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Genome mining Fouille de données Binding site Gene transfer Hmm ESCHERICHIA-COLI Biodiversity Data mining Génome BIOSYNTHESIS HMM2 STREPTOMYCES AMBOFACIENS Streptomyces ambofaciens STREPTOMYCES COELICOLOR COMPLETE GENOME SEQUENCE TERMINAL INVERTED REPEATS Biosynthetic gene cluster Antibiotic LINEAR CHROMOSOME Streptomyces
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134

Pierre Leblond

 

Bio

I received my PhD in molecular genetics in 1990 under the supervision of Prof. Bernard Decaris at Université Henri Poincaré in Nancy. Then, I did my military service (1 yr) as a scientist in the lab of Profs. I. Gresser and M. Tovey at Hôpital Paul Brousse (CNRS, Villejuif). Afterwards, I joined for 2 years Pr. J. Cullum at Kaiserslautern (Germany) thanks to EMBO and European Community fellowships. I was appointed to the position of Maître de Conférences at Université Henri Poincaré and was granted a professorship in 1995. Since then, I lead a research team; today named Streptomyces Adaptation, StrAda.

In the past, I was director of the research unit from 2007 to 2018 (co-director from 2001 to 2007). At the national level, I sat at the National University Committee (CNU 65, cellular biology, 3 terms between 2004 and 2018). I sat in several instances of the Université de Lorraine (executive board, cluster council, faculty council). I was vice-president UL in charge of technology transfer in 2017-18, and currently project manager for the construction of a research building at the Faculty of Sciences.

Research

The guiding thread of all my research is to better understand the molecular mechanisms of bacterial genome evolution. Early in my career, I met Streptomyces and it became my pet bacteria. I developed methods (pulsed-field gel electrophoresis) and applied approaches (genome mapping, comparative genomics, genome mining) to study genome structure, organization and dynamics. Notably, I focused on recombination mechanisms shaping the genome (homologous and illegitimate recombination). Hence, these soil bacteria have to face variable environmental (biotic and abiotic parameters) conditions. They show an extraordinary capacity to adapt and to evolve through horizontal gene transfer. We currently study this dynamic in natural populations of Streptomyces (isolated from grains of forest soil) in terms of acquisition and diversification of new genes (secondary metabolite gene clusters, nutriment utilization, mobile genetic elements).

Teaching

I am teaching since 1989 in the field of genetics and microbiology in undergraduate and graduate courses. I continuously managed University programs; from 1995 to 2018 Licence de Biologie, Maîtrise de Génétique Moléculaire et Cellulaire, DESS Ressources Génomiques et Traitements Informatiques, Master de Microbiologie, Master Biotechnologies, Microbiologie, Aliment, Nutrition ; and founded several of them: DESS RGTI (2001), Master de Microbiologie (2008). I also contributed to the creation of the Cursus Master of Engineering (CMI ‘Biologie Santé Environnement’) in 2010 and supervised the cursus at its opening in 2012. Since 2018, I supervise the RIM (Research in Microbiology) orientation of the Master Microbiology (M2), a project-driven course in the omics field with full immersion in research laboratories.

Contact

E-mail : pierre.leblond@univ-lorraine.fr

Téléphone : +33 (0)3 72 74 51 43

IdeHAL pierre-leblond 

Journal articles80 documents

  • Matthieu Nicault, Ali Zaiter, Stéphane Dumarcay, Patrick Chaimbault, Éric Gelhaye, et al.. Elicitation of Antimicrobial Active Compounds by Streptomyces-Fungus Co-Cultures. Microorganisms, MDPI, 2021, 9 (1), pp.178. ⟨10.3390/microorganisms9010178⟩. ⟨hal-03112257⟩
  • Jodelle Degois, Xavier Simon, Frédéric Clerc, Cyril Bontemps, Pierre Leblond, et al.. One-year follow-up of microbial diversity in bioaerosols emitted in a waste sorting plant in France. Waste Management, Elsevier, 2021, 120, pp.257-268. ⟨10.1016/j.wasman.2020.11.036⟩. ⟨hal-03070350⟩
  • Jean-Noël Lorenzi, Olivier Lespinet, Pierre Leblond, Annabelle Thibessard. Subtelomeres are fast-evolving regions of the Streptomyces linear chromosome. Microbial Genomics, Society for General Microbiology, 2021, ⟨10.1099/mgen.0.000525⟩. ⟨hal-03177250v2⟩
  • Virginia S Lioy, Jean-Noel Lorenzi, Soumaya Najah, Thibault Poinsignon, Herve Leh, et al.. Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation. Nature Communications, Nature Publishing Group, 2021, 12, pp.5221. ⟨10.1038/s41467-021-25462-1⟩. ⟨hal-03128776v2⟩
  • Matthieu Nicault, Abdoul-Razak Tidjani, Éric Gelhaye, Cyril Bontemps, Pierre Leblond. Genome Sequences of Five Streptomyces Strains Isolated at Microscale. Microbiology Resource Announcements, American Society for Microbiology, 2020, 9 (23), ⟨10.1128/MRA.00428-20⟩. ⟨hal-02801725⟩
  • Abdoul-Razak Tidjani, Cyril Bontemps, Pierre Leblond. Telomeric and sub-telomeric regions undergo rapid turnover within a Streptomyces population. Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-63912-w⟩. ⟨hal-02569171⟩
  • Matthieu Nicault, Abdoul-Razak Tidjani, Anthony Gauthier, Stéphane Dumarcay, Éric Gelhaye, et al.. Mining the Biosynthetic Potential for Specialized Metabolism of a Streptomyces Soil Community. Antibiotics, MDPI, 2020, 9 (5), pp.271. ⟨10.3390/antibiotics9050271⟩. ⟨hal-02619232⟩
  • Michelle David, Clara Lejeune, Sonia Abreu, Annabelle Thibessard, Pierre Leblond, et al.. Negative Correlation between Lipid Content and Antibiotic Activity in Streptomyces: General Rule and Exceptions. Antibiotics, MDPI, 2020, pp.280. ⟨10.3390/antibiotics9060280⟩. ⟨hal-02624260⟩
  • Abdoul-Razak Tidjani, Jean-Noël Lorenzi, Maxime Toussaint, Erwin van Dijk, Delphine Naquin, et al.. Genome Sequences of 11 Conspecific Streptomyces sp. Strains. Microbiology Resource Announcements, American Society for Microbiology, 2019, 8 (38), ⟨10.1128/MRA.00863-19⟩. ⟨hal-02292599⟩
  • Claire Bertrand, Annabelle Thibessard, Claude Bruand, François Lecointe, Pierre Leblond. Bacterial NHEJ: A never ending story. Molecular Microbiology, Wiley, 2019, ⟨10.1111/mmi.14218⟩. ⟨hal-02044826⟩
  • Jodelle Degois, Xavier Simon, Cyril Bontemps, Pierre Leblond, Philippe Duquenne. Characterization of experimental complex fungal bioaerosols: Impact of analytical method on fungal composition measurements. Aerosol Science and Technology, Taylor & Francis, 2019, 53 (2), pp.146-159. ⟨10.1080/02786826.2018.1557320⟩. ⟨hal-02177356⟩
  • A. Gourmel, R. Perbet, K. Beccaria, C. A. Maurage, F. Escande, et al.. Clinical, Radiological, Histopathological, Molecular Description and Identification of Prognostic Factors for Desmoplastic Infantile Gangliogliomas and Astrocytomas: A Multicentric Cohort Study. PEDIATRIC BLOOD & CANCER, 2019, 66 (4, SI), pp.S176-S177. ⟨hal-03604454⟩
  • Abdoul-Razak Tidjani, Jean-Noël Lorenzi, Maxime Toussaint, Erwin van Dijk, Delphine Naquin, et al.. Massive Gene Flux Drives Genome Diversity between Sympatric Streptomyces Conspecifics. mBio, American Society for Microbiology, 2019, ⟨10.1128/mBio.01533-19⟩. ⟨hal-02278804⟩
  • Mabrouka Benhadj, Djamila Gacemi-Kirane, Maxime Toussaint, Laurence Hotel, Cyril Bontemps, et al.. Diversité et activités antimicrobiennes de souches de Streptomyces de la Fetzara (Algérie). Annales de Biologie Clinique, John Libbey Eurotext, 2018, 76 (1), pp.81-95. ⟨10.1684/abc.2017.1316⟩. ⟨hal-01844922⟩
  • Grégory Hoff, Claire Bertrand, Emilie Piotrowski, Annabelle Thibessard, Pierre Leblond. Genome plasticity is governed by double strand break DNA repair in Streptomyces. Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.5272. ⟨10.1038/s41598-018-23622-w⟩. ⟨hal-01757262⟩
  • Léna Dettori, Florent Ferrari, Xavier Framboisier, Cédric Paris, yann Guiavarc’h, et al.. An aminoacylase activity from Streptomyces ambofaciens catalyzes the acylation of lysine on α-position and peptides on N-terminal position. Engineering in Life Sciences, Wiley-VCH Verlag, 2018, 18 (8), pp.589-599. ⟨10.1002/elsc.201700173⟩. ⟨hal-01959650⟩
  • Annabelle Thibessard, Cláudia M Vicente, Claire Bertrand, Bertrand Aigle, Pierre Leblond. Draft Whole-Genome Shotgun Sequence of Streptomyces sp. Strain ETH9427. Microbiology Resource Announcements, American Society for Microbiology, 2018, 7 (12), pp.e01197. ⟨10.1128/MRA.01197-18⟩. ⟨hal-01887322⟩
  • Cláudia M Vicente, Annabelle Thibessard, Jean-Noël Lorenzi, Mabrouka Benhadj, Laurence Hotel, et al.. Comparative Genomics among Closely Related Streptomyces Strains Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity. Antibiotics, MDPI, 2018, 7 (4), pp.86. ⟨10.3390/antibiotics7040086⟩. ⟨hal-01887213⟩
  • Gregory Hoff, Claire Bertrand, Emilie Piotrowski, Annabelle Thibessard, Pierre Leblond. Implication of RuvABC and RecG in homologous recombination in Streptomyces ambofaciens. Research in Microbiology, Elsevier, 2017, 168 (1), pp.26-35. ⟨10.1016/j.resmic.2016.07.003⟩. ⟨hal-01552147⟩
  • Jodelle Degois, Frédéric Clerc, Xavier Simon, Cyril Bontemps, Pierre Leblond, et al.. First metagenomic survey of the microbial diversity in bioaerosols emitted in waste sorting plants. Annals of Work Exposures and Health, Oxford University Press, 2017, 61 (9), pp.1076 - 1086. ⟨10.1093/annweh/wxx075⟩. ⟨hal-01655252⟩
  • Grégory Hoff, Claire Bertrand, Lingli Zhang, Emilie Piotrowski, Ludovic Chipot, et al.. Multiple and Variable NHEJ-Like Genes Are Involved in Resistance to DNA Damage in Streptomyces ambofaciens. Frontiers in Microbiology, Frontiers Media, 2016, 7, pp.1901. ⟨10.3389/fmicb.2016.01901⟩. ⟨hal-01521993⟩
  • Maxime Toussaint, Cyril Bontemps, Arnaud Besserer, Laurence Hotel, Philippe Gérardin, et al.. Whole-cell biosensor of cellobiose and application to wood decay detection. Journal of Biotechnology, Elsevier, 2016, 239, pp.39 - 46. ⟨10.1016/j.jbiotec.2016.10.003⟩. ⟨hal-01655326⟩
  • Aurélie Deveau, Harald Gross, Béatrice Palin, Samina Mehnaz, Max Schnepf, et al.. Role of secondary metabolites in the interaction between Pseudomonas fluorescensand soil microorganisms under iron-limited conditions. FEMS Microbiology Ecology, Wiley-Blackwell, 2016, 92 (8), pp.1-11. ⟨10.1093/femsec/fiw107⟩. ⟨hal-01490770⟩
  • Nicolas Carraro, Virginie Libante, Florence Charron-Bourgoin, Gérard Guédon, Catherine Morel, et al.. Plasmid-like replication of a minimal streptococcal integrative and conjugative element. Microbiology, Microbiology Society, 2016, 162 (4), pp.622 - 632. ⟨10.1099/mic.0.000219⟩. ⟨hal-01476043⟩
  • Annabelle Thibessard, Pierre Leblond. Complete Genome Sequence of Streptomyces ambofaciens DSM 40697, a Paradigm for Genome Plasticity Studies.. Genome Announcements, American Society for Microbiology, 2016, 4 (3), ⟨10.1128/genomeA.00470-16⟩. ⟨hal-01521992⟩
  • Annabelle Thibessard, Drago Haas, Claude Gerbaud, Bertrand Aigle, Sylvie Lautru, et al.. Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the spiramycin producer. Journal of Biotechnology, Elsevier, 2015, 214, pp.117-118. ⟨10.1016/j.jbiotec.2015.09.020⟩. ⟨hal-01258341⟩
  • Justine Galet, Aurélie Deveau, Laurence Hotel, Pascale Frey-Klett, Pierre Leblond, et al.. Pseudomonas fluorescens Pirates both Ferrioxamine and Ferricoelichelin Siderophores from Streptomyces ambofaciens.. Applied and Environmental Microbiology, American Society for Microbiology, 2015, 81 (9), pp.3132-3141. ⟨10.1128/AEM.03520-14⟩. ⟨hal-01269032⟩
  • Annabelle Thibessard, Claire Bertrand, Julien Hiblot, Emilie Piotrowski, Pierre Leblond. Construction of pDYN6902, a new Streptomyces integrative expression vector designed for cloning sequences interfering with Escherichia coli viability. Plasmid, 2015, 82, pp.43-49. ⟨10.1016/j.plasmid.2015.10.003⟩. ⟨hal-01258339⟩
  • Bertrand Aigle, Sylvie Lautru, Dieter Spiteller, Jeroen S. Dickschat, Gregory L. Challis, et al.. Genome mining of Streptomyces ambofaciens. Journal of Industrial Microbiology and Biotechnology, Springer Verlag, 2014, 41 (2), pp.251 - 263. ⟨10.1007/s10295-013-1379-y⟩. ⟨hal-01475037⟩
  • Justine Galet, Aurélie Deveau, Laurence Hotel, Pierre Leblond, Pascale Frey-Klett, et al.. Gluconic acid-producing Pseudomonas sp. prevent γ-actinorhodin biosynthesis by Streptomyces coelicolor A3(2). Archives of Microbiology, Springer Verlag, 2014, 196 (9), pp.619-627. ⟨10.1007/s00203-014-1000-4⟩. ⟨hal-01268576⟩
  • L. Zhang, Cong Tu Nguyen, L. Chipot, E. Piotrowski, C. Bertrand, et al.. The adnAB Locus, Encoding a Putative Helicase-Nuclease Activity, Is Essential in Streptomyces. Journal of Bacteriology, American Society for Microbiology, 2014, 196 (14), pp.2701 - 2708. ⟨10.1128/JB.01513-14⟩. ⟨hal-01474715⟩
  • Lijiang Song, Luisa Laureti, Christophe Eric Corre, Pierre Leblond, Bertrand Aigle, et al.. Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis. Journal of Antibiotics, Nature Publishing Group: Open Access Hybrid Model Option B, 2014, 67 (1), pp.71 - 76. ⟨10.1038/ja.2013.119⟩. ⟨hal-01474997⟩
  • Robert Bunet, Ramona Riclea, Luisa Laureti, Laurence Hotel, Cedric Paris, et al.. A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in Streptomyces ambofaciens ATCC23877. PLoS ONE, Public Library of Science, 2014, 9 (1), pp.e87607. ⟨10.1371/journal.pone.0087607⟩. ⟨hal-01272916⟩
  • Cyril Bontemps, Maxime Toussaint, Pierre-Vincent Revol, Laurence Hotel, Mathilde Jeanbille, et al.. Taxonomic and functional diversity of Streptomyces in a forest soil. FEMS Microbiology Letters, Wiley-Blackwell, 2013, 342 (2), pp.157 - 167. ⟨10.1111/1574-6968.12126⟩. ⟨hal-01655681⟩
  • S. Song, L Laureti, P Gomez-Escribano, D Fox, V yeo, et al.. Bacterial genome mining for novel natural product discovery. Planta Medica, Georg Thieme Verlag, 2012, 78 (11), ⟨10.1055/s-0032-1320194⟩. ⟨hal-01667347⟩
  • Nicolas Carraro, Virginie Libante, Catherine Morel, Bernard Decaris, Florence Charron-Bourgoin, et al.. Differential regulation of two closely related integrative and conjugative elements from Streptococcus thermophilus. BMC Microbiology, BioMed Central, 2011, 11 (238), 13 p. ⟨10.1186/1471-2180-11-238⟩. ⟨hal-02642537⟩
  • R. Bunet, L. Song, M. Vaz Mendez, C. Corre, L. Hotel, et al.. Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of kinamycins. Journal of Bacteriology, American Society for Microbiology, 2011, 193 ((5)), pp. 1142-1153. ⟨10.1128/JB.01269-10⟩. ⟨hal-00606766⟩
  • Catherine Eng, Annabelle Thibessard, Morten Danielsen, Thomas Bovbjerg Rasmussen, Jean-Francois Mari, et al.. In silico prediction of horizontal gene transfer in Streptococcus thermophilus. Archives of Microbiology, Springer Verlag, 2011, 193 (4), pp.287-297. ⟨10.1007/s00203-010-0671-8⟩. ⟨inria-00569081⟩
  • Luisa Laureti, Lijiang Song, Sheng Huang, Christophe Corre, Pierre Leblond, et al.. Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2011, 108 (15), pp.6258 - 6263. ⟨10.1073/pnas.1019077108⟩. ⟨hal-02651598⟩
  • Marisa Haenni, Estelle Saras, Stephane Bertin, Pierre Leblond, Jean-yves Madec, et al.. Diversity and Mobility of Integrative and Conjugative Elements in Bovine Isolates of Streptococcus agalactiae, S. dysgalactiae subsp dysgalactiae, and S. uberis. Applied and Environmental Microbiology, American Society for Microbiology, 2010, 76 (24), pp.7957 - 7965. ⟨10.1128/AEM.00805-10⟩. ⟨hal-01637787⟩
  • Maud Juguet, Sylvie Lautru, François-Xavier Francou, Sárka Nezbedová, Pierre Leblond, et al.. An iterative nonribosomal peptide synthetase assembles the pyrrole-amide antibiotic congocidine in Streptomyces ambofaciens.. Chem Biol, 2009, 16 (4), pp.421-31. ⟨10.1016/j.chembiol.2009.03.010⟩. ⟨hal-00379056⟩
  • Catherine Eng, Charu Asthana, Bertrand Aigle, Sébastien Hergalant, Jean-Francois Mari, et al.. A new data mining approach for the detection of bacterial promoters combining stochastic and combinatorial methods. Journal of Computational Biology, Mary Ann Liebert, 2009, 16 (9), pp.1211-1225. ⟨10.1089/cmb.2008.0122⟩. ⟨inria-00419969⟩
  • Robert Bunet, M. V. V Mendes, Nicolas Rouhier, Xiuhua Pang, L. Hotel, et al.. Regulation of the Synthesis of the Angucyclinone Antibiotic Alpomycin in Streptomyces ambofaciens by the Autoregulator Receptor AlpZ and Its Specific Ligand. Journal of Bacteriology, American Society for Microbiology, 2008, 190 (9), pp.3293 - 3305. ⟨10.1128/JB.01989-07⟩. ⟨hal-01659448⟩
  • Fabrice Touzain, Sophie Schbath, Isabelle Debled-Rennesson, Bertrand Aigle, Gregory Kucherov, et al.. SIGffRid: A tool to search for sigma factor binding sites in bacterial genomes using comparative approach and biologically driven statistics. BMC Bioinformatics, BioMed Central, 2008, 9 (73), pp.on line. ⟨10.1186/1471-2105-9-73⟩. ⟨inria-00580657⟩
  • Frédéric Choulet, Bertrand Aigle, Alexandre Gallois, Sophie Mangenot, Claude Gerbaud, et al.. Evolution of the terminal regions of the streptomyces linear chromosome. Molecular Biology and Evolution, Oxford University Press (OUP), 2006, 23 (12), pp.2361-2369. ⟨10.1093/molbev/msl108⟩. ⟨hal-02661267⟩
  • Francisco Barona-Gómez, Sylvie Lautru, François-Xavier Francou, Pierre Leblond, Jean-Luc Pernodet, et al.. Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877. Microbiology, Microbiology Society, 2006, 152 (11), pp.3355-3366. ⟨10.1099/mic.0.29161-0⟩. ⟨hal-02666177⟩
  • Frédéric Choulet, Alexandre Gallois, B. Aigle, Sophie Mangenot, Claude Gerbaud, et al.. Intraspecific Variability of the Terminal Inverted Repeats of the Linear Chromosome of Streptomyces ambofaciens. Journal of Bacteriology, American Society for Microbiology, 2006, 188 (18), pp.6599 - 6610. ⟨10.1128/JB.00734-06⟩. ⟨hal-01659064⟩
  • F. Choulet, A. Gallois, B. Aigle, S. Mangenot, C. Gerbaud, et al.. Intraspecific variability of the terminal regions of the Streptomyces ambofaciens. Journal of Bacteriology, American Society for Microbiology, 2006, 188, p 6599-6610. ⟨hal-00101141⟩
  • Bertrand Aigle, Xiuhua Pang, Bernard Decaris, Pierre Leblond. Involvement of AlpV, a New Member of the Streptomyces Antibiotic Regulatory Protein Family, in Regulation of the Duplicated Type II Polyketide Synthase alp Gene Cluster in Streptomyces ambofaciens. Journal of Bacteriology, American Society for Microbiology, 2005, 187 (7), pp.2491 - 2500. ⟨10.1128/JB.187.7.2491–2500.2005⟩. ⟨hal-01659049⟩
  • Virginie Roth, Bertrand Aigle, Robert Bunet, Thomas Wenner, Céline Fourrier, et al.. Differential and Cross-Transcriptional Control of Duplicated Genes Encoding Alternative Sigma Factors in Streptomyces ambofaciens. Journal of Bacteriology, American Society for Microbiology, 2004, 186 (16), pp.5355 - 5365. ⟨10.1128/JB.186.16.5355–5365.2004⟩. ⟨hal-01659043⟩
  • Xiuhua Pang, Bertrand Aigle, Jean-Michel Girardet, Sophie Mangenot, Jean-Luc Pernodet, et al.. Functional Angucycline-Like Antibiotic Gene Cluster in the Terminal Inverted Repeats of the Streptomyces ambofaciens Linear Chromosome. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2004, 48 (2), pp.575 - 588. ⟨10.1128/AAC.48.2.575-588.2004⟩. ⟨hal-01659031⟩
  • Sibel Catakli, Axelle Andrieux, Pierre Leblond, Bernard Decaris, Annie Dary. Spontaneous chromosome circularization and amplification of a new amplifiable unit of DNA belonging to the terminal inverted repeats in Streptomyces ambofaciens ATCC 23877.. Archives of Microbiology, Springer Verlag, 2003, 179 (6), pp.387-93. ⟨10.1007/s00203-003-0534-7⟩. ⟨hal-01159934⟩
  • Thomas Wenner, Virginie Roth, Gilles Fischer, Céline Fourrier, Bertrand Aigle, et al.. End-to-end fusion of linear deleted chromosomes initiates a cycle of genome instability in Streptomyces ambofaciens. Molecular Microbiology, Wiley, 2003, 50 (2), pp.411-425. ⟨10.1046/j.1365-2958.2003.03698.x⟩. ⟨hal-01659028⟩
  • Thomas Wenner, Virginie Roth, Bernard Decaris, Pierre Leblond. Intragenomic and intraspecific polymorphism of the 16S–23S rDNA internally transcribed sequences of Streptomyces ambofaciens. Microbiology, Microbiology Society, 2002, 148 (3), pp.633-642. ⟨10.1099/00221287-148-3-633⟩. ⟨hal-01658777⟩
  • Annie Dary, Patricia Martin, Thomas Wenner, Bernard Decaris, Pierre Leblond. DNA rearrangements at the extremities of the Streptomyces ambofaciens linear chromosome: Evidence for developmental control. Biochimie, Elsevier, 2000, 82 (1), pp.29-34. ⟨10.1016/S0300-9084(00)00348-5⟩. ⟨hal-01659018⟩
  • C. Schauner, A. Dary, A. Lebrihi, Pierre Leblond, Bernard Decaris, et al.. Modulation of lipid metabolism and spiramycin biosynthesis in Streptomyces ambofaciens unstable mutants. Applied and Environmental Microbiology, American Society for Microbiology, 1999, 65 (6), pp.2730-2737. ⟨10.1128/AEM.65.6.2730-2737.1999⟩. ⟨hal-02693523⟩
  • Patricia Martin, Annie Dary, Axelle André, Gilles Fischer, Pierre Leblond, et al.. Intraclonal polymorphism in the bacterium Streptomyces ambofaciens ATCC23877: evidence for a high degree of heterogeneity of the wild type clones. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Elsevier, 1999, 430 (1), pp.75-85. ⟨10.1016/S0027-5107(99)00149-9⟩. ⟨hal-01659011⟩
  • Annie Dary, Patricia Martin, Thomas Wenner, Pierre Leblond, Bernard Decaris. Evolution of the linear chromosomal DNA in Streptomyces: is genomic variability developmentally modulated?. Research in Microbiology, Elsevier, 1999, 150 (7), pp.439-445. ⟨hal-01659000⟩
  • Catherine Schauner, Annie Dary, Ahmed Lebrihi, Pierre Leblond, Christine Delorme, et al.. Modulation of Lipid Metabolism and Spiramycin Biosynthesis in Streptomyces ambofaciens Unstable Mutants. Applied and Environmental Microbiology, American Society for Microbiology, 1999, 65 (6), pp.2730-2737. ⟨10.1128/AEM.65.6.2730-2737.1999⟩. ⟨hal-01658995⟩
  • Gilles Fischer, Anne-Catherine Holl, Jean Nicolas Volff, Dominique Vandewiele, Bernard Decaris, et al.. Replication of the linear chromosomal DNA from the centrally located oriC of Streptomyces ambofaciens revealed by PFGE gene dosage analysis. Research in Microbiology, Elsevier, 1998, 149 (3), pp.203-210. ⟨10.1016/S0923-2508(98)80080-6⟩. ⟨hal-01658988⟩
  • Gilles Fischer, Thomas Wenner, Bernard Decaris, Pierre Leblond. Chromosomal arm replacement generates a high level of intraspecific polymorphism in the terminal inverted repeats of the linear chromosomal DNA of Streptomyces ambofaciens. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1998, 7 (6), pp.14296-301. ⟨10.1073/pnas.95.24.14296⟩. ⟨hal-01625341⟩
  • Pierre Leblond, Bernard Decaris. Chromosome geometry and intraspecific genetic polymorphism in Gram-positive bacteria revealed by pulsed-field gel electrophoresis (minireview). Electrophoresis, Wiley-VCH Verlag, 1998, 19 (4), pp.582 - 588. ⟨10.1002/elps.1150190420⟩. ⟨hal-01658981⟩
  • B. Aigle, Anne Catherine Holl, Jaime F. Angulo, Pierre Leblond, Bernard Decaris. Characterization of two Streptomyces ambofaciens recA mutants: identification of the RecA protein by immunoblotting. FEMS Microbiology Letters, Wiley-Blackwell, 1997, 149, pp.181-7. ⟨10.1111/j.1574-6968.1997.tb10326.x⟩. ⟨hal-01658772⟩
  • Gilles Fischer, A Kyriacou, Bernard Decaris, Pierre Leblond. Genetic instabi|ity and its possible evolutionary implications on the chromosomal structure of Streptomyces. Biochimie, Elsevier, 1997, 79, pp.555 - 558. ⟨10.1016/S0300-9084(97)82003-2⟩. ⟨hal-01658975⟩
  • Franca Berger, Gilles Fischer, Adamantini Kyriacou, Bernard Decaris, Pierre Leblond. Mapping of the ribosomal operons on the linear chromosomal DNA of Streptomyces ambofaciens DSM40697. FEMS Microbiology Letters, Wiley-Blackwell, 1996, pp.167-73. ⟨10.1111/j.1574-6968.1996.tb08476.x⟩. ⟨hal-01658770⟩
  • F. Berger, G. Fischer, A. Kyriacou, Bernard Decaris, Pierre Leblond. Mapping of the ribosomal operons on the linear chromosomal DNA of Streptomyces ambofaciens DSM40697. FEMS Microbiology Letters, Wiley-Blackwell, 1996, pp.167-173. ⟨hal-02687566⟩
  • Pierre Leblond, Gilles Fischer, François-Xavier Francou, Franca Berger, Michel Guérineau, et al.. The unstable region of Streptomyces ambofaciens includes 210 kb terminal inverted repeats flanking the extremities of the linear chromosomal DNA. Molecular Microbiology, Wiley, 1996, pp.261-71. ⟨10.1046/j.1365-2958.1996.366894.x⟩. ⟨hal-01658762⟩
  • Pierre Leblond, G. Fischer, X. Francou, F. Berger, M. Guérineau, et al.. The unstable region of Streptomyces ambiofaciens includes 210 kb terminal inverted repeats flanking the extremities of the linear chromosomal DNA. Molecular Microbiology, Wiley, 1996, 19 (2), pp.261-271. ⟨hal-02697136⟩
  • Pierre Leblond, Bernard Decaris. New insights into the genetic instability of streptomyces. FEMS Microbiology Letters, Wiley-Blackwell, 1994, 123, pp.225-232. ⟨hal-02702659⟩
  • Pierre Leblond, Bernard Decaris. Streptomyces: l'instabilité est aux bouts du chromosome. Bulletin - Société Française de Microbiologie, Société Française de Microbiologie, 1994, 9 (2), n.p. ⟨hal-02702159⟩
  • Pierre Leblond, Bernard Decaris. New insights into the genetic instability of streptomyces. FEMS Microbiology Letters, Wiley-Blackwell, 1994, 123 (3), pp.225-32. ⟨hal-01658755⟩
  • Dominique Schneider, Bertrand Aigle, Pierre Leblond, Jean-Marc Simonet, Bernard Decaris. Analysis of genome instability in Streptomyces ambofaciens. Journal of general microbiology, Society for General Microbiology, (Journal Sales), 1993, 139 (11), pp.2559-2567. ⟨10.1099/00221287-139-11-2559⟩. ⟨hal-01658593⟩
  • Pierre Leblond, Matfihias Redenbach, John Cullum. Physical Map of the Streptomyces lividans 66 Genome and Comparison with That of the Related Strain Streptomyces coelicolor A3(2). Journal of Bacteriology, American Society for Microbiology, 1993, 175 (11), pp.3422 - 3429. ⟨hal-01659214⟩
  • R Redenbach, F Flett, P Piendl, I Glocker, R Rauland, et al.. The Streptomyces lividans 66 chromosome contains a 1 MB deletogenic region flanked by two amplifiable regions. Molecular and General Genetics MGG, Springer Verlag, 1993, 241 (3-4), pp.255-62. ⟨hal-01659218⟩
  • Pierre Leblond, Philippe Demuyter, Jean-Marc Simonet, Bernard Decaris. Genetic Instability and Associated Genome Plasticity in Streptomyces ambofaciens: Pulsed-Field Gel Electrophoresis Evidence for Large DNA Alterations in a Limited Genomic Region. Journal of Bacteriology, American Society for Microbiology, 1991, 173 (13), pp.4229 - 4233. ⟨hal-01658749⟩
  • Philippe Demuyter, Dominique Schneider, Pierre Leblond, Jean-Marc Simonet, Bernard Decaris. A chromosomal hotspot for multiple rearrangements associated with genetic instability of Streptomyces ambofaciens DSM 40697. Journal of general microbiology, Society for General Microbiology, (Journal Sales), 1991, 137 (3), pp.491 - 499. ⟨10.1099/00221287-137-3-491⟩. ⟨hal-01658584⟩
  • P. Leblond, P. Demuyter, J. M. Simonet, B. Decaris. Genetic instability and hypervariability in Streptomyces ambofaciens: towards an understanding of a mechanism of genome plasticity. Molecular Microbiology, Wiley, 1990, 4 (5), pp.707 - 714. ⟨10.1111/j.1365-2958.1990.tb00641.x⟩. ⟨hal-01658674⟩
  • Pierre Leblond, F X Francou, J M Simonet, B Decaris. Pulsed-field gel electrophoresis analysis of the genome of Streptomyces ambofaciens strains. FEMS Microbiology Letters, Wiley-Blackwell, 1990, pp.79-88. ⟨hal-01658692⟩
  • Pierre Leblond, Philippe Demuyter, Laurence Moutier, Mohamed Laakel, Bernard Decaris, et al.. Hypervariability, a New Phenomenon of Genetic Instability, Related to DNA Amplification in Streptomyces ambofaciens . Journal of Bacteriology, American Society for Microbiology, 1989, 171 (1), pp.419-423. ⟨10.1128/jb.171.1.419-423.1989⟩. ⟨hal-01658652⟩
  • P. Demuyter, P. Leblond, B. Decaris, J.-M. Simonet. Characterization of Two Families of Spontaneously Amplifiable Units of DNA in Streptomyces ambofaciens. Microbiology, Microbiology Society, 1988, 134 (7), pp.2001 - 2007. ⟨10.1099/00221287-134-7-2001⟩. ⟨hal-01658578⟩

Book sections8 documents

  • Annabelle Thibessard, Claire Bertrand, Edward J Bartlett, Aidan J Doherty, Claude Bruand, et al.. Nonhomologous End-Joining in Bacteria. Joseph Jez. Encyclopedia of Biological Chemistry 3rd Edition,, 4, Elsevier, 2021, 9780128194607. ⟨hal-03319644⟩
  • Sébastien Wielgoss, Pierre Leblond, Catherine Masson-Boivin, Philippe Normand. Evolution Underway in Prokaryotes. Sébastien Wielgoss; Pierre Leblond; Catherine Masson-Boivin; Philippe Normand. Prokaryotes and Evolution, Springer International Publishing, pp.339-391, 2019, 978-3-319-99784-1. ⟨10.1007/978-3-319-99784-1_6⟩. ⟨hal-02477674⟩
  • Annabelle Thibessard, Pierre Leblond. Subtelomere Plasticity in the Bacterium Streptomyces. Edward J Louis, Marion M Becker. Subtelomeres, Springer Berlin Heidelberg, pp.243-258, 2013, 978-3-642-41565-4. ⟨10.1007/978-3-642-41566-1_14⟩. ⟨hal-01478830⟩
  • Jean-Francois Mari, Florence Le Ber, El-Ghali Lazrak, Marc Benoît, Catherine Eng, et al.. Using Markov Models to Mine Temporal and Spatial Data. Kimito Funatsu and Kiyoshi Hasegawa. New Fundamental Technologies in Data Mining, Intech, pp.561--584, 2011, 978-953-307-547-1. ⟨inria-00566801⟩
  • Bertrand Aigle, Robert Bunet, Christophe Corre, Amélie Garenaux, S. Huang, et al.. Genome-guided Exploration of Streptomyces ambofaciens Secondary Metabolism. Paul J Dyson Institute of Life Sciences, School of Medicine, Swansea, UK. Streptomyces: Molecular Biology and Biotechnology, Caister Academic Press, Chapter 10 pp. 179-194, 2011, 978-1-904455-77-6. ⟨hal-01667184⟩
  • Sébastien Hergalant, Bertrand Aigle, Pierre Leblond, Jean-François Mari. Fouille de données du génome à l'aide de modèles de Markov cachés. Extraction et gestion des connaissances. EGC 2005, Cépaduès, 2005, Revue des Nouvelles Technologies de l'Information, 2-85428-677-4 2-85428-682-0 (vol. 1) 2-85428-683-9 (vol. 2). ⟨hal-02832934⟩
  • Pierre Leblond. PFGE: électrophorèse en champs pulsés (pulse field electrophoresis) . INRA. Principes des techniques de biologie moléculaire, INRA Editions, pp.152-153, 2004, 9782738010674. ⟨hal-01659763⟩
  • Pierre Leblond, Bernard Decaris. Unstable Linear Chromosomes: the Case of Streptomyces . Robert L Charlebois. Organization of the prokaryotic genome, ASM Press, pp.235-262, 1999, 1-55581-151-5. ⟨hal-01659748⟩

Patents2 documents

  • Cyril Bontemps, Maxime Toussaint, Pierre Leblond. Biosenseur bactérien de la dégradation du bois. France, N° de brevet: WO2016131665. 2016. ⟨hal-01655306⟩
  • Bertrand Aigle, Gregory L Challis, Luisa Laureti, Lijiang Song, Pierre Leblond. Stambomycin and derivatives: their production and their use as drugs. France, Patent n° : WO2011009938. 2011. ⟨hal-01655316⟩

Other publications2 documents

  • Pierre Leblond. Ne me cassez pas les chromosomes !. 2018. ⟨hal-01889237⟩
  • Pierre Leblond, Nathalie N. Leblond-Bourget, Sophie Payot, Bertrand Aigle. La folle course aux armements des bactéries contre les antibiotiques. 2018. ⟨hal-01889239⟩

Conference papers32 documents

  • Caroline Choufa, Anthony Gauthier, Manar Harb, Vos Michiel, Cyril Bontemps, et al.. Diversity and mobility of conjugative elements in a population of Streptomyces isolated from a rhizospheric micro-habitat.. Journées des Actinobactéries 2020 - ACTINO 2020, Dec 2020, Conférence virtuelle Gif Sur Yvette, France. ⟨hal-03060874⟩
  • Pierre Leblond. Gene flux and chromosomal recombination as key drivers of adaptability and population functioning of Streptomyces. Actino 2020 Journées des actinobactéries (en ligne), Dec 2020, Paris, France. ⟨hal-03059295⟩
  • Jean-Noël Lorenzi, Olivier Lespinet, Pierre Leblond, Annabelle Thibessard. Genome dynamics of the Streptomyces genus. ACTINO 2020 - Journées des actinobactéries, Dec 2020, Gif-sur-Yvette, France. ⟨hal-03060006⟩
  • Abdoul-Razak Tidjani, Jean-Noël Lorenzi, Olivier Lespinet, Cyril Bontemps, Pierre Leblond. Massive gene fluxes in bacterial population fuels adaptation to soil forest ecosystem. Functional Ecology Conference Nancy 2018, Dec 2018, Nancy, France. ⟨hal-02306656⟩
  • Matthieu Nicault, Cyril Bontemps, Éric Gelhaye, Pierre Leblond. Decipher and exploit interactions between bacteria and fungi to identify new bioactive metabolites. Séminaire LUE Impact/Biomolécules du futur : de la découverte aux applications, May 2018, Nancy, France. ⟨hal-03216629⟩
  • Jodelle Degois, Frédéric Clerc, Simon Xavier, Cyril Bontemps, Pierre Leblond, et al.. Suivi sur une année de la biodiversité microbienne dans les bioaerosols émis dans un centre de tri des déchets. Congrès français sur les aérosols 2018 (CFA), Jan 2018, Paris, France. ⟨hal-01582590⟩
  • J Degois, X. Simon, C Bontemps, Pierre Leblond, P Duquenne. Generation of a fungal consortium: impact of analytic tools on biodiversity analysis. European Aerosol Conference EAC 2017, Aug 2017, Zurich, Switzerland. ⟨hal-01657801⟩
  • Grégory Hoff, Claire Bertrand, Emilie Piotrowski, Stephen T Mcgovern, François Lecointe, et al.. Double strand break repair triggers genome plasticity in Streptomyces. International Symposium on the Biology of Actinomycetes, May 2017, Jeju, South Korea. ⟨hal-01655226⟩
  • Drago Haas, Matthieu Barba, Cláudia M Vincente, Géraldine Le Goff, Jamal Ouazzani, et al.. Searching For Specialized Metabolites Gene Clusters By Mining Genomic Islands: A New Comparative Genomics-Based Approach. International Symposium on the Biology of Actinomycetes, May 2017, Jeju, South Korea. ⟨hal-01655211⟩
  • Grégory Hoff, Claire Bertrand, Emilie Piotrowski, Annabelle Thibessard, Pierre Leblond. Double strand break repair triggers genome plasticity in Streptomyces. Prokagenomics 2017 7th European Conference on Prokaryotic and Fungal Genomics, Sep 2017, Göttingen, Germany. ⟨hal-01655261⟩
  • Abdoul-Razak Tidjani, Maxime Toussaint, Jean-Noël Lorenzi, Laurence Hotel, Olivier Lespinet, et al.. Evolution génomique au sein d'une population naturelle de Streptomyces. Actino2017 Journées des Actinobactéries, Oct 2017, Lyon, France. ⟨hal-01655238⟩
  • Grégory Hoff, Claire Bertrand, Emilie Piotrowski, Annabelle Thibessard, Pierre Leblond. Double strand break repair triggers genome plasticity in Streptomyces. Actino2017 Journées des Actinobactéries, Oct 2017, Lyon, France. ⟨hal-01655543⟩
  • J Degois, F. Clerc, X. Simon, C Bontemps, Pierre Leblond, et al.. One year follow up of microbial biodiversity in French waste sorting plant. 9th International Symposium on Modern Principles of Air Monitoring and Biomonitoring (AIRMON 2017), Jun 2017, Dresden, Germany. ⟨hal-01657806⟩
  • Maxime Toussaint, Abdoul-Razak Tidjani, Jean-Noël Lorenzi, Laurence Hotel, Olivier Lespinet, et al.. Micro-time scale genome evolution among natural populations of Streptomyces. International Symposium of the Biology of Actinomycetes, May 2017, Jeju, South Korea. ⟨hal-01625360⟩
  • J Degois, F. Clerc, X. Simon, C Bontemps, Pierre Leblond, et al.. Bioaerosol biodiversity in waste sorting plant: feasibility and uncertainty measurement. European Aerosol Conference EAC 2016, Sep 2016, Tours, France. ⟨hal-01657790⟩
  • Drago Haas, Matthieu Barba, Cláudia M Vicente, Amélie Garenaux, Sárka Nezbedová, et al.. Mining genomic islands with Synteruptor, a new strategy for identifying secondary metabolism gene clusters. The 13th International Symposium on the Genetics of Industrial Microorganisms, Oct 2016, Wuhan, China. ⟨hal-03042549⟩
  • Stephane Uroz, Marie-Pierre M.-P. Turpault, Océane Nicolitch, yannick Colin, Marc Buée, et al.. Impact of nutrient availability on the diversity, function and functioning of the forest soil bacterial communities: insights from the soil succession of the forest experimental site of Montiers.. Labex ARBRE conference, Oct 2016, Champenoux, France. ⟨hal-03339707⟩
  • Cyril Bontemps, Laurence Hotel, Pierre-Vincent Revol, Mathilde Jeanbille, Stéphane Uroz, et al.. Taxonomic and functional diversity of Streptomyces in a forest soil. Journées Actinomycètes, 2012, Nancy, France. ⟨hal-01269133⟩
  • Nicolas Carraro, Virginie Libante, Morel Catherine, Bernard Decaris, Florence Charron-Bourgoin, et al.. Regulation of Streptococcus thermophilus genomic islands. FEMS 2011, Jun 2011, Geneva, Switzerland. ⟨hal-01909338⟩
  • Nicolas Carraro, Virginie Libante, Morel Catherine, Decaris Bernard, Florence Charron-Bourgoin, et al.. Etude de la régulation d'ICESt1 et ICESt3, deux éléments intégratifs conjugatifs de Streptococcus thermophilus. GDR 2157 - Evolution des éléments transposables : des génomes aux populations, Dec 2010, Paris, France. ⟨hal-01909335⟩
  • Nicolas Carraro, Morel Catherine, Bernard Decaris, Pierre Leblond, Gérard Guédon, et al.. Etude de la régulation d'ICESt1 et ICESt3, deux éléments intégratifs conjugatifs de Streptococcus thermophilus. 17éme colloque du Club des Bactéries Lactiques, Oct 2010, Nancy, France. ⟨hal-01909351⟩
  • Catherine Eng, Annabelle Thibessard, Sébastien Hergalant, Jean-François Mari, Pierre Leblond. Data Mining Using Hidden Markov Models (HMM2) to Detect Heterogeneities into Bacteria Genomes. Journées Ouvertes Biologie, Informatique et Mathématiques - JOBIM 2005, JOBIM, Jul 2005, Lyon/France, France. ⟨inria-00000142⟩
  • Sébastien Hergalant, Bertrand Aigle, Pierre Leblond, Jean-François Mari. Fouille de données du génome à l'aide de modèles de Markov cachés. Extraction et Gestion de Connaissances - EGC 2005, Jan 2005, Paris/France, France. pp.141 -- 148. ⟨inria-00001213⟩
  • Fabrice Touzain, Sophie Schbath, Isabelle Debled-Rennesson, Bertrand Aigle, Pierre Leblond, et al.. SIGffRid : Programme de recherche des sites de fixation des facteurs de transcription par approche comparative. Journées Ouvertes Biologie Informatique Mathématiques - JOBIM'05, Guy Perrière, Alain Guénoche et Christophe Geourjon, Jul 2005, Lyon, France. pp.417-425. ⟨inria-00000191⟩
  • Sébastien Hergalant, Bertrand Aigle, Bernard Decaris, Jean-François Mari, Pierre Leblond. Classification non supervisée par HMM de sites de fixation de facteurs de transcription chez les bactéries. 5èmes Journées Ouvertes : Biologie, Informatique et Mathématiques - JOBIM'04, 2004, Montréal, Canada, 1 p. ⟨inria-00107788⟩
  • Sébastien Hergalant, Bertrand Aigle, Bernard Decaris, Jean-François Mari, Pierre Leblond. HMM, an Efficient Way to Detect Transcriptional Promoters in Bacterial Genomes?. European Conference on Computational Biology - ECCB'2003, Sep 2003, Paris, France, pp.417--419. ⟨inria-00099570⟩
  • Patricia Lavigne, Isabelle Debled-Rennesson, Bertrand Aigle, Pierre Leblond, Gregory Kucherov. Identification of transcription factor binding sites in the genome of Streptomyces coelicolor A3(2). 3ème Journées Post-Génomique de la DOUA 2003 - JPGD'03, 2003, Lyon, France. ⟨inria-00099609⟩
  • Fabrice Touzain, Patricia Lavigne, Isabelle Debled-Rennesson, Bertrand Aigle, Pierre Leblond, et al.. Identification of Transcription Factor Binding Sites in Streptomyces coelicolor A3(2) by Phylogenetic Comparison. European Conference for Computer Biology - ECCB'2003, 2003, Paris, France. ⟨inria-00099608⟩
  • Sébastien Hergalant, Bertrand Aigle, Bernard Decaris, Pierre Leblond, Jean-François Mari. Intragenomic reiterations detection using hidden Markov models. 10th International Conference on Intelligent Systems for Molecular Biology - ISMB 2002, Aug 2002, Edmonton, Canada, 1 p. ⟨inria-00100914⟩
  • Sébastien Hergalant, Bertrand Aigle, Bernard Decaris, Pierre Leblond, Jean-François Mari. Fouille de données à l'aide de HMM : Application à la détection de réitérations intragénomiques. Journées Ouvertes Biologie Informatique Mathématiques - JOBIM'02, François Coste - Elisabeth Lebret, 2002, Saint Malo, France, pp.269-273. ⟨inria-00100752⟩
  • Sibel Catakli, Axelle André, Pierre Leblond, Bernard Decaris, Annie Dary. Identification d’une nouvelle séquence amplifiable localisée aux extrémités du chromosome de Streptomyces ambofaciens ATCC23877. 4ème colloque des 3R : Réplication, Recombinaison et Réparation, Jul 2001, Gif-sur-Yvette, France. ⟨hal-01161664⟩
  • Sibel Catakli, Axelle André, Pierre Leblond, Bernard Decaris, Annie Dary. Identification of a new amplifiable unit of DNA located in the Terminal Inverted repeats of the chromosomal DNA of Streptomyces ambofaciens ATCC23877. 12th International Symposium on the Biology of Actinomycetes (ISBA), Aug 2001, Vancouver, Canada. ⟨hal-01161665⟩

Poster communications10 documents

  • Abdoul-Razak Tidjani, Jean-Noël Lorenzi, Olivier Lespinet, Cyril Bontemps, Pierre Leblond. Massive gene flux in bacterial population fuels adaptation to forest soil ecosystem. 15ème congrès de la Société Française de Microbiologie, Sep 2019, Paris 19ème, France. 2019. ⟨hal-02314235⟩
  • Matthieu Nicault, Cyril Bontemps, Éric Gelhaye, P. Leblond. Activation of cryptic biosynthetic pathways by bacterial/fungal co-cultures. Biomolecules: Research & Development, Markets and Acceptability - LUE Impact Biomolecule seminar, Oct 2019, Palma de Mallorca, Spain. ⟨hal-03216601⟩
  • Caroline Choufa, Abdoul-Razak Tidjani, Claire Veneault-Fourrey, Vos Michiel, Cyril Bontemps, et al.. Interplay between lateral gene transfer and rhizosphere functioning. Functional ecology conference 2018, Dec 2018, Nancy, France. ⟨hal-03060574⟩
  • Matthieu Nicault, Cyril Bontemps, Éric Gelhaye, Pierre Leblond. Deciphering and exploiting bacteria-fungi dialogues to identify new bioactive metabolites. 12èmes Rencontres de Phytopathologie - Mycologie de la Société Française de Phytopathologie, Jan 2018, Aussois, France. ⟨hal-03216613⟩
  • Matthieu Nicault, Cyril Bontemps, Éric Gelhaye, Pierre Leblond. Bacteria/fungi Interactions (BFI): a way to awake secondary metabolite gene clusters. Lorraine Université d'Excellence (LUE) Séminaire Impact Biomolécules, May 2018, Nancy, France. ⟨hal-03216622⟩
  • Cláudia M Vicente, Matthieu Barba, Drago Haas, Sylvie Lautru, Olivier Lespinet, et al.. Searching for novel specialized metabolite gene clusters, a new comparative genomics-based approach. Directing Biosynthesis V, Mar 2017, Warwick, United Kingdom. ⟨hal-03042555⟩
  • Nicolas Carraro, Rossi Emmanuel, Antoine Persoons, Morel Catherine, Pierre Leblond, et al.. Dynamics and maintenance of ICEs from Streptococcus thermophilus. FEMS 2011, Jun 2011, Geneva, Switzerland. ⟨hal-01909343⟩
  • Nicolas Carraro, Morel Catherine, Bernard Decaris, Pierre Leblond, Gérard Guédon, et al.. Etude de la régulation du transfert d'éléments intégratifs conjugatifs chez Streptococcus thermophilus. 16éme colloque du Club des Bactéries Lactiques, May 2009, Toulouse, France. ⟨hal-01909347⟩
  • Catherine Eng, Annabelle Thibessard, Sébastien Hergalant, Jean-François Mari, Pierre Leblond. Data Mining Using Hidden Markov Models (HMM2) to Detect Heterogeneities into Bacteria Genomes. 6. Journées Ouvertes Biologie, Informatique et Mathématiques - JOBIM, Jul 2005, Lyon, France. 1 p., 2005. ⟨hal-02833554⟩
  • Frédéric Choulet, Bertrand Aigle, F. X. Francou, Alexandre Gallois, Céline Fourrier, et al.. Evidence for a High Heterogeneity Between the Terminal Regions of the Chromosomes of Two Phylogenetically Close Species, Streptomyces ambofaciens and Streptomyces coelicolor by Genome Comparison. Streptomyces dissemination meeting, Jul 2003, Guilford, United Kingdom. 2003, Streptomyces dissemination meeting. ⟨hal-01182814⟩