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Ronan Le Goffic

46 ans, nationalité française, pacsé, 2 enfants.

Situation professionnelle : chercheur INRAE

Laboratoire de rattachement : Unité de Virologie & Immunologie Moléculaires (VIM UMR 892), Jouy-en-Josas.

E-mail : téléphone : 01 34 65 26 05

Fonctions et Formations

- 2019 Directeur de Recherche (DR2) INRA.

- 2016 Responsable de l’équipe, « Virus Influenza » (VIM UR 892).

- 2013 Habilitation à Diriger des Recherches, Université Denis Diderot - Paris VII.

- 2007 Chargé de Recherche INRA, (VIM UR 892).

- 2004 Chercheur post-doctorant, INSERM E336, Institut Pasteur, Paris.

- 2002 Chercheur post-doctorant, University of Washington, Seattle, USA.

- 2002 Doctorat de l’Université de Rennes I, mention biologie.

Journal articles43 documents

  • Christophe Chevalier, Olivier Leymarie, Laura Sedano, Bruno da Costa, Charles-Adrien Richard, et al.. PB1-F2 amyloid-like fibers correlate with proinflammatory signaling and respiratory distress in influenza-infected mice. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (1), ⟨10.1016/j.jbc.2021.100885⟩. ⟨hal-03299147⟩
  • Jennifer Risso-Ballester, Marie Galloux, Jingjing Cao, Ronan Le Goffic, Fortune Hontonnou, et al.. A condensate-hardening drug blocks RSV replication in vivo. Nature, Nature Publishing Group, 2021, 595 (7868), pp.596 - 599. ⟨10.1038/s41586-021-03703-z⟩. ⟨hal-03318345⟩
  • Lydia Meziani, Charlotte Robert, Marion Classe, Bruno da Costa, Michele Mondini, et al.. Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia. International Journal of Radiation Oncology - Biology - Physics, Elsevier, 2021, 110 (5), pp.1283-1294. ⟨10.1016/j.ijrobp.2021.03.022⟩. ⟨hal-03401860⟩
  • Joëlle Mettier, Daniel Marc, Laura Sedano, Bruno da Costa, Christophe Chevalier, et al.. Study of the host specificity of PB1-F2-associated virulence. Virulence, Taylor & Francis, 2021, 12 (1), pp.1647 - 1660. ⟨10.1080/21505594.2021.1933848⟩. ⟨hal-03264952⟩
  • Sandra Axberg Pålsson, Aleksandra Dondalska, Joseph Bergenstråhle, Caroline Rolfes, Albin Björk, et al.. Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection. Frontiers in Immunology, Frontiers, 2020, 11, ⟨10.3389/fimmu.2020.580547⟩. ⟨hal-03109137⟩
  • Bertrand Bryche, Maxence Fretaud, Audrey Saint‐albin Deliot, Marie Galloux, Laura Sedano, et al.. Respiratory syncytial virus tropism for olfactory sensory neurons in mice. Journal of Neurochemistry, Wiley, 2020, ⟨10.1111/jnc.14936⟩. ⟨hal-02899462⟩
  • Olivier Leymarie, Ronan Le Goffic, Frederic Jamme, Christophe Chevalier. Impact of the influenza protein PB1-F2 on the biochemical composition of human epithelial cells revealed by synchrotron Fourier transform infrared spectromicroscopy. Journal of Spectral Imaging, IM Publications, 2020, 8 (18), ⟨10.1255/jsi.2019.a18⟩. ⟨hal-02873862⟩
  • Asma Ayari, Manuel Rosa-Calatrava, Steve Lancel, Johanna Barthelemy, Andrés Pizzorno, et al.. Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Communications Biology, Nature Publishing Group, 2020, 3 (1), ⟨10.1038/s42003-020-0965-6⟩. ⟨hal-02959942v2⟩
  • Bertrand Bryche, Audrey St Albin, Séverine Murri, Sandra Lacôte, Coralie Pulido, et al.. Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters. Brain, Behavior, and Immunity, Elsevier, 2020, 89, pp.579-586. ⟨10.1016/j.bbi.2020.06.032⟩. ⟨hal-02984344⟩
  • J. Oliva, J. Mettier, L. Sedano, M. Delverdier, N. Bourgès-Abella, et al.. Murine Model for the Study of Influenza D Virus. Journal of Virology, American Society for Microbiology, 2020, 94 (4), pp.e01662-19. ⟨10.1128/JVI.01662-19⟩. ⟨hal-02640532⟩
  • Sebastian Blockus, Svenja Sake, Martin Wetzke, Christina Grethe, Theresa Graalmann, et al.. Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry. Antiviral Research, Elsevier Masson, 2020, 177, pp.104774. ⟨10.1016/j.antiviral.2020.104774⟩. ⟨hal-02549192⟩
  • Valentin Sencio, Adeline Barthélémy, Luciana Tavares, Marina Machado, Daphnée Soulard, et al.. Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production. Cell Reports, Elsevier Inc, 2020, 30 (9), pp.2934-2947.e6. ⟨10.1016/j.celrep.2020.02.013⟩. ⟨inserm-02501395⟩
  • Marie Galloux, Nadège Gsponer, Vanessa Gaillard, Brice Fenner, Thibaut Larcher, et al.. Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2020, 64 (10), ⟨10.1128/AAC.00717-20⟩. ⟨hal-03353101⟩
  • Aleksandra Anchim, Najat Raddi, Lena Zig, Patrick Perrieau, Ronan Le Goffic, et al.. Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway. Frontiers in Immunology, Frontiers, 2018, 9, pp.1-11. ⟨10.3389/fimmu.2018.00124⟩. ⟨hal-02126585⟩
  • Valeria Cagno, Patrizia Andreozzi, Marco d'Alicarnasso, Paulo Jacob Silva, Marie Mueller, et al.. Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism. Nature Materials, Nature Publishing Group, 2018, 17 (2), pp.1-10. ⟨10.1038/NMAT5053⟩. ⟨hal-02629404⟩
  • Adeline Barthélémy, Valentin Sencio, Daphnée Soulard, Lucie Deruyter, Christelle Faveeuw, et al.. Interleukin-22 Immunotherapy during Severe Influenza Enhances Lung Tissue Integrity and Reduces Secondary Bacterial Systemic Invasion. Infection and Immunity, American Society for Microbiology, 2018, 86 (7), pp.e00706-17. ⟨10.1128/IAI.00706-17⟩. ⟨hal-02398322⟩
  • Olivier Leymarie, Léa Meyer, Lionel Tafforeau, Vincent Lotteau, Bruno Da Costa, et al.. Influenza virus protein PB1-F2 interacts with CALCOCO2 (NDP52) to modulate innate immune response. Journal of General Virology, Microbiology Society, 2017, 98 (6), pp.1196-1208. ⟨10.1099/jgv.0.000782⟩. ⟨hal-01911416⟩
  • Vanessa Gaillard, Marie Galloux, Dominique Garcin, Jean Francois Eleouet, Ronan Le Goffic, et al.. A short double-stapled peptide inhibits respiratory syncytial virus entry and spreading. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2017, 61 (4), ⟨10.1128/AAC.02241-16⟩. ⟨hal-01605887⟩
  • Léa Meyer, Olivier Leymarie, Christophe Chevalier, Evelyne Esnault, Marco Moroldo, et al.. Transcriptomic profiling of a chicken lung epithelial cell line (CLEC213) reveals a mitochondrial respiratory chain activity boost during influenza virus infection. PLoS ONE, Public Library of Science, 2017, 12 (4), 18 p. ⟨10.1371/journal.pone.0176355⟩. ⟨hal-01605882⟩
  • Olivier Leymarie, Léa Meyer, Pierre Louis Herve, Bruno da Costa, Bernard Delmas, et al.. Host response comparison of H1N1-and H5N1-infected mice identifies two potential death mechanisms. International Journal of Molecular Sciences, MDPI, 2017, 18 (8), ⟨10.3390/ijms18081631⟩. ⟨hal-02617657⟩
  • Christophe Chevalier, Ronan Le Goffic, Frédéric Jamme, Olivier Leymarie, Matthieu Réfrégiers, et al.. Synchrotron Infrared and Deep UV Fluorescent Microspectroscopy Study of PB1-F2 β-Aggregated Structures in Influenza A Virus-infected Cells. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (17), pp.9060 - 9072. ⟨10.1074/jbc.M115.710533⟩. ⟨hal-01724147⟩
  • Aurore Vidy-Roche, Pauline Maisonnasse, Bruno da Costa, Bernard Delmas, Christophe Chevalier, et al.. The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition. PLoS ONE, Public Library of Science, 2016, 11 (10), pp.1-19. ⟨10.1371/journal.pone.0165361⟩. ⟨hal-01608535⟩
  • Léa Meyer, Alix Sausset, Laura Sedano, Bruno da Costa, Ronan Le Goffic, et al.. Codon deletions in the influenza a virus pa gene generate temperature-sensitive viruses. Journal of Virology, American Society for Microbiology, 2016, 90 (7), pp.3684-3693. ⟨10.1128/JVI.03101-15⟩. ⟨hal-02636526⟩
  • Joan Torrent I Mas, Alba del Valle Vilchez Acosta, Diego Muñoz-Torrero, Marie Trovaslet, Florian Nachon, et al.. Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases. Acta Neuropathologica Communications, BioMed Central part of Springer Science, 2015, 3 (1), pp.18. ⟨10.1186/s40478-015-0188-0⟩. ⟨inserm-02335432v2⟩
  • Bruno da Costa, Alix Sausset, Sandie Munier, Alexandre Ghounaris, Nadia Naffakh, et al.. Temperature-sensitive mutants in the influenza A virus RNA polymerase: alterations in the PA linker reduce nuclear targeting of the PB1-PA dimer and result in viral attenuation. Journal of Virology, American Society for Microbiology, 2015, 89 (12), pp.6376-6390. ⟨10.1128/JVI.00589-15⟩. ⟨hal-02631749⟩
  • Olivier Leymarie, Carissa Embury-Hyatt, Christophe Chevalier, Luc Jouneau, Marco Moroldo, et al.. PB1-F2 attenuates virulence of highly pathogenic avian H5N1 influenza virus in chickens. PLoS ONE, Public Library of Science, 2014, 9 (6), ⟨10.1371/journal.pone.0100679⟩. ⟨hal-01194021⟩
  • Marie-Anne Rameix-Welti, Ronan Le Goffic, Pierre-Louis Hervé, Julien Sourimant, Aude Remot, et al.. Visualizing the replication of respiratory syncytial virus in cells and in living mice. Nature Communications, Nature Publishing Group, 2014, 5, ⟨10.1038/ncomms6104⟩. ⟨hal-02633568⟩
  • Anna Miodek, Jasmina Vidic, Helene Sauriat-Dorizon, Charles-Adrien Richard, Ronan Le Goffic, et al.. Electrochemical Detection of the Oligomerization of PB1-F2 Influenza A Virus Protein in Infected Cells. Analytical Chemistry, American Chemical Society, 2014, 86 (18), pp.9098 - 9105. ⟨10.1021/ac5018056⟩. ⟨hal-02635306⟩
  • Jasmina Vidic, Christophe Chevalier, Ronan Le Goffic, Anna Miodek, Christiane Bourdieu, et al.. Surface plasmon resonance immunosensor for detection of pb1-f2 influenza a virus protein in infected biological samples. Journal of Analytical & Bioanalytical Techniques, Omics Publishing Group, 2013, S7, ⟨10.4172/2155-9872.S7-006⟩. ⟨hal-02642777⟩
  • Jasmina Vidic, Ronan Le Goffic, Anna Miodek, Christiane Bourdieu, Charles-Adrien Richard, et al.. Detection of soluble oligomers formed by PB1-F2 influenza A virus protein in vitro. Journal of Analytical & Bioanalytical Techniques, Omics Publishing Group, 2013, 4 (3), pp.1-2. ⟨10.4172/2155-9872.1000169⟩. ⟨hal-02642907⟩
  • Noura Kechaou, Florian Chain, Jean-Jacques Gratadoux, Sebastien Blugeon, Nicolas Bertho, et al.. Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening. Applied and Environmental Microbiology, American Society for Microbiology, 2013, 79 (5), pp.1491 - 1499. ⟨10.1128/AEM.03075-12⟩. ⟨hal-01001569⟩
  • Olivier Leymarie, Gregory Jouvion, Pierre-Louis Hervé, Christophe Chevalier, Valérie Lorin, et al.. Kinetic characterization of PB1-F2-mediated immunopathology during highly pathogenic avian H5N1 influenza virus infection.. PLoS ONE, Public Library of Science, 2013, 8 (3), pp.e57894. ⟨10.1371/journal.pone.0057894⟩. ⟨hal-01004085⟩
  • Jasmina Vidic, Slavica Stankic, Francia Haque, Danica Ciric, Ronan Le Goffic, et al.. Selective antibacterial effects of mixed ZnMgO nanoparticles. Journal of Nanoparticle Research, Springer Verlag, 2013, 15 (5), pp.1595. ⟨10.1007/s11051-013-1595-4⟩. ⟨hal-01243099⟩
  • Ronan Le Goffic, Olivier Leymarie, Christophe Chevalier, Emmanuelle Rebours, Bruno da Costa, et al.. Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein.. PLoS Pathogens, Public Library of Science, 2011, 7 (8), pp.e1002202. ⟨10.1371/journal.ppat.1002202⟩. ⟨hal-00684735⟩
  • Ronan Le Goffic, Muhammad Imran Arshad, Michel Rauch, Annie l'Helgoualc'H, Bernard Delmas, et al.. Infection with influenza virus induces IL-33 in murine lungs.. American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2011, 45 (6), pp.1125-32. ⟨10.1165/rcmb.2010-0516OC⟩. ⟨hal-00681982⟩
  • Christophe Chevalier, Ali Al Bazzal, Jasmina Vidic, Vincent Fevrier, Christiane Bourdieu, et al.. PB1-F2 Influenza A Virus Protein Adopts a beta-Sheet Conformation and Forms Amyloid Fibers in Membrane Environments. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2010, 285 (17), pp.13233-13243. ⟨10.1074/jbc.M109.067710⟩. ⟨hal-02664783⟩
  • Ronan Le Goffic, Edwige Bouguyon, Christophe Chevalier, Jasmina Vidic, Bruno da Costa, et al.. Influenza A Virus Protein PB1-F2 Exacerbates IFN-b Expression of Human Respiratory Epithelial Cells. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (8), pp.4812-4823. ⟨10.4049/jimmunol.0903952⟩. ⟨hal-01193647⟩
  • Benoît Raymond, Dominique Leduc, Lucas Ravaux, Ronan Le Goffic, Thomas Candela, et al.. Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages.. PLoS Pathogens, Public Library of Science, 2007, 3 (12), pp.e187. ⟨10.1371/journal.ppat.0030187⟩. ⟨pasteur-00317899⟩
  • R. Le Goffic, V. Balloy, M. Lagranderie, L. Alexopoulou, N. Escriou, et al.. Detrimental contribution of the Toll-like receptor (TLR) to influenza A virus-induced acute pneumonia. PLoS Pathogens, Public Library of Science, 2006, 2 (6), pp.e53. ⟨10.1371/journal.ppat.0020053⟩. ⟨hal-00086851⟩
  • Ronan Le Goffic, Thomas Mouchel, Annick Ruffault, Jean-Jacques Patard, Bernard Jégou, et al.. Mumps Virus Decreases Testosterone Production and Gamma Interferon-Induced Protein 10 Secretion by Human Leydig Cells. Journal of Virology, American Society for Microbiology, 2003, 77 (5), pp.3297-3300. ⟨10.1128/jvi.77.5.3297-3300.2003⟩. ⟨hal-03318689⟩
  • J. Oyhenart, Ronan Le Goffic, M. Samson, Bernard Jégou, Natacha Raich. Phtf1 Is an Integral Membrane Protein Localized in an Endoplasmic Reticulum Domain in Maturing Male Germ Cells1. Biology of Reproduction, Society for the Study of Reproduction, 2003, 68 (3), pp.1044-1053. ⟨10.1095/biolreprod.102.009787⟩. ⟨hal-03318940⟩
  • M. Irla, Denis Puthier, R. Le Goffic, G. Victorero, T. Freeman, et al.. Spatial, a new nuclear factor tightly regulated during mouse spermatogenesis. Gene Expression Patterns, Elsevier, 2003, 3 (2), pp.135--138. ⟨10.1016/S1567-133X(03)00024-3⟩. ⟨hal-01595826⟩
  • Ronan Le Goffic, Thomas Mouchel, Florence Aubry, Jean-Jacques Patard, Annick Ruffault, et al.. Production of the Chemokines Monocyte Chemotactic Protein-1, Regulated on Activation Normal T Cell Expressed and Secreted Protein, Growth-Related Oncogene, and Interferon-γ-Inducible Protein-10 Is Induced by the Sendai Virus in Human and Rat Testicular Cells. Endocrinology, Endocrine Society, 2002, 143 (4), pp.1434-1440. ⟨10.1210/endo.143.4.8735⟩. ⟨hal-03318654⟩