Pierre-Yves RENARD

Alexis Lossouarn, Kévin Renault, Laëtitia Bailly, Axel Frisby, Patricia Le Nahenec-Martel, et al.. Maleimide-based metal-free ligation with dienes: a comparative study. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18, pp.3874-3887. ⟨10.1039/D0OB00403K⟩. ⟨hal-02535938⟩

Afef Mabrouki, Patricia Le Nahenec-Martel, Abdelkader Kriaa, Ahmed Hedhli, Pierre-Yves Renard, et al.. Dearomatization of a 3-Hydroxypyridine through an unexpected Oxidative Deformylation Process: an Entry to Aza-cyclohexadienones. SYNLETT, Georg Thieme Verlag, 2020, 31 (15), pp.1497-1500. ⟨10.1055/s-0040-1706870⟩. ⟨hal-03010593⟩

Emeline Tanguy, Pierre Costé de Bagneaux, Nawal Kassas, Mohamed-Raafet Ammar, Qili Wang, et al.. Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells. Cell Reports, Elsevier Inc, 2020, 32 (7), pp.108026. ⟨10.1016/j.celrep.2020.108026⟩. ⟨hal-03184867⟩

Ophélie Carmon, Fanny Laguerre, Lina Riachy, Charlène Delestre-Delacour, Qili Wang, et al.. Chromogranin A preferential interaction with Golgi phosphatidic acid induces membrane deformation and contributes to secretory granule biogenesis. FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (5), pp.6769-6790. ⟨10.1096/fj.202000074R⟩. ⟨hal-02525074⟩

émeline Tanguy, Pierre Costé de Bagneaux, Nawal Kassas, Mohamed-Raafet Ammar, Qili Wang, et al.. Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells. Cell Reports, Elsevier Inc, 2020, 32 (7), pp.108026. ⟨10.1016/j.celrep.2020.108026⟩. ⟨hal-02922310⟩

Victor Flon, Magalie Bénard, Damien Schapman, Ludovic Galas, Pierre-Yves Renard, et al.. Fluorophore-Assisted Click Chemistry through Copper(I) Complexation. Biomolecules, MDPI, 2020, 10 (4), pp.619. ⟨10.3390/biom10040619⟩. ⟨hal-02544885⟩

Monika Cieslikiewicz-Bouet, Marina Naldi, Manuela Bartolini, Belén Pérez, Denis Servent, et al.. Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor. Biochemical Pharmacology, Elsevier, 2020, 177, pp.114010. ⟨10.1016/j.bcp.2020.114010⟩. ⟨hal-02560260⟩

Elisabet Viayna, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Pedro Cisternas, Carolina Oliva, et al.. Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice. Journal of Medicinal Chemistry, American Chemical Society, 2020, ⟨10.1021/acs.jmedchem.0c01775⟩. ⟨hal-03094189⟩

Tamara Zorbaz, Petra Mišetić, Nicolas Probst, Suzana Žunec, Antonio Zandona, et al.. Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning. ACS Chemical Neuroscience, American Chemical Society (ACS), 2020, 11 (7), pp.1072-1084. ⟨10.1021/acschemneuro.0c00032⟩. ⟨hal-02505607⟩

Victor Flon, Magalie Bénard, Damien Schapman, Ludovic Galas, Pierre-Yves Renard, et al.. Fluorophore-assisted click chemistry through copper(I) complexation. Biomolecules, MDPI, 2020, 10 (4), pp.619. ⟨10.3390/biom10040619⟩. ⟨hal-03034414⟩

Alexis Lossouarn, Kévin Renault, Laëtitia Bailly, Axel Frisby, Patricia Le Nahenec-Martel, et al.. Maleimide-based metal-free ligation with dienes: a comparative study. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18 (20), pp.3874-3887. ⟨10.1039/D0OB00403K⟩. ⟨hal-03010566⟩

Maxime Patout, Florian Guisier, Xavier Brune, Pierre Bohn, Anthony Romieu, et al.. Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer. BMC Pulmonary Medicine, BioMed Central, 2019, 19, pp.3. ⟨10.1186/s12890-018-0760-z⟩. ⟨hal-02353026⟩

Kévin Renault, Clément Guillou, Pierre-Yves Renard, Cyrille Sabot. Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2019, 17 (2), pp.388-396. ⟨10.1039/C8OB02108B⟩. ⟨hal-02329641⟩

Pierrick Bruyat, Ludovic Jean, Pierre-Yves Renard. Regioselective Solid-Phase Synthesis of Peptide Analogues Containing 3,4- or 3,5-Disubstituted Isoxazole as s-cis or s-trans Peptide Bond Mimics. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2019, 2019 (20), pp.3134-3141. ⟨10.1002/ejoc.201900378⟩. ⟨hal-02319741⟩

Mégane Pons, Sylvie Chalon, Ludovic Jean, Pierre-Yves Renard, Frederic Buron, et al.. Toward an Innovative Treatment of Alzheimer’s Disease: Design of MTDLs Targeting Acetylcholinesterase and α-7 Nicotinic Receptors. Proceedings, MDPI, 2019, 22 (1), pp.88. ⟨10.3390/proceedings2019022088⟩. ⟨hal-02352595⟩

Killian Oukoloff, Nicolas Coquelle, Manuela Bartolini, Marina Naldi, Rémy Le Guével, et al.. Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. European Journal of Medicinal Chemistry, Elsevier, 2019, 168, pp.58-77. ⟨10.1016/j.ejmech.2018.12.063⟩. ⟨hal-02055769⟩

Jean Wilfried Fredy, Giuliano Cutolo, Benjamin Poret, Reine Nehmé, Marie Hubert-Roux, et al.. Diverted Natural Lossen-type Rearrangement for Bioconjugation through in Situ Myrosinase-Triggered Isothiocyanate Synthesis. Bioconjugate Chemistry, American Chemical Society, 2019, 30 (5), pp.1385-1394. ⟨10.1021/acs.bioconjchem.9b00153⟩. ⟨hal-02280045⟩

Valentin Quesneau, Benoît Roubinet, Pierre-Yves Renard, Anthony Romieu. Reinvestigation of the synthesis of “covalent-assembly” type probes for fluoride ion detection. Identification of novel 7-(diethylamino)coumarins with aggregation-induced emission properties. Tetrahedron Letters, Elsevier, 2019, 60 (48), pp.151279. ⟨10.1016/j.tetlet.2019.151279⟩. ⟨hal-02320124⟩

Kévin Renault, Pierre-Yves Renard, Cyrille Sabot. Detection of Biothiols with a Fast-Responsive and Water-Soluble Pyrazolone-Based Fluorogenic Probe. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2018, 2018 (46), pp.6494-6498. ⟨10.1002/ejoc.201801157⟩. ⟨hal-02024529⟩

Kévin Renault, J.W. Fredy, Pierre-Yves Renard, Cyrille Sabot. Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies. Bioconjugate Chemistry, American Chemical Society, 2018, 29 (8), pp.2497-2513. ⟨10.1021/acs.bioconjchem.8b00252⟩. ⟨hal-02024527⟩

G. Cutolo, F. Reise, M. Schuler, R. Nehmé, G. Despras, et al.. Bifunctional mannoside-glucosinolate glycoconjugates as enzymatically triggered isothiocyanates and FimH ligands. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (26), pp.4900-4913. ⟨10.1039/C8OB01128A⟩. ⟨hal-02024493⟩

Pierrick Bruyat, Arnaud Gautier, Ludovic Jean, Pierre-Yves Renard. Use of an Air-Stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles. Journal of Organic Chemistry, American Chemical Society, 2018, 83 (21), pp.13515-13522. ⟨10.1021/acs.joc.8b01490⟩. ⟨hal-01916360⟩

Gianluca Santoni, J. de Sousa, Eugenio de la Mora, J. Dias, Ludovic Jean, et al.. Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents. Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (17), pp.7630-7639. ⟨10.1021/acs.jmedchem.8b00592⟩. ⟨hal-02024531⟩

Tamara Zorbaz, Anissa Braïki, Nikola Marakovic, Julien Renou, Eugenio de la Mora, et al.. Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration. Chemistry - A European Journal, Wiley-VCH Verlag, 2018, 24 (38), pp.9675-9691. ⟨10.1002/chem.201801394⟩. ⟨hal-02024542⟩

T.N. Pashirova, Anissa Braïki, I.V. Zueva, K.A. Petrov, V.M. Babaev, et al.. Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection. Journal of Controlled Release, Elsevier, 2018, 290, pp.102-111. ⟨10.1016/j.jconrel.2018.10.010⟩. ⟨hal-02024524⟩

Carles Galdeano, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Manuela Bartolini, Belén Pérez, et al.. Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis. Molecules, MDPI, 2018, 23 (3), pp.634. ⟨10.3390/molecules23030634⟩. ⟨hal-01807857⟩

Hasan Mtiraoui, Kévin Renault, Morgane Sanselme, Moncef Msaddek, Pierre-Yves Renard, et al.. Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2017, 15 (14), pp.3060-3068. ⟨10.1039/C7OB00205J⟩. ⟨hal-02329806⟩

Mirella Vivoli, Julien Renou, Arnaud Chevalier, Isobel H. Norville, Suraya Diaz, et al.. A miniaturized peptidyl-prolyl isomerase enzyme assay. Analytical Biochemistry, Elsevier Masson, 2017, 536, pp.59-68. ⟨10.1016/j.ab.2017.08.004⟩. ⟨hal-02046314⟩

Kévin Renault, Pierre-Yves Renard, Cyrille Sabot. Photophysical properties of quinoxalin-2(1H)-ones: Application in the preparation of an azide-based fluorogenic probe for the detection of hydrogen sulfide. New Journal of Chemistry, Royal Society of Chemistry, 2017, 41 (18), pp.10432-10437. ⟨10.1039/c7nj01893b⟩. ⟨hal-02046306⟩

André-Guilhem Calas, José Dias, Catherine Rousseau, Mélanie Arboléas, Mélanie Touvrey-Loiodice, et al.. An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice. Chemico-Biological Interactions, Elsevier, 2017, 267 (1), pp.11-16. ⟨10.1016/j.cbi.2016.03.009⟩. ⟨hal-02046266⟩

Pierre-Yves Renard, Ludovic Jean. Selective and sensitive near‐infrared fluorescent probe for acetylcholinesterase imaging [abstract]. Journal of Neurochemistry, Wiley, 2017, 142 (S2), pp.188-225. ⟨10.1111/jnc.13925⟩. ⟨hal-02329887⟩

Paul Hermant, Damien Bosc, Catherine Piveteau, Ronan Gealageas, Baovy Lam, et al.. Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox. Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (21), pp.9067-9089. ⟨10.1021/acs.jmedchem.7b01444⟩. ⟨hal-03054238⟩

Pierre-Yves Renard, Ludovic Jean. Probing the cholinergic system to understand neurodegenerative diseases. Future Medicinal Chemistry, Future Science, 2017, 9 (2), pp.131-133. ⟨10.4155/fmc-2016-0213⟩. ⟨hal-02046305⟩

Arnaud Chevalier, Pierre-Yves Renard, Anthony Romieu. Azo-based Fluorogenic Probes for Biosensing and Bioimaging: Recent Advances and Upcoming Challenges. Chemistry - An Asian Journal, Wiley-VCH Verlag, 2017, 12 (16), pp.2008-2028. ⟨10.1002/asia.201700682⟩. ⟨hal-01562215⟩

Thomas Driant, Florian Nachon, Cyril Ollivier, Pierre-Yves Renard, Etienne Derat. On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach. ChemBioChem, Wiley-VCH Verlag, 2017, 18 (7), pp.666-675. ⟨10.1002/cbic.201600646⟩. ⟨hal-01644385⟩

H. Mtiraoui, A. Nsira, M. Msaddek, Pierre-Yves Renard, Cyrille Sabot. Regioselective synthesis of o-triazolyl-1,5-benzodiazepin-2-ones and o-isoxazolyl-1,5-benzodiazepin-2-ones via copper-catalyzed 1,3-dipolar cycloaddition reactions. Comptes Rendus Chimie, Institut de France Académie des Sciences, 2017, 20 (7), pp.747-757. ⟨10.1016/j.crci.2017.02.004⟩. ⟨hal-02046301⟩

Kévin Renault, Laurie-Anne Jouanno, Antoine Lizzul-Jurse, Pierre-Yves Renard, Cyrille Sabot. Fluorogenic Behaviour of the Hetero-Diels–Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications. Chemistry - A European Journal, Wiley-VCH Verlag, 2016, 22 (51), pp.18522-18531. ⟨10.1002/chem.201603617⟩. ⟨hal-02046236⟩

Laurie-Anne Jouanno, Kévin Renault, Cyrille Sabot, Pierre-Yves Renard. 5-Alkoxyoxazole –A Versatile Building Block in (Bio)organic Synthesis. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2016, 2016 (20), pp.3264-3281. ⟨10.1002/ejoc.201600127⟩. ⟨hal-02046218⟩

Hasan Mtiraoui, Rafik Gharbi, Moncef Msaddek, Yann Bretonnière, Chantal Andraud, et al.. 1,5-Benzodiazepin-2-ones: Investigation of a Family of Photoluminescent Materials. Journal of Organic Chemistry, American Chemical Society, 2016, 81 (11), pp.4720-4727. ⟨10.1021/acs.joc.6b00627⟩. ⟨hal-01526233⟩

Hasan Mtiraoui, Rafik Gharbi, Moncef Msaddek, Yann Bretonnière, Chantal Andraud, et al.. Solution and solid-state fluorescence of 2-(2′-hydroxyphenyl)-1,5-benzodiazepin-2-one (HBD) borate complexes. RSC Advances, Royal Society of Chemistry, 2016, 6 (89), pp.86352-86360. ⟨10.1039/C6RA19246G⟩. ⟨hal-01526238⟩

Antoine Lizzul-Jurse, Laëtitia Bailly, Marie Hubert-Roux, Carlos Afonso, Pierre-Yves Renard, et al.. Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2016, 14 (32), pp.7777-7791. ⟨10.1039/c6ob01080f⟩. ⟨hal-02046223⟩

Julien Renou, José Dias, Guillaume Mercey, Tristan Verdelet, Catherine Rousseau, et al.. Synthesis and in vitro evaluation of donepezil-based reactivators and analogues for nerve agent-inhibited human acetylcholinesterase. RSC Advances, Royal Society of Chemistry, 2016, 6 (22), pp.17929-17940. ⟨10.1039/c5ra25477a⟩. ⟨hal-02046237⟩

Sovy Chao, Eric Krejci, Véronique Bernard, Jacqueline Leroy, Ludovic Jean, et al.. A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging. Chemical Communications, Royal Society of Chemistry, 2016, 52 (77), pp.11599-11602. ⟨10.1039/c6cc05936h⟩. ⟨hal-03013508⟩

Killian Oukoloff, Sovy Chao, Monika Cieslikiewicz-Bouet, Romain Mougeot, Ludovic Jean, et al.. Improved Access to Huprine Derivatives Functionalized at Position 9. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2016, 2016 (7), pp.1337-1343. ⟨10.1002/ejoc.201501433⟩. ⟨hal-02046230⟩

Paulina C. Glowacka, Nicolas Maindron, G. Richard Stephenson, Anthony Romieu, Pierre-Yves Renard, et al.. Synthesis and photophysical properties of iron-carbonyl complex–coumarin conjugates as potential bimodal IR–fluorescent probes. Tetrahedron Letters, Elsevier, 2016, 57 (45), pp.4991-4996. ⟨10.1016/j.tetlet.2016.09.091⟩. ⟨hal-01428754⟩

Arnaud Chevalier, Wen Piao, Kenjiro Hanaoka, Tetsuo Nagano, Pierre-Yves Renard, et al.. Azobenzene-caged sulforhodamine dyes: A novel class of 'turn-on' reactive probes for hypoxic tumor cell imaging. Methods and Applications in Fluorescence, IOP Science, 2015, 3 (4), pp.044004. ⟨10.1088/2050-6120/3/4/044004⟩. ⟨hal-02046143⟩

Arnaud Chevalier, Kévin Renault, Frederic Boschetti, Pierre-Yves Renard, Anthony Romieu. Rapid Synthesis of Unsymmetrical Sulforhodamines Through Nucleophilic Amination of a Monobrominated Sulfoxanthene Dye. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2015, 2015 (1), pp.152-165. ⟨10.1002/ejoc.201403165⟩. ⟨hal-01150274⟩

Alicia Jacquemet, Sandra Rihn, Gilles Ulrich, Pierre-Yves Renard, Anthony Romieu, et al.. Rational Design of Latent Fluorophores from Water-​Soluble Hydroxyphenyltriazine Dyes Suitable for Lipase Sensing. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2015, 2015 (8), pp.1664-1669. ⟨10.1002/ejoc.201500047⟩. ⟨hal-01150275⟩

Kévin Renault, Cyrille Sabot, Pierre-Yves Renard. Fast-Responsive Nitroso-Based Turn-On Probe for Hydrogen Sulfide. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2015, 2015 (36), pp.7992-7996. ⟨10.1002/ejoc.201501140⟩. ⟨hal-02046170⟩

Benoît Roubinet, Laëtitia Bailly, Emilie Petit, Pierre-Yves Renard, Anthony Romieu. A FRET-​based probe for fluorescence sensing of sulfide​/sulfite analytes, using a novel long-​wavelength water-​soluble 7-​hydroxycoumarin as reporter fluorophore. Tetrahedron Letters, Elsevier, 2015, 56 (8), pp.1015-1019. ⟨10.1016/j.tetlet.2015.01.042⟩. ⟨hal-01150270⟩

E. Oueis, Cyrille Sabot, Pierre-Yves Renard. New insights into the kinetic target-guided synthesis of protein ligands. Chemical Communications, Royal Society of Chemistry, 2015, 51 (61), pp.12158-12169. ⟨10.1039/c5cc04183j⟩. ⟨hal-02046164⟩

Benoît Roubinet, Cédrik Massif, Mathieu Moreau, F. Boschetti, Gilles Ulrich, et al.. New 3-(Heteroaryl)-2-iminocoumarin-based Borate Complexes: Synthesis, Photophysical Properties, and Rational Functionalization for Biosensing/Biolabeling Applications. Chemistry - A European Journal, Wiley-VCH Verlag, 2015, 21 (41), pp.14589-14601. ⟨10.1002/chem.201502126⟩. ⟨hal-02046171⟩

Benoît Roubinet, Arnaud Chevalier, Pierre-Yves Renard, Anthony Romieu. A Synthetic Route to 3-​(Heteroaryl)​-​7-​hydroxycoumarins Designed for Biosensing Applications. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2015, 2015 (1), pp.166-182. ⟨10.1002/ejoc.201403215⟩. ⟨hal-01150273⟩

Killian Oukoloff, Frederic Buron, Sylvain Routier, Ludovic Jean, Pierre-Yves Renard. Synthetic Route to Rare Isoindolones Derivatives. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2015, 2015 (11), pp.2450-2456. ⟨10.1002/ejoc.201403649⟩. ⟨hal-01150276⟩

Rómulo Aráoz, Monika Bouet, Manuela Bartolini, Nicolas Coquelle, Jacques-Philippe Colletier, et al.. Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of α7 nicotinic acetylcholine receptor. Biochemical Pharmacology, Elsevier, 2015, 97 (4), pp.621. ⟨10.1016/j.bcp.2015.08.006⟩. ⟨hal-02329901⟩

Killian Oukoloff, Monika Cieslikiewicz-Bouet, Sovy Chao, Emilie da Costa Branquinho, C. Bouteiller, et al.. PET and SPECT radiotracers for Alzheimer's disease. Current Medicinal Chemistry, Bentham Science Publishers, 2015, 22 (28), pp.3278-3304. ⟨10.2174/0929867322666150805094645⟩. ⟨hal-02046165⟩

Catherine Nury, Virginie Redeker, Sébastien Dautrey, Anthony Romieu, Guillaume van der Rest, et al.. A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis. Analytical Chemistry, American Chemical Society, 2015, 87 (3), pp.1853-1860. ⟨10.1021/ac503892c⟩. ⟨hal-01144840⟩

Benoît Roubinet, Pierre-Yves Renard, Anthony Romieu. New insights into the water-​solubilization of thiol-​sensitive fluorogenic probes based on long-​wavelength 7-​hydroxycoumarin scaffolds. Dyes and Pigments, Elsevier, 2014, 110, pp.270-284. ⟨10.1016/j.dyepig.2014.02.004⟩. ⟨hal-01150279⟩

Arnaud Chevalier, Pierre-Yves Renard, Anthony Romieu. Azo-Sulforhodamine Dyes: A Novel Class of Broad Spectrum Dark Quenchers. Organic Letters, American Chemical Society, 2014, 16 (15), pp.3946-3949. ⟨10.1021/ol501753b⟩. ⟨hal-02335871⟩

Arnaud Chevalier, Pierre-Yves Renard, Anthony Romieu. Straightforward synthesis of bioconjugatable azo dyes. Part 2: Black Hole Quencher-​2 (BHQ-​2) and BlackBerry Quencher 650 (BBQ-​650) scaffolds. Tetrahedron Letters, Elsevier, 2014, 50 (55), pp.6764-6768. ⟨10.1016/j.tetlet.2014.10.054⟩. ⟨hal-01150282⟩

Arnaud Chevalier, Pierre-Yves Renard, Anthony Romieu. Straightforward synthesis of bioconjugatable azo dyes. Part 1: Black Hole Quencher-​1 (BHQ-​1) scaffold. Tetrahedron Letters, Elsevier, 2014, 55 (50), pp.6759-6763. ⟨10.1016/j.tetlet.2014.10.053⟩. ⟨hal-01150281⟩

Laurie-Anne Jouanno, Vincent Di Mascio, Vincent Tognetti, Laurent Joubert, Cyrille Sabot, et al.. Metal-Free Decarboxylative Hetero-Diels-Alder Synthesis of 3-Hydroxypyridines: A Rapid Access to N-Fused Bicyclic Hydroxypiperidine Scaffolds.. Journal of Organic Chemistry, American Chemical Society, 2014, 79 (3), pp.1303-1319. ⟨10.1021/jo402729a⟩. ⟨hal-00996570⟩

Arnaud Chevalier, Pierre-Yves Renard, Anthony Romieu. Straightforward Access to Water-​Soluble Unsymmetrical Sulfoxanthene Dyes: Application to the Preparation of Far-​Red Fluorescent Dyes with Large Stokes' Shifts. Chemistry - A European Journal, Wiley-VCH Verlag, 2014, 20 (27), pp.8330-8337. ⟨10.1002/chem.201402306⟩. ⟨hal-01150280⟩

Emilia Oueis, Florian Nachon, Cyrille Sabot, Pierre-Yves Renard. First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors.. Chemical Communications, Royal Society of Chemistry, 2014, 50 (16), pp.2043-2045. ⟨10.1039/c3cc48871c⟩. ⟨hal-00996567⟩

Valérie Jolivel, Sébastien Arthaud, Béatrice Botia, Christophe Portal, Bruno Delest, et al.. Biochemical Characterization of a Caspase-3 Far-red Fluorescent Probe for Non-invasive Optical Imaging of Neuronal Apoptosis. Journal of Molecular Neuroscience, Humana Press, 2014, 54 (3), pp.451-462. ⟨10.1007/s12031-014-0325-4⟩. ⟨hal-01196843⟩

Laurie-Anne Jouanno, Arnaud Chevalier, Nawal Sekkat, Nicolas Perzo, Hélène Castel, et al.. Kondrat'eva ligation: Diels-Alder-based irreversible reaction for bioconjugation. Journal of Organic Chemistry, American Chemical Society, 2014, 79 (21), pp.10353-10366. ⟨10.1021/jo501972m⟩. ⟨hal-01144842⟩

Julien Renou, Melanie Loiodice, Melanie Arboleas, Rachid Baati, Ludovic Jean, et al.. Tryptoline-​3-​hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterase. Chemical Communications, Royal Society of Chemistry, 2014, 50 (30), pp.3947-3950. ⟨10.1039/C4CC00561A⟩. ⟨hal-01150284⟩

Lucie Aliouane, Sovy Chao, Brizuela Leyre, Emmanuel Pfund, Cuvillier Olivier, et al.. Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1. Bioorganic and Medicinal Chemistry, Elsevier, 2014, 22 (17), pp.4955-4960. ⟨10.1016/j.bmc.2014.06.038⟩. ⟨hal-01063240⟩

Maria Kliachyna, Gianluca Santoni, Valentin Nussbaum, Julien Renou, Benoît Sanson, et al.. Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase. European Journal of Medicinal Chemistry, Elsevier, 2014, 78, pp.455-467. ⟨10.1016/j.ejmech.2014.03.044⟩. ⟨hal-01131268⟩

Emilia Oueis, Gianluca Santoni, Cyril Ronco, Olga A. Syzgantseva, Vincent Tognetti, et al.. Reaction site-driven regioselective synthesis of AChE inhibitors. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2014, 12 (1), pp.156-161. ⟨10.1039/C3OB42109K⟩. ⟨hal-02335933⟩

Anthony Romieu, Cédrik Massif, Sandra Rihn, Gilles Ulrich, Raymond Ziessel, et al.. The first comparative study of the ability of different hydrophilic groups to water-solubilize fluorescent BODIPY dyes. New Journal of Chemistry, Royal Society of Chemistry, 2013, 37 (4), pp.1016-1027. ⟨10.1039/C3NJ41093E⟩. ⟨hal-01015523⟩

Guillaume Viault, Sébastien Dautrey, Nicolas Maindron, Julie Hardouin, Pierre-Yves Renard, et al.. The first "ready-to-use" benzene-based heterotrifunctional cross-linker for multiple bioconjugation.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2013, 11 (16), pp.2693-2705. ⟨10.1039/c3ob40086g⟩. ⟨hal-00996541⟩

Thomas Priem, Cédric Bouteiller, Davide Camporese, Xavier Brune, Julie Hardouin, et al.. A novel sulfonated prosthetic group for [18F]-radiolabelling and imparting water solubility of biomolecules and cyanine fluorophores.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2013, 11 (3), pp.469-479. ⟨10.1039/c2ob26659h⟩. ⟨hal-00996532⟩

Laurie-Anne Jouanno, Vincent Tognetti, Laurent Joubert, Cyrille Sabot, Pierre-Yves Renard. Thermally controlled decarboxylative [4 + 2] cycloaddition between alkoxyoxazoles and acrylic acid: expedient access to 3-hydroxypyridines.. Organic Letters, American Chemical Society, 2013, 15 (10), pp.2530-2533. ⟨10.1021/ol4010195⟩. ⟨hal-00996416⟩

Arnaud Chevalier, Julie Hardouin, Pierre-Yves Renard, Anthony Romieu. Universal dark quencher based on "clicked" spectrally distinct azo dyes.. Organic Letters, American Chemical Society, 2013, 15 (23), pp.6082-6085. ⟨10.1021/ol402972y⟩. ⟨hal-00996556⟩

Ivan Smirnov, Alexey Belogurov, Alain Friboulet, Patrick Masson, Alexander Gabibov, et al.. Strategies for the selection of catalytic antibodies against organophosphorus nerve agents.. Chemico-Biological Interactions, Elsevier, 2013, 203 (1), pp.196-201. ⟨10.1016/j.cbi.2012.10.011⟩. ⟨hal-00996534⟩

Arnaud Chevalier, Cédrik Massif, Pierre-Yves Renard, Anthony Romieu. Bioconjugatable azo-based dark-quencher dyes: synthesis and application to protease-activatable far-red fluorescent probes.. Chemistry - A European Journal, Wiley-VCH Verlag, 2013, 19 (5), pp.1686-1699. ⟨10.1002/chem.201203427⟩. ⟨hal-00996530⟩

Arnaud Chevalier, Claire Mercier, Laura Saurel, Sylvain Orenga, Pierre-Yves Renard, et al.. The first latent green fluorophores for the detection of azoreductase activity in bacterial cultures.. Chemical Communications, Royal Society of Chemistry, 2013, 49 (78), pp.8815-8817. ⟨10.1039/c3cc44798g⟩. ⟨hal-00996553⟩

Arnaud Chevalier, Martine Dubois, Vadim Le Joncour, Sébastien Dautrey, Céline Lecointre, et al.. Synthesis, biological evaluation, and in vivo imaging of the first camptothecin-fluorescein conjugate.. Bioconjugate Chemistry, American Chemical Society, 2013, 24 (7), pp.1119-1133. ⟨10.1021/bc3005304⟩. ⟨hal-00996547⟩

Emilie da Costa Branquinho, Guillaume Becker, Cédric Bouteiller, Ludovic Jean, Pierre-Yves Renard, et al.. Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase. Nuclear Medicine and Biology, Elsevier, 2013, 40 (4), pp.554-560. ⟨10.1016/j.nucmedbio.2013.02.004⟩. ⟨hal-00847401⟩

Julien Renou, Guillaume Mercey, Tristan Verdelet, Emilia Păunescu, Emilie Gillon, et al.. Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.. Chemico-Biological Interactions, Elsevier, 2013, 203 (1), pp.81-84. ⟨10.1016/j.cbi.2012.09.023⟩. ⟨hal-00996535⟩

Florian Nachon, Eugénie Carletti, Cyril Ronco, Marie Trovaslet, Yvain Nicolet, et al.. Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.. Biochemical Journal, Portland Press, 2013, 453 (3), pp.393-399. ⟨10.1042/BJ20130013⟩. ⟨hal-00996550⟩

I.V. Smirnov, A.A. Belogurov, A. Friboulet, P. Masson, A.G. Gabibov, et al.. Strategies for the selection of catalytic antibodies against organophosphorus nerve agents.. Chemico-Biological Interactions, Elsevier, 2013, 203, pp.196-201. ⟨hal-00866388⟩

Cédrik Massif, Sébastien Dautrey, Alexandre Haefele, Raymond Ziessel, Pierre-Yves Renard, et al.. New insights into the water-solubilisation of fluorophores by post-synthetic "click" and Sonogashira reactions. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10 (22), pp.4330-4336. ⟨10.1039/c2ob25428j⟩. ⟨hal-00996469⟩

Laurie-Anne Jouanno, Cyrille Sabot, Pierre-Yves Renard. Expeditious microwave-assisted synthesis of 5-alkoxyoxazoles from α-triflyloxy esters and nitriles.. Journal of Organic Chemistry, American Chemical Society, 2012, 77 (19), pp.8549-8555. ⟨10.1021/jo301527t⟩. ⟨hal-00996502⟩

Cyrille Sabot, Emilia Oueis, Xavier Brune, Pierre-Yves Renard. Synthesis of polysubstituted 3-hydroxypyridines via the revisited hetero-Diels-Alder reaction of 5-alkoxyoxazoles with dienophiles.. Chemical Communications, Royal Society of Chemistry, 2012, 48 (5), pp.768-770. ⟨10.1039/c1cc16562c⟩. ⟨hal-00996467⟩

Song-Lin Niu, Cédrik Massif, Gilles Ulrich, Pierre-Yves Renard, Anthony Romieu, et al.. Water-soluble red-emitting distyryl-borondipyrromethene (BODIPY) dyes for biolabeling. Chemistry - A European Journal, Wiley-VCH Verlag, 2012, 18 (23), pp.7229-7242. ⟨10.1002/chem.201103613⟩. ⟨hal-00996473⟩

Thomas Priem, Cédric Bouteiller, David Camporese, Anthony Romieu, Pierre-Yves Renard. Synthesis and reactivity of a bis-sultone cross-linker for peptide conjugation and [18F]-radiolabelling via unusual "double click" approach.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10 (5), pp.1068-1078. ⟨10.1039/c1ob06600e⟩. ⟨hal-00996479⟩

Xavier Brazzolotto, Marielle Wandhammer, Cyril Ronco, Marie Trovaslet, Ludovic Jean, et al.. Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure.. FEBS Journal, Wiley, 2012, 279 (16), pp.2905-2916. ⟨10.1111/j.1742-4658.2012.08672.x⟩. ⟨hal-00996490⟩

Cyril Ronco, Eugénie Carletti, Jacques-Philippe Colletier, Martin Weik, Florian Nachon, et al.. Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.. ChemMedChem, Wiley-VCH Verlag, 2012, 7 (3), pp.400-405. ⟨10.1002/cmdc.201100438⟩. ⟨hal-00996475⟩

Guillaume Mercey, Julien Renou, Tristan Verdelet, Maria Kliachyna, Rachid Baati, et al.. Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.. Journal of Medicinal Chemistry, American Chemical Society, 2012, 55 (23), pp.10791-10795. ⟨10.1021/jm3015519⟩. ⟨hal-00996512⟩

Anna Ziemianin, Cyril Ronco, Romain Dolé, Ludovic Jean, Pierre-Yves Renard, et al.. Screening of new huprines--inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2012, 70, pp.1-5. ⟨10.1016/j.jpba.2012.01.038⟩. ⟨hal-00996397⟩

Guillaume Mercey, Tristan Verdelet, Julien Renou, Maria Kliachyna, Rachid Baati, et al.. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Accounts of Chemical Research, American Chemical Society, 2012, 45 (5), pp.756-766. ⟨10.1021/ar2002864⟩. ⟨hal-01015972⟩

Romain Le Provost, Timo Wille, Ludivine Louise, Nicolas Masurier, Susanne Müller, et al.. Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2011, 9 (8), pp.3026-3032. ⟨10.1039/c0ob00931h⟩. ⟨hal-00991907⟩

Song Lin Niu, Cédrik Massif, Gilles Ulrich, Raymond Ziessel, Pierre-Yves Renard, et al.. Water-solubilisation and bio-conjugation of a red-emitting BODIPY marker. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2011, 9 (1), pp.66-69. ⟨10.1039/c0ob00693a⟩. ⟨hal-00991914⟩

Jan Kočí, Virgile Grandclaude, Marc Massonneau, Jean-Alexandre Richard, Anthony Romieu, et al.. A novel and unusually long-lived chemiluminophore based on the 7-hydroxycoumarin scaffold.. Chemical Communications, Royal Society of Chemistry, 2011, 47 (23), pp.6713-6715. ⟨10.1039/c1cc11919b⟩. ⟨hal-00991904⟩

Anthony Romieu, Thomas Bruckdorfer, Guillaume Clavé, Virgile Grandclaude, Cédrik Massif, et al.. N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2011, 9 (15), pp.5337-5342. ⟨10.1039/c1ob05730h⟩. ⟨hal-00991917⟩

Manuelle Debunne, Christophe Portal, Bruno Delest, Ebba Brakenhielm, Françoise Lallemand, et al.. In Vitro and Ex Vivo Evaluation of Smart Infra-Red Fluorescent Caspase-3 Probes for Molecular Imaging of Cardiovascular Apoptosis. International Journal of Molecular Imaging, Hindawi Publishing Corporation, 2011, 2011, pp.413290. ⟨10.1155/2011/413290⟩. ⟨inserm-02296580⟩

Géraldine Saint-André, Maria Kliachyna, Sanjeevarao Kodepelly, Ludivine Louise-Leriche, Emilie Gillon, et al.. Design, synthesis and evaluation of new alpha-nucleophiles for the hydrolysis of organophosphorus nerve agents: application to the reactivation of phosphorylated acetylcholinesterase. Tetrahedron, Elsevier, 2011, 67 (34), pp.6352-6361. ⟨10.1016/j.tet.2011.05.130⟩. ⟨hal-01017442⟩

Nicolas Maindron, Séverine Poupart, Maxime Hamon, Jean-Baptiste Langlois, Nelly Plé, et al.. Synthesis and luminescence properties of new red-shifted absorption lanthanide(III) chelates suitable for peptide and protein labelling.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2011, 9 (7), pp.2357-2370. ⟨10.1039/c0ob00832j⟩. ⟨hal-00991910⟩

Emilia Paunescu, Ludivine Louise, Ludovic Jean, Anthony Romieu, Pierre-Yves Renard. A versatile access to new halogenated 7-azidocoumarins for photoaffinity labeling: Synthesis and photophysical properties. Dyes and Pigments, Elsevier, 2011, 91 (3), pp.427-434. ⟨10.1016/j.dyepig.2011.05.008⟩. ⟨hal-01017388⟩

Cyril Ronco, Ludovic Jean, Hakim Outaabout, Pierre-Yves Renard. Palladium-Catalyzed Preparation of N-Alkylated Tacrine and Huprine Compounds. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2011, 2011 (2), pp.302-310. ⟨10.1002/ejoc.201001158⟩. ⟨hal-01017284⟩

Cyril Ronco, Richard Foucault, Emilie Gillon, Pierre Bohn, Florian Nachon, et al.. New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors.. ChemMedChem, Wiley-VCH Verlag, 2011, 6 (5), pp.876-888. ⟨10.1002/cmdc.201000523⟩. ⟨hal-00991920⟩

Tristan Verdelet, Guillaume Mercey, Nobi Correa, Ludovic Jean, Pierre-Yves Renard. Straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals. Tetrahedron, Elsevier, 2011, 67 (45), pp.8757-8762. ⟨10.1016/j.tet.2011.09.024⟩. ⟨hal-01017528⟩

Guillaume Mercey, Tristan Verdelet, Géraldine Saint-André, Emilie Gillon, Alain Wagner, et al.. First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.. Chemical Communications, Royal Society of Chemistry, 2011, 47 (18), pp.5295-5297. ⟨10.1039/c1cc10787a⟩. ⟨hal-00991912⟩

Lucie Aliouane, Baptiste Rigaud, Emmanuel Pfund, Ludovic Jean, Pierre-Yves Renard, et al.. Synthesis of difluoromethylphosphonamidates by direct addition of amine. Tetrahedron Letters, Elsevier, 2011, 52 (28), pp.3681-3685. ⟨10.1016/j.tetlet.2011.05.034⟩. ⟨hal-01017309⟩

Ténin Traoré, Guillaume Clavé, Léa Delacour, Naoko Kotera, Pierre-Yves Renard, et al.. The first metal-free water-soluble cryptophane-111.. Chemical Communications, Royal Society of Chemistry, 2011, 47 (34), pp.9702-9704. ⟨10.1039/c1cc13378k⟩. ⟨hal-00991921⟩

Anthony Romieu, Delphine Tavernier-Lohr, S Pellet-Rostaing, Marc Lemaire, Pierre-Yves Renard. Water solubilization of xanthene dyes by post-synthetic sulfonation in organic media. Tetrahedron Letters, Elsevier, 2010, 51 (25), pp.3304-3308. ⟨10.1016/j.tetlet.2010.04.080⟩. ⟨hal-01018665⟩

G. Clavé, C. Ronco, H. Boutal, N. Kreich, H. Volland, et al.. Facile and rapid access to linear and truncated microcystin analogues for the implementation of immunoassays.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2010, 8 (3), pp.676-690. ⟨10.1039/b920193a⟩. ⟨hal-00991885⟩

Yves Meyer, Jean-Alexandre Richard, Bruno Delest, Pauline Noack, Pierre-Yves Renard, et al.. A comparative study of the self-immolation of para-aminobenzylalcohol and hemithioaminal-based linkers in the context of protease-sensitive fluorogenic probes.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2010, 8 (8), pp.1777-1780. ⟨10.1039/b926316k⟩. ⟨hal-00991894⟩

Ludivine Louise-Leriche, Emilia Paunescu, Géraldine Saint-André, Rachid Baati, Anthony Romieu, et al.. A HTS assay for the detection of organophosphorus nerve agent scavengers.. Chemistry - A European Journal, Wiley-VCH Verlag, 2010, 16 (11), pp.3510-3523. ⟨10.1002/chem.200902986⟩. ⟨hal-00991892⟩

Guillaume Clavé, Hervé Volland, Mélanie Flaender, Didier Gasparutto, Anthony Romieu, et al.. A universal and ready-to-use heterotrifunctional cross-linking reagent for facile synthetic access to sophisticated bioconjugates.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2010, 8 (19), pp.4329-4345. ⟨10.1039/c0ob00133c⟩. ⟨hal-00991898⟩

Cyril Ronco, Ludovic Jean, Pierre-Yves Renard. Improved synthetic pathway for the derivatization of huprine scaffold. Tetrahedron, Elsevier, 2010, 66 (37), pp.7399-7404. ⟨10.1016/j.tet.2010.07.021⟩. ⟨hal-01019278⟩

M. Lapeyre, Jérôme Leprince, M. Massonneau, Hassan Oulyadi, Pierre-Yves Renard, et al.. Aryldithioethyloxycarbonyl(Ardec) : a new family of aminoe protecting groups removable under mild reducing conditions and their applications to peptide synthesis.. Chemistry - A European Journal, Wiley-VCH Verlag, 2006, 12, pp.3655-3671. ⟨hal-00023718⟩

Milaine Lapeyre, Jérôme Leprince, Marc Massonneau, Hassan Oulyadi, Pierre-Yves Renard, et al.. Aryldithioethyloxycarbonyl (Ardec): A New Family of Amine Protecting Groups Removable under Mild Reducing Conditions and Their Applications to Peptide Synthesis. Chemistry - A European Journal, Wiley-VCH Verlag, 2006, 12 (13), pp.3655-3671. ⟨10.1002/chem.200501538⟩. ⟨hal-01962803⟩

Pierre-Yves Renard, Philippe Vayron, Eric Leclerc, Alain Valleix, Charles Mioskowski. Lewis Acid Catalyzed Room-Temperature Michaelis–Arbuzov Rearrangement. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2003, 42 (21), pp.2389-2392. ⟨10.1002/anie.200250270⟩. ⟨hal-02345149⟩

Cyrille Poirel, P.Y. Renard, J.Y. Lallemand. Stereoselective access to polyfunctionalized decalins. Tetrahedron Letters, Elsevier, 1994, 35 (35), pp.6485-6488. ⟨hal-02710197⟩

Pierre-Yves Renard. Multi-target drug Ligands design and synthesis for Alzheimer disease backed by X-ray crystal analyses. Annual Conference of AnalytiX (7, 2019), Nov 2019, Berlin, Germany. ⟨hal-02404227⟩

Pierre-Yves Renard. Sondes pro-fluorescentes et chémiluminescentes pour la détection d'analyses d'intérêt biologique. Séminaire national, Institut Brestois Santé Agro Matière (IBSAM), May 2019, Brest, France. ⟨hal-02404291⟩

Pierre-Yves Renard. Pro-fluorescent and chemiluminescent probes for enzymatic activities detection. Séminaire national, Laboratoire des biomolécules (LBM, UMR 7203), May 2018, Paris, France. ⟨hal-02393089⟩

Pierre-Yves Renard. Réactions de ligation fluorogéniques. Journées scientifiques de chémobiologie, Nov 2018, Lille, France. ⟨hal-02389306⟩

Pierre-Yves Renard. Sondes fluorogéniques pour la détection d'activités enzymatiques et d'analytes d'intérêt biologiques. Séminaire national, Institut des biomolécules Max Mousseron (IBMM, UMR 5247), Oct 2018, Montpellier, France. ⟨hal-02393849⟩

Pierre-Yves Renard. Chimiluminescence in vivo. Rencontre ChiMi. Fluorescence : de la paillasse à l'utilisation clinique, Jan 2018, Dijon, France. ⟨hal-02395824⟩

Pierre-Yves Renard. Overview of 3-hydroxy-pyridindaldoxime based reactivators. International workshop on nerve agents, North Atlantic Treaty Organisation (NATO), Nov 2018, Paris, France. ⟨hal-02403935⟩

Pierre-Yves Renard. Fluorogenic Behaviour of the Hetero-Diels-Alder Ligation of 5-Alkoxyoxazoles with Maleimides and their Applications. International Caparica Conference on Chromogenic and Emissive Materials (3, 2018), Jun 2018, Lisbonne, Portugal. ⟨hal-02388673⟩

Cyrille Sabot, Laura Nogueira de Faria Cardoso, Pierre-Yves Renard, Wadih Ghattas, Jean-Pierre Mahy. Méthode de criblage : identification de catalyseurs de la réaction de Diels-Alder. Journée scientifique du LabEx Chimie des Architectures Moléculaires Multifonctionnelles et des Matériaux (CHARMMMAT, 6, 2018)), Jun 2018, Cachan, France. ⟨hal-02372510⟩

Cyrille Sabot, Laura Nogueira de Faria Cardoso, Pierre-Yves Renard, Wadih Ghattas, Jean-Pierre Mahy. Méthode de criblage : identification de catalyseurs de la réaction de Diels-Alder. Journée scientifique du LabEx Chimie des Architectures Moléculaires Multifonctionnelles et des Matériaux (CHARMMMAT, 6, 2018)), Jun 2018, Cachan, France. ⟨hal-03098307⟩

T. Zorbaz, M. Katalinic, A. Zandona, Anissa Braïki, Ludovic Jean, et al.. Novel centrally active antidote for intoxication by sarin and VX nerve agents. Congress of the Federation-of-European-Biochemical-Societies (FEBS) on From Molecules to Cells and Back (42, 2017), Sep 2017, Jérusalem, Israel. pp.242, ⟨10.1111/febs.14174⟩. ⟨hal-02024992⟩

Pierre-Yves Renard. New oximes for OP poisoned cholinesterases reactivation. International workshop on chemical warfare agents: toxicity, emergency response and medical countermeasures, Sep 2016, Paris, France. ⟨hal-02388800⟩

Pierre-Yves Renard. L'acétylcholinestérase. Séminaire industriel, Servier, Mar 2016, Croissy-sur-Seine, France. ⟨hal-02391648⟩

Pierre-Yves Renard. Heterotrifunctionnal linkers for bioconjugate reactions. The Missing link biologically driven ligation of carbohydrates and proteins, Jun 2016, Kiel, Germany. ⟨hal-02389804⟩

Pierre-Yves Renard. Water soluble unsymmetrical sulfoxanthene dyes - access to a novel class of broad spectrum dark quenchers. International Caparica Conference on Chromogenic and Emissive Materials (2, 2016), Sep 2016, Lisbonne, Portugal. ⟨hal-02388670⟩

Pierre-Yves Renard. Exemples d'utilisation de sondes fluorescentes pour détecter l'évolution et les impacts de traitements antitumoraux. Journée de présentation et d´échanges Chimie, Biologie et Cancer dans l´inter-région Nord-Ouest, Apr 2016, Amiens, France. ⟨hal-02395831⟩

Pierre-Yves Renard. Pro-fluorescent and chemiluminescent probes for enzymatic activities detection. Séminaire national, Institut de chimie de Nice (ICN, UMR 7272), Mar 2016, Nice, France. ⟨hal-02393073⟩

Monika Cieslikiewicz-Bouet, Sovy Chao, Ludovic Jean, R. Araoz, D. Servent, et al.. Toward an innovative treatment of Alzheimer's disease: Synthesis and evaluation of multi-target directed ligands (MTDLs) targeting acetylcholinesterase (AChE) and alpha7 nicotinic acetylchloline receptors (alpha7 nAChRs). International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. pp.209-210. ⟨hal-02024978⟩

E. David, C. Ronco, Ludovic Jean, X. Brazzolotto, F. Nachon, et al.. Hupresin, a new affinity resin to purify butyrylcholinesterase. International Symposium on Cholinergic Mechanisms (ISCM, 15, 2017), Oct 2016, Marseille, France. pp.210, ⟨10.1111/jnc.13925⟩. ⟨hal-02024979⟩

Sovy Chao, Ludovic Jean, E. Krejci, Pierre-Yves Renard. Selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging. International Symposium on Cholinergic Mechanisms (ISCM, 15, 2017), Oct 2016, Marseille, France. pp.209, ⟨10.1111/jnc.13925⟩. ⟨hal-02024977⟩

T. Zorbaz, M. Katalinic, I. Pavicic, Anissa Braïki, J. Renou, et al.. The effects of organophosphorus compounds and novel antidotes on human neuronal cells. International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. pp.224-225. ⟨hal-02024991⟩

Pierre-Yves Renard. L'acétylcholinestérase : une enzyme modèle pour le chimiste bio-organicien. Séminaire national, Institut de chimie moléculaire de l'Université de Bourgogne (ICMUB, UMR 6302), Apr 2015, Dijon, France. ⟨hal-02391659⟩

E. Oueis, Ronco C., F. Nachon, Cyrille Sabot, Ludovic Jean, et al.. Insights on two in situ click chemistry reactions for the synthesis of AChE inhibitors. International Meeting on Cholinesterases - Sixth International Conference on Paraoxonases (12, 2015), Sep 2015, Elche, Spain. ⟨hal-02379142⟩

G. Santoni, E. Mora, J.-P. Colletier, Ludovic Jean, Y. Xu, et al.. Dynamic mapping of acetylcholinesterase for structural-dynamics based reactivator design. 12th International Meeting on Cholinesterases, Sep 2015, Elche, Spain. ⟨hal-02024984⟩

Z. Kovarik, M. Katalinic, Ludovic Jean, Pierre-Yves Renard, Renou J., et al.. Evaluation of three novel hydroxypicolinaldehyde oximes as efficient uncharged reactivators of VX-inhibited human acetylcholinesterase. FEBS-EMBO Anniversary Conference, Federation of European Biochemical Societies, Aug 2014, Paris, France. pp.65, ⟨10.1111/febs.12919⟩. ⟨hal-02395537⟩

Anissa Braïki, Julien Renou, Romain Mougeot, Florian Nachon, André-Guilhem Calas, et al.. Synthesis and evaluations of uncharged reactivators for cholinesterases inhibited by organophosphate agents. International Conference on Chemical Biological Radiological and Nuclear agents (CBRN) - Research & Innovation (3, 2019), May 2019, Nantes, France. ⟨hal-02543439⟩

Anissa Braïki, Julien Renou, Romain Mougeot, Florian Nachon, José Dias, et al.. Synthesis and in vitro and in vivo evaluations of New Uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents. Medical Chemical Defense Conference (MCDC, 17, 2019), Mar 2019, Munich, Germany. ⟨hal-02543452⟩

Steven Vertueux, Kathleen Solmont, Alexandre Haefele, Philippe Durand, Pierre-Yves Renard. Development of chemiluminescent probes for enzymatic activity detection.. Journées du Groupement de recherche agents d'imagerie moléculaire (GDR AIM, 2, 2019), May 2019, Dijon, France. ⟨hal-02556313⟩

Dorra Gargouri, Abdelaaziz Ouahrouch, Alexandre Haefele, Julien Vieillard, Xavier Franck, et al.. Development of miniaturized fluorescence-based device for mycotoxin detection. Journée de l’Ecole doctorale normande de chimie (JEDNC, 2018), Jun 2018, Rouen, France. ⟨hal-02556309⟩

Dorra Gargouri, Abdelaaziz Ouahrouch, Alexandre Haefele, Julien Vieillard, Xavier Franck, et al.. Development of miniaturized fluorescence-based device for mycotoxin detection. Rencontres en chimie organique biologique (RECOB, 17, 2018), Mar 2018, Aussois, France. ⟨hal-02556310⟩

Morgane Detraz, Alexandre Haefele, Pierre-Yves Renard, Pierre Bohn. Development of a caspase-3 probe for apoptosis detection by dual optical-nuclear imaging. Rencontre ChiMi. Fluorescence : de la paillasse à l'utilisation clinique, Jan 2018, Dijon, France. ⟨hal-02556303⟩

Nicolas Probst, Anissa Braïki, Pierre Warnault, Julien Renou, Catherine Gomez, et al.. Uncharged reactivators of cholinesterases inhibited by organophosphorus nerve agents.. International Meeting on Cholinesterases (13, 2018) and International Conference on Paraoxonases (7, 2018)), Sep 2018, Hradec Králové, Czech Republic. ⟨hal-02543467⟩

Alexandre Haefele, Kathleen Solmont, Philippe Durand, Pierre-Yves Renard. Development of chemiluminescent probes for enzymatic activity detection.. Journées du Groupement de recherche agents d'imagerie moléculaire (GDR AIM, 1, 2018), Jun 2018, Orléans, France. ⟨hal-02556312⟩

Dorra Gargouri, Abdelaaziz Ouahrouch, Alexandre Haefele, Julien Vieillard, Xavier Franck, et al.. Development of miniaturized fluorescence-based device for mycotoxin detection. Journée Nord-Ouest Européennes des Jeunes Chercheurs et du Groupe Français des Polymères Grand Ouest (JNOEJC), Jun 2017, Caen, France. ⟨hal-02556308⟩

Morgane Detraz, Alexandre Haefele, Pierre-Yves Renard, Pierre Bohn. Development of a caspase-3 probe for apoptosis detection by dual optical-nuclear imaging. Journées de l’Ecole doctorale normande Biologie Intégrative, Santé, Environnement (EdN BISE, 20, 2017), Mar 2017, Le Havre, France. ⟨hal-02556299⟩

Dorra Gargouri, Abdelaaziz Ouahrouch, Alexandre Haefele, Julien Vieillard, Xavier Franck, et al.. Development of miniaturized fluorescence-based device for mycotoxin detection. Journée de l’Ecole doctorale normande de chimie (JEDNC, 2017), Jun 2017, Rouen, France. ⟨hal-02556306⟩

Anissa Braïki, Julien Renou, Romain Mougeot, Tamara Zorbaz, André-Guilhem Calas, et al.. New Uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents. International Conference on Chemical Biological Radiological nuclear Explosive - Research & Innovation (CBRNE, 2, 2017), May 2017, Lyon, France. ⟨hal-02544823⟩

Morgane Detraz, Alexandre Haefele, Pierre-Yves Renard, Pierre Bohn. Development of a caspase-3 probe for apoptosis detection by dual optical-nuclear imaging. International Caparica Conference on Chromogenic and Emissive Materials (I3CEM, 2, 2016), Sep 2016, Lisbonne, Portugal. ⟨hal-02556296⟩

Morgane Detraz, Alexandre Haefele, Pierre-Yves Renard, Pierre Bohn. Development of a caspase-3 probe for apoptosis detection by dual optical-nuclear imaging. Journées de l’Ecole doctorale normande Biologie Intégrative, Santé, Environnement (EdN BISE, 19, 2016), Mar 2016, Caen, France. ⟨hal-02556291⟩

Sovy Chao, Eric Krejci, Véronique Bernard, Jacqueline Leroy, Ludovic Jean, et al.. Selective and Sensitive Near-Infrared Fluorescent Probe for Acetylcholinesterases Imaging. International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. ⟨hal-02544874⟩

Sovy Chao, Killian Oukoloff, Monika Bouet, Diego Muñoz Torrero, Jacques-Philippe Colletier, et al.. Multi Target directed ligands for the treatment of Alzheimer’s disease. Rencontres internationales de chimie thérapeutique (RICT, 52, 2016), Jul 2016, Caen, France. ⟨hal-02544849⟩

Anissa Braïki, Julien Renou, Catherine Gomez, Romain Mougeot, Florian Nachon, et al.. Synthesis of new uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents. Tetrahedron Symposium (17, 2016), Jun 2016, Barcelone, Spain. ⟨hal-02544884⟩

M Detraz, A Haefele, Py Renard, P Bohn. Development of a caspase-3 probe for apoptosis detection bu dual optical-nuclear imaging. Chemical Biology Symposium, Dec 2016, Paris, France. ⟨hal-01663935⟩

M Detraz, Py Renard, P Vera, A Haefele, P Bohn. Development of a caspase-3 probe for apoptosis detection bu dual optical-nuclear imaging. IC3EM, Sep 2016, Caparica, Portugal. ⟨hal-01663947⟩

Kathleen Solmont, Alexandre Haefele, Philippe Durand, Pierre-Yves Renard. Development of chemiluminescent probes for enzymatic activity detection.. Journée de l’Ecole doctorale normande de chimie (JEDNC, 2016), Jun 2016, Caen, France. ⟨hal-02556287⟩

Kathleen Solmont, Alexandre Haefele, Philippe Durand, Pierre-Yves Renard. Development of chemiluminescent probes for enzymatic activity detection.. PSL Chemical Biology Symposium, Dec 2016, Paris, France. ⟨hal-02556279⟩

Kathleen Solmont, Virgile Grandclaude, Jean-Alexandre Richard, Alexandre Haefele, Philippe Durand, et al.. Development of chemiluminescent probes for enzymatic activity detection.. International Caparica Conference on Chromogenic and Emissive Materials (I3CEM, 2, 2016), Sep 2016, Lisbonne, Portugal. ⟨hal-02556284⟩

Kathleen Solmont, Virgile Grandclaude, Jean-Alexandre Richard, Alexandre Haefele, Philippe Durand, et al.. Development of chemiluminescent probes for enzymatic activity detection.. Anglo-Norman colloquium on organic chemistry (ANORCQ, 13, 2016), Apr 2016, Rouen, France. ⟨hal-02556286⟩

Pierre Warnault, Julien Renou, Catherine Gomez, Guillaume Mercey, Tristan Verdelet, et al.. Uncharged Reactivators of cholinesterases Inhibited by organophosphorus nerve agents. International Meeting on Cholinesterases - Sixth International Conference on Paraoxonases (12, 2015), Sep 2015, Elche, Spain. ⟨hal-02544902⟩

Pierre Warnault, Julien Renou, Catherine Gomez, Guillaume Mercey, Tristan Verdelet, et al.. Design and Development of New Uncharged Reactivators of OP-Inhibited Cholinesterases. International Conference on Chemical Biological Radiological and Nuclear agents (CBRN) - Research & Innovation (1, 2015), Mar 2015, Antibes, France. ⟨hal-02544917⟩

Pierre-Yves Renard, Christopher Timperley, Catherine Gomez. Phosphoryl compounds. Best Synthetic Methods: Organophosphorus (V), Academic press, pp.365-562, 2014, 978-0-08-098212-0. ⟨10.1016/C2011-0-04165-0⟩. ⟨hal-02345183⟩

Thomas Priem, Cedric Bouteiller, David Camporese, Anthony Romieu, Pierre-Yves Renard. Preparation of new nucleophile-​reactive sulfonated compounds for the radiolabeling of biomolecules; precursors and conjugates thereof. France, Patent n° : WO 2014079979. 2014. ⟨hal-01150298⟩

Guillaume Viault, Sébastien Dautrey, Pierre-Yves Renard, Anthony Romieu. Heterotetrafunctional reagents for bioconjugate chemistry. France, Patent n° : EP14 50478. 2014. ⟨hal-01150305⟩

O. Lockridge,, M.A. Larson,, S.H. Schopfer,, S.H. Hinrichs,, Florian Nachon, et al.. Composition and methods for the purification and production of butyrylcholinesterase.. France, Patent n° : PCT/US14/66373. 2014. ⟨hal-01150306⟩

Rachid Baati, Maria Klyachina, Valentin Nussbaum, Pierre-Yves Renard, Ludovic Jean, et al.. Novel uncharged reactivators against OP-inhibition of human acetylcholinesterase. France, Patent n° : EP13306584.7. 2013. ⟨hal-01150304⟩

Cedric Bouteiller, Franco Mariani Maurizio, Cyril Ronco, Pierre-Yves Renard, Ludovic Jean, et al.. Labeled huprine derivatives and their use in medical imaging. France, Patent n° : WO 2011124713 A1. 2011. ⟨hal-01150300⟩

Cyril Ronco, Pierre-Yves Renard, Ludovic Jean, Florian Nachon, Anthony Romieu. Preparation of 7,​11-​Methanocycloocta[b]​quinoline derivative as highly functionalizable acetylcholinesterase inhibitors for treating neurological diseases. France, Patent n° : WO 2011124712 A1. 2011. ⟨hal-01150301⟩