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Romain Yvinec

18
Documents
Identifiants chercheurs

Présentation

I am a permanent [INRAE](https://www.inrae.fr/) researcher since 2013 in the team [Biology of Signalling Systems](http://bios.tours.inra.fr/bios_group/) (BIOS) within the laboratory [Physiologie de la Reproduction et des Comportements](https://www6.val-de-loire.inrae.fr/physiologie_reproduction_comportements) (PRC). The BIOS team is an interdisciplinary team composed of biologists, informaticians and mathematicians. Our main research area is the study of the dynamics of cellular signalling networks induced by G protein coupled receptors (GPCR), using a system biology approach. We particularly focus on GPCR signaling systems involved in reproductive biology and social behavior. I'm mathematician by training. My works deals with deterministic and stochastic models in biology, particulary from cellular and molecular biology (including signalling systems, reaction networks, gene expression, protein aggregation and structured population dynamics). I'm interested in hybrid modelling, and study stochastic processes, limit theorem, asymptotic properties. I'm also interested in parameter estimation for the dynamic model we study. The main applications I'm interested in concern reproductive biology.

Publications

pascale-crepieux
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Pharmacological characterization of low molecular weight biased agonists at the follicle stimulating hormone receptor

Francesco de Pascali , Mohammed Akli Ayoub , Riccardo Benevelli , Silvia Sposini , Jordan Lehoux
International Journal of Molecular Sciences, 2021, 22 (18), pp.1-23. ⟨10.3390/ijms22189850⟩
Article dans une revue hal-03351267v1
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Mathematical modeling approaches of cellular endocrinology within the hypothalamo-pituitary-gonadal axis

Frédérique Clément , Pascale Crépieux , Romain Yvinec , Danielle Monniaux
Molecular and Cellular Endocrinology, 2020, 518, ⟨10.1016/j.mce.2020.110877⟩
Article dans une revue hal-03046096v1
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Biased signaling and allosteric modulation at the FSHR

Flavie Landomiel , Francesco de Pascali , Pauline Raynaud , Frédéric Jean-Alphonse , Romain Yvinec
Frontiers in Endocrinology, 2019, 10, pp.148. ⟨10.3389/fendo.2019.00148⟩
Article dans une revue hal-02362523v1
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Advances in computational modeling approaches of pituitary gonadotropin signaling

Romain Yvinec , Pascale Crépieux , Eric Reiter , Anne Poupon , Frédérique Clément
Expert Opinion on Drug Discovery, 2018, 13 (9), pp.799-813. ⟨10.1080/17460441.2018.1501025⟩
Article dans une revue hal-01913612v1
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β-arrestin signalling and bias in hormone-responsive GPCRs

Eric Reiter , Mohammed Akli Ayoub , Lucie P. Pellissier , Flavie Landomiel , Astrid Musnier
Molecular and Cellular Endocrinology, 2017, 449, pp.28-41. ⟨10.1016/j.mce.2017.01.052⟩
Article dans une revue hal-01604784v1
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Computational modeling approaches in gonadotropin signaling

Mohammed Akli Ayoub , Romain Yvinec , Pascale Crépieux , Anne Poupon
Theriogenology, 2016, 86 (1), pp.22-31. ⟨10.1016/j.theriogenology.2016.04.015⟩
Article dans une revue hal-01409338v1
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Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis

Mohammed Akli Ayoub , Romain Yvinec , Gwenhael Jegot , James A. Dias , Sonia-Maria Poli
Molecular and Cellular Endocrinology, 2016, 436, pp.10-22. ⟨10.1016/j.mce.2016.07.013⟩
Article dans une revue hal-01409332v1

β-arrestins and endocrine-related GPCRs

Francesco de Pascali , Pauline Raynaud , Frédéric Jean-Alphonse , Shifa Tahir , Véronique Bozon
Cellular Endocrinology in Health and Disease, Elsevier, pp.445-458, 2021, 978-0-12-819801-8. ⟨10.1016/B978-0-12-819801-8.00021-1⟩
Chapitre d'ouvrage hal-03462802v1

The follicle-stimulating hormone signaling network in gonadal cells.

Frédérique Clément , Romain Yvinec , Nathalie Gallay , Laurine Gagniac , Florian Guillou
Alfredo Ulloa-Aguirre; Ya-Xiong Tao. Cellular endocrinology in health and disease, Second Edition, Academic Press, 486 p., 2021, 9780128198018. ⟨10.1016/B978-0-12-819801-8.00020-X⟩
Chapitre d'ouvrage hal-03128409v1
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Workflow description to dynamically model beta-arrestin signaling networks

Romain Yvinec , Mohammed Akli Ayoub , Francesco de Pascali , Pascale Crépieux , Eric Reiter
Beta-arrestins- Methods and protocols, 1957, , 2019, Methods in Molecular Biology, ⟨10.1007/978-1-4939-9158-7_13⟩
Chapitre d'ouvrage hal-02374486v1
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Follicle-stimulating hormone receptor: Advances and remaining challenges

Francesco de Pascali , Aurélie Trefier , Flavie Landomiel , Véronique Bozon , Gilles Bruneau
G protein-coupled receptors: emerging paradigms in activation, signaling and regulation- Part A, 338 (1ère ed.), Elsevier, pp.1-58, 2018, International Review of Cell and Molecular Biology, 978-0-12-813772-7. ⟨10.1016/bs.ircmb.2018.02.001⟩
Chapitre d'ouvrage hal-02373607v1
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Accurate parameter optimization leads to predictive dynamical models for systems biology

Thomas Bourquard , Mohammed Akli Ayoub , Domitille Heitzler , Nikolaus Hansen , Jérôme Azé
23. Journée du projet CASCIMODOT, Université d'Orléans (UO). FRA. Université François Rabelais (Tours)., Dec 2015, Tours, France
Communication dans un congrès hal-02793656v1

Accute parameter optimization leads to predictive dynamical models for systems biology

Thomas Bourquard , Mohammed Akli Ayoub , Domitille Heitzler , N. Hansen , Jérôme Azé
Perspectives in Environmental and Systems Biology, Structure Fédérative de Recherche (SFR). FRA., Apr 2015, Grenoble, France
Communication dans un congrès hal-02799266v1
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Accurate parameter optimization leads to predictive dynamical models for systems biology

Thomas Bourquard , Mohammed Akli Ayoub , Domitille Heitzler , Nikolaus Hansen , Jérôme Azé
Design, Optimization and Control in Systems and Synthetic Biology DOC'15, Ecole Normale Supérieure - Paris (ENS Paris). FRA., Nov 2015, Paris, France
Communication dans un congrès hal-02799275v1

The translatome of the FSH receptor reveals tha several FSH-responsive signaling effectors are co-translated in primary rat Sertoli cells

Aurélie Trefier , Romain Yvinec , Thomas Bourquard , Kelly Léon-Huaman , Astrid Musnier
2. Journées du GdR 3606 Repro, Apr 2017, Tours, France. 75 p., 2017, 2èmes Journées Scientifiques du GdR Repro
Poster de conférence hal-01603078v1

Intégration des contraintes spatiales dans la modélisation dynamique d’un système biologique complexe : le réseau de signalisation FSH

Mohammed Akli Ayoub , Thomas Boulo , Thomas Bourquard , Pascale Crépieux , Florian Jean Louis Guillou
Journées d’Animation des Crédits Incitatifs du Département de Physiologie Animale et Systèmes d’Elevage (JACI Phase 2016), Apr 2016, Tours, France. , 115 p., 2016, Crédits Incitatifs financés entre 2011 et 2014
Poster de conférence hal-02742541v1

Beta-arrestin 2 barcode of phosphorylation: impact on beta-arrestin-dependent signaling

Franck Vandermoere , Elisabeth Cassier , Nathalie Langonné Gallay , Thomas Bourquard , Romain Yvinec
3. Annual Meeting of the GDR 3545 RCPG-PhysioMed, Oct 2014, Montpellier, France. 2014
Poster de conférence hal-02793437v1

Parameter estimation in signaling systems

Thomas Bourquard , Domitille Heitzler , Guillaume Durand , Romain Yvinec , Nikolaus Hansen
International Conference on Gonadotropins & Receptors, Sep 2014, Tours, France. , 2014, ICGRIII International Conference on Gonadotropins & Receptors
Poster de conférence hal-02740420v1