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Rodolphe Thiébaut

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Présentation

**Position title** · ***Professor (PUPH) of* *Public Health,* *Bordeaux University*** · ***Director the* *INSERM/**INRIA team SISTM: Statistics in Systems Biology and Translational Medicine*** (Since 2013, 25 people, [http://www.bordeaux-population-health.center/en/teams/statistics-in-systems-biology-and-translationnal-medicine-sistm/*)*](http://www.bordeaux-population-health.center/en/teams/statistics-in-systems-biology-and-translationnal-medicine-sistm/)) · ***Director of the Bioinformatics/Biostatistics Division of the Vaccine Research Institute*** (VRI, <http://vaccine-research-institute.fr/en/)> · ***Director of the Department of research in Public Health at the Bordeaux University*** (Since 2019) and ***Deputy Director of the INSERM Research Centre U1219*** (Since 2008, formally U897, 460 people, <http://www.bordeaux-population-health.center/en/)> · *Director of the Medical Information Department at Bordeaux Hospital* (Since 2019) · ***Director of the Digital Public Health Graduate School*** (Since 2018) · ***Member of the INSERM scientific committee*** (Since 2017) Education ========= Institution and location Degree Year Field of study Bordeaux University M.D. 2000 Public Health Bordeaux University Ph.D. 2002 Biostatistics Bordeaux University Diploma for PhD student supervision (HDR) 2004 - Previous Positions ================== ü 2013-2019: Director of the Bordeaux Hospital Clinical Trial Unit (Since 2013, 25 people, <http://usmr.isped.u-bordeaux2.fr)> ü 2012-2014: Deputy director of the Institute of Research in Public Health (IReSP http://www.iresp.net/) ü 2009-2014: Deputy Director of the Bordeaux School of Public Health (ISPED) for Research (www.isped.u-bordeaux.fr) ü 2002-2013: Researcher (CR2, CR1) and Research Director (DR2) at the French Institute for Health and Medical Research (INSERM), Research Centre U897 “Epidemiology and Biostatistics” (Tenure Track since 2002) Teaching activities =================== ü Director of the Master in Science “Public Health Data Science” (Since 2018) ü Responsible of the modelling unit for medical students and of the mathematics unit for medicine/science cursus ü Analysis of longitudinal data for Master Students (Since 2000, 30 hours/year) and Summer School

Publications

Redefining pandemic preparedness: Multidisciplinary insights from the CERP modelling workshop in infectious diseases, workshop report

Marta Nunes , Edward Thommes , Holger Fröhlich , Antoine Flahault , Julien Arino
Infectious Disease Modelling, 2024, 9 (2), pp.501-518. ⟨10.1016/j.idm.2024.02.008⟩
Article dans une revue hal-04501375v1
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Rapid access to innovative medicinal products while ensuring relevant health technology assessment. Position of the French National Authority for Health

Antoine Vanier , Judith Fernandez , Sophie Kelley , Lise Alter , Patrick Semenzato
BMJ Evidence-Based Medicine, 2024, 29 (1), pp.1-5. ⟨10.1136/bmjebm-2022-112091⟩
Article dans une revue hal-04056273v1
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Post-clustering difference testing: valid inference and practical considerations

Benjamin Hivert , Denis Agniel , Rodolphe Thiébaut , Boris P. Hejblum
Computational Statistics and Data Analysis, 2024, 193, pp.107916. ⟨10.1016/j.csda.2023.107916⟩
Article dans une revue hal-03889565v1
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Estimating the population effectiveness of interventions against COVID-19 in France: A modelling study

Iris Ganser , David L Buckeridge , Jane Heffernan , Mélanie Prague , Rodolphe Thiébaut
Epidemics, 2024, 46, pp.100744. ⟨10.1016/j.epidem.2024.100744⟩
Article dans une revue hal-04505758v1

ChatGPT et au-delà avec l’intelligence artificielle en santé : des leçons à tirer

Rodolphe Thiébaut , Boris P. Hejblum , Fleur Mougin , Christophe Tzourio , Laura Richert
Revue du Rhumatisme, 2024, 91 (1), pp.12-15. ⟨10.1016/j.rhum.2023.07.007⟩
Article dans une revue hal-04466670v1
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Development and external validation of a prediction model for the transition from mild to moderate or severe form of COVID-19

Maéva Zysman , Julien Asselineau , Olivier Saut , Eric Frison , Mathilde Oranger
European Radiology, 2023, 33, pp.9262-9274. ⟨10.1007/s00330-023-09759-x⟩
Article dans une revue hal-04153209v1
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Impact of non-pharmaceutical interventions, weather, vaccination, and variants on COVID-19 transmission across departments in France

Juliette Paireau , Marie-Laure Charpignon , Sophie Larrieu , Clémentine Calba , Nathanaël Hozé
BMC Infectious Diseases, 2023, 23 (190), ⟨10.1186/s12879-023-08106-1⟩
Article dans une revue hal-03791761v2
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On the Choice of Longitudinal Models for the Analysis of Antitumor Efficacy in Mouse Clinical Trials of Patient-derived Xenograft Models

Hélène Savel , Sandrine Barbier , Cécile Proust-Lima , Virginie Rondeau , Rodolphe Thiébaut
Cancer Research Communications, 2023, 3 (1), pp.140-147. ⟨10.1158/2767-9764.CRC-22-0238⟩
Article dans une revue hal-04403048v1
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Parameter estimation in nonlinear mixed effect models based on ordinary differential equations: An optimal control approach

Quentin Clairon , Chloé Pasin , Irene Balelli , Rodolphe Thiébaut , Mélanie Prague
Computational Statistics, 2023
Article dans une revue hal-03335826v2
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Modeling the kinetics of the neutralizing antibody response against SARS-CoV-2 variants after several administrations of Bnt162b2

Quentin Clairon , Mélanie Prague , Delphine Planas , Timothée Bruel , Laurent Hocqueloux
PLoS Computational Biology, 2023, 19 (8), pp.e1011282. ⟨10.1371/journal.pcbi.1011282⟩
Article dans une revue pasteur-04369645v1
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Evaluating the Use of Generalized Dynamic Weighted Ordinary Least Squares for Individualized Hiv Treatment Strategies

Larry Dong , Erica E. M. Moodie , Laura Villain , Rodolphe Thiébaut
Annals of Applied Statistics, 2023, 17 (3), pp.2432-2451. ⟨10.1214/22-aoas1726⟩
Article dans une revue hal-04344321v1
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Assessment of circulating blood lymphocytes in adult patients on rituximab to treat immune thrombocytopenia: Circulating number of NK cells is associated with the response at 6 months.

Etienne Rivière , Rodolphe Thiébaut , Estibaliz Lazaro , Alexandre Guy , Chloé James
British Journal of Haematology, inPress, ⟨10.1111/bjh.18818⟩
Article dans une revue hal-04095049v1
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Using Population Based Kalman Estimator to Model COVID-19 Epidemic in France: Estimating the Effects of Non-Pharmaceutical Interventions on the Dynamics of Epidemic

Annabelle Collin , Boris P. Hejblum , Carole Vignals , Laurent Lehot , Rodolphe Thiébaut
The international journal of biostatistics, In press, ⟨10.1515/ijb-2022-0087⟩
Article dans une revue hal-04151651v1
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Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in infants: a phase 2, randomised, double-blind, active-controlled trial in Guinea and Sierra Leone

Edward Man-Lik Choi , Boris Lacarra , Muhammed O Afolabi , Boni Maxime Ale , Frank Baiden
The Lancet global health, 2023, 11 (11), pp.e1743-e1752. ⟨10.1016/S2214-109X(23)00410-2⟩
Article dans une revue hal-04384862v1
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ChatGPT and beyond with artificial intelligence (AI) in health: Lessons to be learned.

Rodolphe Thiebaut , Boris P. Hejblum , Fleur Mougin , Christophe Tzourio , Laura Richert
Joint Bone Spine, 2023, 90 (5), pp.105607. ⟨10.1016/j.jbspin.2023.105607⟩
Article dans une revue hal-04236822v1
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Doubly-robust evaluation of high-dimensional surrogate markers

Denis Agniel , Boris Hejblum , Rodolphe Thiébaut , Layla Parast
Biostatistics, 2023, 24 (4), pp.985-999. ⟨10.1093/biostatistics/kxac020⟩
Article dans une revue hal-03100499v1
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Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19

Hakim Hocini , Aurélie Wiedemann , Fabiola Blengio , Cécile Lefebvre , Minerva Cervantes-Gonzalez
Journal of Clinical Immunology, 2023, 43 (5), pp.882-893. ⟨10.1007/s10875-023-01459-x⟩
Article dans une revue hal-04373844v1
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Prediction of long-term humoral response induced by the two-dose heterologous Ad26.ZEBOV, MVA-BN-Filo vaccine against Ebola

Marie Alexandre , Mélanie Prague , Chelsea Mclean , Viki Bockstal , Macaya Douoguih
NPJ vaccines, 2023, 8 (174), ⟨10.1038/s41541-023-00767-y⟩
Article dans une revue hal-04226696v2
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Identification of early gene expression profiles associated with long-lasting antibody responses to the Ebola vaccine Ad26.ZEBOV/MVA-BN-Filo

Fabiola Blengio , Hakim Hocini , Laura Richert , Cécile Lefebvre , Melany Durand
Cell Reports, 2023, 42 (9), pp.113101. ⟨10.1016/j.celrep.2023.113101⟩
Article dans une revue hal-04273901v1
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Modeling the evolution of the neutralizing antibody response against SARS-CoV-2 variants after several administrations of Bnt162b2

Quentin Clairon , Mélanie Prague , Delphine Planas , Timothée Bruel , Laurent Hocqueloux
PLoS Computational Biology, 2023
Article dans une revue hal-03946556v1

Within-host models of SARS-CoV-2: What can it teach us on the biological factors driving virus pathogenesis and transmission?

Mélanie Prague , Marie Alexandre , Rodolphe Thiébaut , Jérémie Guedj
Anaesthesia Critical Care & Pain Medicine, 2022, 41 (2), pp.101055. ⟨10.1016/j.accpm.2022.101055⟩
Article dans une revue hal-03691907v1

Enriching single-arm clinical trials with external controls: possibilities and pitfalls

Jérôme Lambert , Etienne Lengliné , Raphaël Porcher , Rodolphe Thiébaut , Sarah Zohar
Blood Advances, In press, ⟨10.1182/bloodadvances.2022009167⟩
Article dans une revue hal-03914596v1

Incidence of cytomegalovirus infection in seropositive kidney transplant recipients treated with everolimus: A randomized, open‐label, multicenter phase 4 trial

Hannah Kaminski , Nassim Kamar , Olivier Thaunat , Nicolas Bouvier , Sophie Caillard
American Journal of Transplantation, 2022, ⟨10.1111/ajt.16946⟩
Article dans une revue hal-03605036v1
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NK Cell Subset Redistribution and Antibody Dependent Activation after Ebola Vaccination in Africans

Helen R Wagstaffe , Omu Anzala , Hannah Kibuuka , Zacchaeus Anywaine , Sodiomon B Sirima
Vaccines, 2022, 10 (6), pp.884. ⟨10.3390/vaccines10060884⟩
Article dans une revue hal-04418906v1
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Data-Driven Sparse Partial Least Squares

Hadrien Lorenzo , Olivier Cloarec , Rodolphe Thiébaut , Jérôme Saracco
Statistical Analysis and Data Mining, 2022, 15 (2), pp.264-282. ⟨10.1002/sam.11558⟩
Article dans une revue hal-03368956v1

Global Variations in Event-Based Surveillance for Disease Outbreak Detection: Time Series Analysis

Iris Ganser , Rodolphe Thiébaut , David Buckeridge
JMIR Public Health and Surveillance, 2022, 8 (10), pp.e36211. ⟨10.2196/36211⟩
Article dans une revue hal-03919665v1

The benefit of augmenting open data with clinical data-warehouse EHR for forecasting SARS-CoV-2 hospitalizations in Bordeaux area, France

Thomas Ferté , Vianney Jouhet , Romain Griffier , Boris Hejblum , Rodolphe Thiébaut
JAMIA open, 2022, 5 (4), ⟨10.1093/jamiaopen/ooac086⟩
Article dans une revue hal-03908260v1
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Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection

Marie Alexandre , Romain Marlin , Mélanie Prague , Séverin Coleon , Nidhal Kahlaoui
eLife, 2022, 11, pp.e75427. ⟨10.7554/eLife.75427⟩
Article dans une revue hal-03482728v2
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Inhaled ciclesonide for outpatient treatment of COVID-19 in adults at risk of adverse outcomes: a randomised controlled trial (COVERAGE)

Alexandre Duvignaud , Edouard Lhomme , Racha Onaisi , Rémi Sitta , Ambre Gelley
Clinical Microbiology and Infection, 2022, 28 (7), pp.1010-1016. ⟨10.1016/j.cmi.2022.02.031⟩
Article dans une revue hal-03690132v1

Incidence of cytomegalovirus infection in seropositive kidney transplant recipients treated with everolimus: A randomized, open‐label, multicenter phase 4 trial

Hannah Kaminski , Nassim Kamar , Olivier Thaunat , Nicolas Bouvier , Sophie Caillard
American Journal of Transplantation, 2022, 22 (5), pp.1430-1441. ⟨10.1111/ajt.16946⟩
Article dans une revue hal-03848627v1
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Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection

Marie Alexandre , Romain Marlin , Mélanie Prague , Severin Coleon , Nidhal Kahlaoui
eLife, 2022, 11, ⟨10.7554/elife.75427⟩
Article dans une revue hal-04510052v1

Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in children and adolescents in Africa: A randomised, placebo-controlled, multicentre Phase II clinical trial

Zacchaeus Anywaine , Houreratou Barry , Omu Anzala , Gaudensia Mutua , Sodiomon Sirima
PLoS Medicine, 2022, 19 (1), pp.e1003865. ⟨10.1371/journal.pmed.1003865⟩
Article dans une revue hal-03690128v1

Methodological guidelines to estimate population-based health indicators using linked data and/or machine learning techniques

Romana Haneef , Mariken Tijhuis , Rodolphe Thiébaut , Ondřej Májek , Ivan Pristaš
Archives of Public Health, 2022, 80 (9), pp.9. ⟨10.1186/s13690-021-00770-6⟩
Article dans une revue hal-03692820v1

T Cell Immunogenicity, Gene Expression Profile, and Safety of Four Heterologous Prime-Boost Combinations of HIV Vaccine Candidates in Healthy Volunteers: Results of the Randomized Multi-Arm Phase I/II ANRS VRI01 Trial

Laura Richert , Jean-Daniel Lelievre , Christine Lacabaratz , Lucile Hardel , Hakim Hocini
Journal of Immunology, 2022, 208 (12), pp.2663-2674. ⟨10.4049/jimmunol.2101076⟩
Article dans une revue hal-03690137v1
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The respiratory microbiota alpha-diversity in chronic lung diseases: first systematic review and meta-analysis

Marta Avalos , Clémence Métayer , Thibaud Alin , Rodolphe Thiébaut , Raphaël Enaud
Respiratory Research, 2022, 23 (214), ⟨10.1186/s12931-022-02132-4⟩
Article dans une revue hal-03762542v1

High temporal resolution transcriptomic profiling delineates distinct patterns of interferon response following Covid-19 mRNA vaccination and SARS-CoV2 infection

Darawan Rinchai , Sara Deola , Gabriele Zoppoli , Basirudeen Syed Ahamed Kabeer , Sara Taleb
Science Advances , 2022, 8 (45), eabp9961. ⟨10.1126/sciadv.abp9961⟩
Article dans une revue hal-03530948v1

Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine

Séverin Coléon , Aurélie Wiedemann , Mathieu Surénaud , Christine Lacabaratz , Sophie Hue
EBioMedicine, 2022, 80, pp.104062. ⟨10.1016/j.ebiom.2022.104062⟩
Article dans une revue hal-03692817v1
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Evolution of body composition following successful kidney transplantation is strongly influenced by physical activity: results of the CORPOS study

Karine Moreau , Aurélie Desseix , Christine Germain , Pierre Merville , Lionel Couzi
BMC Nephrology, 2021, 22 (1), pp.31. ⟨10.1186/s12882-020-02214-9⟩
Article dans une revue hal-03142794v1

Random forests for high-dimensional longitudinal data

Louis Capitaine , Robin Genuer , Rodolphe Thiébaut
Statistical Methods in Medical Research, 2021, 30 (1), pp.166-184. ⟨10.1177/0962280220946080⟩
Article dans une revue hal-03481508v1
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Health Care Students’ Knowledge of and Attitudes, Beliefs, and Practices Toward the French COVID-19 App: Cross-sectional Questionnaire Study

Ilaria Montagni , Nicolas Roussel , Rodolphe Thiébaut , Christophe Tzourio
Journal of Medical Internet Research, 2021, 23 (3), pp.e26399. ⟨10.2196/26399⟩
Article dans une revue hal-03189015v1
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mTOR Inhibitors Prevent CMV Infection through the Restoration of Functional αβ and γδ T cells in Kidney Transplantation

Hannah Kaminski , Gabriel Marseres , Nathalie Yared , Marie-Julie Nokin , Vincent Pitard
Journal of the American Society of Nephrology, inPress, pp.121-137. ⟨10.1681/ASN.2020121753⟩
Article dans une revue hal-03451674v1

Influence of the Antiretroviral Regimen on the Early Changes in Plasma HIV RNA and Immune Activation at Initiation of Antiretroviral Therapy in Naïve HIV-1–Infected Patients

Assia Samri , Mathieu Chalouni , Julià Blanco , Georg Behrens , Peter Kelleher
Journal of Acquired Immune Deficiency Syndromes - JAIDS, 2021, 86 (5), pp.e146-e149. ⟨10.1097/QAI.0000000000002594⟩
Article dans une revue hal-03526543v1
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Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques

Romain Marlin , Veronique Godot , Sylvain Cardinaud , Mathilde Galhaut , Severin Coleon
Nature Communications, 2021, 12, pp.5215. ⟨10.1038/s41467-021-25382-0⟩
Article dans une revue hal-03481526v1

Safety and immunogenicity of 2-dose heterologous Ad26.ZEBOV, MVA-BN-Filo Ebola vaccination in healthy and HIV-infected adults: A randomised, placebo-controlled Phase II clinical trial in Africa

Houreratou Barry , Gaudensia Mutua , Hannah Kibuuka , Zacchaeus Anywaine , Sodiomon Sirima
PLoS Medicine, 2021, 18 (10), pp.e1003813. ⟨10.1371/journal.pmed.1003813⟩
Article dans une revue hal-03481531v1
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mTOR Inhibitors Prevent CMV Infection through the Restoration of Functional αβ and γδ T cells in Kidney Transplantation.

Hannah Kaminski , Gabriel Marseres , Nathalie Yared , Marie-Julie Nokin , Vincent Pitard
Journal of the American Society of Nephrology, 2021, ⟨10.1681/ASN.2020121753⟩
Article dans une revue hal-03452119v1
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Between group comparison of AUC in clinical trials with censored follow-up: Application to HIV therapeutic vaccines

Marie Alexandre , Mélanie Prague , Rodolphe Thiébaut
Statistical Methods in Medical Research, 2021, ⟨10.1177/09622802211023963⟩
Article dans une revue hal-03241637v2
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EpidemiOptim: a Toolbox for the Optimization of Control Policies in Epidemiological Models

Cédric Colas , Boris P. Hejblum , Sébastien Rouillon , Rodolphe Thiébaut , Pierre-Yves Oudeyer
Journal of Artificial Intelligence Research, 2021, 71, pp.479-515. ⟨10.1613/jair.1.12588⟩
Article dans une revue hal-03099898v2
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Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques

Romain Marlin , Veronique Godot , Sylvain Cardinaud , Mathilde Galhaut , Severin Coleon
Nature Communications, 2021, 12, ⟨10.1038/s41467-021-25382-0⟩
Article dans une revue hal-04510002v1

Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries

Moses Badio , Edouard Lhomme , Mark Kieh , Abdoul Habib Beavogui , Stephen Kennedy
Trials, 2021, 22 (1), pp.86. ⟨10.1186/s13063-021-05035-9⟩
Article dans une revue hal-03526667v1

Correction to: Evolution of body composition following successful kidney transplantation is strongly influenced by physical activity: results of the CORPOS study

Karine Moreau , Aurélie Desseix , Christine Germain , Pierre Merville , Lionel Couzi
BMC Nephrology, 2021, 22 (1), ⟨10.1186/s12882-021-02258-5⟩
Article dans une revue hal-03186351v1
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Barrier Gesture Relaxation during Vaccination Campaign in France: Modelling Impact of Waning Immunity

Carole Vignals , David W Dick , Rodolphe Thiébaut , Linda Wittkop , Mélanie Prague
COVID, 2021, 1 (2), pp.472-488. ⟨10.3390/covid1020041⟩
Article dans une revue hal-03375281v1
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A randomized placebo-controlled efficacy study of a prime boost therapeutic vaccination strategy in HIV-1 infected individuals: VRI02 ANRS 149 LIGHT Phase II trial

Y. Levy , C. Lacabaratz , Edouard Lhomme , A. Wiedemann , Claire Bauduin
Journal of Virology, inPress, ⟨10.1128/jvi.02165-20⟩
Article dans une revue hal-03188939v1
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A Conceptual Discussion about R0 of SARS-COV-2 in Healthcare Settings

Laura Temime , Marie-Paule Gustin , Audrey Duval , Niccolò Buetti , Pascal Crepey
Clinical Infectious Diseases, 2021, pp.ciaa682. ⟨10.1093/cid/ciaa682⟩
Article dans une revue hal-02859847v1
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CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death

Yves Lévy , Aurélie Wiedemann , Boris P. Hejblum , Mélany Durand , Cécile Lefebvre
iScience, 2021, 24 (7), pp.102711. ⟨10.1016/j.isci.2021.102711⟩
Article dans une revue hal-03477973v1
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Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

Matthew C Altman , Darawan Rinchai , Nicole Baldwin , Mohammed Toufiq , Elizabeth Whalen
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-24584-w⟩
Article dans une revue hal-03481522v1
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New Insights in Microbial Species Predicting Lung Function Decline in CF: Lessons from the MucoFong Project

Florence Francis , Raphael Enaud , Perrine Soret , Florian Lussac-Sorton , Marta Avalos
Journal of Clinical Medicine, 2021, 10 (16), pp.3725. ⟨10.3390/jcm10163725⟩
Article dans une revue hal-03328143v1
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Durable natural killer cell responses after heterologous two-dose Ebola vaccination

Helen R. Wagstaffe , Giada Susannini , Rodolphe Thiébaut , Laura Richert , Yves Lévy
NPJ vaccines, 2021, 6 (1), pp.19. ⟨10.1038/s41541-021-00280-0⟩
Article dans une revue hal-03158135v1
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A machine learning approach for predicting suicidal thoughts and behaviours among college students

Melissa Macalli , Marie Navarro , Massimiliano Orri , Marie Tournier , Rodolphe Thiebaut
Scientific Reports, 2021, 11 (1), pp.11363. ⟨10.1038/s41598-021-90728-z⟩
Article dans une revue hal-03323054v1
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ESO Guideline on covert cerebral small vessel disease

Joanna M. Wardlaw , Stephanie Debette , Hanna Jokinen , Frank-Erik de Leeuw , Leonardo Pantoni
European Stroke Journal, 2021, ⟨10.1177/23969873211012132⟩
Article dans une revue hal-03282826v1

The impact of clopidogrel on plasma-soluble CD40 ligand levels in systemic lupus erythematosus patients: the CLOPUS phase I/II pilot study

Guillaume Vial , Noémie Gensous , Hélène Savel , Christophe Richez , Estibaliz Lazaro
Joint Bone Spine, 2021, 88 (2), pp.105097. ⟨10.1016/j.jbspin.2020.105097⟩
Article dans une revue hal-03142764v1
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Immune Alterations in a Patient with SARS-CoV-2-Related Acute Respiratory Distress Syndrome

Lila Bouadma , Aurélie Wiedemann , Juliette Patrier , Mathieu Surénaud , Paul-Henri Wicky
Journal of Clinical Immunology, 2020, 40, pp.1082-1092. ⟨10.1007/s10875-020-00839-x⟩
Article dans une revue hal-03160737v2
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Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1–positive individuals

Mathieu Chalouni , Javier Rodriguez-Centeno , Assia Samri , Julian Blanco , Natalia Stella-Ascariz
PLoS ONE, 2020, 15 (4), pp.e0230772. ⟨10.1371/journal.pone.0230772⟩
Article dans une revue inserm-02543732v1
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Safety and immunogenicity of a two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Europe (EBOVAC2): a randomised, observer-blind, participant-blind, placebo-controlled, phase 2 trial

Andrew Pollard , Odile Launay , Jean-Daniel Lelievre , Christine Lacabaratz , Sophie Grande
The Lancet Infectious Diseases, 2020, ⟨10.1016/S1473-3099(20)30476-X⟩
Article dans une revue hal-03142752v1
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A model for establishment, maintenance and reactivation of the immune response after vaccination against Ebola virus

Irene Balelli , Chloé Pasin , Mélanie Prague , Fabien Crauste , Thierry van Effelterre
Journal of Theoretical Biology, 2020, 495, pp.110254. ⟨10.1016/j.jtbi.2020.110254⟩
Article dans une revue hal-03160892v2

The impact of clopidogrel on plasma-soluble CD40 ligand levels in systemic lupus erythematosus patients: the CLOPUS phase I/II pilot study

Guillaume Vial , Noémie Gensous , Hélène Savel , Christophe Richez , Estibaliz Lazaro
Joint Bone Spine, 2020, 88 (2), pp.105097. ⟨10.1016/j.jbspin.2020.105097⟩
Article dans une revue hal-03160699v1
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Long-lasting severe immune dysfunction in Ebola virus disease survivors

Aurélie Wiedemann , Emile Foucat , Hakim Hocini , Cécile Lefebvre , Boris Hejblum
Nature Communications, 2020, 11 (1), pp.3730. ⟨10.1038/s41467-020-17489-7⟩
Article dans une revue hal-03160838v2

A Comparison of Cell Activation, Exhaustion, and Expression of HIV Coreceptors and Restriction Factors in HIV-1- and HIV-2-Infected Nonprogressors

Mariama Sadjo Diallo , Assia Samri , Charlotte Charpentier , Mélanie Bertine , Rémi Cheynier
AIDS Research and Human Retroviruses, inPress, 37 (3), pp.214-223. ⟨10.1089/AID.2020.0084⟩
Article dans une revue hal-03090206v1
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Correlation between blood telomere length and CD4+ CD8+ T-cell subsets changes 96 weeks after initiation of antiretroviral therapy in HIV-1-positive individuals

Mathieu Chalouni , Javier Rodriguez-Centeno , Assia Samri , Julian Blanco , Natalia Stella-Ascariz
PLoS ONE, 2020, 15 (4), 9 p
Article dans une revue hal-03160741v1

Comment la modélisation peut-elle aider au développement des vaccins ?

Rodolphe Thiébaut , Joanna Jongwane
Interstices, 2020
Article dans une revue hal-02929092v1

Influence of the ARV regimen on the early changes in plasma HIV RNA and immune activation at initiation of antiretroviral therapy in naïve HIV-1-infected patients

Assia Samri , Mathieu Chalouni , Julià Blanco , Georg Behrens , Peter Kelleher
Journal of Acquired Immune Deficiency Syndromes - JAIDS, 2020, Publish Ahead of Print, ⟨10.1097/QAI.0000000000002594⟩
Article dans une revue hal-03142789v1

Optimal priming of poxvirus vector (NYVAC)-based HIV vaccine regimens for T cell responses requires three DNA injections. Results of the randomized multicentre EV03/ANRS VAC20 Phase I/II Trial

Yves Lévy , Christine Lacabaratz , Kim Ellefsen-Lavoie , Wolfgang Stöhr , Jean-Daniel Lelièvre
PLoS Pathogens, 2020, 16 (6), pp.e1008522. ⟨10.1371/journal.ppat.1008522⟩
Article dans une revue hal-03142733v1
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Conventional Dendritic Cells and Slan + Monocytes During HIV-2 Infection

Marco Iannetta , Stéphane Isnard , Jennifer Manuzak , Jean-Baptiste Guillerme , Mathilde Notin
Frontiers in Immunology, 2020, 1, pp.1658. ⟨10.3389/fimmu.2020.01658⟩
Article dans une revue hal-02944641v1
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Public Health and Epidemiology Informatics: Recent Research Trends Moving toward Public Health Data Science

Sébastien Cossin , Rodolphe Thiébaut
IMIA Yearbook of Medical Informatics, 2020, 29 (1), pp.231-234. ⟨10.1055/s-0040-1702020⟩
Article dans une revue hal-03116855v1
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Exogenous acquisition of Pseudomonas aeruginosa in intensive care units: a prospective multi-centre study (DYNAPYO study)

Maider Coppry , Camille Leroyer , Marion Saly , Anne Gaëlle Venier , Celine Slekovec
Journal of Hospital Infection, 2020, 104 (1), pp.40-45. ⟨10.1016/j.jhin.2019.08.008⟩
Article dans une revue hal-03161089v2
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dearseq: a variance component score test for RNA-Seq differential analysis that effectively controls the false discovery rate

Marine Gauthier , Denis Agniel , Rodolphe Thiébaut , Boris Hejblum
NAR Genomics and Bioinformatics, 2020, 2 (4), pp.lqaa093. ⟨10.1093/nargab/lqaa093⟩
Article dans une revue hal-02138664v1

Prospective Evaluation of the First Option, Second-Line Therapy in Childhood Chronic Immune Thrombocytopenia: Splenectomy or Immunomodulation

Stéphane Ducassou , Helder Fernandes , Hélène Savel , Yves Bertrand , Thierry Leblanc
The Journal of Pediatrics, 2020, ⟨10.1016/j.jpeds.2020.12.018⟩
Article dans une revue hal-03142779v1
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Prospective Evaluation of the First Option, Second-Line Therapy in Childhood Chronic Immune Thrombocytopenia: Splenectomy or Immunomodulation

Stéphane Ducassou , Helder Fernandes , Hélène Savel , Yves Bertrand , Thierry Leblanc
The Journal of Pediatrics, 2020, 231, pp.223-230. ⟨10.1016/j.jpeds.2020.12.018⟩
Article dans une revue hal-03481515v1
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Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial)

Alexandre Duvignaud , Edouard Lhomme , Thierry Pistone , Racha Onaisi , Rémi Sitta
Trials, 2020, 21 (1), ⟨10.1186/s13063-020-04619-1⟩
Article dans une revue hal-03142773v1
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Respiratory mycobiome and suggestion of inter-kingdom network during acute pulmonary exacerbation in cystic fibrosis

Perrine Soret , Louise-Eva Vandenborght , Florence Francis , Noémie Coron , Raphaël Enaud
Scientific Reports, 2020, 10 (1), pp.3589. ⟨10.1038/s41598-020-60015-4⟩
Article dans une revue inserm-02497484v1
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Analyzing cellular immunogenicity in vaccine clinical trials: a new statistical method including non-specific responses for accurate estimation of vaccine effect

Édouard Lhomme , Boris Hejblum , Christine Lacabaratz , Aurélie Wiedemann , Jean-Daniel Lelièvre
Journal of Immunological Methods, 2020, 477, pp.112711. ⟨10.1016/j.jim.2019.112711⟩
Article dans une revue hal-03161945v2
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PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study

Sodiomon B Sirima , Laura Richert , Arnaud Chêne , Amadou T Konate , Cécilia Campion
The Lancet Infectious Diseases, 2020, 20 (5), pp.585-597. ⟨10.1016/S1473-3099(19)30739-X⟩
Article dans une revue hal-03161802v2
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Sequential Dirichlet process mixture of skew $t$-distributions for model-based clustering of flow cytometry data

Boris P. Hejblum , Chariff Alkhassim , Raphael Gottardo , François Caron , Rodolphe Thiébaut
Annals of Applied Statistics, 2019, 13 (1), pp.638-660
Article dans une revue hal-03161057v1
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Microbial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV

Felicity Fitzgerald , Edouard Lhomme , Kathryn Harris , Julia Kenny , Ronan Doyle
Journal of Infectious Diseases, 2019, 219 (1), pp.89-100. ⟨10.1093/infdis/jiy495⟩
Article dans une revue hal-03160724v2
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Dynamics of the humoral immune response to a prime-boost Ebola vaccine: quantification and sources of variation

Chloé Pasin , Irene Balelli , Thierry van Effelterre , Viki Bockstal , Laura Solforosi
Journal of Virology, 2019, 93 (18), pp.e00579-19. ⟨10.1128/jvi.00579-19⟩
Article dans une revue hal-02280792v2

Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

Elena Gonçalves , Olivia Bonduelle , Angèle Soria , Pierre Loulergue , Alexandra Rousseau
The Journal of clinical investigation, 2019, 129 (5), pp.1960-1971. ⟨10.1172/jci125372⟩
Article dans une revue hal-03160706v1

New insights are game-changers in HIV-2 disease management

Quentin Le Hingrat , Charlotte Charpentier , Jade Ghosn , Rodolphe Thiébaut , Gilles Peytavin
The Lancet HIV, 2019, 6 (4), pp.e214. ⟨10.1016/s2352-3018(19)30088-8⟩
Article dans une revue hal-03160755v1
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Effects of a physical activity programme to prevent physical performance decline in onco-geriatric patients: a randomized multicentre trial

Haritz Arrieta , Cyril Astrugue , Sophie C Regueme , Jessica Durrieu , Aline Maillard
Journal of Cachexia, Sarcopenia and Muscle, 2019, 10 (2), pp.287-297. ⟨10.1002/jcsm.12382⟩
Article dans une revue hal-03160734v1
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Sequential Dirichlet Process Mixtures of Multivariate Skew t-distributions for Model-based Clustering of Flow Cytometry Data

Boris P. Hejblum , Chariff Alkhassim , Raphael Gottardo , François Caron , Rodolphe Thiébaut
Annals of Applied Statistics, 2019, 13 (1), pp.638-660. ⟨10.1214/18-AOAS1209⟩
Article dans une revue hal-01579063v1

Artificial Intelligence for Surveillance in Public Health

Rodolphe Thiébaut , Sebastien Cossin
IMIA Yearbook of Medical Informatics, 2019, 28 (1), pp.232-234. ⟨10.1055/s-0039-1677939⟩
Article dans une revue hal-03161020v1
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Temporal trends of population viral suppression in the context of Universal Test and Treat: the ANRS 12249 TasP trial in rural South Africa

Joseph Larmarange , Mamadou Diallo , Nuala Mcgrath , Collins Iwuji , Mélanie Plazy
Journal of the International AIDS Society, 2019, 22 (10), ⟨10.1002/jia2.25402⟩
Article dans une revue hal-03161847v3

Viral rebound in semen after antiretroviral treatment interruption in an HIV therapeutic vaccine double-blind trial

Romain Palich , Jade Ghosn , Antoine Chaillon , Valerie Boilet , Marie-Laure Nere
AIDS. Official journal of the international AIDS Society, 2019, 33 (2), pp.279-284. ⟨10.1097/qad.0000000000002058⟩
Article dans une revue hal-03161003v1
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Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

Eléna Gonçalves , Olivia Bonduelle , Angèle Soria , Pierre Loulergue , Alexandra Rousseau
Journal of Clinical Investigation, 2019, 129 (5), pp.1960-1971. ⟨10.1172/JCI125372⟩
Article dans une revue hal-03028295v1
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HIV Controllers Have Low Inflammation Associated with a Strong HIV-Specific Immune Response in Blood

Hakim Hocini , Henri Bonnabau , Christine Lacabaratz , Cécile Lefebvre , Pascaline Tisserand
Journal of Virology, 2019, 93 (10), pp.e01690-18. ⟨10.1128/JVI.01690-18⟩
Article dans une revue pasteur-02549956v1
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Multi-arm, multi-stage randomised controlled trials for evaluating therapeutic HIV cure interventions

Cecilia Moore , Wolfgang Stohr , Laura Richert , Jean-Daniel Lelievre , Angela Crook
The Lancet HIV, 2019, 6 (5), pp.e334-e340. ⟨10.1016/s2352-3018(19)30082-7⟩
Article dans une revue hal-02426904v2
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Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy

Luuk Gras , Margaret May , Lars Peter Ryder , Adam Trickey , Marie Helleberg
Journal of Acquired Immune Deficiency Syndromes - JAIDS, 2019, 80 (3), pp.292-300. ⟨10.1097/QAI.0000000000001913⟩
Article dans une revue hal-03161868v2
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Limited HIV-2 reservoirs in central-memory CD4 T-cells associated to CXCR6 co-receptor expression in attenuated HIV-2 infection

Assia Samri , Charlotte Charpentier , Mariama Sadjo Diallo , Mélanie Bertine , Sophie Even
PLoS Pathogens, 2019, 15 (5), pp.e1007758. ⟨10.1371/journal.ppat.1007758⟩
Article dans une revue hal-03160709v2
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Gene Expression Signatures Associated With Immune and Virological Responses to Therapeutic Vaccination With Dendritic Cells in HIV-Infected Individuals

Rodolphe Thiébaut , Boris P. Hejblum , Hakim Hocini , Henri Bonnabau , Jason Skinner
Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.00874⟩
Article dans une revue hal-02267014v2
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Risk factors for colonization and infection by Pseudomonas aeruginosa in patients hospitalized in intensive care units in France

S. Hoang , A. Georget , J. Asselineau , Anne-Gaëlle Venier , Camille Leroyer
PLoS ONE, inPress, 13 (3), pp.e0193300. ⟨10.1371/journal.pone.0193300⟩
Article dans une revue hal-03008120v1
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Ebola vaccine development: Systematic review of pre-clinical and clinical studies, and meta-analysis of determinants of antibody response variability after vaccination

Lise Gross , Édouard Lhomme , Chloé Pasin , Laura Richert , Rodolphe Thiébaut
International Journal of Infectious Diseases, 2018, 74, pp.83-96. ⟨10.1016/j.ijid.2018.06.022⟩
Article dans une revue hal-01888913v1
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Lasso regularization for left-censored Gaussian outcome and high-dimensional predictors

Perrine Soret , Marta Fernandez Avalos , Linda Wittkop , Daniel Commenges , Rodolphe Thiébaut
BMC Medical Research Methodology, 2018, 18, pp.13. ⟨10.1186/s12874-018-0609-4⟩
Article dans une revue hal-03160825v2

Visualizing omics and clinical data: which challenges for dealing with their variety?

Fleur Mougin , David Auber , Romain Bourqui , Gayo Diallo , Isabelle Dutour
Methods, 2018, 132, pp.3-18. ⟨10.1016/j.ymeth.2017.08.012⟩
Article dans une revue hal-03160796v2

A Phase Ia/B Study To Assess The Safety And Immunogenicity Of Placental Malaria Vaccine Candidate: Preliminary Results Of The Primalvac Trial

Amadou Konate , Laura Richert , Arnaud Chene , Jean-Philippe Semblat , Gwenaelle Roguet
American Journal of Tropical Medicine and Hygiene, 2018, 99 (4), pp.469-469. ⟨10.1136/bmjgh-2019-EDC.35⟩
Article dans une revue hal-03019490v1
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HIV-1 T cell epitopes targeted to Rhesus macaque CD40 and DCIR: A comparative study of prototype dendritic cell targeting therapeutic vaccine candidates

Anne-Laure Flamar , Henri Bonnabau , Sandra Zurawski , Christine Lacabaratz , Monica Montes
PLoS ONE, 2018, 13 (11), pp.e0207794. ⟨10.1371/journal.pone.0207794⟩
Article dans une revue hal-03160760v1
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Controlling IL-7 injections in HIV-infected patients

Chloé Pasin , François Dufour , Laura Villain , Huilong Zhang , Rodolphe Thiébaut
Bulletin of Mathematical Biology, 2018, ⟨10.1007/s11538-018-0465-8⟩
Article dans une revue hal-03063888v2
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The impact of population dynamics on the population HIV care cascade: results from the ANRS 12249 Treatment as Prevention trial in rural KwaZulu-Natal (South Africa)

Joseph Larmarange , Hassimiou Mamadou Diallo , Nuala Mcgrath , Collins Iwuji , Melanie Plazy
Journal of the International AIDS Society, 2018, Population mobility: challenges for universal HIV testing and treatment, 21 (Suppl 4), pp.e25128. ⟨10.1002/jia2.25128⟩
Article dans une revue hal-03160878v1

Artificial Intelligence in Public Health and Epidemiology

Rodolphe Thiébaut , Frantz Thiessard
IMIA Yearbook of Medical Informatics, 2018, 27 (1), pp.207-210. ⟨10.1055/s-0038-1667082⟩
Article dans une revue hal-03160811v1

T-cell and Transcriptomic Responses to Prime-boost Strategies of 3 HIV Vaccines(MVA HIV-B; LIPO-5; GTU-MultiHIV B)-ANRS/INSERM VRI01 Trial

Laura Richert , Aurelie Wiedemann , Odile Launay , Frederic Lucht , Isabelle Poizot-Martin
AIDS Research and Human Retroviruses, 2018, pp.16-16
Article dans une revue hal-03160938v1
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Adaptive protocols based on predictions from a mechanistic model of the effect of IL7 on CD4 counts

Laura Villain , Daniel Commenges , Chloé Pasin , Mélanie Prague , Rodolphe Thiébaut
Statistics in Medicine, 2018, 38 (2), pp.221-235. ⟨10.1002/sim.7957⟩
Article dans une revue hal-03161958v2

Prenatal therapy with pyrimethamine + sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis: a multicenter, randomized trial

Laurent Mandelbrot , Francois Kieffer , Rémi Sitta , Hélène Laurichesse-Delmas , Norbert Winer
American Journal of Obstetrics and Gynecology, 2018, 219 (4), pp.386.e1-386.e9. ⟨10.1016/j.ajog.2018.05.031⟩
Article dans une revue hal-01987714v1

Sparse partial least squares with group and subgroup structure

Matthew Sutton , Rodolphe Thiébaut , Benoit Liquet
Statistics in Medicine, 2018, 37 (23), pp.3338-3356. ⟨10.1002/sim.7821⟩
Article dans une revue hal-03161896v1
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Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomised trial

Collins C. Iwuji , Joanna Orne-Gliemann , Joseph Larmarange , Eric Balestre , Rodolphe Thiébaut
The Lancet HIV, 2018, 5 (3), pp.e116-e125. ⟨10.1016/s2352-3018(17)30205-9⟩
Article dans une revue hal-03161049v1
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A new method for evaluating the impacts of semantic similarity measures on the annotation of gene sets

Aarón Ayllón-Benítez , Fleur Mougin , Julien Allali , Rodolphe Thiébaut , Patricia Thebault
PLoS ONE, 2018, 13 (11), pp.e0208037. ⟨10.1371/journal.pone.0208037⟩
Article dans une revue hal-01938961v1
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cytometree: A binary tree algorithm for automatic gating in cytometry analysis

Daniel Commenges , Chariff Alkhassim , Raphael Gottardo , Boris P. Hejblum , Rodolphe Thiébaut
Cytometry Part A, 2018, 93 (11), pp.1132-1140. ⟨10.1002/cyto.a.23601⟩
Article dans une revue hal-03161874v2

Prevention of Ebola virus disease through vaccination: where we are in 2018

Yves Levy , Clifford Lane , Peter Piot , Abdul Habib Beavogui , Mark Kieh
The Lancet, 2018, 392 (10149), pp.787-790. ⟨10.1016/S0140-6736(18)31710-0⟩
Article dans une revue hal-03160681v1

Dynamic models for estimating the effect of HAART on CD4 in observational studies: Application to the Aquitaine Cohort and the Swiss HIV Cohort Study

Mélanie Prague , Daniel Commenges , Jon Michael Gran , Bruno Ledergerber , Jim Young
Biometrics, 2017, 73 (1), pp.294 - 304. ⟨10.1111/biom.12564⟩
Article dans une revue hal-01406614v2
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Modeling CD4 + T cells dynamics in HIV-infected patients receiving repeated cycles of exogenous Interleukin 7

Ana Jarne , Daniel Commenges , Mélanie Prague , Yves Levy , Rodolphe Thiébaut
Annals of Applied Statistics, 2017
Article dans une revue hal-01579008v1

Serum suppression of tumorigenicity 2 level is an independent predictor of all-cause mortality in HIV-infected patients

Rodolphe Thiebaut , Sophie Hue , Fabien Le Marec , Jean-Daniel Lelievre , Michel Dupon
AIDS. Official journal of the international AIDS Society, 2017, 31 (17), pp.2355 - 2365. ⟨10.1097/QAD.0000000000001628⟩
Article dans une revue hal-01666072v1

Reference curves for CD4 T-cell count response to combination antiretroviral therapy in HIV-1-infected treatment-naïve patients

Vincent Bouteloup , Caroline Sabin , Amanda Mocroft , Luuk Gras , Nikos Pantazis
HIV Medicine, 2017, 18 (1), pp.33 - 44. ⟨10.1111/hiv.12389⟩
Article dans une revue hal-01579158v1

No compensatory lung growth after resection in a one-year follow-up cohort of patients with lung cancer

Stéphane Glénet , Claire De Bisschop , Frédéric Delcambre , Rodolphe Thiébaut , Laurent Francois
Journal of Thoracic Disease, 2017, 9 (10), pp.3938-3945. ⟨10.21037/jtd.2017.08.135⟩
Article dans une revue hal-03010145v1

Serum ST2 level is an independent predictor of all-cause mortality in HIV-infected patients. Aquitaine Cohort, France

Rodolphe Thiebaut , Sophie Hue , Fabien Le Marec , Jean-Daniel Lelievre , Michel Dupon
AIDS. Official journal of the international AIDS Society, 2017
Article dans une revue hal-01671081v1

Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients

Marie-Quitterie Picat , Isabelle Pellegrin , Juliette Bitard , Linda Wittkop , Cécile Proust-Lima
PLoS ONE, 2017, 12 (1), ⟨10.1371/journal.pone.0169164⟩
Article dans une revue hal-01579159v1
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Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV

Anne Rechtien , Laura Richert , Hadrien Lorenzo , Gloria Martrus , Boris P. Hejblum
Cell Reports, 2017, 20 (9), pp.2251 - 2261. ⟨10.1016/j.celrep.2017.08.023⟩
Article dans une revue hal-01579246v1

Public Health and Epidemiology Informatics

Rodolphe Thiebaut , Frantz Thiessard
IMIA Yearbook of Medical Informatics, 2017, ⟨10.15265/IY-2017-035⟩
Article dans une revue hal-01671095v1

CD4 Cell Count Response to First-Line Combination ART in HIV-2+ Patients Compared with HIV-1+ Patients: A Multinational, Multicohort European Study

Linda Wittkop , Julie Arsandaux , Ana Trevino , Maarten Schim van der Loeff , Jane Anderson
Journal of Antimicrobial Chemotherapy, 2017, 72 (10), pp.2869--2878. ⟨10.1093/jac/dkx210⟩
Article dans une revue hal-03704080v1
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Immunologic response in treatment-naïve HIV-2-infected patients: the IeDEA West Africa cohort

Eric Balestre , Didier Koumavi Ekouevi , Boris Tchounga , Serge Paul Eholie , Eugène Messou
Journal of the International AIDS Society, 2016, 19 (1), pp.20044. ⟨10.7448/IAS.19.1.20044⟩
Article dans une revue hal-01288896v1

Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates

Roger Le Grand , Nathalie Dereuddre-Bosquet , Stefania Dispinseri , Leslie Gosse , Delphine Desjardins
Journal of Virology, 2016, 90 (11), pp.5315 - 5328
Article dans une revue hal-01406364v1
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Low CD4/CD8 Ratio Is Associated with Non AIDS-Defining Cancers in Patients on Antiretroviral Therapy: ANRS CO8 (Aproco/Copilote) Prospective Cohort Study

Mariam Noelie Hema , Tristan Ferry , Michel Dupon , Lise Cuzin , Renaud Verdon
PLoS ONE, 2016, 11 (8), pp.e0161594. ⟨10.1371/journal.pone.0161594⟩
Article dans une revue hal-01406618v1
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Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques

Gerard Zurawski , Sandra Zurawski , Anne-Laure Flamar , Laura Richert , Ralf Wagner
PLoS ONE, 2016, 11 (4), ⟨10.1371/journal.pone.0153484⟩
Article dans une revue hal-01389087v1
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No Positive Association between Vitamin D Level and Immune Responses to Hepatitis B and Streptococcus pneumoniae Vaccination in HIV-Infected Adults

Jean-Paul Viard , Alex Assuied , Yves Lévy , Jean-Claude Souberbielle , Rodolphe Thiébaut
PLoS ONE, 2016, 11 (12), pp.e0168640. ⟨10.1371/journal.pone.0168640⟩
Article dans une revue hal-01449359v1

Repeated Cycles of Recombinant Human Interleukin 7 in HIV-Infected Patients With Low CD4 T-Cell Reconstitution on Antiretroviral Therapy: Results of 2 Phase II Multicenter Studies

Rodolphe Thiébaut , Ana Jarne , Jean-Pierre Routy , Irini Sereti , Margaret Fischl
Clinical Infectious Diseases, 2016, 62 (9), pp.1178 - 1185
Article dans une revue hal-01406362v1

Group and sparse group partial least square approaches applied in genomics context

Benoit Liquet , Pierre Lafaye de Micheaux , Boris P. Hejblum , Rodolphe Thiébaut
Bioinformatics, 2016, 32 (1), pp.35-42. ⟨10.1093/bioinformatics/btv535⟩
Article dans une revue hal-01288891v1
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Uptake of Home-Based HIV Testing, Linkage to Care, and Community Attitudes about ART in Rural KwaZulu-Natal, South Africa: Descriptive Results from the First Phase of the ANRS 12249 TasP Cluster-Randomised Trial

Collins C. Iwuji , Joanna Orne-Gliemann , Joseph Larmarange , Nonhlanhla Okesola , Frank Tanser
PLoS Medicine, 2016, 13 (8), ⟨10.1371/journal.pmed.1002107⟩
Article dans une revue hal-01406616v1
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Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.

Mathieu Angin , Glenn Wong , Laura Papagno , Pierre Versmisse , Annie David
Journal of Immunology, 2016, 197 (7), pp.2787-95. ⟨10.4049/jimmunol.1600693⟩
Article dans une revue hal-01406621v1

A method to estimate the size and characteristics of HIV-positive populations using an individual-based stochastic simulation model

Fumiyo Nakagawa , Ard van Sighem , Rodolphe Thiébaut , Colette Smith , Oliver Ratmann
Epidemiology, 2016, 27 (2), pp.247-256. ⟨10.1097/EDE.0000000000000423⟩
Article dans une revue hal-01288889v1
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Early CD4+ T Cell Responses Are Associated with Subsequent CD8+ T Cell Responses to an rAd5-Based Prophylactic Prime-Boost HIV Vaccine Strategy

Edouard Lhomme , Laura Richert , Zoe Moodie , Chloé Pasin , Spyros A. Kalams
PLoS ONE, 2016, 11 (4)
Article dans une revue hal-01406611v1

Intrinsic Defect in Keratinocyte Function Leads to Inflammation in Hidradenitis Suppurativa

Claire Hotz , Michele Boniotto , Aurélie Guguin , Mathieu Surénaud , Francette Jean-Louis
Journal of Investigative Dermatology, 2016, 136 (9), pp.1768 - 1780
Article dans une revue hal-01406612v1
Image document

Superior efficacy of an HIV vaccine combined with ARV prevention in SHIV challenged non-human primates

Roger Le Grand , Nathalie Bosquet , Stefania Dispinseri , Leslie Gosse , Delphine Desjardins
Journal of Virology, 2016, ⟨10.1128/JVI.00230-16⟩
Article dans une revue hal-01579552v1

Early initiation of combined antiretroviral therapy preserves immune function in the gut of HIV-infected patients

Ayrin Kök , Laurent Hocqueloux , Hakim Hocini , Marie Carrière , Laurent Lefrou
Mucosal Immunology, 2015, 8 (1), pp.127-140. ⟨10.1038/mi.2014.50⟩
Article dans une revue hal-01288851v1

Parameters identification for a model of T cell homeostasis

Houssein Ayoub , Bedreddine Ainseba , Michel Langlais , Rodolphe Thiébaut
Mathematical Biosciences and Engineering, 2015, 12 (5), pp.917--936. ⟨10.3934/mbe.2015.12.917⟩
Article dans une revue hal-01164668v1

Diabetes and cognitive decline in a French cohort of patients infected with HIV-1

Carole Dufouil , Laura Richert , Rodolphe Thiébaut , Mathias Bruyand , Hélène Amieva
Neurology, 2015, 85 (12), pp.1065-1073. ⟨10.1212/WNL.0000000000001815⟩
Article dans une revue hal-01288876v1

Dose finding with longitudinal data: simpler models, richer outcomes

Xavier Paoletti , Adélaïde Doussau , Monia Ezzalfani , Elisa Rizzo , Rodolphe Thiébaut
Statistics in Medicine, 2015, 34 (22), ⟨10.1002/sim.6552⟩
Article dans une revue hal-01288874v1
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Optimization and evaluation of Luminex performance with supernatants of antigen-stimulated peripheral blood mononuclear cells

Mathieu Surénaud , Céline Manier , Laura Richert , Rodolphe Thiébaut , Yves Levy
BMC Immunology, 2015, 17 (1), pp.44. ⟨10.1186/s12865-016-0182-8⟩
Article dans une revue inserm-01395760v1

Recent developments in clinical trial designs for HIV vaccine research.

Laura Richert , Edouard Lhomme , Catherine Fagard , Yves Levy , Geneviève Chêne
Human Vaccines & Immunotherapeutics, 2015, 11 (4), pp.1022--9. ⟨10.1080/21645515.2015.1011974⟩
Article dans une revue hal-01164644v1

A new approach to integrate toxicity grade and repeated treatment cycles in the analysis and reporting of phase I dose-finding trials

Adélaide Doussau , Rodolphe Thiebaut , B. Geoerger , Patrick Schoffski , Anne Floquet
Annals of Oncology, 2015, 26 (2), pp.422-428. ⟨10.1093/annonc/mdu523⟩
Article dans une revue hal-01288869v1

Guidelines for reporting methodological challenges and evaluating potential bias in dementia research

Jennifer Weuve , Cécile Proust-Lima , Melinda C. Power , Alden L. Gross , Scott M. Hofer
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2015, 11 (9), pp.1098-1109. ⟨10.1016/j.jalz.2015.06.1885⟩
Article dans une revue hal-01288885v1

Decreased HIV-Specific T-Regulatory Responses Are Associated with Effective DC-Vaccine Induced Immunity

Vedran Brezar , Nicolas Ruffin , Laura Richert , Mathieu Surénaud , Christine Lacabaratz
PLoS Pathogens, 2015, 11 (3), pp.e1004752. ⟨10.1371/journal.ppat.1004752⟩
Article dans une revue hal-01288864v1
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Proposal for a European Public Health Research Infrastructure for Sharing of health and Medical administrative data (PHRIMA).

Anita Burgun , Dina V Oksen , Wolfgang Kuchinke , Hans-Ulrich Prokosch , Thomas Ganslandt
Studies in Health Technology and Informatics, 2015, 216, pp.1005. ⟨10.3233/978-1-61499-564-7-1005⟩
Article dans une revue hal-01232643v1

CD41 T cell recovery during suppression of HIV replication: an international comparison of the immunological efficacy of antiretroviral therapy in North America, Asia and Africa.

Elvin H Geng , Torsten B Neilands , Rodolphe Thièbaut , Mwebesa Bosco Bwana , Denis Nash
International Journal of Epidemiology, 2015, 44 (1), pp.251-63
Article dans une revue hal-01288872v1

Association of immune-activation and senescence markers with non-AIDS-defining comorbidities in HIV-suppressed patients

Pierre Duffau , Linda Wittkop , Estibaliz Lazaro , Fabien Le Marec , Céline Cognet
AIDS. Official journal of the international AIDS Society, 2015, 29 (16), pp.2099-2108. ⟨10.1097/QAD.0000000000000807⟩
Article dans une revue hal-01288887v1

Surveillance of γδ T Cells Predicts Cytomegalovirus Infection Resolution in Kidney Transplants.

Hannah Kaminski , Isabelle Garrigue , Lionel Couzi , Benjamin Taton , Thomas Bachelet
Journal of the American Society of Nephrology, 2015, 27 (2), pp.637-645. ⟨10.1681/ASN.2014100985⟩
Article dans une revue hal-01164667v1
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Time-Course Gene Set Analysis for Longitudinal Gene Expression Data

Boris P. Hejblum , Jason Skinner , Rodolphe Thiébaut
PLoS Computational Biology, 2015, 11 (6), pp.e1004310. ⟨10.1371/journal.pcbi.1004310⟩
Article dans une revue hal-01203446v1
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Reproducibility issues in science, is P value really the only answer?

Jean Gaudart , Laetitia L. Huiart , P. J. Milligan , Rodolphe Thiebaut , Roch Giorgi
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (19), pp.e1934. ⟨10.1073/pnas.1323051111⟩
Article dans une revue hal-01307492v1

[Mathematical dynamical models for personalized medicine].

Rodolphe Thiébaut , Mélanie Prague , Daniel Commenges
Médecine/Sciences, 2014, 30 Spec No 2, pp.23-6
Article dans une revue hal-01108013v1
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T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults.

Marie-Quitterie Picat , Rodolphe Thiébaut , François Lifermann , Xavier Delbrel , Daniel Adoue
BMC Immunology, 2014, 15 (1), pp.13. ⟨10.1186/1471-2172-15-13⟩
Article dans une revue inserm-00981320v1
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Accelerating clinical development of HIV vaccine strategies: methodological challenges and considerations in constructing an optimised multi-arm phase I/II trial design.

Laura Richert , Adélaïde Doussau , Jean-Daniel Lelièvre , Vincent Arnold , Véronique Rieux
Trials, 2014, 15 (1), pp.68. ⟨10.1186/1745-6215-15-68⟩
Article dans une revue inserm-00955157v1

The Impact of the 2013 WHO Antiretroviral Therapy Guidelines on the Feasibility of HIV Population Prevention Trials

Eric Ross , Frank Tanser , Pamela Pei , Marie-Louise Newell , Elena Losina
HIV Clinical Trials, 2014, 15 (5), pp.185-98. ⟨10.1310/hct1505-185⟩
Article dans une revue hal-01108183v1

Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study

Nikos Pantazis , Kholoud Porter , Dominique Costagliola , Andrea de Luca , Jade Ghosn
Lancet HIV, 2014, 1 (3), pp.e119 - e126. ⟨10.1016/S2352-3018(14)00002-2⟩
Article dans une revue hal-01579153v1

Body composition in 98 patients awaiting kidney transplantation.

Karine Moreau , Aurélie Desseix , Christine Germain , Nicole Barthe , Thomas Bachelet
Nutrition, 2014, 30 (2), pp.186-91
Article dans une revue hal-01108163v1

Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination.

David Furman , Boris P. Hejblum , Noah Simon , Vladimir Jojic , Cornelia L. Dekker
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (2), pp.869-74. ⟨10.1073/pnas.1321060111⟩
Article dans une revue inserm-00933693v1

L’analyse des « Big Data » en recherche clinique

Rodolphe Thiébaut , Boris P. Hejblum , Laura Richert
Epidemiology and Public Health = Revue d'Epidémiologie et de Santé Publique, 2014, 62 (1), pp.1-4. ⟨10.1016/j.respe.2013.12.021⟩
Article dans une revue inserm-00933691v1

Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral load.

Yves Lévy , Rodolphe Thiébaut , Matthieu Montes , Christine Lacabaratz , Louis Sloan
European Journal of Immunology, 2014, 44 (9), pp.2802-10
Article dans une revue hal-01108024v1

Quantifying and Predicting the Effect of Exogenous Interleukin-7 on CD4+T Cells in HIV-1 Infection

Rodolphe Thiébaut , Julia Drylewicz , Mélanie Prague , Christine Lacabaratz , Stéphanie Beq
PLoS Computational Biology, 2014, 10 (5), pp.e1003630. ⟨10.1371/journal.pcbi.1003630⟩
Article dans une revue hal-01108204v1
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An Evaluation of HIV Elite Controller Definitions within a Large Seroconverter Cohort Collaboration

Ashley D. Olson , Laurence Meyer , Maria Prins , Rodolphe Thiébaut , Deepti Gurdasani
PLoS ONE, 2014, 9 (1), pp.e86719. ⟨10.1371/journal.pone.0086719⟩
Article dans une revue hal-01368387v1

Effect of cytomegalovirus-induced immune response, self antigen-induced immune response, and microbial translocation on chronic immune activation in successfully treated HIV type 1-infected patients: the ANRS CO3 Aquitaine Cohort.

Linda Dr Wittkop , Juliette Bitard , Estibaliz Lazaro , Didier Neau , Fabrice Bonnet
Journal of Infectious Diseases, 2013, 207 (4), pp.622-7. ⟨10.1093/infdis/jis732⟩
Article dans une revue inserm-00936482v1

Cytokine and gene transcription profiles of immune responses elicited by HIV lipopeptide vaccine in HIV-negative volunteers.

Laura Richert , Sophie Hue , Hakim Hocini , Mathieu Raimbault , Christine Lacabaratz
AIDS. Official journal of the international AIDS Society, 2013, 27 (9), pp.1421-31. ⟨10.1097/QAD.0b013e32835f5b60⟩
Article dans une revue hal-00948406v1

NIMROD: a program for inference via a normal approximation of the posterior in models with random effects based on ordinary differential equations.

Mélanie Prague , Daniel Commenges , Jérémie Guedj , Drylewicz Julia , Rodolphe Thiébaut
Computer Methods and Programs in Biomedicine, 2013, 111 (2), pp.447-458. ⟨10.1016/j.cmpb.2013.04.014⟩
Article dans une revue hal-00933752v1

Is the current use of 'positivity' thresholds meaningful for evaluating HIV-vaccine immunogenicity endpoints?

Laura Richert , Rodolphe Thiébaut
AIDS. Official journal of the international AIDS Society, 2013, 27 (8), pp.1362-5. ⟨10.1097/QAD.0b013e328360d52e⟩
Article dans une revue inserm-00933696v1

Effect of cytomegalovirus-induced immune response, self antigen-induced immune response, and microbial translocation on chronic immune activation in successfully treated HIV type 1-infected patients: the ANRS CO3 Aquitaine Cohort.

Linda Wittkop , Juliette Bitard , Estibaliz Lazaro , Didier Neau , Fabrice Bonnet
The Internet Journal of Infectious Diseases, 2013, 207, pp.622-7
Article dans une revue hal-01101196v1

Dose-finding design using mixed-effect proportional odds model for longitudinal graded toxicity data in phase I oncology clinical trials.

Adélaïde Doussau , Rodolphe Thiébaut , Xavier Paoletti
Statistics in Medicine, 2013, 32 (30), pp.5430-47. ⟨10.1002/sim.5960⟩
Article dans une revue hal-00936325v1

NIMROD: a program for inference via a normal approximation of the posterior in models with random effects based on ordinary differential equations.

Mélanie Prague , Daniel Commenges , Jérémie Guedj , Julia Drylewicz , Rodolphe Thiébaut
Computer Methods and Programs in Biomedicine, 2013, 111 (2), pp.447-58. ⟨10.1016/j.cmpb.2013.04.014⟩
Article dans une revue inserm-00939447v1

Dynamical models of biomarkers and clinical progression for personalized medicine: the HIV context.

Mélanie Prague , Daniel Commenges , Rodolphe Thiébaut
Advanced Drug Delivery Reviews, 2013, 65 (7), pp.954-65. ⟨10.1016/j.addr.2013.04.004⟩
Article dans une revue inserm-00939450v1

Clonally diverse T cell homeostasis is maintained by a common program of cell-cycle control.

Thea Hogan , Andrey Shuvaev , Daniel Commenges , Andrew Yates , Robin Callard
Journal of Immunology, 2013, 190 (8), pp.3985-93. ⟨10.4049/jimmunol.1203213⟩
Article dans une revue inserm-00939457v1
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A novel approach for biomarker selection and the integration of repeated measures experiments from two assays.

Benoit Liquet , Kim-Anh Lê Cao , Hakim Hocini , Rodolphe Thiébaut
BMC Bioinformatics, 2012, 13 (1), pp.325. ⟨10.1186/1471-2105-13-325⟩
Article dans une revue inserm-00814235v1
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Treatment Monitoring of HIV Infected Patients based on Mechanistic Models

Mélanie Prague , Daniel Commenges , Julia Drylewicz , Rodolphe Thiébaut
Biometrics, 2012, 14, pp.171 - 911. ⟨10.1191/0962280205sm390oa⟩
Article dans une revue hal-01579531v1
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A new method for integrated analysis applied to gene expression and cytokines secretion in response to LIPO-5 vaccine in HIV-negative volunteers

Rodolphe Thiébaut , Benoit Liquet , Hakim Hocini , Sophie Hue , Laura Richert
Retrovirology, 2012, 9 (Suppl 2), pp.P121
Article dans une revue inserm-00731770v1
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Mean CD4 cell count changes in patients failing a first-line antiretroviral therapy in resource-limited settings.

Alexandra Calmy , Eric Balestre , Fabrice Bonnet , Andrew Boulle , Eduardo Sprinz
BMC Infectious Diseases, 2012, 12 (1), pp.147. ⟨10.1186/1471-2334-12-147⟩
Article dans une revue inserm-00788673v1
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Vaccination with dendritic cells loaded with HIV-1 lipopeptides elicits broad T cell immunity and control of viral load in HIV infected patients

Yves Lévy , Rodolphe Thiébaut , Monica Montes , Christine Lacabaratz , Louis Sloan
Retrovirology, 2012, 9 (Suppl 2), pp.P328
Article dans une revue inserm-00731768v1

Heterogeneity in outcomes of treated HIV-positive patients in Europe and North America: relation with patient and cohort characteristics.

Margaret T May , Robert S Hogg , Amy C Justice , Bryan E Shepherd , Dominique Costagliola
International Journal of Epidemiology, 2012, 41 (6), pp.1807-20. ⟨10.1093/ije/dys164⟩
Article dans une revue hal-00875138v1

CMV plasma DNAemia and risk of cancer among HIV-infected patients: a case-control study nested in the ANRS CO3 Aquitaine Cohort, France, 2002-2007.

Mathias Bruyand , Marie-Anne Vandenhende , Guillaume Marcel , Estibaliz Lazaro , Marie-Edith Lafon
J Clin Virol, 2011, 50 (2), pp.177-80. ⟨10.1016/j.jcv.2010.10.021⟩
Article dans une revue hal-00594705v1
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Universal definition of loss to follow-up in HIV treatment programs: a statistical analysis of 111 facilities in Africa, Asia, and Latin America.

Benjamin H. Chi , Constantin T. Yiannoutsos , Andrew O. Westfall , Jamie E. Newman , Jialun Zhou
PLoS Medicine, 2011, 8 (10), pp.e1001111. ⟨10.1371/journal.pmed.1001111⟩
Article dans une revue inserm-00702729v1
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Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV-infection.

Marjet Elemans , Rodolphe Thiébaut , Amitinder Kaur , Becca Asquith
PLoS Computational Biology, 2011, 7 (3), pp.e1001103. ⟨10.1371/journal.pcbi.1001103⟩
Article dans une revue inserm-00704808v1
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Prevalence and factors associated with renal impairment in HIV-infected patients, ANRS C03 Aquitaine Cohort, France.

E. Kossi Déti , Rodolphe Thiébaut , Fabrice Bonnet , Sylvie Lawson-Ayayi , Michel Dupon
HIV Medicine, 2010, 11 (5), pp.308-17. ⟨10.1111/j.1468-1293.2009.00780.x⟩
Article dans une revue inserm-00411631v1
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Comparison of early CD4 T-cell count in HIV-1 seroconverters in Côte d'Ivoire and France: the ANRS PRIMO-CI and SEROCO cohorts.

Charlotte Lewden , Rodolphe Thiébaut , Faroudy Boufassa , Ali Coulibaly , Karen Malateste
Journal of Acquired Immune Deficiency Syndromes - JAIDS, 2010, 53 (2), pp.260-5. ⟨10.1097/QAI.0b013e3181b84260⟩
Article dans une revue inserm-00416572v1
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First-year lymphocyte T CD4+ response to antiretroviral therapy according to the HIV type in the IeDEA West Africa collaboration.

Julia Drylewicz , Serge Eholie , Moussa Maiga , Djimon-Marcel Zannou , Papa-Salif Sow
AIDS. Official journal of the international AIDS Society, 2010, 24 (7), pp.1043-50
Article dans une revue inserm-00414621v1

Evolution of 2-long terminal repeat (2-LTR) episomal HIV-1 DNA in raltegravir-treated patients and in in vitro infected cells.

Sandrine Reigadas , Marie-Line Andréola , Linda Wittkop , Ophélie Cosnefroy , Guerric Anies
Journal of Antimicrobial Chemotherapy, 2010, 65 (3), pp.434-7. ⟨10.1093/jac/dkp473⟩
Article dans une revue hal-00522698v1
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Influence of mannose-binding lectin genotypes and serostatus in allo-SCT: analysis of 131 recipients and donors.

Olaf-Werner Neth , Ulrike Bacher , Purnima Das , Tatjana Zabelina , Hartmut Kabisch
Bone Marrow Transplantation, 2010, 45 (1), pp.13-9. ⟨10.1038/bmt.2009.90⟩
Article dans une revue inserm-00414612v1
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Virological and immunological response in HIV-1-infected patients with multiple treatment failures receiving raltegravir and optimized background therapy, ANRS CO3 Aquitaine Cohort.

Linda Wittkop , Dominique Breilh , Daniel Da-Silva , Pierre Duffau , Patrick Mercié
Journal of Antimicrobial Chemotherapy, 2009, 63 (6), pp.1251-5. ⟨10.1093/jac/dkp114⟩
Article dans une revue inserm-00372614v1
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A new endpoint definition improved clinical relevance and statistical power in a vaccine trial.

Gaëlle Pédrono , Rodolphe Thiébaut , Ahmadou Alioum , Philippe Lesprit , Bernard Fritzell
Journal of Clinical Epidemiology, 2009, 62 (10), pp.1054-61. ⟨10.1016/j.jclinepi.2008.10.014⟩
Article dans une revue inserm-00339872v1
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Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment.

Yves Levy , Christine Lacabaratz , Laurence Weiss , Jean-Paul Viard , Cecile Goujard
Journal of Clinical Investigation, 2009, 119 (4), pp.997-1007. ⟨10.1172/JCI38052⟩
Article dans une revue inserm-00484803v1
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Non-AIDS-defining deaths and immunodeficiency in the era of combination antiretroviral therapy.

Benoît Marin , Rodolphe Thiébaut , Heiner C. Bucher , Virginie Rondeau , Dominique Costagliola
AIDS. Official journal of the international AIDS Society, 2009, 23 (13), pp.1743-53. ⟨10.1097/QAD.0b013e32832e9b78⟩
Article dans une revue inserm-00388946v1
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Role of uncontrolled HIV RNA level and immunodeficiency in the occurrence of malignancy in HIV-infected patients during the combination antiretroviral therapy era: Agence Nationale de Recherche sur le Sida (ANRS) CO3 Aquitaine Cohort.

Mathias Bruyand , Rodolphe Thiébaut , Sylvie Lawson-Ayayi , Pierre Joly , Annie-Jeanne Sasco
Clinical Infectious Diseases, 2009, 49 (7), pp.1109-16. ⟨10.1086/605594⟩
Article dans une revue inserm-00391182v1
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When it is better to estimate a slope with only one point.

Thiebaut Rodolphe , Sarah Walker
QJM, 2008, 101 (10), pp.821-4. ⟨10.1093/qjmed/hcn099⟩
Article dans une revue inserm-00336900v1
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Association of non-HDL cholesterol with subclinical atherosclerosis in HIV-positive patients.

Stéphanie Badiou , Rodolphe Thiébaut , Valérie Aurillac-Lavignolle , Francois Dabis , Frédéric Laporte
Journal of Infection, 2008, 57 (1), pp.47-54. ⟨10.1016/j.jinf.2008.05.007⟩
Article dans une revue inserm-00280760v1
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Transmission of HIV-1 minority-resistant variants and response to first-line antiretroviral therapy.

Olivia Peuchant , Rodolphe Thiébaut , Sophie Capdepont , Valerie Lavignolle-Aurillac , Didier Neau
AIDS. Official journal of the international AIDS Society, 2008, 22 (12), pp.1417-23. ⟨10.1097/QAD.0b013e3283034953⟩
Article dans une revue inserm-00270200v1
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Comparison of viro-immunological marker changes between HIV-1 and HIV-2-infected patients in France.

Julia Drylewicz , Sophie Matheron , Estibaliz Lazaro , Florence Damond , Fabrice Bonnet
AIDS. Official journal of the international AIDS Society, 2008, 22 (4), pp.457-68. ⟨10.1097/QAD.0b013e3282f4ddfc⟩
Article dans une revue inserm-00258131v1
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Antiretroviral therapy in pregnant women with advanced HIV disease and pregnancy outcomes in Abidjan, Côte d'Ivoire.

Didier Koumavi Ekouevi , Patrick A. Coffie , Renaud Becquet , Besigin Tonwe-Gold , Apollinaire Horo
AIDS. Official journal of the international AIDS Society, 2008, 22 (14), pp.1815-20. ⟨10.1097/QAD.0b013e32830b8ab9⟩
Article dans une revue inserm-00285869v1
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Alternative methods to analyse the impact of HIV mutations on virological response to antiviral therapy.

Linda Wittkop , Daniel Commenges , Isabelle Pellegrin , Dominique Breilh , Didier Neau
BMC Medical Research Methodology, 2008, 8 (1), pp.68. ⟨10.1186/1471-2288-8-68⟩
Article dans une revue inserm-00333577v1
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Reduced bone mineral density in HIV-infected patients: prevalence and associated factors.

Charles Cazanave , Michel Dupon , Valérie Lavignolle-Aurillac , Nicole Barthe , Sylvie Lawson-Ayayi
AIDS. Official journal of the international AIDS Society, 2008, 22 (3), pp.395-402. ⟨10.1097/QAD.0b013e3282f423dd⟩
Article dans une revue inserm-00186715v1
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Maximum likelihood estimation in dynamical models of HIV.

Jérémie Guedj , Rodolphe Thiébaut , Daniel Commenges
Biometrics, 2007, 63 (4), pp.1198-206. ⟨10.1111/j.1541-0420.2007.00812.x⟩
Article dans une revue inserm-00204269v1
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Robustness of the linear mixed model to misspecied error distribution

Hélène Jacqmin-Gadda , Solenne Sibillot , Cécile Proust , Jean-Michel Molina , Rodolphe Thiébaut
Computational Statistics and Data Analysis, 2007, 51 (10), pp.5142-5154. ⟨10.1016/j.csda.2006.05.021⟩
Article dans une revue inserm-00084214v1
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Prevalence of resistance to nevirapine in mothers and children after single-dose exposure to prevent vertical transmission of HIV-1: a meta-analysis.

Elise Arrivé , Marie-Louise Newell , Didier K. Ekouevi , Marie-Laure Chaix , Rodolphe Thiébaut
International Journal of Epidemiology, 2007, 36 (5), pp.1009-21. ⟨10.1093/ije/dym104⟩
Article dans une revue inserm-00187308v1
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Practical identifiability of HIV dynamics models.

Jérémie Guedj , Rodolphe Thiébaut , Daniel Commenges
Bulletin of Mathematical Biology, 2007, 69 (8), pp.2493-513. ⟨10.1007/s11538-007-9228-7⟩
Article dans une revue inserm-00204273v1
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Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients' data

Rodolphe Thiébaut , Sandy Leproust , Geneviève Chêne , Ruth Gilbert
The Lancet, 2007, 369 (9556), pp.115-122
Article dans une revue hal-00143965v1
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Change in T-lymphocyte count after initiation of highly active antiretroviral therapy in HIV-infected patients with history of Mycobacterium avium complex infection.

Estibaliz Lazaro , Gaelle Coureau , Jérémie Guedj , Patrick Blanco , Isabelle Pellegrin
Antiviral Therapy, 2006, 11 (3), pp.343-50
Article dans une revue hal-00143964v1
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Estimation of dynamical model parameters taking into account undetectable marker values.

Rodolphe Thiébaut , Jérémie Guedj , Hélène Jacqmin-Gadda , Geneviève Chêne , Pascale Trimoulet
BMC Medical Research Methodology, 2006, 6, pp.38. ⟨10.1186/1471-2288-6-38⟩
Article dans une revue inserm-00101223v1
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Immunological markers after long-term treatment interruption in chronically HIV-1 infected patients with CD4 cell count above 400 x 10(6) cells/l.

Rodolphe Thiébaut , Isabelle Pellegrin , Geneviève Chêne , Jean François Viallard , Hervé Fleury
AIDS. Official journal of the international AIDS Society, 2005, 19 (1), pp.53-61
Article dans une revue hal-00143966v1
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Modèles de sélection pour données longitudinales gaussiennes : application à l'étude du vieillissement cognitif

Hélène Jacqmin-Gadda , Rodolphe Thiébaut
Journal de la Société Française de Statistique, 2004, 145 (2), pp.19-32
Article dans une revue inserm-00262012v1
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Modélisation longitudinale de données incomplètes : exemple de la charge virale plasmatique du VIH

Rodolphe Thiébaut , Hélène Jacqmin-Gadda
Journal de la Société Française de Statistique, 2004, 145 (2), pp.33-47
Article dans une revue inserm-00149860v1
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[Joint modeling of quantitative longitudinal data and censored survival time]

Hélène Jacqmin-Gadda , Rodolphe Thiébaut , Jean-François Dartigues
Epidemiology and Public Health = Revue d'Epidémiologie et de Santé Publique, 2004, 52 (6), pp.502-10
Article dans une revue inserm-00262018v1
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Mixed models for longitudinal left-censored repeated measures.

Rodolphe Thiébaut , Hélène Jacqmin-Gadda
Computer Methods and Programs in Biomedicine, 2004, 74 (3), pp.255-60. ⟨10.1016/j.cmpb.2003.08.004⟩
Article dans une revue hal-00143962v1
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Changes over calendar time in the risk of specific first AIDS-defining events following HIV seroconversion, adjusting for competing risks.

Abdel Babiker , Janet Darbyshire , Patrizio Pezzotti , Kholoud Porter , Giovanni Rezza
International Journal of Epidemiology, 2002, 31 (5), pp.951-8
Article dans une revue inserm-00263560v1
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Bivariate linear mixed models using SAS proc MIXED.

Rodolphe Thiébaut , Hélène Jacqmin-Gadda , Geneviève Chêne , Catherine Leport , Daniel Commenges
Computer Methods and Programs in Biomedicine, 2002, 69 (3), pp.249-56
Article dans une revue hal-00143963v1
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Weight loss and body mass index as predictors of HIV disease progression to AIDS in adults. Aquitaine cohort, France, 1985-1997.

Denis Malvy , Rodolphe Thiébaut , Catherine Marimoutou , François Dabis , Groupe d'Épidémiologie Clinique Du Sida En Aquitaine
Journal of the American College of Nutrition, 2001, 20 (6), pp.609-15
Article dans une revue inserm-00263470v1
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Méthodes pour l'inférence post-clustering appliquées à l'expression génique

Benjamin Hivert , Denis Agniel , Rodolphe Thiébaut , Boris P. Hejblum
SFDS 2022 - Journées de Statistique de la SFdS, Jun 2022, Lyon, France
Communication dans un congrès hal-03906534v1

Une PLS parcimonieuse entre Statistique et Apprentissage

Jérôme Saracco , Hadrien Lorenzo , Olivier Cloarec , Rodolphe Thiébaut
Journées de Statistique 2021 – Société Française de Statistique, Jun 2021, Nice, France
Communication dans un congrès hal-03842522v1
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Inférence post-clustering pour l'identification des variables responsables de la séparation de paires de clusters

Benjamin Hivert , Denis Agniel , Rodolphe Thiébaut , Boris Hejblum
Journées nationales « Statistiques & Santé » 2021, Oct 2021, Virtuel, France
Communication dans un congrès hal-03906520v1

Multiblock supervised analyses, should we really normalize blocks?

Jérôme Saracco , Hadrien Lorenzo , Olivier Cloarec , Rodolphe Thiébaut
17th Scandinavian Symposium on Chemometrics (SSC17), Sep 2021, Aalborg, Denmark
Communication dans un congrès hal-03842510v1

Comparison of AUC in clinical trials with follow up censoring: Application to HIV therapeutic vaccines

Marie Alexandre , Mélanie Prague , Yves Lévy , Thiebaut Rodolphe
ISCB 2020 - 41th Annual Conference of the International Society for Clinical Biostatistics, Aug 2020, Krakow / Virtual, Poland
Communication dans un congrès hal-03151377v1

High-Dimensional Multi-Block Analysis of Factors Associated with Thrombin Generation Potential

Hadrien Lorenzo , Misbah Razzaq , Jacob Odeber , Pierre-Emmanuel Morange , Jérôme Saracco
CBMS 2019 - 32nd IEEE International Symposium on Computer-Based Medical Systems (CBMS), Jun 2019, Cordoba, Spain. pp.453-458, ⟨10.1109/CBMS.2019.00094⟩
Communication dans un congrès hal-02429302v1
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From individual care trajectories to HIV care cascade at population level in rural KwaZulu-Natal (South Africa): the impact of population dynamics

Joseph Larmarange , Hassimiou Mamadou Diallo , Nuala Mcgrath , Collins Iwuji , Rodolphe Thiébaut
Life History Research Society Conference, May 2018, Paris, France
Communication dans un congrès ird-04088658v1

Une PLS multivoie parcimonieuse avec observations manquantes pour données hétérogènes

Hadrien Lorenzo , Jérôme Saracco , Rodolphe Thiébaut
Journées de Statistique 2018 - Société Française de Statistique, May 2018, EDF Lab Paris Saclay, France
Communication dans un congrès hal-01963431v1
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Use of mathematical modeling for optimizing and adapting immunotherapy protocols in HIV-infected patients

Chloé Pasin , Laura Villain , François Dufour , Daniel Commenges , Mélanie Prague
Population Approach Group Europe, May 2018, Montreux, Switzerland
Communication dans un congrès hal-01934340v1

Multi-block high-dimensional lasso-penalized analysis with imputation of missing data applied to postgenomic data in an Ebola vaccine trial

Hadrien Lorenzo , Rodolphe Thiébaut , Jérôme Saracco
Annual workshop on Statistical Methods for Post Genomic Data - SMPGD 2018, Jan 2018, Montpellier, France
Communication dans un congrès hal-01664610v1
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Adaptive protocols based on predictions from a mechanistic model of the effect of IL7 on CD4 counts

Laura Villain , Daniel Commenges , Mélanie Prague , Chloé Pasin , Rodolphe Thiébaut
International Biometric Conference, Jul 2018, Bacelone, Spain
Communication dans un congrès hal-01973877v1
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Joint-state and parameters estimation using nudging and SEIK filters for HIV mechanistic models

Mélanie Prague , Rodolphe Thiébaut , Philippe Moireau , Annabelle Collin
Journée de la statistique francaise, Jun 2017, Avignon, France
Communication dans un congrès hal-01579068v1
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High-dimensional compositional microbiota data: state-of-the-art of methods and software implementations

Perrine Soret , Marta Fernandez Avalos , Soon Cheng , Rodolphe Thiebaut
2017 - GDR « Statistiques et santé », Oct 2017, Bordeaux, France
Communication dans un congrès hal-01667295v1

Linking health and administrative data for maternal, child and young adult health

Anita Burgun , Dina V Oksen , Wolfgang Kuchinke , Hans-Ulrich Prokosch , Thomas Ganslandt
9. European Public Health Conference, Nov 2016, Vienne, Austria. ⟨10.1093/eurpub/ckw168.038⟩
Communication dans un congrès hal-01861720v1

Lasso-type estimators for non-parametric mixed-effects models: application to high-dimensional data from a vaccine clinical trial for HIV

Perrine Soret , Cristian Meza , Marta Fernandez Avalos , Karine Bertin , Rodolphe Thiébaut
3rd conference of the International Society for Non-Parametric Statistics (ISNPS), Jun 2016, Avignon, France
Communication dans un congrès hal-01396378v1
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The impact of universal test and treat on HIV incidence in a rural South African population: ANRS 12249 TasP trial, 2012-2016

Collins Iwuji , Joanna Orne-Gliemann , Eric Balestre , Joseph Larmarange , Rodolphe Thiébaut
21st International AIDS Conference (AIDS 2016), IAS, Jul 2016, Durban, South Africa
Communication dans un congrès hal-04118928v1

Lasso pour données censurées à gauche : une comparaison par simulation d’algorithmes proposés dans la littérature

Perrine Soret , Marta Fernandez Avalos , Linda Wittkop , Rodolphe Thiébaut , Daniel Commenges
47èmes Journées de la Statistique, SFdS, 2015, Lille, France
Communication dans un congrès hal-01578293v1

Feasibility and acceptability of an antiretroviral treatment as prevention (TasP) intervention in rural South Africa: results from the ANRS 12249 TasP cluster-randomised trial

Collins Iwuji , Joanna Orne-Gliemann , Frank Tanser , Rodolphe Thiébaut , Joseph Larmarange
20th International AIDS Conference, IAS, Jul 2014, Melbourne, Australia
Communication dans un congrès hal-04118836v1

Prise en compte de la censure à gauche dans la modélisation de données de grande dimension

Nastasia Fouret , Marta Avalos , Linda Wittkop , Rodolphe Thiebaut , Daniel Commenges
46e Journées de Statistique, Jun 2014, Rennes, France
Communication dans un congrès hal-01099341v1
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Test du score pour l'exploration de modèles complexes: Application à la modélisation dynamique du VIH.

Julia Drylewicz , Daniel Commenges , Rodolphe Thiébaut
41èmes Journées de Statistique, SFdS, Bordeaux, 2009, Bordeaux, France, France
Communication dans un congrès inria-00386586v1

Fréchet random forests for metric space valued regression with non Euclidean predictors

Louis Capitaine , Jérémie Bigot , Rodolphe Thiébaut , Robin Genuer
2024
Pré-publication, Document de travail hal-03066146v1

Neglecting normalization impact in semi-synthetic RNA-seq data simulation generates artificial false positives

Boris Hejblum , Kalidou Ba , Rodolphe Thiébaut , Denis Agniel
2022
Pré-publication, Document de travail hal-03908246v1

Gene Set Analysis for time-to-event outcome with the Generalized Berk–Jones statistic

Laura Villain , Thomas Ferté , Rodolphe Thiébaut , Boris P. Hejblum
2021
Pré-publication, Document de travail hal-03478102v1

Distribution-free complex hypothesis testing for single-cell RNA-seq differential expression analysis

Marine Gauthier , Denis Agniel , Rodolphe Thiébaut , Boris P. Hejblum
2021
Pré-publication, Document de travail hal-03478097v1
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Estimating R0 of SARS-COV-2 in healthcare settings

Laura Temime , Marie-Paule Gustin , Audrey Duval , Niccolo Buetti , Pascal Crepey
2020
Pré-publication, Document de travail hal-02625428v1
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Population modeling of early COVID-19 epidemic dynamics in French regions and estimation of the lockdown impact on infection rate

Mélanie Prague , Linda Wittkop , Quentin Clairon , Dan Dutartre , Rodolphe Thiébaut
2020
Pré-publication, Document de travail hal-02555100v1

Random forests for high-dimensional longitudinal data

Louis Capitaine , Robin Genuer , Rodolphe Thiébaut
2019
Pré-publication, Document de travail hal-02002979v1
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HETEROGENEOUS VIRAL ENVIRONMENT IN A HIV SPATIAL MODEL

Claude-Michel Brauner , Danaelle Jolly , Luca Lorenzi , Rodolphe Thiébaut
2009
Pré-publication, Document de travail hal-00383320v1
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Modélisation longitudinales de marqueur du VIH

Rodolphe Thiébaut
Sciences du Vivant [q-bio]. Université Victor Segalen - Bordeaux II, 2002. Français. ⟨NNT : ⟩
Thèse tel-00121899v1