Accéder directement au contenu

Ronan Le Goffic

58
Documents

Présentation

46 ans, nationalité française, pacsé, 2 enfants. Situation professionnelle : chercheur INRAE Laboratoire de rattachement : Unité de Virologie & Immunologie Moléculaires (VIM UMR 892), Jouy-en-Josas. E-mail : ronan.le-goffic@inrae.fr téléphone : 01 34 65 26 05 **Fonctions et Formations** \- 2019 Directeur de Recherche (DR2) INRA. \- 2016 Responsable de l’équipe, « Virus Influenza » (VIM UR 892). \- 2013 Habilitation à Diriger des Recherches, Université Denis Diderot - Paris VII. \- 2007 Chargé de Recherche INRA, (VIM UR 892). \- 2004 Chercheur post-doctorant, INSERM E336, Institut Pasteur, Paris. \- 2002 Chercheur post-doctorant, University of Washington, Seattle, USA. \- 2002 Doctorat de l’Université de Rennes I, mention biologie.

Publications

Image document

Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor

Svenja Sake , Xiaoyu Zhang , Manoj Kumar Rajak , Melanie Urbanek-Quaing , Arnaud Carpentier
Nature Communications, 2024, 15 (1), pp.1173. ⟨10.1038/s41467-024-45241-y⟩
Article dans une revue hal-04504093v1
Image document

Comparison of PB1-F2 Proximity Interactomes Reveals Functional Differences between a Human and an Avian Influenza Virus

Joëlle Mettier , Clémentine Prompt , Elise Bruder , Bruno da Costa , Christophe Chevalier
Viruses, 2023, 15 (2), pp.328. ⟨10.3390/v15020328⟩
Article dans une revue hal-04023221v1
Image document

Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion

Elisa Franzi , Gregory Mathez , Soraya Dinant , Charlotte Deloizy , Laurent K. Kaiser
International Journal of Molecular Sciences, 2023, 24 (20), pp.15382. ⟨10.3390/ijms242015382⟩
Article dans une revue hal-04271263v1
Image document

An Isolate of Streptococcus mitis Displayed In Vitro Antimicrobial Activity and Deleterious Effect in a Preclinical Model of Lung Infection

Elliot Mathieu , Quentin Marquant , Florian Chain , Edwige Bouguyon , Vinciane Saint-Criq
Nutrients, 2023, 15 (2), pp. 263. ⟨10.3390/nu15020263⟩
Article dans une revue hal-03943007v1
Image document

Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein

Antoine Guillon , Deborah Bréa-Diakite , Adeline Cezard , Alan Wacquiez , Thomas Baranek
EMBO Journal, 2022, 41 (12), pp.e108306. ⟨10.15252/embj.2021108306⟩
Article dans une revue hal-03687124v2

Self-assembled peptide nanorod vaccine confers protection against influenza A virus

Ximena Zottig , Soultan Al-Halifa , Mélanie Côté-Cyr , Cynthia Calzas , Ronan Le Goffic
Article dans une revue hal-03319841v1
Image document

PB1-F2 amyloid-like fibers correlate with proinflammatory signaling and respiratory distress in influenza-infected mice

Christophe Chevalier , Olivier Leymarie , Laura Sedano , Bruno da Costa , Charles-Adrien Richard
Journal of Biological Chemistry, 2021, 297 (1), ⟨10.1016/j.jbc.2021.100885⟩
Article dans une revue hal-03299147v1
Image document

Study of the host specificity of PB1-F2-associated virulence

Joëlle Mettier , Daniel Marc , Laura Sedano , Bruno da Costa , Christophe Chevalier
Virulence, 2021, 12 (1), pp.1647 - 1660. ⟨10.1080/21505594.2021.1933848⟩
Article dans une revue hal-03264952v1
Image document

Immunogenicity and Protective Potential of Mucosal Vaccine Formulations Based on Conserved Epitopes of Influenza A Viruses Fused to an Innovative Ring Nanoplatform in Mice and Chickens

Cynthia Calzas , Molida Mao , Mathilde Turpaud , Quentin Viboud , Joelle Mettier
Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.772550⟩
Article dans une revue hal-03575999v1

A condensate-hardening drug blocks RSV replication in vivo

Jennifer Risso-Ballester , Marie Galloux , Jingjing Cao , Ronan Le Goffic , Fortune Hontonnou
Nature, 2021, 595 (7868), pp.596-599. ⟨10.1038/s41586-021-03703-z⟩
Article dans une revue hal-03352787v1

A condensate-hardening drug blocks RSV replication in vivo

Jennifer Risso-Ballester , Marie Galloux , Jingjing Cao , Ronan Le Goffic , Fortune Hontonnou
Nature, 2021, 595 (7868), pp.596 - 599. ⟨10.1038/s41586-021-03703-z⟩
Article dans une revue hal-03318345v1
Image document

Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia

Lydia Meziani , Charlotte Robert , Marion Classe , Bruno da Costa , Michele Mondini
International Journal of Radiation Oncology, Biology, Physics, 2021, 110 (5), pp.1283-1294. ⟨10.1016/j.ijrobp.2021.03.022⟩
Article dans une revue hal-03401860v1
Image document

Influenza Virus Infection Impairs the Gut’s Barrier Properties and Favors Secondary Enteric Bacterial Infection through Reduced Production of Short-Chain Fatty Acids

Valentin Sencio , Alexandre Gallerand , Marina Gomes Machado , Lucie Deruyter , Séverine Heumel
Infection and Immunity, 2021, 89 (9), ⟨10.1128/IAI.00734-20⟩
Article dans une revue inserm-03385672v1
Image document

Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges

Olivier Terrier , Mustapha Si-Tahar , Mariette Ducatez , Christophe Chevalier , Andrés Pizzorno
PLoS Pathogens, 2021, 17 (12), pp.e1010106. ⟨10.1371/journal.ppat.1010106⟩
Article dans une revue hal-03518306v1
Image document

Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

Valentin Sencio , Adeline Barthélémy , Luciana Tavares , Marina Machado , Daphnée Soulard
Cell Reports, 2020, 30 (9), pp.2934-2947.e6. ⟨10.1016/j.celrep.2020.02.013⟩
Article dans une revue inserm-02501395v1
Image document

Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry

Sebastian Blockus , Svenja Sake , Martin Wetzke , Christina Grethe , Theresa Graalmann
Antiviral Research, 2020, 177, pp.104774. ⟨10.1016/j.antiviral.2020.104774⟩
Article dans une revue hal-02549192v1

Murine Model for the Study of Influenza D Virus

J. Oliva , J. Mettier , L. Sedano , M. Delverdier , N. Bourgès-Abella
Journal of Virology, 2020, 94 (4), pp.e01662-19. ⟨10.1128/JVI.01662-19⟩
Article dans une revue hal-02640532v1
Image document

Impact of the influenza protein PB1-F2 on the biochemical composition of human epithelial cells revealed by synchrotron Fourier transform infrared spectromicroscopy

Olivier Leymarie , Ronan Le Goffic , Frederic Jamme , Christophe Chevalier
Journal of Spectral Imaging, 2020, 8 (18), ⟨10.1255/jsi.2019.a18⟩
Article dans une revue hal-02873862v1
Image document

Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice

Marie Galloux , Nadège Gsponer , Vanessa Gaillard , Brice Fenner , Thibaut Larcher
Antimicrobial Agents and Chemotherapy, 2020, 64 (10), ⟨10.1128/AAC.00717-20⟩
Article dans une revue hal-03353101v1

Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues

Asma Ayari , Manuel Rosa-Calatrava , Steve Lancel , Johanna Barthelemy , Andrés Pizzorno
Communications Biology, 2020, 3 (1), pp.237. ⟨10.1038/s42003-020-0965-6⟩
Article dans une revue hal-04397678v1
Image document

Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection

Sandra Axberg Pålsson , Aleksandra Dondalska , Joseph Bergenstråhle , Caroline Rolfes , Albin Björk
Frontiers in Immunology, 2020, 11, ⟨10.3389/fimmu.2020.580547⟩
Article dans une revue hal-03352841v1

Respiratory syncytial virus tropism for olfactory sensory neurons in mice

Bertrand Bryche , Maxence Fretaud , Audrey Saint‐albin Deliot , Marie Galloux , Laura Sedano
Journal of Neurochemistry, 2020, ⟨10.1111/jnc.14936⟩
Article dans une revue hal-02899462v1
Image document

Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection

Sandra Axberg Pålsson , Aleksandra Dondalska , Joseph Bergenstråhle , Caroline Rolfes , Albin Björk
Frontiers in Immunology, 2020, 11, pp.580547. ⟨10.3389/fimmu.2020.580547⟩
Article dans une revue hal-03109137v1
Image document

Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

Bertrand Bryche , Audrey St Albin , Séverine Murri , Sandra Lacôte , Coralie Pulido
Brain, Behavior, and Immunity, 2020, 89, pp.579-586. ⟨10.1016/j.bbi.2020.06.032⟩
Article dans une revue hal-02984344v1
Image document

Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues

Asma Ayari , Manuel Rosa-Calatrava , Steve S. Lancel , Johanna Barthelemy , Andrés Pizzorno
Communications Biology, 2020, 3 (1), ⟨10.1038/s42003-020-0965-6⟩
Article dans une revue hal-02959942v2

Interleukin-22 Immunotherapy during Severe Influenza Enhances Lung Tissue Integrity and Reduces Secondary Bacterial Systemic Invasion

Adeline Barthélémy , Valentin Sencio , Daphnée Soulard , Lucie Deruyter , Christelle Faveeuw
Infection and Immunity, 2018, 86 (7), pp.e00706-17. ⟨10.1128/IAI.00706-17⟩
Article dans une revue hal-02398322v1
Image document

Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway

Aleksandra Anchim , Najat Raddi , Lena Zig , Patrick Perrieau , Ronan Le Goffic
Frontiers in Immunology, 2018, 9, pp.1-11. ⟨10.3389/fimmu.2018.00124⟩
Article dans une revue hal-02126585v1

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

Valeria Cagno , Patrizia Andreozzi , Marco d'Alicarnasso , Paulo Jacob Silva , Marie Mueller
Nature Materials, 2018, 17 (2), pp.1-10. ⟨10.1038/NMAT5053⟩
Article dans une revue hal-02629404v1

Influenza virus protein PB1-F2 interacts with CALCOCO2 (NDP52) to modulate innate immune response

Olivier Leymarie , Léa Meyer , Lionel Tafforeau , Vincent Lotteau , Bruno da Costa
Journal of General Virology, 2017, 98 (6), pp.1196-1208. ⟨10.1099/jgv.0.000782⟩
Article dans une revue hal-01911416v1
Image document

Transcriptomic profiling of a chicken lung epithelial cell line (CLEC213) reveals a mitochondrial respiratory chain activity boost during influenza virus infection

Léa Meyer , Olivier Leymarie , Christophe Chevalier , Evelyne Esnault , Marco Moroldo
PLoS ONE, 2017, 12 (4), 18 p. ⟨10.1371/journal.pone.0176355⟩
Article dans une revue hal-01605882v1
Image document

A short double-stapled peptide inhibits respiratory syncytial virus entry and spreading

Vanessa Gaillard , Marie Galloux , Dominique Garcin , Jean Francois Eleouet , Ronan Le Goffic
Antimicrobial Agents and Chemotherapy, 2017, 61 (4), ⟨10.1128/AAC.02241-16⟩
Article dans une revue hal-01605887v1
Image document

Host response comparison of H1N1-and H5N1-infected mice identifies two potential death mechanisms

Olivier Leymarie , Léa Meyer , Pierre Louis Herve , Bruno da Costa , Bernard Delmas
International Journal of Molecular Sciences, 2017, 18 (8), ⟨10.3390/ijms18081631⟩
Article dans une revue hal-02617657v1
Image document

The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition

Aurore Vidy-Roche , Pauline Maisonnasse , Bruno da Costa , Bernard Delmas , Christophe Chevalier
PLoS ONE, 2016, 11 (10), pp.1-19. ⟨10.1371/journal.pone.0165361⟩
Article dans une revue hal-01608535v1

Codon deletions in the influenza a virus pa gene generate temperature-sensitive viruses

Léa Meyer , Alix Sausset , Laura Sedano , Bruno B. da Costa , Ronan Le Goffic
Journal of Virology, 2016, 90 (7), pp.3684-3693. ⟨10.1128/JVI.03101-15⟩
Article dans une revue hal-02636526v1
Image document

Synchrotron Infrared and Deep UV Fluorescent Microspectroscopy Study of PB1-F2 β-Aggregated Structures in Influenza A Virus-infected Cells

Christophe Chevalier , Ronan Le Goffic , Frédéric Jamme , Olivier Leymarie , Matthieu Réfrégiers
Journal of Biological Chemistry, 2016, 291 (17), pp.9060 - 9072. ⟨10.1074/jbc.M115.710533⟩
Article dans une revue hal-01724147v1
Image document

Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases

Joan Torrent I Mas , Alba del Valle Vilchez Acosta , Diego Muñoz-Torrero , Marie Trovaslet , Florian Nachon
Acta Neuropathologica Communications, 2015, 3 (1), pp.18. ⟨10.1186/s40478-015-0188-0⟩
Article dans une revue inserm-02335432v2

Temperature-sensitive mutants in the influenza A virus RNA polymerase: alterations in the PA linker reduce nuclear targeting of the PB1-PA dimer and result in viral attenuation

Bruno B. da Costa , Alix Sausset , Sandie Munier , Alexandre Ghounaris , Nadia Naffakh
Journal of Virology, 2015, 89 (12), pp.6376-6390. ⟨10.1128/JVI.00589-15⟩
Article dans une revue hal-02631749v1
Image document

Visualizing the replication of respiratory syncytial virus in cells and in living mice

Marie-Anne Rameix-Welti , Ronan Le Goffic , Pierre-Louis Hervé , Julien Sourimant , Aude Remot
Nature Communications, 2014, 5, ⟨10.1038/ncomms6104⟩
Article dans une revue hal-02633568v1
Image document

PB1-F2 attenuates virulence of highly pathogenic avian H5N1 influenza virus in chickens

Olivier Leymarie , Carissa Embury-Hyatt , Christophe Chevalier , Luc Jouneau , Marco Moroldo
PLoS ONE, 2014, 9 (6), ⟨10.1371/journal.pone.0100679⟩
Article dans une revue hal-01194021v1

Electrochemical Detection of the Oligomerization of PB1-F2 Influenza A Virus Protein in Infected Cells

Anna Miodek , Jasmina Vidic , Helene Sauriat-Dorizon , Charles-Adrien Richard , Ronan Le Goffic
Analytical Chemistry, 2014, 86 (18), pp.9098 - 9105. ⟨10.1021/ac5018056⟩
Article dans une revue hal-02635306v1
Image document

Surface plasmon resonance immunosensor for detection of pb1-f2 influenza a virus protein in infected biological samples

Jasmina Vidic , Christophe Chevalier , Ronan Le Goffic , Anna Miodek , Christiane Bourdieu
Journal of Analytical & Bioanalytical Techniques, 2013, S7, ⟨10.4172/2155-9872.S7-006⟩
Article dans une revue hal-02642777v1
Image document

Detection of soluble oligomers formed by PB1-F2 influenza A virus protein in vitro

Jasmina Vidic , Ronan Le Goffic , Anna Miodek , Christiane Bourdieu , Charles-Adrien Richard
Journal of Analytical & Bioanalytical Techniques, 2013, 4 (3), pp.1-2. ⟨10.4172/2155-9872.1000169⟩
Article dans une revue hal-02642907v1

Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

Noura N. Kechaou , Florian F. Chain , Jean-Jacques J.-J. Gratadoux , Sebastien S. Blugeon , Nicolas N. Bertho
Applied and Environmental Microbiology, 2013, 79 (5), pp.1491 - 1499. ⟨10.1128/AEM.03075-12⟩
Article dans une revue hal-01001569v1
Image document

Selective antibacterial effects of mixed ZnMgO nanoparticles

Jasmina Vidic , Slavica Stankic , Francia Haque , Danica Ciric , Ronan Le Goffic
Journal of Nanoparticle Research, 2013, 15 (5), pp.1595. ⟨10.1007/s11051-013-1595-4⟩
Article dans une revue hal-01243099v1
Image document

Kinetic characterization of PB1-F2-mediated immunopathology during highly pathogenic avian H5N1 influenza virus infection.

Olivier O. Leymarie , Gregory G. Jouvion , Pierre-Louis P.-L. Hervé , Christophe Chevalier , Valérie V. Lorin
PLoS ONE, 2013, 8 (3), pp.e57894. ⟨10.1371/journal.pone.0057894⟩
Article dans une revue hal-01004085v1
Image document

Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein.

Ronan Le Goffic , Olivier Leymarie , Christophe Chevalier , Emmanuelle Rebours , Bruno da Costa
PLoS Pathogens, 2011, 7 (8), pp.e1002202. ⟨10.1371/journal.ppat.1002202⟩
Article dans une revue hal-00684735v1
Image document

Infection with influenza virus induces IL-33 in murine lungs.

Ronan Le Goffic , Muhammad Imran Arshad , Michel Rauch , Annie L'Helgoualc'H , Bernard Delmas
American Journal of Respiratory Cell and Molecular Biology, 2011, 45 (6), pp.1125-32. ⟨10.1165/rcmb.2010-0516OC⟩
Article dans une revue hal-00681982v1

Influenza A Virus Protein PB1-F2 Exacerbates IFN-b Expression of Human Respiratory Epithelial Cells

Ronan Le Goffic , Edwige Bouguyon , Christophe Chevalier , Jasmina Vidic , Bruno da Costa
Journal of Immunology, 2010, 185 (8), pp.4812-4823. ⟨10.4049/jimmunol.0903952⟩
Article dans une revue hal-01193647v1
Image document

PB1-F2 Influenza A Virus Protein Adopts a beta-Sheet Conformation and Forms Amyloid Fibers in Membrane Environments

Christophe Chevalier , Ali Al Bazzal , Jasmina Vidic , Vincent Fevrier , Christiane Bourdieu
Journal of Biological Chemistry, 2010, 285 (17), pp.13233-13243. ⟨10.1074/jbc.M109.067710⟩
Article dans une revue hal-02664783v1

Cutting Edge: Influenza A Virus Activates TLR3-Dependent Inflammatory and RIG-I-Dependent Antiviral Responses in Human Lung Epithelial Cells

Ronan Le Goffic , Julien Pothlichet , Damien Vitour , Takashi Fujita , Eliane Meurs
Journal of Immunology, 2007, 178 (6), pp.3368-3372. ⟨10.4049/jimmunol.178.6.3368⟩
Article dans une revue hal-03319510v1
Image document

Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages.

Benoît Raymond , Dominique Leduc , Lucas Ravaux , Ronan Le Goffic , Thomas Candela
PLoS Pathogens, 2007, 3 (12), pp.e187. ⟨10.1371/journal.ppat.0030187⟩
Article dans une revue pasteur-00317899v1
Image document

Detrimental contribution of the Toll-like receptor (TLR) to influenza A virus-induced acute pneumonia

Ronan Le Goffic , V. Balloy , M. Lagranderie , L. Alexopoulou , N. Escriou
PLoS Pathogens, 2006, 2 (6), pp.e53. ⟨10.1371/journal.ppat.0020053⟩
Article dans une revue hal-00086851v1
Image document

Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus

Loïc Guillot , Ronan Le Goffic , Sarah Bloch , Nicolas Escriou , Shizuo Akira
Journal of Biological Chemistry, 2005, 280 (7), pp.5571-5580. ⟨10.1074/jbc.M410592200⟩
Article dans une revue hal-03318968v1
Image document

Mumps Virus Decreases Testosterone Production and Gamma Interferon-Induced Protein 10 Secretion by Human Leydig Cells

Ronan Le Goffic , Thomas Mouchel , Annick Ruffault , Jean-Jacques Patard , Bernard Jégou
Journal of Virology, 2003, 77 (5), pp.3297-3300. ⟨10.1128/jvi.77.5.3297-3300.2003⟩
Article dans une revue hal-03318689v1

Phtf1 Is an Integral Membrane Protein Localized in an Endoplasmic Reticulum Domain in Maturing Male Germ Cells1

J. Oyhenart , Ronan Le Goffic , M. Samson , Bernard Jégou , Natacha Raich
Biology of Reproduction, 2003, 68 (3), pp.1044-1053. ⟨10.1095/biolreprod.102.009787⟩
Article dans une revue hal-03318940v1

Spatial, a new nuclear factor tightly regulated during mouse spermatogenesis

M. Irla , Denis Puthier , Ronan Le Goffic , G. Victorero , T. Freeman
Gene Expression Patterns, 2003, 3 (2), pp.135--138. ⟨10.1016/S1567-133X(03)00024-3⟩
Article dans une revue hal-01595826v1

Production of the Chemokines Monocyte Chemotactic Protein-1, Regulated on Activation Normal T Cell Expressed and Secreted Protein, Growth-Related Oncogene, and Interferon-γ-Inducible Protein-10 Is Induced by the Sendai Virus in Human and Rat Testicular Cells

Ronan Le Goffic , Thomas Mouchel , Florence Aubry , Jean-Jacques Patard , Annick Ruffault
Endocrinology, 2002, 143 (4), pp.1434-1440. ⟨10.1210/endo.143.4.8735⟩
Article dans une revue hal-03318654v1

Le virus ourlien et l'orchite : vers une approche physiopathologique

Thomas Mouchel , Ronan Le Goffic , Jean-Jacques Patard , Michel Samson
Progrès en Urologie, 2002, 12 (1), pp.124-8
Article dans une revue hal-03318963v1