY VALUE PROBLEM FOR THE LIFSHITZ-SLYOZOV EQUATION WITH NON-SMOOTH RATES AT THE BOUNDARY. Nonlinearity, IOP Publishing, In press. ⟨hal-03109431⟩
  • Frédérique Clément, Frédérique Robin, Romain Yvinec. Stochastic nonlinear model for somatic cell population dynamics during ovarian follicle activation. Journal of Mathematical Biology, Springer Verlag (Germany), In press. ⟨hal-02057983⟩
  • Celine Bonnet, Keltoum Chahour, Frédérique Clément, Marie Postel, Romain Yvinec. Multiscale population dynamics in reproductive biology: singular perturbation reduction in deterministic and stochastic models. ESAIM: Proceedings and Surveys, EDP Sciences, 2020, 67, pp.72-99. ⟨10.1051/proc/202067006⟩. ⟨hal-03047923⟩
  • Frédérique Clément, Pascale Crépieux, Romain Yvinec, Danielle Monniaux. Mathematical modeling approaches of cellular endocrinology within the hypothalamo-pituitary-gonadal axis. Molecular and Cellular Endocrinology, Elsevier, 2020, 518, pp.110877. ⟨10.1016/j.mce.2020.110877⟩. ⟨hal-03046096⟩
  • Flavie Landomiel, Francesco de Pascali, Pauline Raynaud, Frédéric Jean-Alphonse, Romain Yvinec, et al.. Biased Signaling and Allosteric Modulation at the FSHR. Frontiers in Endocrinology, Frontiers, 2019, 10, pp.148. ⟨10.3389/fendo.2019.00148⟩. ⟨hal-02362523⟩
  • Frédérique Clément, Frédérique Robin, Romain Yvinec. Analysis and calibration of a linear model for structured cell populations with unidirectional motion : Application to the morphogenesis of ovarian follicles. SIAM Journal on Applied Mathematics, Society for Industrial and Applied Mathematics, 2019, 79 (1), pp.207-229. ⟨10.1137/17M1161336⟩. ⟨hal-01852560v2⟩
  • Flavie Landomiel, Francesco de Pascali, Pauline Raynaud, Frédéric Jean-Alphonse, Romain Yvinec, et al.. Biased Signaling and Allosteric Modulation at the FSHR. Frontiers in Endocrinology, Frontiers, 2019, 10, ⟨10.3389/fendo.2019.00148⟩. ⟨hal-03117089⟩
  • Erwan Hingant, Romain Yvinec. The Becker-Doring Process: Pathwise Convergence and Phase Transition Phenomena. Journal of Statistical Physics, Springer Verlag, 2018, 177 (5), pp.506-527. ⟨10.1007/s10955-019-02377-2⟩. ⟨hal-01852561⟩
  • Romain Yvinec, Pascale Crepieux, Eric Reiter, Anne Poupon, Frédérique Clément. Advances in computational modeling approaches of pituitary gonadotropin signaling. Expert Opinion on Drug Discovery, Informa Healthcare, 2018, 13 (9), pp.799-813. ⟨10.1080/17460441.2018.1501025⟩. ⟨hal-01913612⟩
  • Julien Deschamps, Erwan Hingant, Romain Yvinec. Quasi steady state approximation of the small clusters in Becker–Döring equations leads to boundary conditions in the Lifshitz–Slyozov limit. Communications in Mathematical Sciences, International Press, 2017, 15 (5), pp.1353-1384. ⟨10.4310/CMS.2017.v15.n5.a7⟩. ⟨hal-01608844v1⟩
  • Eric Reiter, Mohammed Akli Ayoub, Lucie Pellissier, Flavie Landomiel, Astrid Musnier, et al.. β-arrestin signalling and bias in hormone-responsive GPCRs. Molecular and Cellular Endocrinology, Elsevier, 2017, 449, pp.28-41. ⟨10.1016/j.mce.2017.01.052⟩. ⟨hal-01604784⟩
  • Bertrand Cloez, Renaud Dessalles, Alexandre Genadot, Florent Malrieu, Aline Marguet, et al.. Probabilistic and Piecewise Deterministic models in Biology. ESAIM: Proceedings and Surveys, EDP Sciences, 2017, 60, pp.225-245. ⟨10.1051/proc/201760225⟩. ⟨hal-01549687⟩
  • Laura Riccetti, Romain Yvinec, Danièle Klett, Nathalie Langonné, Yves Combarnous, et al.. Human luteinizing hormone and chorionic gonadotropin display biased agonism at the LH and LH/CG receptors. Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.1-11. ⟨10.1038/s41598-017-01078-8⟩. ⟨hal-01594546⟩
  • Romain Yvinec, Samuel Bernard, Erwan Hingant, Laurent Pujo-Menjouet. First passage times in homogeneous nucleation: Dependence on the total number of particles. Journal of Chemical Physics, American Institute of Physics, 2016, 144 (3), pp.1-17. ⟨10.1063/1.4940033⟩. ⟨hal-01353266⟩
  • Mohammed Akli Ayoub, Romain Yvinec, Pascale Crepieux, Anne Poupon. Computational modeling approaches in gonadotropin signaling. Theriogenology, Elsevier, 2016, 86 (1), pp.22-31. ⟨10.1016/j.theriogenology.2016.04.015⟩. ⟨hal-01409338⟩
  • Mohammed Akli Ayoub, Romain Yvinec, Gwenhael Jegot, James A. Dias, Sonia-Maria Poli, et al.. Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis. Molecular and Cellular Endocrinology, Elsevier, 2016, 436, pp.10-22. ⟨10.1016/j.mce.2016.07.013⟩. ⟨hal-01409332⟩
  • Romain Yvinec, Changjing Zhuge, Jinzhi Lei, Michael C. Mackey. Adiabatic reduction of a model of stochastic gene expression with jump Markov process. Journal of Mathematical Biology, Springer Verlag (Germany), 2014, 68 (5), pp.1051-1070. ⟨10.1007/s00285-013-0661-y⟩. ⟨hal-01136285⟩
  • M.C. Mackey, M. Tyran-Kamińska, Romain Yvinec. Dynamic behavior of stochastic gene expression models in the presence of bursting. SIAM Journal on Applied Mathematics, Society for Industrial and Applied Mathematics, 2013, 73 (5), pp.1830-1852. ⟨10.1137/12090229X⟩. ⟨hal-02650825⟩
  • Romain Yvinec, Maria R. d'Orsogna, Tom Chou. First passage times in homogeneous nucleation and self-assembly. Journal of Chemical Physics, American Institute of Physics, 2012, 137 (24), pp.1-18. ⟨10.1063/1.4772598⟩. ⟨hal-02649185⟩
  • Michael C. Mackey, Marta Tyran-Kamińska, Romain Yvinec. Molecular distributions in gene regulatory dynamics. Journal of Theoretical Biology, Elsevier, 2011, 274 (1), pp.84--96. ⟨10.1016/j.jtbi.2011.01.020⟩. ⟨hal-00651585⟩

Book sections3 documents

  • Romain Yvinec, Mohammed Akli Ayoub, Francesco de Pascali, Pascale Crepieux, Eric Reiter, et al.. WORKFLOW DESCRIPTION TO DYNAMICALLY MODEL β-ARRESTIN SIGNALING NETWORKS. Beta-arrestins- Methods and protocols, 1957, 2019, Methods in Molecular Biology, ⟨10.1007/978-1-4939-9158-7_13⟩. ⟨hal-02374486⟩
  • Francesco de Pascali, Aurélie Trefier, Flavie Landomiel, Véronique Bozon, Gilles Bruneau, et al.. Follicle-Stimulating Hormone Receptor: Advances and Remaining Challenges. G protein-coupled receptors: emerging paradigms in activation, signaling and regulation- Part A, 338 (1ère ed.), Elsevier, pp.1-58, 2018, International Review of Cell and Molecular Biology, 978-0-12-813772-7. ⟨10.1016/bs.ircmb.2018.02.001⟩. ⟨hal-02373607⟩
  • Erwan Hingant, Romain Yvinec. Deterministic and stochastic Becker-Döring equations: Past and recent mathematical developments. Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology, Editions Springer; Editions Springer, pp.175-204, 2016, ⟨10.1007/978-3-319-62627-7⟩. ⟨hal-01512134v1⟩

Theses1 document

Conference papers33 documents

  • Romain Yvinec. Kinetic biased signaling: towards a system biology definition of drugs selectivity. Networks and molecular biology - Thematic Month on Mathematical Issues in Biology, Mar 2020, Luminy, France. ⟨hal-03115087⟩
  • Romain Yvinec. Modeling GPCR-induced biased signaling Towards a system biology definition of drugs selectivity. 9th GDR3545-GPCR international meeting, Nov 2020, Online, France. ⟨hal-03115093⟩
  • Romain Yvinec. Modeling (some aspects of ) the female reproductive system. Mathematics of complex systems in biology and medicine - Thematic Month on Mathematical Issues in Biology, Feb 2020, Luminy, France. ⟨hal-03115069⟩
  • Romain Yvinec. Ovarian follicle morphogenesis. CompuCell3D Multicell Virtual-Tissue Modeling Summer School, Aug 2020, Online, United States. ⟨hal-03115079⟩
  • Romain Yvinec. Dynamical modeling of reaction networks Mathematics of system biology. 2020 Workshop: ‘bioinformatics and biomathematical approaches to integrate the GPCR signal, Nov 2020, Online, France. ⟨hal-03115099⟩
  • Romain Yvinec. Stochastic population dynamics applied to ovarian follicles development. BioHasard 2019, Aug 2019, Rennes, France. ⟨hal-03115063⟩
  • Romain Yvinec. Modélisation mathématique de processus d’assemblage (protéı̈ques). 1ere réunion du GDR MéDynA, Oct 2019, Sainte-Montaine, France. ⟨hal-03115106⟩
  • Romain Yvinec, Samuel Bernard, Tom Chou, Julien Deschamps, Maria R. d'Orsogna, et al.. Stochastic model of nucleation Becker-Döring Model. 1ere réunion du GDR MéDynA, Oct 2019, Sainte-Montaine, France. ⟨hal-03115114⟩
  • Romain Yvinec. Dynamique de populations cellulaires structures : morphogenèse des follicules ovariens. ATMOSPHASE, Mar 2019, Paris, France. ⟨hal-03115057⟩
  • Romain Yvinec. Using dynamical reaction network to infer drugs selectivity in pharmacology. ICSB 2018, Oct 2018, Lyon, France. ⟨hal-03115045⟩
  • Frederique Clement, Danielle Monniaux, Marie Postel, Frédérique Robin, Romain Yvinec. Modeling (some aspects of) the female reproductive system : Gonadotropin and follicular dynamics. CEMRACS 2018, Jul 2018, Luminy, France. ⟨hal-03115049⟩
  • Romain Yvinec, Michael C. Mackey, Marta Tyran-Kamińska, Changjiing Zhuge, Jinzhi Lei. Bursting in gene expression model. Reverse mathematical methods for reconstructing molecular dynamics in single cell, Oct 2018, Pise, Italy. ⟨hal-03115052⟩
  • Romain Yvinec. Building GPCR signalisation networks. Example of the FSH receptor. 6.Annual Meeting of the CNRS GDR-3545 G Protein-coupled Receptors: from Physiology to Drugs (RCPG-Physio-Med), Nov 2017, Paris, France. ⟨hal-02794534⟩
  • Romain Yvinec. Biased signaling and L1 penalization. ODE Modelling in Systems Biology, Sep 2017, freibourg, Germany. ⟨hal-02785169⟩
  • Romain Yvinec. Time scales in a coagulation-fragmentation model, Nucleation Time in Stochastic Becker-Döring Model. Workshop on Protein Aggregation: Biophysics and Mathematics, Jun 2017, vienna, Austria. ⟨hal-02785742⟩
  • Frédérique Clément, Frédérique Robin, Romain Yvinec. Dynamiques de populations cellulaires structurées Morphogenèse des follicules ovariens. Session du GDR Mamovi 2017, 2017, Villeurbanne, France. ⟨hal-02785500⟩
  • Romain Yvinec, Samuel Bernard, Tom Chou, Julien Deschamps, Maria R. d'Orsogna, et al.. Nucleation time in stochastic Becker-Doring model. 11. AIMS Conference on Dynamical Systems, Differential Equations and Applications, American Institute of Mathematical Science (AIMS). USA., Jul 2016, Orlando, United States. 45 diapositives. ⟨hal-02797058⟩
  • Romain Yvinec. Les maths de la biologie des systèmes. Seminar at the Groupe de travail Bio-Maths Tours/Orléans, 2016, Tours, France. ⟨hal-02794535⟩
  • Romain Yvinec. Time scales in a coagulation-fragmentation model. 2. BCAM Workshop on Nonlinear Dynamics in Biological Systems, Basque Center for Applied Mathematics (BCAM). ESP., Sep 2016, Bilbao, Spain. ⟨hal-02792839⟩
  • Romain Yvinec, Samuel Bernard, Tom Chou, Julien Deschamps, Maria R. d'Orsogna, et al.. Stochastic coagulation-fragmentation models for the study of protein aggregation phenomena. Stochastic Dynamical Systems in Biology: Numerical Methods and Applications, Isaac Newton Institute. GBR., Jan 2016, Cambridge, United Kingdom. 31 diapositives. ⟨hal-02795563⟩
  • Bertrand Cloez, Renaud Dessalles, Alexandre Genadot, Florent Malrieu, Aline Marguet, et al.. Probalistic and piecewise deterministic models in biology. Journées MAS 2016. Phénomènes complexes et hétérogènes, Société de Mathématiques Appliquées et Industrielles (SMAI). FRA., Aug 2016, Grenoble, France. pp.1-19. ⟨hal-01595098⟩
  • Romain Yvinec, Michael C. Mackey, Marta Tyran-Kamińska, Changjing Zhuge. Bursting in gene expression model. Colloque PDMP, Agence Nationale de la Recherche (ANR). FRA., May 2015, Saint Martin de Londres, France. ⟨hal-02797859⟩
  • Romain Yvinec, Michael C. Mackey, Marta Tyran-Kamińska, Changjing Zhuge. Bursting in gene expression. Colloque PDMP, Agence Nationale de la Recherche (ANR). FRA., Nov 2015, Tours, France. ⟨hal-02797860⟩
  • Romain Yvinec, Julien Deschamps, Erwan Hingant. From Becker-Doring to Lifshitz-Slyozov: deriving the boundary condition. BIOMAT 2015, Instituto Nacional de Matemática Pura e Aplicada. BRA., Mar 2015, Cabo Frio, Brazil. ⟨hal-02792548⟩
  • Romain Yvinec, Julien Deschamps, Erwan Hingant. Nucleation time in coagulation-fragmentation models. Journées Modélisation Aléatoire et Statistique de la SMAI (Société de Mathématiques Appliquées et Industrielles), Société de Mathématiques Appliquées et Industrielles (SMAI). FRA., Jun 2015, Les Karellis, France. ⟨hal-02794818⟩
  • Romain Yvinec, Julien Deschamps, Erwan Hingant. From Becker-Döring to Lifshitz-Slyozov: deriving the non-local boundary condition of a non-linear transport equation. Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, Université Pierre et Marie Curie - Paris 6 (UPMC). Paris, FRA., Mar 2015, Paris, France. ⟨10.1051/itmconf/20150500017⟩. ⟨hal-02741964⟩
  • Thomas Bourquard, Mohammed Akli Ayoub, Domitille Heitzler, N. Hansen, Jérôme Azé, et al.. Accute parameter optimization leads to predictive dynamical models for systems biology. Perspectives in Environmental and Systems Biology, Structure Fédérative de Recherche (SFR). FRA., Apr 2015, Grenoble, France. ⟨hal-02799266⟩
  • Thomas Bourquard, Mohammed Akli Ayoub, Domitille Heitzler, Nikolaus Hansen, Jérôme Azé, et al.. Accurate parameter optimization leads to predictive dynamical models for systems biology. Design, Optimization and Control in Systems and Synthetic Biology DOC'15, Ecole Normale Supérieure - Paris (ENS Paris). FRA., Nov 2015, Paris, France. ⟨hal-02799275⟩
  • Thomas Bourquard, Mohammed Akli Ayoub, Domitille Heitzler, Nikolaus Hansen, Jérôme Azé, et al.. Accurate parameter optimization leads to predictive dynamical models for systems biology. 23. Journée du projet CASCIMODOT, Université d'Orléans (UO). FRA. Université François Rabelais (Tours)., Dec 2015, Tours, France. ⟨hal-02793656⟩
  • Romain Yvinec, Michael C. Mackey, M. Tyran-Kamińska, A. Marciniak-Czochra. Towards nonlinear cell population model structured by molecular content. Structured Integro-Differential models in Mathematical Biology, Vienna International Science Conferences and Events Association. AUT., Apr 2014, Vienne, Austria. ⟨hal-02797854⟩
  • Romain Yvinec, M. Mackey, M. Tyran-Kamińska, A. Marciniak-Czochra. Towards nonlinear cell population model structured by molecular content. 9. European Conference on Mathematical and Theoretical Biology - ECMTB14, Chalmers University of Technology. SWE., Jun 2014, Göteborg, Sweden. ⟨hal-02797850⟩
  • Romain Yvinec. Modèle probabiliste multi-échelle de différentiation cellulaire. Groupe de Travail Maths bio et santé, Laboratoire Jacques-Louis Lions, Feb 2013, Paris, France. ⟨hal-03115016⟩
  • Romain Yvinec, Maria R. d'Orsogna, Tom Chou, Laurent Pujo-Menjouet, Samuel Bernard, et al.. Temps de premier passage pour le modèle de nucléation aléatoire de Becker-Doring. Séminaire du Laboratoire de Mathématiques Appliquées de Compiègne, Feb 2013, Compiègne, France. ⟨hal-03115032⟩

Poster communications8 documents

  • Romain Yvinec. KINETIC BIASED SIGNALING : A SYSTEM BIOLOGY DEFINITION OF DRUGS SELECTIVITY. 8ème conférence internationale GDR3545-GPCR, Oct 2019, Montpellier, France. ⟨hal-03115082⟩
  • Celine Bonnet, Keltoum Chahour, Frederique Clement, Marie Postel, Frédérique Robin, et al.. Modeling Ovarian Folliculogenesis: Morphogenesis and Population Dynamics. REPROSCIENCES 2019, Apr 2019, Toulouse, France. ⟨hal-03115058⟩
  • Frédérique Clément, Frédérique Robin, Romain Yvinec. Multiscale modeling of the morphogenesis of ovarian follicles: a cell-dynamics based approach. 2. Journées du GdR 3606 Repro, Apr 2017, Tours, France. 75 p., 2017, 2èmes Journées Scientifiques du GdR Repro. ⟨hal-01606594⟩
  • Aurélie Trefier, Romain Yvinec, Thomas Bourquard, Kelly Léon-Huaman, Astrid Musnier, et al.. The translatome of the FSH receptor reveals tha several FSH-responsive signaling effectors are co-translated in primary rat Sertoli cells. 2. Journées du GdR 3606 Repro, Apr 2017, Tours, France. 75 p., 2017, 2èmes Journées Scientifiques du GdR Repro. ⟨hal-01603078⟩
  • Mohammed Akli Ayoub, Thomas Boulo, Thomas Bourquard, Pascale Crépieux, Florian Jean Louis Guillou, et al.. Intégration des contraintes spatiales dans la modélisation dynamique d’un système biologique complexe : le réseau de signalisation FSH. Journées d’Animation des Crédits Incitatifs du Département de Physiologie Animale et Systèmes d’Elevage (JACI Phase 2016), Apr 2016, Tours, France. 115 p., 2016, Crédits Incitatifs financés entre 2011 et 2014. ⟨hal-02742541⟩
  • Romain Yvinec. Bursting and division in a nonlinear cell population model. Stochastic Biology: from Cells to Populations, May 2014, Vienne, Austria. 1 p., 2014. ⟨hal-02796022⟩
  • Franck Vandermoere, Elisabeth Cassier, Nathalie Langonné Gallay, Thomas Bourquard, Romain Yvinec, et al.. Beta-arrestin 2 barcode of phosphorylation: impact on beta-arrestin-dependent signaling. 3. Annual Meeting of the GDR 3545 RCPG-PhysioMed, Oct 2014, Montpellier, France. 2014. ⟨hal-02793437⟩
  • Thomas Bourquard, Domitille Heitzler, Guillaume Durand, Romain Yvinec, Nikolaus Hansen, et al.. Parameter estimation in signaling systems. International Conference on Gonadotropins & Receptors, Sep 2014, Tours, France. 2014, ICGRIII International Conference on Gonadotropins & Receptors. ⟨hal-02740420⟩

Lectures2 documents

  • Romain Yvinec. Chemical Reaction Network Theory, notations and selected results. 2016. ⟨hal-02794650⟩
  • Romain Yvinec. Piecewise deterministic Markov processes, applications in biology. 3rd cycle. Mini-cours chercheur (Laboratoire Jacques Louis-Lions, Université Paris VI), 2015, 24 p. ⟨hal-02795547⟩

Other publications4 documents

  • Julien Deschamps, Erwan Hingant, Romain Yvinec. Boundary value for a nonlinear transport equation emerging from a stochastic coagulation-fragmentation type model. 2015. ⟨hal-02801324⟩
  • Romain Yvinec, Julien Deschamps, Erwan Hingant. From a stochastic Becker-Döring model to the Lifschitz-Slyozov equation with boundary value. 2014. ⟨hal-01123221⟩
  • Romain Yvinec. Adiabatic reduction of models of stochastic gene expression with bursting. 2013. ⟨hal-02806255⟩
  • Romain Yvinec, Alexandre F. Ramos. On the bursting of gene products. 2011. ⟨hal-00651588⟩