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Solid-phase receptor-based assay for the detection of cyclic imines by chemiluminescence, fluorescence, or colorimetry.

 Laura P Rodríguez , Natalia Vilariño , Jordi Molgó , Rómulo Aráoz , Alvaro Antelo , et al.
Analytical Chemistry, 2011, 83 (15), pp.5857-63. ⟨10.1021/ac200423s⟩
Article dans une revue hal-00637241v1

The cyclic imine Prorocentrolide-A obtained from cultured Japanese Prorocentrum lima dinoflagellates target muscle- and neuronal-type nicotinic acetylcholine receptors

 Muriel Amar , Rómulo Aráoz , Bogdan Iorga , Takeshi Yasumoto , Denis Servent , et al.
Toxicon, 2018, 149, pp.103-104. ⟨10.1016/j.toxicon.2018.02.029⟩
Article dans une revue hal-03164771v1

Spiroimine toxins in complex with nicotinic acetylcholine receptors: structure and dynamics

 Romulo Araoz , Laurent Chabaud , Catherine Guillou , Jordi Molgó , Bogdan Iorga
Biophysical Journal, 2011, 100 (3, suppl1), pp.347a. ⟨10.1016/j.bpj.2010.12.2093⟩
Article dans une revue hal-00647637v1
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The neurotoxic effect of 13, 19-didesmethyl and 13-desmethyl spirolide C phycotoxins is mainly mediated by nicotinic rather than muscarinic acetylcholine receptors.

 Rómulo Aráoz , Gilles Ouanounou , Bogdan I Iorga , Amélie Goudet , Doria Alili , et al.
Toxicological Sciences, 2015, 147 (1), pp.156-167. ⟨10.1093/toxsci/kfv119⟩
Article dans une revue hal-01165573v1
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Synthetic Pinnatoxins A and G Reversibly Block Mouse Skeletal Neuromuscular Transmission In Vivo and In Vitro

 Evelyne Benoit , Aurélie Couesnon , Jiri Lindovsky , Bogdan Iorga , Rómulo Aráoz , et al.
Marine drugs, 2019, 17 (E306), pp.1-17. ⟨10.3390/md17050306⟩
Article dans une revue hal-02194723v1

Cyclic imine toxins: chemistry, origin, metabolism, pharmacology, toxicology, and detection

 Jordi Molgó , Romulo Aráoz , Evelyne Benoit , Bogdan I Iorga
Botana, L.M. Seafood and freshwater toxins. Pharmacology physiology and detection. 3rd, Taylor & Francis, pp.951-990, 2014, 978-1-4665-0514-8. ⟨10.1201/b16662-39⟩
Chapitre d'ouvrage hal-00955771v1
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Metabolism of the lipophilic phycotoxin 13-Desmethylspirolide C using human and rat in vitro liver models

 Jimmy H Alarcan , Estelle Dubreil-Cheneau , Antoine H Huguet , Romulo Araoz , Françoise Brée , et al.
Toxicology Letters, 2019, 307, pp.17-25. ⟨10.1016/j.toxlet.2019.02.012⟩
Article dans une revue anses-02083152v1
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Diversity in the binding interactions of nicotinic ligands to the nAChRs and associated conformational fluctuations − Insights into the core motif dictating antagonism

 Yves Bourne , Gerlind Sulzenbacher , Zoran Radić , Laurent Chabaud , Rómulo Aráoz , et al.
RT26 – 26th Meeting of the French Society of Toxinology – Bioengineering of Toxins, French Society of Toxinology (SFET), Dec 2019, Paris, France
Communication dans un congrès hal-04469851v1
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The cyclic imine family of dinoflagellate toxins targeting nicotinic acetylcholine receptors

 Jordi Molgó , Muriel Amar , Rómulo Aráoz , Evelyne Benoit , Bogdan Iorga , et al.
19th World Congress of the International Society on Toxinology (IST), Toxicon, 158, pp.S22, 2019, ⟨10.1016/j.toxicon.2018.10.080⟩
Proceedings/Recueil des communications hal-02334357v1

Les spirolides: une famille de toxines émergentes qui contaminent les mollusques bivalves

 Riadh Marrouchi , Sébastien Schlumberger , Evelyne Benoit , Rómulo Aráoz , Riadh Kharrat , et al.
Benoit E., Goudey-Perrière F., Marchot P. & Servent D. Toxines et fonctions cholinergiques neuronales et non neuronales, Editions de la SFET, Châtenay-Malabry, France, pp.13-17, 2008, Collection Rencontres en toxinologie
Chapitre d'ouvrage hal-00348267v1

Development of a Solid-Phase Receptor-Based Assay for the Detection of Cyclic Imines Using a Microsphere-Flow Cytometry System.

 Laura Pérez Rodríguez , Natalia Vilariño , Jordi Molgó , Rómulo Aráoz , M. Carmen Louzao , et al.
Analytical Chemistry, 2013, 85 (4), pp.2340-7. ⟨10.1021/ac3033432⟩
Article dans une revue hal-00781176v1

Detection of 13, 19-didesmethyl C spirolide by fluorescence polarization using Torpedo electrocyte membranes.

 Eva S Fonfría , Natalia Vilariño , Jordi Molgó , Rómulo Aráoz , Paz Otero , et al.
Analytical Biochemistry, 2010, 403 (1-2), pp.102-7. ⟨10.1016/j.ab.2010.04.006⟩
Article dans une revue istex hal-00474310v1

Cyclic imine toxins: From shellfish poisoning to neuroscience: The case of acyl derivatives

 Rómulo Aráoz , Philipp Hess , Franck Pélissier , Evelyne Benoit , Denis Servent , et al.
5th nAChR satellite symposium on « Nicotinic Acetylcholine Receptors as Therapeutic Targets: Emerging Frontiers in Basic Research & Clinical Science », Oct 2015, Chicago, United States. pp.622, ⟨10.1016/j.bcp.2015.08.007⟩
Communication dans un congrès hal-02334385v1

6,6-Spiroimine analogs of (-)-gymnodimine A: synthesis and biological evaluation on nicotinic acetylcholine receptors.

 Leslie Duroure , Thierry Jousseaume , Rómulo Aráoz , Elvina Barré , Pascal Retailleau , et al.
Organic & Biomolecular Chemistry, 2011, 9 (23), pp.8112-8. ⟨10.1039/c1ob06257c⟩
Article dans une revue hal-00637236v1
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Towards an immunodiagnostic test for leprosy.

 Romulo Aráoz , Nadine Honoré , Sayera Banu , Caroline Demangel , Yakouba Cissoko , et al.
Microbes and Infection, 2006, 8 (8), pp.2270-6. ⟨10.1016/j.micinf.2006.04.002⟩
Article dans une revue pasteur-01370874v1

Colorimetric microtiter plate receptor-binding assay for the detection of freshwater and marine neurotoxins targeting the nicotinic acetylcholine receptors.

 Fernando Rubio , Lisa Kamp , Justin Carpino , Erin Faltin , Keith Loftin , et al.
Toxicon, 2014, 91, pp.45-56. ⟨10.1016/j.toxicon.2014.08.073⟩
Article dans une revue hal-01165541v1

Detection of gymnodimine-A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization.

 Natalia Vilariño , Eva S Fonfría , Jordi Molgó , Rómulo Aráoz , Luis M Botana
Analytical Chemistry, 2009, 81 (7), pp.2708-14. ⟨10.1021/ac900144r⟩
Article dans une revue hal-00378092v1

Total synthesis of pinnatoxins A and G and revision of the mode of action of pinnatoxin A.

 Romulo Araoz , Denis Servent , Jordi Molgó , Bogdan I Iorga , Carole Fruchart-Gaillard , et al.
Journal of the American Chemical Society, 2011, 133 (27), pp.10499-10511. ⟨10.1021/ja201254c⟩
Article dans une revue hal-00634136v1

Physical and virtual screening methods for marine toxins and drug discovery targeting nicotinic acetylcholine receptors.

 Jordi Molgó , Rómulo Aráoz , Evelyne Benoit , Bogdan I Iorga
Expert Opinion on Drug Discovery, 2013, 8 (10), pp.1203-1223. ⟨10.1517/17460441.2013.822365⟩
Article dans une revue hal-00856775v1
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The block of skeletal muscle nicotinic acetylcholine receptors caused by cyclic imine toxins can be antagonized by 3,4-diaminopyridine at isolated mouse neuromuscular preparation

 Nicolas Lamassiaude , Evelyne Benoit , Rómulo Aráoz , Armen Zakarian , Denis Servent , et al.
PHYCOTOX 2023 - GDR Annual Conference on Toxic Microalgae, Institut Francais de Recherche pour l’Exploitation de la Mer (Ifremer), May 2023, Nantes, France
Communication dans un congrès hal-04473953v1

Micro-transplantation de membranes natives dans l'ovocyte de Xénope pour la reconstitution des récepteurs nicotiniques à l'acétylcholine in vitro et l'étude d'agents neurotoxiques.

 Rómulo Aráoz , Muriel Amar , Sandrine Lecardeur , Roland Bournaud , Philippe Fossier , et al.
Journée scientifique NRBC mars 2006, 2006, Grenoble, France
Communication dans un congrès hal-00125071v1
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Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α12βγδ nAChRs.

 Yves Bourne , Gerlind Sulzenbacher , Zoran Radić , Rómulo Aráoz , Morgane Reynaud , et al.
Structure (London, England : 1993), 2015, 23 (6), pp.1106-15. ⟨10.1016/j.str.2015.04.009⟩
Article dans une revue hal-01178822v1
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NeuroTorp, a lateral flow test based on toxin-receptor affinity for in-situ early detection of cyclic imine toxins

 Fanny Noirmain , Julie Dano , Nathalie Hue , Jesús Gonzalez-Jartin , Luis Botana , et al.
Analytica Chimica Acta, 2022, 1221, pp.339941. ⟨10.1016/j.aca.2022.339941⟩
Article dans une revue hal-03876882v1

Pinnatoxins: an emergent family of marine phycotoxins targeting nicotinic acetylcholine receptors with high affinity

 Rómulo Aráoz , Denis Servent , Jordi Molgo , Bogdan Iorga , C. Fruchard-Gaillard , et al.
J. Barbier, E. Benoit, N. Gilles, D. Ladant, M.-F. Martin-Eauclaire, C. Mattéi, J. Molgó, M.R. Poppof & D. Servent. Toxins and Ion transfers, SFET Publications, pp.43-47, 2011, Collection Rencontres en Toxinologie, 1760-6004
Chapitre d'ouvrage hal-02334617v1
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Spirolides and Cyclic Imines: Toxicological Profile

 Jordi Molgó , Evelyne Benoit , Rómulo Aráoz , Armen Zakarian , Bogdan Iorga
Marine and Freshwater Toxins, Springer Netherlands, pp.193-217, 2016, ⟨10.1007/978-94-007-6419-4_23⟩
Chapitre d'ouvrage hal-02334618v1

Diversity in the binding interactions of marine phycotoxins to AChBP, the soluble nAChR surrogate

 Pascale Marchot , Gerlind Sulzenbacher , Zoran Radic , Rómulo Aráoz , Emmanuelle Reynaud , et al.
XVth International Symposium on Cholinergic Mechanisms, Oct 2017, Marseille, France. pp.196, ⟨10.1111/jnc.13925⟩
Communication dans un congrès hal-02334376v1

Parazoanthoxanthin A blocks Torpedo nicotinic acetylcholine receptors.

 Klara Bulc Rozman , Rómulo Aráoz , Kristina Sepčić , Jordi Molgó , Dušan Suput
Chemico-Biological Interactions, 2010, 187 (1-3), pp.384-7. ⟨10.1016/j.cbi.2010.03.016⟩
Article dans une revue istex hal-00464523v1
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Antigen discovery: a postgenomic approach to leprosy diagnosis.

 Romulo Aráoz , Nadine Honoré , Sungae Cho , Jong-Pill Kim , Sang-Nae Cho , et al.
Infection and Immunity, 2006, 74 (1), pp.175-82. ⟨10.1128/IAI.74.1.175-182.2006⟩
Article dans une revue pasteur-00204119v1

Mechanism-Based Inactivation of VanX, a d -Alanyl- d -alanine Dipeptidase Necessary for Vancomycin Resistance †

 Rómulo Aráoz , Elizabeth Anhalt , Loïc René , Marie-Ange Badet-Denisot , Patrice Courvalin , et al.
Biochemistry, 2000, 39 (51), pp.15971-15979. ⟨10.1021/bi001408b⟩
Article dans une revue istex hal-02144715v1

Bioassays for detection and identification of cyclic imine toxins

 Rómulo Aráoz , Jordi Molgó , Denis Servent
Harmful Algae 2018 – From Ecosystems to Socio-Ecosystems, Philipp Hess, Oct 2018, Nantes, France. pp.118-121
Communication dans un congrès hal-03091407v1
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